RESUMEN

Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica.

Asunto(s)

Salmonella enterica/patogenicidad , Metiltransferasa de ADN de Sitio Específico (Adenina Especifica)/fisiología , Factores de Virulencia/fisiología , Animales , Modelos Animales de Enfermedad , Regulación Bacteriana de la Expresión Génica , Modelos Biológicos , Salmonelosis Animal/microbiología , Vacunas contra la Salmonella/genética , Vacunas contra la Salmonella/inmunología , Salmonella enterica/citología , Salmonella enterica/enzimología , Salmonella enterica/fisiología , Metiltransferasa de ADN de Sitio Específico (Adenina Especifica)/deficiencia , Vacunas Atenuadas/genética , Vacunas Atenuadas/inmunología , Virulencia , Factores de Virulencia/deficiencia