RESUMEN
We found previously that immunizing cyclophosphamide-treated mice with one Paramyxoviridae virus mixed with dimethyl dioctadecyl ammonium bromide induces T cells which apparently also recognize other Paramyxoviridae viruses. This finding and the fact that respiratory syncytial virus (RSV) and parainfluenza viruses (PIVs) infect children early in life led us to ask if prior RSV or PIV infections influence the antibody response to measles and mumps vaccine viruses. Detection of virus-specific IgG in serum specimens collected randomly or at defined times after measles/mumps/rubella (MMR) vaccination was done with solid-phase enzyme immunoassays. The antibody-binding data obtained were converted to serum antibody titers by an immunoassay curve-fitting computer program. Prior infection by RSV and PIVs correlated with an augmented IgG response not only to measles and mumps virus, but also to rubella virus. Furthermore, the augmentation was greater for responders below the median response. These data show that common early childhood viral infections can influence immunity induced by the MMR vaccine.
Asunto(s)
Anticuerpos Antivirales/biosíntesis , Inmunoglobulina G/biosíntesis , Vacuna Antisarampión/farmacología , Vacuna contra la Parotiditis/farmacología , Infecciones por Paramyxoviridae/inmunología , Infecciones por Virus Sincitial Respiratorio/inmunología , Vacuna contra la Rubéola/farmacología , Anticuerpos Antivirales/sangre , Especificidad de Anticuerpos , Preescolar , Herpesvirus Humano 1/inmunología , Humanos , Técnicas para Inmunoenzimas , Lactante , Vacuna Antisarampión/sangre , Vacuna contra el Sarampión-Parotiditis-Rubéola , Vacuna contra la Parotiditis/sangre , Reproducibilidad de los Resultados , Infecciones por Virus Sincitial Respiratorio/sangre , Virus Sincitiales Respiratorios/inmunología , Respirovirus/inmunología , Vacuna contra la Rubéola/sangre , Vacunas Combinadas/sangre , Vacunas Combinadas/farmacologíaAsunto(s)
Inmunoglobulinas Intravenosas/sangre , Vacuna Antisarampión/farmacocinética , Vacuna contra la Parotiditis/farmacocinética , Vacuna contra la Rubéola/farmacocinética , Formación de Anticuerpos , Niño , Esquema de Medicación , Combinación de Medicamentos , Interacciones Farmacológicas , Humanos , Inmunoglobulinas Intravenosas/administración & dosificación , Vacuna Antisarampión/sangre , Vacuna contra el Sarampión-Parotiditis-Rubéola , Vacuna contra la Parotiditis/sangre , Vacuna contra la Rubéola/sangreRESUMEN
Four hundred and twenty children were randomly assigned to receive either mumps measles rubella (MMR) vaccine (207) or measles vaccine (213) in a single blind study, to investigate the reactogenicity and serology of the MMR vaccine. There was no significant difference between the number of children developing symptoms after MMR vaccination to those developing symptoms after measles vaccination. Both vaccines are associated with a rash, temperature and restlessness five to thirteen days after vaccination. The serological response to measles vaccine was similar in both groups with 92-6% seroconverting with MMR, and 96-8% with measles. Seroconvertion against mumps and rubella with the MMR vaccine was 88% and 96% respectively. This study confirms the safety and efficacy of the MMR vaccine in a UK population.