RESUMEN
PURPOSE: This study sought to compare the long-term outcomes of surgeries for retinal detachment (RD) secondary to viral or parasitic infectious retinitis. METHODS: A total of 47 eyes that received pars plana vitrectomy with or without scleral buckling due to RD secondary to polymerase chain reaction-proven viral (cytomegalovirus, varicella zoster virus, and herpes zoster virus) or parasitic (toxoplasma and toxocara) retinitis from October 1, 2006, to June 30, 2023, in a single medical center were retrospectively enrolled. RESULTS: Mean follow-up period was 59.03 ± 55.24 months in viral retinitis and 34.80 ± 33.78 months in parasitic retinitis after primary reattachment surgery. During follow-up, nine eyes (24.3%) with viral retinitis and five eyes (50.0%) with parasitic retinitis developed retinal redetachment. Visual acuity success at final follow-up was achieved in 19 eyes (51.4%) with viral retinitis and six eyes (60.0%) with parasitic retinitis (p = 0.64). The incidence of retinal redetachment during the 1st postoperative year was significantly higher in parasitic retinitis compared with viral retinitis (crude incidence, 0.21 vs. 0.85; p = 0.02). Hazard ratio analysis adjusted for age and sex showed 4.58-fold (95% confidence interval, 1.22-17.27; p = 0.03) increased risk of retinal redetachment in parasitic retinitis compared with viral retinitis during the 1st postoperative year. Tamponade with silicone oil and preoperative diagnostic vitrectomy were associated with significantly decreased risk of retinal redetachment in patients with parasitic retinitis. CONCLUSIONS: Compared with RD secondary to viral retinitis, RD secondary to parasitic retinitis showed higher incidence of retinal redetachment during the 1st postoperative year. Tamponade with silicone oil and preoperative diagnostic vitrectomy were associated with significantly decreased risk of retinal redetachment in patients with parasitic retinitis.
Asunto(s)
Infecciones Parasitarias del Ojo , Infecciones Virales del Ojo , Desprendimiento de Retina , Retinitis , Agudeza Visual , Vitrectomía , Humanos , Desprendimiento de Retina/cirugía , Desprendimiento de Retina/etiología , Desprendimiento de Retina/diagnóstico , Femenino , Masculino , Estudios Retrospectivos , Vitrectomía/métodos , Adulto , Estudios de Seguimiento , Persona de Mediana Edad , Infecciones Parasitarias del Ojo/diagnóstico , Infecciones Parasitarias del Ojo/parasitología , Infecciones Parasitarias del Ojo/cirugía , Infecciones Parasitarias del Ojo/complicaciones , Infecciones Virales del Ojo/diagnóstico , Infecciones Virales del Ojo/virología , Infecciones Virales del Ojo/complicaciones , Retinitis/diagnóstico , Retinitis/parasitología , Retinitis/cirugía , Retinitis/virología , Curvatura de la Esclerótica/métodos , Adulto Joven , Adolescente , Incidencia , Anciano , Resultado del Tratamiento , Factores de Tiempo , NiñoRESUMEN
PURPOSE: To determine classification criteria for toxoplasmic retinitis. DESIGN: Machine learning of cases with toxoplasmic retinitis and 4 other infectious posterior uveitides / panuveitides. METHODS: Cases of infectious posterior uveitides / panuveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used on the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the infectious posterior uveitides / panuveitides. The resulting criteria were evaluated on the validation set. RESULTS: Eight hundred three cases of infectious posterior uveitides / panuveitides, including 174 cases of toxoplasmic retinitis, were evaluated by machine learning. Key criteria for toxoplasmic retinitis included focal or paucifocal necrotizing retinitis and either positive polymerase chain reaction assay for Toxoplasma gondii from an intraocular specimen or the characteristic clinical picture of a round or oval retinitis lesion proximal to a hyperpigmented and/or atrophic chorioretinal scar. Overall accuracy for infectious posterior uveitides / panuveitides was 92.1% in the training set and 93.3% (95% confidence interval 88.2, 96.3) in the validation set. The misclassification rates for toxoplasmic retinitis were 8.2% in the training set and 10% in the validation set. CONCLUSIONS: The criteria for toxoplasmic retinitis had a low misclassification rate and seemed to perform sufficiently well for use in clinical and translational research.
