RESUMEN
OBJECTIVE: Autonomic nervous system, especially the sympathetic nervous system, may stimulate the expression of peroxisome proliferator-activated receptor γ coactivator-1α, which regulates irisin. This study aimed to explore whether there was any association between autonomic function as assessed by heart rate related indices and irisin release following acute exercise. SUBJECTS AND METHODS: Seventeen healthy adults were asked to perform an incremental exhaustive cycling as well as an incremental exhaustive running separately on different days. Heart rate was monitored, and blood samples were collected before, immediately, 10-, and 60-minutes post-exercise. Serum irisin was measured using ELISA kit. RESULTS: Markers for autonomic function, such as heart rate at rest, peak, or recovery, heart rate reserve, heart rate recovery, and chronotropic index, were comparable between cycling and running (all P > 0.10). Irisin was increased immediately following both exercise. No significant association was observed between heart rate at rest, peak, or recovery and irisin level at the corresponding time-point, as well as between heart rate reserve, heart rate recovery, or chronotropic index and exercise induced irisin release, with or without controlling for age, body mass index, and glucose (all P > 0.10). CONCLUSIONS: Autonomic function might not be associated with irisin release in healthy adults. Arch Endocrinol Metab. 2020;64(3):201-4.
Asunto(s)
Sistema Nervioso Autónomo/irrigación sanguínea , Sistema Nervioso Autónomo/fisiología , Fibronectinas/sangre , Frecuencia Cardíaca/fisiología , Carrera/fisiología , Adulto , Estudios Cruzados , Ensayo de Inmunoadsorción Enzimática , Femenino , Humanos , Masculino , Distribución Aleatoria , Adulto JovenRESUMEN
ABSTRACT Objective Autonomic nervous system, especially the sympathetic nervous system, may stimulate the expression of peroxisome proliferator-activated receptor γ coactivator-1α, which regulates irisin. This study aimed to explore whether there was any association between autonomic function as assessed by heart rate related indices and irisin release following acute exercise. Subjects and methods Seventeen healthy adults were asked to perform an incremental exhaustive cycling as well as an incremental exhaustive running separately on different days. Heart rate was monitored, and blood samples were collected before, immediately, 10-, and 60-minutes post-exercise. Serum irisin was measured using ELISA kit. Results Markers for autonomic function, such as heart rate at rest, peak, or recovery, heart rate reserve, heart rate recovery, and chronotropic index, were comparable between cycling and running (all P > 0.10). Irisin was increased immediately following both exercise. No significant association was observed between heart rate at rest, peak, or recovery and irisin level at the corresponding time-point, as well as between heart rate reserve, heart rate recovery, or chronotropic index and exercise induced irisin release, with or without controlling for age, body mass index, and glucose (all P > 0.10). Conclusions Autonomic function might not be associated with irisin release in healthy adults. Arch Endocrinol Metab. 2020;64(3):201-4
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Adulto Joven , Carrera/fisiología , Sistema Nervioso Autónomo/fisiología , Sistema Nervioso Autónomo/irrigación sanguínea , Fibronectinas/sangre , Frecuencia Cardíaca/fisiología , Ensayo de Inmunoadsorción Enzimática , Distribución Aleatoria , Estudios CruzadosRESUMEN
OBJECTIVES: Brain death is typically followed by autonomic changes that lead to hemodynamic instability, which is likely associated with microcirculatory dysfunction and inflammation. We evaluated the role of the microcirculation in the hemodynamic and inflammatory events that occur after brain death and the effects of autonomic storm inhibition via thoracic epidural blockade on mesenteric microcirculatory changes and inflammatory responses. METHODS: Male Wistar rats were anesthetized and mechanically ventilated. Brain death was induced via intracranial balloon inflation. Bupivacaine (brain death-thoracic epidural blockade group) or saline (brain death group) infusion via an epidural catheter was initiated immediately before brain death induction. Sham-operated animals were used as controls (SH group). The mesenteric microcirculation was analyzed via intravital microscopy, and the expression of adhesion molecules was evaluated via immunohistochemistry 180 min after brain death induction. RESULTS: A significant difference in mean arterial pressure behavior was observed between the brain death-thoracic epidural blockade group and the other groups, indicating that the former group experienced autonomic storm inhibition. However, the proportion of perfused small vessels in the brain death-thoracic epidural blockade group was similar to or lower than that in the brain death and SH groups, respectively. The expression of intercellular adhesion molecule 1 was similar between the brain death-thoracic epidural blockade and brain death groups but was significantly lower in the SH group than in the other two groups. The number of migrating leukocytes in the perivascular tissue followed the same trend for all groups. CONCLUSIONS: Although thoracic epidural blockade effectively inhibited the autonomic storm, it did not affect mesenteric hypoperfusion or inflammation induced by brain death.
