RESUMEN
BACKGROUND: A 15-year-old western lowland gorilla (Gorilla gorilla gorilla) died shortly after transfer to the North Carolina Zoo. METHODS: Complete blood count, serum biochemical analysis, and necropsy were performed. RESULTS: Combination of compatible clinical signs, biochemical and histopathological findings fulfilled all of the CDC definition criteria of Reye's or a Reye's like syndrome. CONCLUSIONS: This report describes a case of Reye's syndrome or Reye's-like syndrome in a non-human primate.
Asunto(s)
Enfermedades del Simio Antropoideo/patología , Gorilla gorilla , Síndrome de Reye/veterinaria , Animales , Enfermedades del Simio Antropoideo/sangre , Resultado Fatal , Femenino , Riñón/patología , Hígado/patología , Síndrome de Reye/sangre , Síndrome de Reye/patologíaRESUMEN
The clinical, biochemical and histopathological findings of an infantile disease occurring in the C3H-H-2 degree strain of mice, which has similarities with Reye's syndrome in children, is described.
Asunto(s)
Hígado/patología , Ratones Endogámicos C3H , Síndrome de Reye/veterinaria , Enfermedades de los Roedores/patología , Vísceras/patología , Animales , Animales Lactantes , Femenino , Riñón/patología , Hígado/ultraestructura , Masculino , Ratones , Microscopía Electrónica , Linaje , Síndrome de Reye/genética , Síndrome de Reye/patología , Enfermedades de los Roedores/genética , DesteteRESUMEN
In five spontaneous outbreaks, sixty-four BALB/cByJ mice developed Reye's-like syndrome 4 to 33 days after introduction into mouse rooms known to harbor a variety of indigenous murine viruses. The clinical course lasted 24 hours and consisted of progressively deteriorating consciousness and hyperventilation, usually leading to death. Mice killed and necropsied while stuporous or comatose had serum ammonia levels of 2524 +/- 179 versus 66 +/- 8 micrograms/dl for control BALB/cByJ mice. Necropsy findings included swollen, diffusely pale yellow livers with panlobular microvesicular fatty change, pale renal cortices with epithelial fat droplets of the proximal convoluted tubules, and Alzheimer type II astrocytosis of the neocortex, corpus striatum, hippocampus, and thalamus. In three of the five outbreaks involving 66% of affected animals, mice had active coronaviral enteritis. Electron microscopic changes in hepatocytes, neocortical astrocytes, and neurons were similar to or identical with those described for the acute phase of Reye's syndrome in man. The epizootiology of these outbreaks and the apparent synchrony between Reye's syndrome-like illness and the stage of intestinal coronavirus infections in some of these outbreaks suggest that one or more naturally occurring murine viruses were of etiologic significance.