RESUMEN

226Ra is a natural radioelement emitting α and γ radiations. It can be highly concentrated in TENORM materials from the petroleum or fertilizer industries. In Switzerland, 226Ra is currently a radioactive inheritance problem from the watch industry. Furthermore, 223Ra is a radium isotope used in nuclear medicine to treat bone metastasis. There exist several methods to measure radium using alpha or gamma spectrometry or using 222Rn emanation technique. The limitations of these methods are due to the required detection limits and the nature of the samples. When using alpha spectrometry to reach very low detection limits, critical technical hitches often arise because of the difficulties in separating radium from barium, in removing organics eluted from the separating chromatography column, and in plating radium. Moreover, overall chemical recovery of radium is often not reproducible, depending on the studies. Here we propose a method that separates radium from other alkaline-earth cations using cation exchange chromatography and selective complex formation by EDTA and DCTA. Radium is completely free of the 229Th tracer and its daughter products, particularly 225Ac. Organics from the column are removed in a further purification step so that radium can be plated with acceptable yields in a HCl/HNO3/ethanol solution. We successfully applied the method to soil, water, urine and human bone samples and further extended it to the determination of 223Ra in a bone biopsy, using 226Ra as an internal tracer.

Asunto(s)

Partículas alfa , Huesos/química , Radio (Elemento)/análisis , Conteo por Cintilación , Huesos/metabolismo , Huesos/patología , Rayos gamma , Humanos , Radio (Elemento)/sangre , Radio (Elemento)/orina , Suelo/química , Torio/análisis , Torio/sangre , Torio/orina , Contaminantes Radiactivos del Agua/análisis

RESUMEN

The implementation of the one-pass-through separation technique using two stacked chromatography columns of TEVA - TRU resins for the separation of 237Np, 241Am, thorium, plutonium and uranium from environmental and urine samples was investigated. The sequential separation technique proved to be successful and gave similar results to those obtained when using individual separations. The analysis time was considerably improved. The amount of chemical waste was also reduced by 50% and the use of HClO4 was avoided. The technique of ICP-MS was also investigated as a complementary technique to alpha-spectrometry.

Asunto(s)

Americio/análisis , Neptunio/análisis , Plutonio/análisis , Contaminantes Radiactivos/análisis , Torio/análisis , Uranio/análisis , Partículas alfa , Americio/aislamiento & purificación , Americio/orina , Cromatografía Liquida/métodos , Humanos , Espectrometría de Masas/métodos , Neptunio/aislamiento & purificación , Neptunio/orina , Plutonio/aislamiento & purificación , Plutonio/orina , Contaminantes Radiactivos/aislamiento & purificación , Contaminantes Radiactivos/orina , Análisis Espectral/métodos , Torio/aislamiento & purificación , Torio/orina , Uranio/aislamiento & purificación , Uranio/orina

RESUMEN

Two essential technical requirements of ISO 17025 guide for accreditation of testing and calibration laboratories are the validation of methods and the estimation of all sources of uncertainty that may affect the analytical result. Bioelimination Laboratory from Radiation Dosimetry Service of CIEMAT (Spain) uses alpha spectrometry to quantify alpha emitters (Pu, Am, Th, U and Cm isotopes) in urine and faecal samples from workers exposed to internal radiation. Therefore and as a step previous to achieving the ISO 17025 accreditation, the laboratory has performed retrospective studies based on the obtained results in the past few years to validate the analytical method. Uncertainty estimation was done identifying and quantifying all the contributions, and finally the overall combined standard uncertainty was calculated.

