RESUMEN

A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.

Asunto(s)

Tejido Adiposo/metabolismo , Proteínas del Citoesqueleto/metabolismo , Grasas de la Dieta/administración & dosificación , Proteína Oncogénica v-cbl/metabolismo , Transducción de Señal/fisiología , Animales , Proteínas del Citoesqueleto/genética , Glucosa/metabolismo , Insulina/metabolismo , Masculino , Músculo Esquelético/metabolismo , Proteína Oncogénica v-cbl/genética , Fosfatidilinositol 3-Quinasas/metabolismo , Ratas , Ratas Wistar