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5.
Ann Pharmacother ; 35(7-8): 881-4, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11485139

RESUMEN

OBJECTIVE: To report five cases of ingrown toenails (IGTN) associated with indinavir/ritonavir (IDV/RTV) combination therapy. CASE SUMMARY: The median onset of IGTN from initiation of IDV/RTV therapy was 18.4 weeks. Four patients previously received IDV, with one of these experiencing prior IGTN. All patients required surgical management of IGTN. All patients received virologic benefit from ongoing antiretroviral therapy, and the majority of patients elected to maintain IDV/RTV combination therapy. Two patients experienced recurrent IGTN while receiving ongoing IDV/RTV combination therapy. DISCUSSION: IGTN and paronychia have previously been reported with IDV and lamivudine. IGTN in patients with HIV infection is more likely to present acutely, involve more digits, and require surgical management IDV increases retinoic acid signaling and, based on elevated IDV concentrations from concomitant RTV therapy, the risk of IGTN may be increased in patients receiving IDV/RTV combination therapy. CONCLUSIONS: With the increasing popularity of IDV/RTV combination therapy, clinicians should be aware of the potential increase in frequency of dose-related toxicities including IGTN. Evaluation of hands and feet on physical examination should be recommended for all patients being treated with lamivudine and IDV, especially when used in combination with RTV.


Asunto(s)
Inhibidores de la Proteasa del VIH/efectos adversos , Indinavir/efectos adversos , Uñas Encarnadas/inducido químicamente , Ritonavir/efectos adversos , Adulto , Relación Dosis-Respuesta a Droga , Quimioterapia Combinada , Femenino , Humanos , Masculino , Persona de Mediana Edad , Uñas Encarnadas/cirugía , Estudios Prospectivos , Recurrencia
6.
Cutis ; 66(3): 211-2, 2000 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-11006857

RESUMEN

The authors report an unusual case of multiple onychocryptosis, which developed following treatment of onychomycosis with oral terbinafine. With new growth of the healthy nail plate, the distal aspect of multiple toenails became ingrown with periungual inflammation. This required several minor surgical procedures to alleviate the onychocryptosis. The authors present this case report as a potential complication of oral antifungal therapy.


Asunto(s)
Antifúngicos/efectos adversos , Dermatosis del Pie/tratamiento farmacológico , Uñas Encarnadas/inducido químicamente , Naftalenos/efectos adversos , Onicomicosis/tratamiento farmacológico , Administración Oral , Antifúngicos/administración & dosificación , Humanos , Masculino , Persona de Mediana Edad , Naftalenos/administración & dosificación , Terbinafina
8.
Haemophilia ; 6(3): 191-4, 2000 May.
Artículo en Inglés | MEDLINE | ID: mdl-10792478
9.
Cutis ; 64(4): 277-8, 1999 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-10544885

RESUMEN

Lamivudine and indinavir are two medications used to treat human immunodeficiency virus (HIV) that have recently been reported to cause paronychia. The nails of the great toes are commonly affected. This is the second report of paronychia and ingrown toenails due to indinavir and the first report of recurrent paronychia and ingrown toenails associated with this drug.


Asunto(s)
Infecciones por VIH/tratamiento farmacológico , Inhibidores de la Proteasa del VIH/efectos adversos , VIH-1/aislamiento & purificación , Indinavir/efectos adversos , Uñas Encarnadas/inducido químicamente , Paroniquia/inducido químicamente , Adulto , Inhibidores de la Proteasa del VIH/uso terapéutico , Humanos , Indinavir/uso terapéutico , Masculino , Uñas Encarnadas/fisiopatología , Paroniquia/fisiopatología , Recurrencia , Dedos del Pie
11.
J Am Podiatr Med Assoc ; 89(8): 424-6, 1999 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-10466297

RESUMEN

With the advent of effective oral therapies for onychomycosis, there have been anecdotal reports of an increased incidence of onychocryptosis associated with the use of these new agents. The authors undertook a chart review of 100 consecutive patients treated for onychomycosis in a private medical practice to determine the incidence of onychocryptosis. A total of 37 of these patients (37%) developed paronychia ranging from simple pain to a severe inflammatory response with redness, drainage, and granuloma formation. Of these, 19 patients (19%) required surgical procedures to control onychocryptotic symptoms. Podiatric physicians should be aware that ingrown toenails may be an adverse consequence of effective treatment for onychomycosis.


Asunto(s)
Antifúngicos/efectos adversos , Uñas Encarnadas/inducido químicamente , Onicomicosis/tratamiento farmacológico , Administración Oral , Adulto , Antifúngicos/uso terapéutico , Femenino , Humanos , Persona de Mediana Edad , Uñas Encarnadas/complicaciones
12.
Body Posit ; 12(10): 12, 1999 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-11366875

RESUMEN

AIDS: A French study confirms recent reports of hair loss in men as a side effect of the protease inhibitor Crixivan (Indinavir). All ten men in the study experienced various types of hair loss, which grew back several months after switching to another protease inhibitor or NNRTI. Ingrown toenails are another side effect recorded by a different French study, corroborating reports from patients taking Crixivan. Patients on Crixivan, experiencing these symptoms, should discuss them with their doctor.^ieng


Asunto(s)
Alopecia/inducido químicamente , Inhibidores de la Proteasa del VIH/efectos adversos , Indinavir/efectos adversos , Uñas Encarnadas/inducido químicamente , Infecciones por VIH/tratamiento farmacológico , Inhibidores de la Proteasa del VIH/uso terapéutico , Humanos , Indinavir/uso terapéutico , Masculino , Dedos del Pie
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