RESUMEN
Blood levels of two different preparations of Rifampicin were determined after a standard dose of 600mg. Three hours later, blood concentrations showed no statistical differences. Six hours later the levels were statiscally significant well above the minimum inhibitory levels for Mycobacterium Tuberculosis. For practical purposes it may be said that no diference in th bioavailability existis between the two drugs studied...
Asunto(s)
Masculino , Femenino , Humanos , Adulto , Persona de Mediana Edad , Adolescente , Absorción Intestinal , Evaluación de Medicamentos , Disponibilidad Biológica , Ensayos Clínicos como Asunto , Factores de Tiempo , Rifampin/metabolismo , Rifampin/sangre , Rifampin/orinaRESUMEN
Rifampicin in urine was detected by a simple plate diffusion assay using as the test organism a strain of Staphylococcus aureus made resistant to other antituberculosis drugs. The specificity of the method was ensured by a parallel test with a rifampicin-resistant variant of this strain. The method was more sensitive than available chemical techniques and yieldeld reliably positive results for at least twelve hours after a 600 mg. dose of rifampicin.
Asunto(s)
Humanos , Almacenaje de Medicamentos , Bioensayo , Factores de Tiempo , Farmacorresistencia Microbiana , Rifampin/metabolismo , Rifampin/orina , Rifampin/uso terapéutico , Staphylococcus , Tuberculosis Pulmonar/tratamiento farmacológicoRESUMEN
The results obtained from the study of absorption, diffusion and elimination of 3-(4-methylpiperazinyliminomethyl) rifamycin SV(rifampicin, AMP) in humans show that the aim of obtaining a new rifamycin well absorbed when administered by mouth has been reached with the synthesis of this antibiotic. After oral administration of 150 mg, AMP is found in the blood serum in therapeutically active concentrations during about 8th. When the dose is increased to 450 mg, serum levels are present for about 24h, and with 900mg they are very high and long-lasting. The elimination of the antibiotic is slow and takes place mainly in the bile, although bactericidal concentrations are found also in the urine. The half-life has thus a high value, while the total clearance is low. Furthermore, AMP shows a high distribution volume, which points to a very good difusion confirmed by the direct determinations of the antibiotic in the different organs and body fluids.