RESUMEN

1. Several sub-lethal doses of cyanide were assayed with the aim of obtaining significant differences in the parameters studied. A dose of 4 mg/kg s.c. was selected. 2. Present studies were carried out to determine the time dependence of the effects produced by s.c. administration of a single dose of potassium cyanide as well as the recovery time of some of the toxicity indicative parameters. 3. It was found that cyanide effects continued for at least 3 days; after the parameters had recovered normal values.

Asunto(s)

Encéfalo/metabolismo , Hígado/metabolismo , Cianuro de Potasio/toxicidad , Tiosulfato Azufretransferasa/metabolismo , Animales , Relación Dosis-Respuesta a Droga , Complejo IV de Transporte de Electrones/antagonistas & inhibidores , Inyecciones Subcutáneas , Ratones , Miocardio/enzimología , Cianuro de Potasio/administración & dosificación , Cianuro de Potasio/sangre , Cianuro de Potasio/metabolismo , Tiosulfato Azufretransferasa/sangre , Factores de Tiempo