Asunto(s)
Humor Acuoso/parasitología , Infecciones Parasitarias del Ojo/clasificación , Aprendizaje Automático , Retinitis/clasificación , Toxoplasma/aislamiento & purificación , Toxoplasmosis Ocular/clasificación , Adulto , Animales , Anticuerpos Antiprotozoarios/análisis , ADN Protozoario/análisis , Infecciones Parasitarias del Ojo/diagnóstico , Infecciones Parasitarias del Ojo/parasitología , Femenino , Humanos , Masculino , Retinitis/diagnóstico , Retinitis/parasitología , Toxoplasma/genética , Toxoplasma/inmunología , Toxoplasmosis Ocular/diagnóstico , Toxoplasmosis Ocular/parasitología , Adulto JovenAsunto(s)
Síndrome de Inmunodeficiencia Adquirida/complicaciones , Retinitis/parasitología , Toxoplasmosis Ocular/complicaciones , Síndrome de Inmunodeficiencia Adquirida/diagnóstico , Síndrome de Inmunodeficiencia Adquirida/tratamiento farmacológico , Antiparasitarios/uso terapéutico , Antivirales/uso terapéutico , Femenino , Infecciones por VIH/complicaciones , Infecciones por VIH/diagnóstico , Infecciones por VIH/tratamiento farmacológico , Humanos , Imagen por Resonancia Magnética/métodos , Persona de Mediana Edad , Retinitis/diagnóstico , Retinitis/tratamiento farmacológico , Toxoplasma/patogenicidad , Toxoplasmosis Ocular/diagnóstico , Toxoplasmosis Ocular/tratamiento farmacológico , Resultado del TratamientoRESUMEN
Purpose: To describe the distinguishing features of retinitis-like lesions seen in vitreoretinal lymphoma (VRL) from viral and toxoplasma retinitis.Methods: In this multicenter, retrospective study, we reviewed charts and imaging of consecutive patients with VRL. The associated features and the characteristics of retinitis-like lesions were assessed and compared with those of viral and toxoplasmic retinochoroiditis. Primary outcome measures were the unique features of VRL retinitis-like lesions.Results: Out of 76 eyes of 38 patients with VRL, retinitis-like lesions were identified in 6 eyes and confirmed on OCT. Distinctive features of VRL retinitis-like lesions were massive retinal thickening, associated sub-retinal pigment epithelium infiltrates and partial restoration of retinal layers after specific therapy.Conclusion: VRL can present with retinitis-like lesions that have distinctive OCT features on presentation as well as healing that can help to differentiate them from other lookalike etiologies and can guide further diagnostic and therapeutic interventions.
Asunto(s)
Linfoma Intraocular/diagnóstico , Neoplasias de la Retina/diagnóstico , Retinitis/diagnóstico , Cuerpo Vítreo/patología , Anciano , Anciano de 80 o más Años , Infecciones Parasitarias del Ojo/diagnóstico , Infecciones Parasitarias del Ojo/parasitología , Infecciones Virales del Ojo/diagnóstico , Infecciones Virales del Ojo/virología , Femenino , Humanos , Linfoma Intraocular/parasitología , Linfoma Intraocular/virología , Masculino , Persona de Mediana Edad , Neoplasias de la Retina/parasitología , Neoplasias de la Retina/virología , Retinitis/parasitología , Retinitis/virología , Estudios Retrospectivos , Tomografía de Coherencia ÓpticaRESUMEN
DUSN is an infectious ocular disease that can lead to severe visual impairment and blindness. It usually occurs in young healthy individuals and depending on the stage of the disease, clinical presentation may range from mild vitritis and multifocal gray-white lesions in outer retina to optic atrophy.Parasites of different sizes and species have been proposed as the etiological agent of this disease. Thus, it is hypothesized that different infectious worms may be considered as the likely cause of a both autoimmune and toxic form of nematode retinopathy.Most patients present with already severe visual impairment and in the later stages of the disease, where the likelihood of improvement is low, despite therapy. In cases of early diagnosis, prompt treatment, whether with oral antihelmintic or direct photocoagulation of the worm, patients may show considerable visual improvement and have a more favorable prognosis.
