RESUMEN

Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor (EGFR), tumor necrosis factor receptor (TNFR), and apoptosis antigen 1 (FAS), causing a reduction of the effects of their respective ligands. In addition, RID inhibits apoptosis by decreasing the secretion of TNF-related apoptosis-inducing ligand (TRAIL) by normal tissue cells. In this article, we report that RID inhibited chemokine expression in human breast cancer cell line MDA-MB-231 but showed no effect in cell line MCF7. These dissimilar results may be due to the different molecular and functional properties of both cell lines. Therefore, it is necessary to replicate this study in other breast cancer cell models.

Asunto(s)

Proteínas E3 de Adenovirus/fisiología , Neoplasias de la Mama/metabolismo , Proteínas de la Membrana/fisiología , FN-kappa B/metabolismo , Factor de Transcripción AP-1/metabolismo , Factor de Necrosis Tumoral alfa/farmacología , Adenoviridae/genética , Proteínas E3 de Adenovirus/genética , Línea Celular Tumoral , Receptores ErbB/metabolismo , Humanos , Células MCF-7 , Proteínas de la Membrana/genética , Receptores del Factor de Necrosis Tumoral/metabolismo , Transducción de Señal/efectos de los fármacos , Receptor fas/metabolismo