Asunto(s)

Elementos de Series Actinoides/análisis , Elementos de Series Actinoides/orina , Radiometría/métodos , Acreditación , Partículas alfa , Americio/orina , Calibración , Curio/orina , Heces , Humanos , Plutonio/orina , Control de Calidad , Radioisótopos/análisis , Radiometría/instrumentación , Estándares de Referencia , Reproducibilidad de los Resultados , Estudios Retrospectivos , Torio/orina , Incertidumbre , Uranio/orina , Orina , Agua

RESUMEN

A relatively less expensive and less time consuming radio analytical technique for quantitative determination of Th(nat) in urine at mBq level is developed and reported in this paper. Th in urine is co-precipitated with Ca(3)(PO(4))(2) from wet oxidized urine matrix and the precipitate is dissolved in HNO(3) and evaporated to dryness. The residue is dissolved in 3M HCl and 200mg of Na-EDTA is added to mask Ca(2+), Mg(2+) and Fe(3+) ions. Th(4+) is extracted into 0.01M PC-88A (2-ethyl hexyl phosphonic acid mono-2-ethylhexyl ester), dissolved in toluene from the experimentally optimized pH 2.5 ± 0.3 in aqueous phase. Th(4+) is stripped into 8.0M HCl and evaporated to dryness. The content of the beaker is dissolved in pH 1.8 HCl and complexed with 3-hydroxy flavone. The sample is excited at 397 nm and fluorescence intensity is measured at 462 nm. The detailed study of the method is presented in this paper. Interference study on elements that are normally present in urine and other actinides (if present) is also given.

Asunto(s)

Fluorometría/métodos , Torio/aislamiento & purificación , Torio/orina , Calibración , Fluorometría/economía , Humanos , Sensibilidad y Especificidad , Solventes

RESUMEN

Thorium is a natural alpha-emitting element occurring in various ores and has numerous industrial applications. Routine monitoring of potentially exposed workers is generally achieved through radiobioassay (urine and faeces). The procedures currently used for analysing actinides such as thorium in urine require lengthy chemical separation associated with long counting times by alpha-spectrometry due to low activity levels. Thus, their main drawback is that they are time-consuming, which limits the frequency and flexibility of individual monitoring. In this context, this study developed new radiochemical procedures based on the use of tertbutylcalix[6]arenes bearing three carboxylic acid groups or three hydroxamic acid groups. These previous works demonstrated that these macrocyclic molecules immobilised on an inert solid support are excellent extractants for uranium, plutonium and americium. In this study, the authors investigated the thorium extraction by calix[6]arene columns. Experiments were performed on synthetic solutions and on real urine samples. The influence of various parameters, such as the thorium solution pH and the column flow rate on thorium extraction, was studied. The results showed that both calix[6]arenes are efficient to extract thorium. Thorium extraction is quantitative from pH = 2 for synthetic solution and from pH = 3 for real urine samples. This study has demonstrated that the column flow rate is a crucial parameter since its value must not be too high to achieve the steady-state complexation equilibrium. Finally, these results will be compared with those obtained for other actinides (U, Pu and Am) and the conditions of actinides' separation will be discussed.

Asunto(s)

Calixarenos/química , Fenoles/química , Monitoreo de Radiación/instrumentación , Radiometría/instrumentación , Torio/aislamiento & purificación , Torio/orina , Urinálisis/métodos , Ácidos Carboxílicos/química , Cromatografía/métodos , Humanos , Concentración de Iones de Hidrógeno , Cinética , Modelos Químicos , Plantas de Energía Nuclear , Exposición Profesional , Polímeros/química , Monitoreo de Radiación/métodos , Protección Radiológica/métodos , Radiometría/métodos , Urinálisis/instrumentación

RESUMEN

The study investigated the changes in urinary thorium excretion by humans following ingestion of a therapeutic soil, which contains about 10 ppm of thorium. This well-known healing earth in Germany has been considered as an alternative medicine for diarrhoea and gastric hyper-acidity. Six adult volunteers ingested this therapeutic soil in varying quantities for 1-15 days at levels approximating those described in the package insert of the medicine (10-60 g of soil per day). The subjects ingested about 0.1-0.6 mg of thorium daily, which is 100-600 times higher than the normal daily intake of about 1 microg thorium in Germany. All 24-h urine samples collected from the subjects during pre-ingestion, ingestion and post-ingestion periods of the soil were analyzed for (232)Th using inductively coupled plasma mass spectrometry (ICP-MS). The measured excretion values varied in a wide range. Apparently, the high thorium amounts administered did not increase the (232)Th excretion in urine as expected, suggesting that this soil ingestion will not result in a considerably higher and harmful uptake of thorium into the human body.