Asunto(s)
Infecciones Parasitarias del Ojo/complicaciones , Granuloma/complicaciones , Mácula Lútea/patología , Retinitis/etiología , Toxoplasma/aislamiento & purificación , Toxoplasmosis Ocular/complicaciones , Agudeza Visual , Adolescente , Diagnóstico Diferencial , Infecciones Parasitarias del Ojo/diagnóstico , Infecciones Parasitarias del Ojo/parasitología , Angiografía con Fluoresceína/métodos , Fondo de Ojo , Granuloma/diagnóstico , Granuloma/parasitología , Humanos , Mácula Lútea/parasitología , Masculino , Retinitis/diagnóstico , Retinitis/parasitología , Tomografía de Coherencia Óptica , Toxoplasmosis Ocular/diagnóstico , Toxoplasmosis Ocular/parasitologíaAsunto(s)
Infecciones Parasitarias del Ojo/diagnóstico , Angiografía con Fluoresceína/métodos , Retinitis/diagnóstico , Tomografía de Coherencia Óptica/métodos , Cuerpo Vítreo/diagnóstico por imagen , Adulto , Animales , Artefactos , Diagnóstico Diferencial , Infecciones Parasitarias del Ojo/parasitología , Femenino , Fondo de Ojo , Humanos , Disco Óptico/patología , Retinitis/parasitología , Cuerpo Vítreo/parasitologíaRESUMEN
A 45-year-old woman presented with diminished vision in the left eye. Visual acuity was 6/9 and fundus showed a very large live nematode near the macula along with inflammatory outer retinal lesions in the periphery. We diagnosed the case as diffuse unilateral subacute neuroretinitis and treated with immediate focal photocoagulation of the worm along with oral antihelminthic drugs and corticosteroids. The report highlights the importance of prompt laser and steroids in achieving good structural as well as the functional outcome, and the added significance of advanced imaging techniques in prognosticating such patients.
Asunto(s)
Infecciones Parasitarias del Ojo/diagnóstico por imagen , Infecciones Parasitarias del Ojo/terapia , Infecciones por Nematodos/diagnóstico por imagen , Infecciones por Nematodos/terapia , Retinitis/diagnóstico por imagen , Retinitis/terapia , Antihelmínticos/uso terapéutico , Infecciones Parasitarias del Ojo/complicaciones , Femenino , Humanos , Fotocoagulación , Persona de Mediana Edad , Imagen Multimodal , Infecciones por Nematodos/complicaciones , Retinitis/parasitologíaRESUMEN
BACKGROUND AND OBJECTIVE: To report a unique case series of diffuse unilateral subacute neuroretinitis (DUSN) patients imaged with optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: In this retrospective case series, multimodal imaging was performed in four patients with DUSN at the time of patient visit. The study patients underwent standard clinical treatment for DUSN. RESULTS: The clinical findings were consistent with the diagnosis of DUSN. Cross-sectional OCT showed disruption of outer retinal layers in the foveal area and an irregular structure of the outer plexiform layer. En face OCT revealed hyperreflective spots and a large hyperreflective lesion in the foveal area correspondent to the outer retina disruption seen on cross-sectional OCT. OCTA demonstrated decreased vascular perfusion in both the superficial and deep retinal capillary plexuses along with choriocapillaris preservation. CONCLUSION: OCTA may provide a more detailed assessment of the retinal microvascular changes, allowing a more precise anatomical-functional correlation in DUSN. [Ophthalmic Surg Lasers Imaging Retina. 2020;51:76-83.].
