RESUMEN
CONTEXT: Presbycusis can be mediated by the effects of inflammatory processes on the auditory system, and these aging biological mechanisms remain poorly studied. AIMS: The aim of this study was to determine whether plasma biomarkers are associated with hearing disorders caused by aging in the elderly. SETTINGS AND DESIGN: Cross-sectional study with 106 participants in the Active Aging Project, 93 (88%) females and 13 (12%) males, with an average age of 70 years. METHODS AND MATERIAL: Audiological evaluation was performed with pure tone audiometry and collection of peripheral blood for the measurement of plasma levels of interleukins 2, 4, 6, and 10, tumor necrosis factor-α, and interferon-γ by means of flow cytometry. STATISTICAL ANALYSIS USED: The SPSS (v.0, SPSS Inc., Chicago, USA) was used for the analysis of the data obtained. For all data analyzed, the significance level adopted was P < 0.05 and 95% confidence interval. RESULTS: There were statistically significant correlations between male and IL-2 (P = 0.031; rs = 0.210), mean II of the right ear (P = 0.004; rs = 0.279), longer in years (P = 0.002; rs = 0.307) and in hours (P = 0.004; rs = 0.281) of noise exposure also in males. CONCLUSIONS: In the present study, there was an association between the male gender and higher plasma levels of IL-2, an increase in the average hearing in the right ear, and greater time in years and hours of exposure to noise. There was a predominance of mild sensorineural hearing loss and worsening of hearing related to age, characteristics of presbycusis.
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Audiometría de Tonos Puros , Biomarcadores , Interleucina-2 , Presbiacusia , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Envejecimiento/sangre , Envejecimiento/fisiología , Biomarcadores/sangre , Estudios Transversales , Interferón gamma/sangre , Interleucina-2/sangre , Presbiacusia/sangre , Presbiacusia/etiología , Factor de Necrosis Tumoral alfa/sangreRESUMEN
BACKGROUND: Age-related hearing loss (ARHL) is a general term used to describe the sensorineural type of hearing loss occurring in both ears in older adults. Neurotrophins are the most promising candidates for supporting the auditory nerve by increasing neuronal survival. This study aimed to help elucidate the pathophysiology of ARHL by determining whether any relationship exists between brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) levels in serum samples from patients diagnosed with ARHL. MATERIALS AND METHOD: Seventy-seven individuals, a study group of 41 patients diagnosed with ARHL, and a control group of 36 participants without hearing loss were evaluated. Serum samples were collected and used to measure serum BDNF and NT-3 levels with the new Nepenthe enzyme-linked immunosorbent assay method. RESULTS: Median pure-tone average results in the 2000, 4000, and 6000 Hz ranges were 52.5 (44.3-67.3) dB HL in the ARHL group and 13.5 (11.1-17.1) dB HL in the control group. The difference was statistically significant (p = .001). Although NT-3 and BDNF levels were both lower in ARHL patients than in participants without hearing loss, only the BDNF levels were significantly (p = .002) lower. Mean left and right ear word recognition scores were also lower in ARHL patients than in control groups. The ARHL group was further divided into two subgroups based on word recognition scores to evaluate significant differences in BDNF and NT-3 levels. No statistically significant difference was observed in BDNF and NT-3 levels between these subgroups. However, there was a significant difference in word recognition scores. CONCLUSIONS: Low BDNF levels in the ARHL group suggest that BDNF may play a role in the pathogenesis of ARHL. Patients with low (ARHL1) and high (ARHL2) word recognition scores were compared for the first time in the literature in terms of BDNF and NT-3 levels. However, the results were not statistically significant. This article is a preliminary study and was written to provide guidance for our next comprehensive project.
