RESUMEN
Movidos por el nuevo paradigma "eres lo que consumes", los consumidores responsables encuentran en la fitocosmética productos con beneficios diferenciales para su salud y el medio ambiente. Los grupos fitoquímicos de interés presentes en los fitoingredientes permiten predecir el tipo de extracto a utilizar, los métodos de extracción y control de calidad apropiados, ya que son los responsables de su actividad cosmética. Clasificados en forma general como polifenoles, sponinas, hidratos de carbono, lípidos, aceites esenciales, resias, vitaminas, péptidos, entre otros grupos, pueden aportar actividades cosméticas específicas como antioxidantes, antiinflamatorios, reguladores de la síntesis y degradación de proteínas dérmicas, inhibidores de la tirosinasa, tensioacticos, por interaccionar en los procesos de comunicación celular, o por sus propiedades emolientes, oclusivas e hidratantes, entre otras. La fitocosmética sustentada en evidencias científicas desarrolla productos eficaces (AU)
Diven by the new paradigm of "you are what you consume", responsible customers finds in phytocosmetics products differential health and environmental benefits. The phytochemical groups of interest in the composition of phytoingredients allow to predict the type of extract, the extraction methods and the appropriate quality control, since they are responsible their cosmetic activity. Generally classified as polyphenols, sponins, carbohydrates, lipids, essential oils, resins, vitamins, peptides, among other groups, they may provide specific cosmetic activities as antioxidants, anti-inflammatory agents, regulators of synthesis and degradation os skin proteins, tyrosinase inhibitors, tensioactive, through the interaction with the cellular communication processes, or by its emollient, moisturizing and occlusiveness properties, among many other. The phytocosmetics supported by scientific evidence help in the development of effective products (AU)
Asunto(s)
Humanos , Masculino , Femenino , Enfermedades de la Piel/terapia , Cuidados de la Piel/métodos , Cuidados de la Piel/normas , Cuidados de la Piel , Comunicación Celular/inmunología , Comunicación Celular/fisiología , Emolientes/uso terapéutico , Cuidados de la Piel/tendencias , Industria Cosmética , Antioxidantes/uso terapéutico , Antiinflamatorios/uso terapéutico , Tirosina Fenol-Liasa/uso terapéutico , Fitoterapia/métodos , Fitoterapia/tendencias , FitoterapiaRESUMEN
Administration of L-tyrosine phenol-lyase inhibited growth of established B16 melanomas in BDF1 mice. Under the conditions used, the enzyme exerted a cytostatic effect on the tumors. The addition of L-tyrosine phenol-lyase to growing melanoma cultures blocked cell division and caused an accumulation of cells in the G1 (G0) pultures was suppressed, the most pronounced effect of L-tyrosine phenol-lyase was a rapid and near-complete cessation of uridine uptake and incorporation. This block in RNA synthesis was also observed in human fibroblasts treated with L-tyrosine phenol-lyase.
Asunto(s)
Liasas/uso terapéutico , Melanoma/tratamiento farmacológico , Tirosina Fenol-Liasa/uso terapéutico , Animales , Ciclo Celular/efectos de los fármacos , División Celular/efectos de los fármacos , Células Cultivadas , ADN de Neoplasias/biosíntesis , Femenino , Melanoma/metabolismo , Ratones , Neoplasias Experimentales/tratamiento farmacológico , ARN Neoplásico/biosíntesisRESUMEN
Tyrosine phenol-lyase from Erwinia herbicola was purified with the goal of assessing its effect on growth of malignant melanoma. Ammonium sulfate-sodium citrate fractionation and diethylaminoethyl cellulose-hydroxylapatite chromatography were used. The purified enzyme was shown to reduce plasma tyrosine levels when administered to normal C57BL x DBA/2 F1 mice. The plasma half-life value of the enzyme was found to be 6 to 7 hr. Unlike results reported with glutaminase and asparaginase preparations, the lactate dehydrogenase-elevating virus had no significant influence on plasma clearance of tyrosine phenol-lyase. The enzyme significantly inhibited growth of established B-16 melanoma tumors.