Asunto(s)

Contaminantes Radiactivos del Suelo/orina , Suelo , Torio/orina , Administración Oral , Adulto , Monitoreo del Ambiente , Femenino , Alemania , Humanos , Masculino , Persona de Mediana Edad , Contaminantes Radiactivos del Suelo/farmacocinética , Contaminantes Radiactivos del Suelo/uso terapéutico , Torio/farmacocinética , Torio/uso terapéutico

RESUMEN

A worker provided a routine faecal sample for plutonium and americium analysis. In the course of this analysis 500 mBq of (228)Th was discovered. There seemed no credible occupational route for intake of thorium. Further investigation revealed that the worker consumed approximately 25 g d(-1) of nuts, including Brazil nuts. A sample of these nuts was analysed and found to contain activities of (228)Th in sufficient quantity to account for the faecal activity. However, follow-up urine samples taken from the worker showed 0.6-0.7 mBq of (228)Th. The intake of (228)Th via nuts is insufficient to account for this activity in urine. However, it is likely that the intake of (228)Th was accompanied by similar activity of the parent (228)Ra, and biokinetic calculations show that decay of (228)Ra in vivo would produce sufficient (228)Th to account for the observed urine activity.

Asunto(s)

Bertholletia/química , Ingestión de Alimentos , Heces/química , Contaminación Radiactiva de Alimentos/análisis , Torio/orina , Adulto , Carga Corporal (Radioterapia) , Humanos , Masculino , Tasa de Depuración Metabólica , Efectividad Biológica Relativa , Torio/análisis

RESUMEN

A sensitive and efficient flow-injection (FI) preconcentration and matrix-separation technique coupled to sector field ICP-mass spectrometry (SF-ICP-MS) has been developed and validated for simultaneous determination of ultra-low levels of uranium (U) and thorium (Th) in human urine. The method is based on selective retention of U and Th from a urine matrix, after microwave digestion, on an extraction chromatographic TRU resin, as an alternative to U/TEVA resin, and their subsequent elution with ammonium oxalate. Using a 10 mL sample, the limits of detection achieved for 238U and 232Th were 0.02 and 0.03 ng L(-1), respectively. The accuracy of the method was checked by spike-recovery measurements. Levels of U and Th in human urine were found to be in the ranges 1.86-5.50 and 0.176-2.35 ng L(-1), respectively, well in agreement with levels considered normal for non-occupationally exposed persons. The precision obtained for five replicate measurements of a urine sample was 2 and 3% for U and Th, respectively. The method also enables on-line measurements of the 235U/238U isotope ratios in urine. Precision of 0.82-1.04% (RSD) was obtained for 235U/238U at low ng L(-1) levels, using the FI transient signal approach.

Asunto(s)

Espectrometría de Masas/métodos , Torio/orina , Uranio/orina , Análisis de Inyección de Flujo/métodos , Humanos , Isótopos/orina

RESUMEN

Data on the daily urinary excretion of thorium (Th) was obtained from 15 non-exposed adult German subjects. A radiochemical neutron activation analysis method was developed and standardised especially for this purpose. The daily urinary excretion of 232Th was found to be in the range 1.9-14.9 microBq d(-1) with a mean (+/-SD) value of 6.5 (+/-4.3) microBq d(-1). Using this excretion value and reported data on dietary intake of Th for a similar German population, the gastrointestinal absorption factor (f1 value) proposed by the International Commission on Radiological Protection (ICRP) was tested. Although the daily excretion of 232Th observed in the present study was comparable to some of the currently reported values in certain other countries, it was higher than the excretion value calculated by applying the biokinetic model of Th proposed by ICRP for the dietary intake values. The study showed that the default ICRP values of the f1 factor for diet-incorporated Th may not be applicable.