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Umbral Auditivo , Factor Neurotrófico Derivado del Encéfalo , Neurotrofina 3 , Humanos , Factor Neurotrófico Derivado del Encéfalo/sangre , Neurotrofina 3/sangre , Masculino , Femenino , Anciano , Persona de Mediana Edad , Umbral Auditivo/fisiología , Presbiacusia/sangre , Presbiacusia/fisiopatología , Presbiacusia/diagnóstico , Audiometría de Tonos Puros , Anciano de 80 o más Años , Estudios de Casos y ControlesRESUMEN
Objective: Tinnitus is associated with various conditions such as presbycusis, infectious, autoimmune and many other diseases. Our study aims to identify an association between inflammatory markers and the presence of tinnitus or hearing loss (HL).Design: Exploratory study including a structured interview, complete ENT observation, audiological and inflammatory markers evaluation.Study Sample: Sixty women and 54 men (55 to 75 years) from the Portuguese population, with or without sensory presbycusis and/or tinnitus.Results: IL10 levels were significantly lower in participants with tinnitus than in those without tinnitus. Moreover, TGF-ß was lower in older participants (p = 0.034), IL1α was higher in participants with tonal tinnitus (p = 0.033), and IL2 was lower in participants who reported partial or complete residual inhibition (p = 0.019). Additionally, we observed a negative correlation between tinnitus duration and IL10 levels (r= -.281), and between HSP70 levels and tinnitus loudness (r= -.377). TNF-α and HSP70 levels appears to be sensitive to the time when samples were collected (morning or afternoon).Conclusions: The results of our study showing fluctuations in inflammatory markers along the hearing loss process, reinforce the idea that inflammatory mechanisms are involved in hearing loss pathogenesis but also in tinnitus. IL10 levels appear significantly altered in tinnitus but not in hearing loss.
Asunto(s)
Mediadores de Inflamación/sangre , Presbiacusia/sangre , Acúfeno/sangre , Anciano , Envejecimiento/sangre , Biomarcadores/sangre , Femenino , Proteínas HSP70 de Choque Térmico/sangre , Humanos , Inflamación , Interleucina-10/sangre , Interleucina-1alfa/sangre , Interleucina-2/sangre , Masculino , Persona de Mediana Edad , Estrés Oxidativo , Portugal , Presbiacusia/etiología , Factores de Tiempo , Acúfeno/complicaciones , Factor de Crecimiento Transformador beta/sangre , Factor de Necrosis Tumoral alfa/sangreRESUMEN
BACKGROUND: MIAT may be implicated in the pathogenesis of age-related hearing loss (AHL). This study aimed to clarify the effect of a MIAT signaling pathway on the risk of AHL. METHODS: Terminal deoxynucleotidyl transferase dUTP nick-end labeling assay, auditory brainstem response (ABR) and quantitative hair cell counts were used to compare the hearing functions in different groups of mice. 5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide (JC-1) dye method was used to establish the potential association between mitochondrial dysfunction and aging. Real-time polymerase chain reaction, Western blot analysis, computational analysis, and luciferase assay were conducted to establish a myocardial infarction associated transcript (MIAT) signaling pathway, whose role in the pathogenesis of AHL was further validated by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and flow cytometry. RESULTS: Aged C57BL/6 mice were associated with a more severe level of hair cell loss, while exhibiting a higher ABR threshold at various frequencies as well as a lower percentage of inner/outer hair cells. A reduced mitochondrial membrane potential in the cochleae of aged C57BL/6 mice indicated the presence of mitochondrial dysfunction in these mice. Relative expression of MIAT, Sirtuin1 (SIRT1), and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) was downregulated in aged mice, with microRNA-29b (miR-29b) being highly expressed. Also, MIAT binds to miR-29b, an inhibitor of SIRT1 expression. The regulatory relationship among MIAT, miR-29b, and SIRT1 was further validated by comparing the differentiated expression of these factors in cells treated with phosphate-buffered saline + H2 O2, a negative control + H2 O2, MIAT + H2 O2 , or H2 O2 + anti-miR-29b. CONCLUSION: MIAT could elevate the expression of SIRT1/PGC-1α via downregulating miR-29b. And the downregulated SIRT/PGC-1α increased the incidence of AHL via promoting the apoptosis of cochlear hair cells.
