RESUMEN
Mycobacterium avium infection was diagnosed in an adult cat showing acute lameness of the right hind limb, enlargement of the right popliteal lymph node and two cutaneous nodular lesions of the right chest wall. Conventional radiography of the proximal tibia showed a proliferative osteolytic lesion. Cytological examination of the right popliteal lymph node and the nodular skin lesions fine needle aspiration smears, demonstrated granulomatous inflammation with many negative staining bacilli within macrophages or in smears background. The diagnosis was confirmed by ZiehlNeelsen staining of the smears and the identification of mycobacteria was performed by microbiological and molecular methods. Histopathology performed after the necropsy revealed disseminated mycobacteriosis with granulomatous mesenteric lymphadenitis, granulomatous pneumonia, hepatitis and tibial osteomyelitis. M. avium is a wellknown agent of gastroenteric, respiratory or disseminated disease in immunocompromised cats but there are few cases reported in literature of bone involvement in systemic mycobacteriosis.
Asunto(s)
Cojera Animal/diagnóstico , Mycobacterium avium/aislamiento & purificación , Tuberculosis Aviar/complicaciones , Animales , Enfermedades de los Gatos , Gatos , Resultado Fatal , Cojera Animal/microbiología , Masculino , Tuberculosis Aviar/diagnóstico , Tuberculosis Aviar/diagnóstico por imagenRESUMEN
BACKGROUND: Small-cell lung cancer (SCLC) rarely coexists with pulmonary Mycobacterium avium intracellular complex (MAC) infection. The key drug for SCLC treatment is etoposide, which is metabolized by cytochrome P-450 (CYP) 3A4. Meanwhile, the key drugs for pulmonary MAC infection are clarithromycin (CAM) and rifampicin (RFP), and their metabolism influences CYP3A4. Therefore, treatment of concurrent SCLC and pulmonary MAC infection is difficult, and to the best of our knowledge, no report of treatments for concurrent SCLC and pulmonary MAC infection has been published. Patient Concerns and Diagnoses: A 65-year-old man presented to our hospital with abnormal findings of chest computed tomography: (1) a hilar region nodule in the left lung and mediastinal lymphadenopathy and (2) a thick-walled cavity lesion in the right upper lobe of the lung. After further examinations, the former lesions were diagnosed as SCLC, cT4N3M0, stage IIIC and the latter as pulmonary MAC infection, fibrocavitary disease. INTERVENTIONS AND OUTCOMES: Concurrent treatment was conducted with discontinuation of CAM and RFP before and after etoposide administration. Specifically, intravenous cisplatin and etoposide were administered on day 1 and days 1-3, respectively, and CAM, RFP, and ethambutol (EB) were administered orally on days 6-22 every 4 weeks. Concurrent radiotherapy was added to the drug administration on days 1-27 of the first cycle. The chemotherapy was continued for 4 cycles, followed by continuation of CAM and RFP administration. EB was discontinued because of optic nerve disorder. The treatments were conducted completely and safely, and both of the SCLC lesions and the MAC lesion were improved. CONCLUSIONS: Treatments for concurrent SCLC and pulmonary MAC infection may be successfully conducted with discontinuation of CAM and RFP before and after etoposide administration.
Asunto(s)
Neoplasias Pulmonares/patología , Mycobacterium avium/aislamiento & purificación , Carcinoma Pulmonar de Células Pequeñas/patología , Tuberculosis Aviar/diagnóstico , Anciano , Animales , Antibacterianos/uso terapéutico , Antineoplásicos Fitogénicos/uso terapéutico , Broncoscopía , Claritromicina/uso terapéutico , Quimioterapia Combinada , Etopósido/uso terapéutico , Humanos , Pulmón/diagnóstico por imagen , Neoplasias Pulmonares/complicaciones , Neoplasias Pulmonares/terapia , Masculino , Fragmentos de Péptidos/sangre , Proteínas Recombinantes/sangre , Rifampin/uso terapéutico , Carcinoma Pulmonar de Células Pequeñas/complicaciones , Carcinoma Pulmonar de Células Pequeñas/terapia , Tomografía Computarizada por Rayos X , Tuberculosis Aviar/complicaciones , Tuberculosis Aviar/tratamiento farmacológico , Tuberculosis Aviar/microbiologíaRESUMEN
A pair of capercaillies (Tetrao urogallus) were newly introduced from Austria into a museum in Japan, and the female bird died on the way to the museum. Autopsy revealed cardiac tamponade filled with a large quantity of blood coagulum in the pericardial cavity and cardiac rupture along the apex around 1.5 cm in length. Microscopically, myocardial necrosis associated with cellular infiltration was observed. The results indicated that the bird suffered from cardiac rupture on the way to the museum. Myocardial infarction was considered to be a predisposing factor for the incident.
Asunto(s)
Rotura Cardíaca/etiología , Tuberculosis Aviar/complicaciones , Animales , Aves , Resultado Fatal , Femenino , Mycobacterium avium , Tuberculosis Aviar/patologíaRESUMEN
Chickens from lines selectively bred for either a high-antibody (HA) or low-antibody (LA) response to sheep erythrocytes were injected intravenously with Mycobacterium avium while being held in low, medium, or high levels of social stress for 5 days (first environment). During the remaining 6 weeks, they were held under either low or medium levels of social stress (second environment). Infection led to lesions consisting of granulomas, some of which had necrotic centers. There was a positive correlation between numbers of lesions with necrotic centers and M. avium cells recovered from livers. The numbers and nature of lesions were influenced by both genetic and environmental factors. Numbers of necrotizing lesions increased with stressfulness of the first environment. Total numbers of lesions were reduced by the medium-stress second environment, and the total number of necrotizing lesions was reduced among LA chickens in the low-stress second environment.