Asunto(s)
Infecciones Parasitarias del Ojo/diagnóstico , Angiografía con Fluoresceína , Vasos Retinianos/patología , Retinitis/diagnóstico , Tomografía de Coherencia Óptica , Enfermedad Aguda , Administración Oral , Adolescente , Adulto , Albendazol/uso terapéutico , Antiprotozoarios/uso terapéutico , Niño , Estudios Transversales , Infecciones Parasitarias del Ojo/tratamiento farmacológico , Infecciones Parasitarias del Ojo/parasitología , Femenino , Humanos , Masculino , Imagen Multimodal , Vasos Retinianos/efectos de los fármacos , Retinitis/tratamiento farmacológico , Retinitis/parasitología , Estudios Retrospectivos , Agudeza Visual/fisiología , Adulto JovenRESUMEN
A 43-year-old immunocompetent male presented with focal macular retinitis with overlying vitritis in the right eye. His BCVA was counting fingers close to face. OCT showed increased intraretinal thickness at the area of retinitis with adjacent hypo reflectivity of the choroid. Serology was positive for IgM and IgG antibodies for toxoplasma. He received oral clindamycin 300 mg 4 times/day for 8 weeks. At 6 weeks, his BCVA was CF 2 metres. Fundus showed complete resolution of retinitis with formation of near, full thickness macular hole with intact overlying ILM. A small hyper reflective scar was seen at the base of the macular hole.
Asunto(s)
Infecciones Parasitarias del Ojo/complicaciones , Mácula Lútea/patología , Perforaciones de la Retina/etiología , Retinitis/complicaciones , Toxoplasma/aislamiento & purificación , Toxoplasmosis Ocular/complicaciones , Vitrectomía/métodos , Enfermedad Aguda , Adulto , Infecciones Parasitarias del Ojo/diagnóstico , Infecciones Parasitarias del Ojo/parasitología , Humanos , Masculino , Perforaciones de la Retina/diagnóstico , Perforaciones de la Retina/cirugía , Retinitis/diagnóstico , Retinitis/parasitología , Tomografía de Coherencia Óptica , Toxoplasmosis Ocular/diagnóstico , Toxoplasmosis Ocular/parasitologíaRESUMEN
ABSTRACT Purpose: To evaluate the prevalence, clinical characteristics, and types of optic nerve involvement in patients with ocular toxoplasmosis. Methods: For this retrospective cross-sectional study, we examined all patients with active ocular toxoplasmosis referred to our Uveitis Section during the last 12 years, and we included patients with optic nerve involvement in the study. The primary outcome was the prevalence of optic nerve involvement, and secondary outcomes included the types of optic nerve involvement and the final best-corrected visual acuity after treatment. Results: The prevalence of optic nerve involvement was 14.4%, with the leading cause being the activation of a juxtapapillary lesion (70.5%). We found papillitis in two eyes and neuroretinitis in two eyes (11.7% for each). We only detected one optic nerve involvement secondary to a distant active lesion (5.8%). Sixteen patients (94.1%) had unilateral ocular toxoplasmosis. The overall final best-corrected visual acuity after treatment was 10/10 (LogMAR = 0.0) excluding the three patients with a juxtapapillary scar involving the macula. Conclusions: Optic nerve involvement was common in patients with ocular toxoplasmosis. The main type of optic nerve involvement was caused by activation of an old juxtapapillary lesion. Treatment was quickly effective, but the best-corrected visual acuity was dependent on the presence of a scar in the papillomacular bundle.