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MicroARNs/metabolismo , Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/metabolismo , Polimorfismo de Nucleótido Simple , Presbiacusia/genética , ARN Largo no Codificante/genética , Sirtuina 1/metabolismo , Anciano , Animales , Apoptosis/genética , Sitios de Unión , Línea Celular Tumoral , Proliferación Celular/genética , Modelos Animales de Enfermedad , Femenino , Humanos , Masculino , Ratones , Ratones Endogámicos C57BL , MicroARNs/genética , Persona de Mediana Edad , Presbiacusia/sangre , ARN Largo no Codificante/metabolismo , TransfecciónRESUMEN
AIMS: To investigate the independent associations between hearing loss and dysglycaemia in a sample of middle-aged adults, including separate analysis of those aged < 60 years. METHODS: The first 2023 participants in the cross-sectional Busselton Health Ageing Survey were assessed for hearing loss ≥ 26 dB (better ear) for four-frequency average (4FA) of pure-tone thresholds at 500, 1000, 2000 and 4000 Hz, and high-frequency average (HFA) of pure-tone thresholds at 4000 and 8000 Hz. RESULTS: Valid data from 1864 participants in the Busselton Health Ageing Survey [92.1%; mean ± sd age 56.2 ± 5.5 years, 46.0% men, 120 (7.0%) with diabetes, 274 (14.7%) with prediabetes] were analysed, of whom 103 (5.5%) had four-frequency average hearing loss and 561 (30.1%) had high-frequency average hearing loss. In multivariable analyses, glycaemic status was not independently associated with four-frequency or high-frequency average hearing loss. In the 1286 participants aged < 60 years, there was no relationship between dysglycaemia and high-frequency average hearing loss, but the prevalence of four-frequency average hearing loss increased from 2.3% (95% CI 1.5-3.4) in participants with normoglycaemia to 5.7% (95% CI 3.0-10.6) in those with prediabetes and 10.2% (4.2-21.5) in those with diabetes (trend P = 0.003). In multivariable analysis with normoglycaemia as reference, the odds ratios for four-frequency average hearing loss were 2.84 (95% CI 1.29-6.27) for prediabetes and 5.93 (95% CI 1.67-21.05) for diabetes (P ≤ 0.01) in the < 60 year age group. CONCLUSIONS: There was progressively increasing mid-range hearing loss with worsening glucose tolerance in younger individuals, suggesting dysglycaemia-associated early-onset presbycusis.
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Diabetes Mellitus Tipo 2/epidemiología , Pérdida Auditiva/epidemiología , Estado Prediabético/epidemiología , Edad de Inicio , Envejecimiento/sangre , Envejecimiento/fisiología , Glucemia/metabolismo , Estudios Transversales , Diabetes Mellitus Tipo 2/sangre , Diabetes Mellitus Tipo 2/complicaciones , Femenino , Trastornos del Metabolismo de la Glucosa/sangre , Trastornos del Metabolismo de la Glucosa/complicaciones , Trastornos del Metabolismo de la Glucosa/epidemiología , Pérdida Auditiva/sangre , Pérdida Auditiva/etiología , Humanos , Masculino , Persona de Mediana Edad , Estado Prediabético/sangre , Estado Prediabético/complicaciones , Presbiacusia/sangre , Presbiacusia/epidemiología , PrevalenciaRESUMEN
Age-related hearing impairment (ARHI) is a progressive and a common sensory disorder in the elderly and will become an increasingly important clinical problem given the growing elderly population. Apoptosis of cochlear cells is an important factor in animal models of ARHI. As these cells cannot regenerate, their loss leads to irreversible hearing impairment. Identification of molecular mechanisms can facilitate disease prevention and effective treatment. In this study, we compared the expression of the genes BAK1 and BCL2 as two arms of the intrinsic apoptosis pathway between patients with ARHI and healthy subjects. ARHI and healthy subjects were selected after an ear nose throat examination, otoscopic investigation, and pure tone audiometry. RNA was extracted from peripheral blood samples, and relative gene expression levels were measured using quantitative real-time polymerase chain reaction. BAK1 and the BAK1/BCL2 ratio were statistically significantly upregulated in the ARHI subjects. The BAK1/BCL2 ratio was positively correlated with the results of the audiometric tests. Our results indicate that BAK-mediated apoptosis may be a core mechanism in the progression of ARHI in humans, similar to finding in animal models. Moreover, the gene expression changes in peripheral blood samples could be used as a rapid and simple biomarker for early detection of ARHI.