Asunto(s)

Contaminación Radiactiva de Alimentos/análisis , Dosis de Radiación , Protección Radiológica/normas , Torio/farmacocinética , Adulto , Anciano , Carga Corporal (Radioterapia) , Dieta , Femenino , Alemania , Humanos , Cinética , Masculino , Persona de Mediana Edad , Neutrones , Probabilidad , Factores Sexuales , Torio/orina , Factores de Tiempo , Orina

RESUMEN

The daily urinary excretion of Th (Th) was estimated in 11 adult German subjects who were not exposed occupationally to thorium and its related compounds. Thirty-one urine samples were collected over 24-h periods on different occasions from these subjects and were analyzed using high resolution sector field inductively coupled plasma mass spectrometry (HR-SF-ICP-MS). Using this instrument a limit of detection of 20 pg L for thorium in the reagent blank was achieved. The median (mean) daily urinary thorium excretion was obtained as 1.0 (1.8) ng. This was in good agreement with the mean value of 1.5 ng Th (6 microBq) reported by another group for German population, but is significantly lower in comparison to the daily excretion range of 3.6 to 105 ng reported from other countries. The expected daily urinary excretion of thorium for the adult German population was also calculated by applying the new ICRP biokinetic model of thorium assuming reference intake values. The expected urinary thorium excretion rate for this age group is about 0.1 ng per day. Even if a small contribution from the inhalation is considered, the calculated value will be much lower than the measured values. The reason for the disagreement appears to be the use of a low gastrointestinal absorption factor (f1) of 5 x 10 in the ICRP model. Based on the present study, a higher f1 factor might be proposed separately for dietary incorporated thorium.

Asunto(s)

Guías como Asunto , Modelos Biológicos , Radiometría/métodos , Radiometría/normas , Medición de Riesgo/métodos , Medición de Riesgo/normas , Torio/farmacocinética , Torio/orina , Adulto , Anciano , Carga Corporal (Radioterapia) , Simulación por Computador , Femenino , Humanos , Internacionalidad , Cinética , Masculino , Persona de Mediana Edad , Garantía de la Calidad de Atención de Salud/métodos , Dosificación Radioterapéutica , Efectividad Biológica Relativa , Reproducibilidad de los Resultados , Factores de Riesgo , Sensibilidad y Especificidad

RESUMEN

The daily intake of natural Th and its contents in lungs, skeleton and liver of an Indian adult population group were estimated using radiochemical neutron activation analysis (RNAA) technique. These data on daily intake (through inhalation and ingestion) were used to compute Th contents in lungs and other systemic organs such as skeleton and liver using the new human respiratory tract model (HRTM) and the new biokinetic model of Th. The theoretically computed Th contents in lungs, skeleton and liver of an average Indian adult are 2.56, 4.00 and 0.17 microg, respectively which are comparable with the corresponding experimentally measured values of 4.31, 3.45 and 0.14 microg in an urban population group living in Mumbai. The measured lung contents of Th in a group of five occupational workers were used to compute their total body Th contents and the corresponding daily urinary excretions. The computed total body contents and daily urinary excretions of Th in the five subjects compared favourably with their measured values. These studies, thus, validate the new biokinetic model of Th in natural as well as in occupational exposures in Indian conditions.

Asunto(s)

Pulmón/metabolismo , Modelos Biológicos , Exposición Profesional/análisis , Radiometría/métodos , Medición de Riesgo/métodos , Torio/análisis , Torio/farmacocinética , Adolescente , Adulto , Carga Corporal (Radioterapia) , Niño , Simulación por Computador , Contaminación Radiactiva de Alimentos/análisis , Guías como Asunto , Humanos , India , Internacionalidad , Cinética , Tasa de Depuración Metabólica , Reactores Nucleares , Especificidad de Órganos , Contaminantes Radiactivos/análisis , Contaminantes Radiactivos/farmacocinética , Radiometría/normas , Reproducibilidad de los Resultados , Medición de Riesgo/normas , Factores de Riesgo , Sensibilidad y Especificidad , Torio/orina