RESUMO Objetivos: Avaliar a prevalência, características clínicas e tipos de acometimento do nervo óptico em pacientes com toxoplasmose ocular. Métodos: Para este estudo retrospectivo transversal, examinamos todos os pacientes com toxoplasmose ocular ativa encaminhados ao nosso Setor de Uveíte nos últimos 12 anos, e incluímos pacientes com comprometimento do nervo óptico no estudo. O resultado primário foi a prevalência do envolvimento do nervo óptico, e os resultados secundários incluíram os tipos de envolvimento do nervo óptico e a acuidade visual final melhor corrigida após o tratamento. Resultados: A prevalência de acometimento do nervo óptico foi 14,4%, sendo a principal causa a ativação de uma lesão justapapilar (70,5%). Encontramos papilite em dois olhos e neuroretinite em dois olhos (11,7% para cada um). Apenas detectamos um comprometimento do nervo óptico secundário a uma lesão ativa distante (5,8%). Dezesseis pacientes (94,1%) apresentavam toxoplasmose ocular unilateral. A acuidade visual final com melhor correção após o tratamento foi 10/10 (LogMAR= 0,0) excluindo os três pacientes com uma cicatriz justapapilar envolvendo a mácula. Conclusões: O comprometimento do nervo óptico foi comum em pacientes com toxoplasmose ocular. O principal tipo de comprometimento do nervo óptico foi causado pela ativação de uma lesão justapapilar antiga. O tratamento foi rapidamente eficaz, mas a acuidade visual final com melhor correção foi dependente da presença de uma cicatriz no feixe papilomacular.
Asunto(s)
Humanos , Masculino , Femenino , Niño , Adolescente , Adulto , Adulto Joven , Enfermedades del Nervio Óptico/parasitología , Enfermedades del Nervio Óptico/patología , Toxoplasmosis Ocular/patología , Nervio Óptico/patología , Nervio Óptico/diagnóstico por imagen , Retinitis/parasitología , Retinitis/patología , Factores de Tiempo , Turquía/epidemiología , Agudeza Visual , Enfermedades del Nervio Óptico/tratamiento farmacológico , Enfermedades del Nervio Óptico/epidemiología , Papiledema/parasitología , Papiledema/patología , Toxoplasmosis Ocular/tratamiento farmacológico , Prevalencia , Estudios Transversales , Estudios Retrospectivos , Tomografía de Coherencia Óptica/métodos , Centros de Atención TerciariaRESUMEN
PURPOSE: To evaluate the prevalence, clinical characteristics, and types of optic nerve involvement in patients with ocular toxoplasmosis. METHODS: For this retrospective cross-sectional study, we examined all patients with active ocular toxoplasmosis referred to our Uveitis Section during the last 12 years, and we included patients with optic nerve involvement in the study. The primary outcome was the prevalence of optic nerve involvement, and secondary outcomes included the types of optic nerve involvement and the final best-corrected visual acuity after treatment. RESULTS: The prevalence of optic nerve involvement was 14.4%, with the leading cause being the activation of a juxtapapillary lesion (70.5%). We found papillitis in two eyes and neuroretinitis in two eyes (11.7% for each). We only detected one optic nerve involvement secondary to a distant active lesion (5.8%). Sixteen patients (94.1%) had unilateral ocular toxoplasmosis. The overall final best-corrected visual acuity after treatment was 10/10 (LogMAR = 0.0) excluding the three patients with a juxtapapillary scar involving the macula. CONCLUSIONS: Optic nerve involvement was common in patients with ocular toxoplasmosis. The main type of optic nerve involvement was caused by activation of an old juxtapapillary lesion. Treatment was quickly effective, but the best-corrected visual acuity was dependent on the presence of a scar in the papillomacular bundle.