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Sistema Nervioso Autónomo/irrigación sanguínea , Muerte Encefálica , Hemodinámica/fisiología , Microcirculación/fisiología , Circulación Esplácnica/fisiología , Anestesia Epidural , Animales , Presión Arterial/fisiología , Sistema Nervioso Autónomo/fisiopatología , Corticosterona/sangre , Citocinas/sangre , Inflamación/metabolismo , Molécula 1 de Adhesión Intercelular/metabolismo , Masculino , Modelos Animales , Ratas WistarRESUMEN
OBJECTIVES: Brain death is typically followed by autonomic changes that lead to hemodynamic instability, which is likely associated with microcirculatory dysfunction and inflammation. We evaluated the role of the microcirculation in the hemodynamic and inflammatory events that occur after brain death and the effects of autonomic storm inhibition via thoracic epidural blockade on mesenteric microcirculatory changes and inflammatory responses. METHODS: Male Wistar rats were anesthetized and mechanically ventilated. Brain death was induced via intracranial balloon inflation. Bupivacaine (brain death-thoracic epidural blockade group) or saline (brain death group) infusion via an epidural catheter was initiated immediately before brain death induction. Sham-operated animals were used as controls (SH group). The mesenteric microcirculation was analyzed via intravital microscopy, and the expression of adhesion molecules was evaluated via immunohistochemistry 180 min after brain death induction. RESULTS: A significant difference in mean arterial pressure behavior was observed between the brain death-thoracic epidural blockade group and the other groups, indicating that the former group experienced autonomic storm inhibition. However, the proportion of perfused small vessels in the brain death-thoracic epidural blockade group was similar to or lower than that in the brain death and SH groups, respectively. The expression of intercellular adhesion molecule 1 was similar between the brain death-thoracic epidural blockade and brain death groups but was significantly lower in the SH group than in the other two groups. The number of migrating leukocytes in the perivascular tissue followed the same trend for all groups. CONCLUSIONS: Although thoracic epidural blockade effectively inhibited the autonomic storm, it did not affect mesenteric hypoperfusion or inflammation induced by brain death. .
Asunto(s)
Animales , Masculino , Sistema Nervioso Autónomo/irrigación sanguínea , Muerte Encefálica , Hemodinámica/fisiología , Microcirculación/fisiología , Circulación Esplácnica/fisiología , Anestesia Epidural , Presión Arterial/fisiología , Sistema Nervioso Autónomo/fisiopatología , Corticosterona/sangre , Citocinas/sangre , Inflamación/metabolismo , Molécula 1 de Adhesión Intercelular/metabolismo , Modelos Animales , Ratas WistarRESUMEN
Un texto completo, excelentemente ilustrado sobre el tema: Organización general, estructura y origen del sistema nervioso. El sistema nervioso central y sus envolturas:cráneo y raquis. Médula espinal. Tronco encefálico. Cerebelo. Desarrollo del cerebro. Diencéfalo. Hemisferios cerebrales. Corteza cerebral. Circulación encefálica. Topografía craneoencefálica. El sistema nervioso periferico. Organización anatomo-funcional del sistema nervioso
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Neuroanatomía/educación , Sistema Nervioso/anatomía & histología , Tejido Nervioso/anatomía & histología , Cerebelo/anatomía & histología , Cerebelo/embriología , Cerebelo/irrigación sanguínea , Columna Vertebral/anatomía & histología , Columna Vertebral/embriología , Cráneo/anatomía & histología , Cráneo/embriología , Cerebro/anatomía & histología , Cerebro/embriología , Cerebro/irrigación sanguínea , Diencéfalo/anatomía & histología , Diencéfalo/embriología , Espacio Subaracnoideo/anatomía & histología , Meninges/anatomía & histología , Meninges/embriología , Sistema Nervioso Autónomo/anatomía & histología , Sistema Nervioso Autónomo/embriología , Sistema Nervioso Autónomo/irrigación sanguínea , Sistema Nervioso Central/anatomía & histología , Sistema Nervioso Central/embriología , Sistema Nervioso Central/irrigación sanguínea , Sistema Nervioso/embriología , Tejido Nervioso/ultraestructura , Ventrículos Cerebrales/anatomía & histología , Ventrículos Cerebrales/embriologíaRESUMEN
Un texto completo, excelentemente ilustrado sobre el tema: Organización general, estructura y origen del sistema nervioso. El sistema nervioso central y sus envolturas:cráneo y raquis. Médula espinal. Tronco encefálico. Cerebelo. Desarrollo del cerebro. Diencéfalo. Hemisferios cerebrales. Corteza cerebral. Circulación encefálica. Topografía craneoencefálica. El sistema nervioso periferico. Organización anatomo-funcional del sistema nervioso