RESUMEN

Inductively coupled plasma mass spectrometry (ICP-MS) has been used for the determination of (232)Th and (238)U in urine of unexposed Jordanian subjects living in six cities. The range of (232)Th excretion in all subjects was found to be 1.4-640 microBq d(-1) with an average of 34.8 microBq d(-1) (geometric mean 15.8 microBq d(-1)). Results showed no statistically significant correlation with age and residential area. The average value obtained is in agreement with levels considered normal in some recent publications. The average value of (238)U in all samples was found to be 3955 microBq d(-1) (geometric mean 1107 microBq d(-1)), which is higher than reported figures from Germany and India, but in agreement with those figures given in ICRP publication, number 23. The mean values of the different groups were found to be proportional to age up to 60 years. A noticeable drop is observed for subjects greater than 60 years old.

Asunto(s)

Vivienda , Torio/orina , Uranio/orina , Adolescente , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Niño , Femenino , Humanos , Jordania , Masculino , Espectrometría de Masas , Persona de Mediana Edad , Valores de Referencia , Población Urbana

RESUMEN

Thorium is naturally occurring in various ores used for industrial purposes and has numerous applications. This paper sets out to investigate urine analysis as a suitable monitoring approach for workers potentially exposed to thorium. Due to its biokinetic behavior and its low solubility, urinary concentrations are generally very low, requiring therefore high sensitivity analytical methods. An analytical procedure has been developed for detecting 232Th concentrations of below 1 mBq L(-1) quickly and easily. Due to the long half-life (1.41 x 10(10) y) of 232Th, the potential of a procedure based on urine sample dilution and ICP-MS (inductively coupled plasma-mass spectrometry) measurement was investigated first. Two dilution factors were chosen: 100, which is more suitable for long-term measurement trials, and 20, which increases sensitivity. It has been shown that a 100-fold dilution can be used to measure concentrations of below 1 mBq L(-1), whereas a 20-fold one can be used to reach concentrations of below 0.06 mBq L(-1). Then, on the basis of the limitation of the procedure based on urine dilution, the suitable field of application for the different procedures (100-fold and 20-fold dilution and also a chemical purification followed by an ICP-MS measurement) was determined in relation to monitoring objectives.

Asunto(s)

Monitoreo de Radiación/métodos , Torio/orina , Humanos , Espectrometría de Masas , Exposición Profesional , Dosis de Radiación

RESUMEN

We measured uranium and thorium in urine of 500 U. S. residents to establish reference range concentrations using a magnetic-sector inductively coupled argon plasma mass spectrometer (ICP-MS). We found uranium at detectable concentrations in 96.6% of the urine specimens and thorium in 39.6% of the specimens. The 95th percentile concenetration for uranium was 34.5 ng/L (parts per trillion); concentrations ranged up to 4080 ng/L. Thorium had a 95th percentile concentration of 3.09 ng/L; concentrations ranged up to 7.7 ng/L.

Asunto(s)

Espectrometría de Masas/métodos , Contaminantes Radiactivos/orina , Torio/orina , Uranio/orina , Carga Corporal (Radioterapia) , Encuestas Epidemiológicas , Humanos , Contaminantes Radiactivos/normas , Valores de Referencia , Estados Unidos

RESUMEN

A method for rapid and sensitive determination of thorium in urine by inductively coupled plasma mass spectometry (ICP-MS) is described. The method is sufficiently sensitive to detect 1 ng/L 232Th in urine without any sample preparation. The mean urinary 232Th excretion in 23 unexposed subjects was 6.2 +/- 3.3 ng/d.