Asunto(s)
Enfermedades del Nervio Óptico/patología , Enfermedades del Nervio Óptico/parasitología , Toxoplasmosis Ocular/patología , Adolescente , Adulto , Niño , Estudios Transversales , Femenino , Humanos , Masculino , Nervio Óptico/diagnóstico por imagen , Nervio Óptico/patología , Enfermedades del Nervio Óptico/tratamiento farmacológico , Enfermedades del Nervio Óptico/epidemiología , Papiledema/parasitología , Papiledema/patología , Prevalencia , Retinitis/parasitología , Retinitis/patología , Estudios Retrospectivos , Centros de Atención Terciaria , Factores de Tiempo , Tomografía de Coherencia Óptica/métodos , Toxoplasmosis Ocular/tratamiento farmacológico , Toxoplasmosis Ocular/epidemiología , Turquía/epidemiología , Agudeza Visual , Adulto JovenRESUMEN
[Full article available at http://rimed.org/rimedicaljournal-2019-03.asp].
Asunto(s)
Retinitis/diagnóstico , Toxoplasmosis Ocular/diagnóstico , Adulto , Femenino , Humanos , Retinitis/parasitología , Retinitis/fisiopatología , Toxoplasma/aislamiento & purificación , Toxoplasmosis Ocular/fisiopatología , Agudeza VisualRESUMEN
Purpose: To analyze the patterns and causes of intraocular inflammation in patients attending uveitis referral clinics in Egypt. Methods: The study included 454 patients with uveitis examined both at the Department of Ophthalmology, Alexandria Faculty of Medicine, and tertiary uveitis referral clinics in Cairo and the International Eye Clinic in Upper Egypt, between August 2013 and March 2016. All patients had a comprehensive ocular examination and systemic work-up. Standard diagnostic criteria for uveitis syndromes were employed for all patients and ancillary ocular or systemic investigations were ordered as required by the suspected uveitis entity. Results: The mean age at presentation was 30 years (range: 4-75). The male to female ratio was 1.1:1. Panuveitis was the most common anatomic pattern (43%), followed by anterior (40.7%), posterior (9%), and intermediate uveitis (7.3%). Anterior uveitis was most commonly attributed to pediatric parasitic anterior chamber granulomas (22.2%). Intermediate uveitis was most commonly idiopathic (81.8%). Toxoplasma retinitis was the most common cause of posterior uveitis (31.7%). Behçet disease was the most common cause of panuveitis followed by Vogt-Koyanagi-Harada (VKH) disease (45.6% and 22.1%, respectively). Among non-infectious etiologies, Behçet disease was the most frequent etiology (28.6%), while for infectious causes, herpetic uveitis was found to be the most frequent cause (39.8%). Conclusions: In this uveitis patient population from Egypt, panuveitis was the most commonly encountered anatomic diagnosis. Behçet disease was the most common identified cause of uveitis followed by VKH disease. Herpes-related uveitides and parasitic granulomas represented the most evident causes of infectious uveitis.
Asunto(s)
Síndrome de Behçet/complicaciones , Toxoplasmosis Ocular/complicaciones , Uveítis/epidemiología , Uveítis/etiología , Síndrome Uveomeningoencefálico/complicaciones , Adolescente , Adulto , Distribución por Edad , Anciano , Niño , Preescolar , Estudios de Cohortes , Egipto/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Retinitis/parasitología , Estudios Retrospectivos , Distribución por Sexo , Uveítis/diagnósticoRESUMEN
Diffuse unilateral subacute neuroretinitis (DUSN) is caused by a subretinal live and mobile nematode. Acute phase: Patients usually present with severe pain, decreased vision, vitritis/papillitis, and tracks of grayish-white lesions-and a live nematode. Late phase: Arterial narrowing, optic atrophy, diffuse disruption of the retinal pigment epithelium (RPE), with severe visual loss.