Asunto(s)

Espectrometría de Masas/métodos , Torio/orina , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Alemania , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Sensibilidad y Especificidad

RESUMEN

To investigate the theoretic possibility of excessive exposure to thorium during the process of tungsten inert gas (TIG) welding using thoriated rods we carried out a cross-sectional study of TIG welders and an age- and skill-matched group. We measured the radiation doses from inhaled thorium that was retained in the body and investigated whether any differences in health or biologic indices could have been attributable to the welding and tip-grinding process. Sixty-four TIG welders, 11 non-TIG welders, and 61 control subjects from an airline engineering population participated. All of the subjects were interviewed for biographic, occupational history and morbidity details. All of the welders and eight control subjects carried out large-volume urine sampling to recover thorium 232 and thorium 228; this group also had chest radiographs. All of the subjects had a blood sample taken to estimate liver enzymes, and they provided small-volume urine samples for the estimation of retinol-binding protein and beta 2-microglobulin. We found no excess of morbidity among the TIG or non-TIG welding groups, and the levels of retinol-binding protein and beta 2-microglobulin were the same for both groups. There was a higher aspartate aminotransferase level in the control group. The internal radiation doses were estimated at less than an annual level of intake in all cases, and considerably less if the exposure (as was the case) was assumed to be chronic over many years. Some additional precautionary measures are suggested to reduce further any potential hazard from this process.

Asunto(s)

Ingeniería , Exposición Profesional , Torio , Soldadura , Adulto , Aeronaves , Estudios Transversales , Inglaterra , Humanos , Pruebas de Función Renal , Pruebas de Función Hepática , Masculino , Gases Nobles , Dosis de Radiación , Torio/orina , Tungsteno

RESUMEN

The concentration of thorium in the blood serum and urine of Western Australian mineral sands workers was studied to complement estimates of radiation dose derived from air sampling measurements. The concentration of thorium in urine samples from occupationally unexposed persons and pooled serum samples was also investigated. The concentration of thorium in the urine of the workers varied from 3-210 ng L-1 (geometric mean = 31 ng L-1, n = 34) while the concentration of thorium in the serum varied from 170-2,000 ng L-1 (geometric mean = 480 ng L-1, n = 25). No correlation was found between the bioassay results and cumulative airborne thorium exposure. The geometric mean ratio of daily excretion of thorium in urine to total thorium in the serum pool was 2.5%, considerably lower than the value of 10% proposed by the ICRP. These data indicate that more information is required to clarify the biokinetic models for thorium and that doses assessed from air sampling data must be interpreted with caution.

Asunto(s)

Minerales , Minería , Exposición Profesional , Torio/metabolismo , Contaminantes Radiactivos del Aire , Bioensayo , Humanos , Metales de Tierras Raras , Torio/sangre , Torio/orina , Australia Occidental

Asunto(s)

Exposición Profesional , Torio/farmacocinética , Carga Corporal (Radioterapia) , Huesos/metabolismo , Humanos , Hígado/metabolismo , Torio/sangre , Torio/orina , Distribución Tisular

RESUMEN

A simple and rapid method for the simultaneous estimation of thorium and calcium in urine was developed. Thorium and calcium were coprecipitated as oxalates at pH 3-4 and were determined using Thoronol as reagent. A multi-wave-length linear regression analysis procedure was applied. Thorium recovery was found to be 78.3% +/- 5.1% (1 sigma) and that of calcium was 93.7 +/- 3.0% (1 sigma). The minimum detection limit for thorium was found to be 2.54 mBq/dm3. The analytical results of calcium agree very well with those determined by EDTA titrimetry.

Asunto(s)

Calcio/orina , Torio/orina , Humanos , Espectrofotometría/métodos

RESUMEN

The contributors propose a radiometric technique of detecting thorium in urine. The technique is based on a prior concentrating of the nuclide on phosphate residues, with its further separation in extraction-chromatographic vessel filled with diethylhexylphosphorus acid, and reextraction with oxalic acid. Measurements were made in the hard scintillator layer at 90 percent effectiveness. Thorium chemical output was at 85 +/- 3 percent, sensitivity at 5 mBk for a sample. If the sample contained an equal quantity of uranium, the percentage of cleaning thorium from uranium was 100. The proposed technique is economical, simple to perform, and is designed for natural thorium content measurements in human organism.

Asunto(s)

Torio/orina , Cromatografía/métodos , Humanos , Organofosfatos , Radiometría/métodos , Torio/análisis , U.R.S.S.