Asunto(s)
Infecciones Parasitarias del Ojo/fisiopatología , Infecciones por Nematodos/fisiopatología , Retinitis/fisiopatología , Humanos , Epitelio Pigmentado de la Retina/parasitología , Retinitis/parasitologíaRESUMEN
The aim of this study was to report a case of atypical toxoplasma retinochoroiditis following intravitreal triamcinolone acetonide (IVTA) injection and to review the literature pertaining to toxoplasma retinochoroiditis following intravitreal injection of corticosteroid. Clinical data were collected from a 64-year-old male who developed toxoplasma retinitis 2 months after IVTA. A review of the literature was conducted to identify additional reports on similar cases. A 64-year-old male, known diabetic with nonproliferative diabetic retinopathy in both the eyes and optic atrophy in the left eye, presented with atypical retinitis inferior to the disc following IVTA. Real-time polymerase chain reaction and serology confirmed the toxoplasma etiology, and the patient was started on anti-toxoplasma therapy along with oral corticosteroid leading to regression of the lesion by 3 months. A high index of suspicion and proper microbiological diagnosis with appropriate antimicrobial therapy can aid in the management of toxoplasma retinochoroiditis following intravitreal injection of corticosteroid.
Asunto(s)
Infecciones Parasitarias del Ojo/etiología , Retina/patología , Retinitis/etiología , Toxoplasma/aislamiento & purificación , Toxoplasmosis Ocular/etiología , Triamcinolona Acetonida/efectos adversos , Infecciones Parasitarias del Ojo/diagnóstico , Infecciones Parasitarias del Ojo/parasitología , Glucocorticoides/administración & dosificación , Glucocorticoides/efectos adversos , Humanos , Inyecciones Intravítreas , Masculino , Persona de Mediana Edad , Retina/parasitología , Retinitis/diagnóstico , Retinitis/parasitología , Tomografía de Coherencia Óptica , Toxoplasmosis Ocular/diagnóstico , Toxoplasmosis Ocular/parasitología , Triamcinolona Acetonida/administración & dosificaciónAsunto(s)
Ceguera/diagnóstico , Infecciones Parasitarias del Ojo/diagnóstico por imagen , Infecciones por Nematodos/diagnóstico por imagen , Retinitis/diagnóstico por imagen , Tomografía de Coherencia Óptica , Enfermedad Aguda , Administración Oral , Albendazol/uso terapéutico , Antiprotozoarios/uso terapéutico , Ceguera/parasitología , Terapia Combinada , Infecciones Parasitarias del Ojo/parasitología , Infecciones Parasitarias del Ojo/terapia , Femenino , Humanos , Coagulación con Láser , Infecciones por Nematodos/parasitología , Infecciones por Nematodos/terapia , Retinitis/parasitología , Retinitis/terapia , Agudeza Visual , Adulto JovenRESUMEN
We report the first case of Trypanosoma cruzi-associated retinitis diagnosed using 28s ribosomal DNA sequencing. The case highlights the utility of broad-range molecular diagnostics for detecting rare and unsuspected ocular pathogens. Ocular involvement in Chagas disease is also discussed.
Asunto(s)
Enfermedad de Chagas/complicaciones , Enfermedad de Chagas/diagnóstico , Huésped Inmunocomprometido , Retinitis/parasitología , Trypanosoma cruzi/aislamiento & purificación , Anciano , ADN Protozoario/genética , ADN Ribosómico/genética , Humanos , Masculino , Técnicas de Diagnóstico Molecular , Mieloma Múltiple/complicaciones , Reacción en Cadena de la Polimerasa , Retinitis/diagnóstico , Análisis de Secuencia de ADNRESUMEN
Two patients (a 37-year-old man and a 28-year-old woman) who had choroidal neovascular membrane (CNVM) secondary to inactive toxoplasma retinochoroiditis scarring were evaluated. Multimodal imaging including fluorescein angiography, optical coherence tomography (OCT), and OCT angiography (OCTA) was used. CNVM secondary to inactive toxoplasma retinochoroiditis scarring was detected. Representative images of CNVM were demonstrated in the outer retinal layer and choriocapillary layer on OCTA. OCTA, a relatively new technique, is useful in the diagnosis of the CNVMs secondary to retinochoroiditis. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:509-511.].