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Apoptosis/genética , Presbiacusia/genética , Proteínas Proto-Oncogénicas c-bcl-2/biosíntesis , Proteína Destructora del Antagonista Homólogo bcl-2/biosíntesis , Anciano , Apoptosis/fisiología , Audiometría , Biomarcadores , Cóclea/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Presbiacusia/sangre , Presbiacusia/patología , Proteínas Proto-Oncogénicas c-bcl-2/sangre , Reacción en Cadena en Tiempo Real de la Polimerasa , Proteína Destructora del Antagonista Homólogo bcl-2/sangreRESUMEN
BACKGROUND: The aim of this study was to investigate whether glycosylated hemoglobin (HbA1c) level in nondiabetic patients is associated with hearing impairment in the general Korean population. PATIENTS AND METHODS: Data from the Korean National Health and Nutrition Examination Survey 2011-2013 were used in the analyses. Participants were excluded from this study for the following reasons: they could not provide data regarding pure tone audiometry, they had ear disease, they had brain disorders, asymmetric sensory neural hearing loss (HL), or they were younger than 40 years or had diabetes mellitus. Finally, 7449 participants were included in this study. RESULTS: The mean HbA1c levels in the low, middle, and high tertiles were 5.3% ± 0.2%, 5.7% ± 0.1%, and 6.1% ± 0.2%, respectively. The numbers of participants in the low, middle, and high tertiles were 2808, 2509, and 2132, respectively. The low-frequency, mid-frequency, high-frequency, and average hearing thresholds were significantly increased with increasing HbA1c tertile. Linear regression analyses showed that HbA1c level in the nondiabetic participants was associated with components of metabolic syndrome. The mean numbers of metabolic syndrome components in the low, middle, and high HbA1c tertiles were 1.22, 1.53, and 2.02, respectively. The participants in the middle and high HbA1c tertiles had a 1.239- and 1.253-fold increased risk of HL, respectively, compared with those in the low HbA1c tertile. CONCLUSION: HbA1c level was associated with hearing impairment in the nondiabetic participants of this study. Therefore, the participants with high HbA1c levels should be closely monitored for hearing impairment.
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Percepción Auditiva , Hemoglobina Glucada/análisis , Pérdida Auditiva Sensorineural/sangre , Audición , Presbiacusia/sangre , Estimulación Acústica , Adulto , Anciano , Audiometría de Tonos Puros , Umbral Auditivo , Biomarcadores/sangre , Distribución de Chi-Cuadrado , Femenino , Encuestas Epidemiológicas , Pérdida Auditiva Sensorineural/diagnóstico , Pérdida Auditiva Sensorineural/fisiopatología , Pérdida Auditiva Sensorineural/psicología , Humanos , Modelos Lineales , Modelos Logísticos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Presbiacusia/diagnóstico , Presbiacusia/fisiopatología , Presbiacusia/psicología , República de Corea , Estudios Retrospectivos , Factores de RiesgoRESUMEN
Age-related hearing loss (AHL) is a progressive neurodegenerative disease that is largely silent in its initial stages. There is no sensitive blood biomarker for diagnosis or early detection of AHL. MicroRNAs (miRNAs or miRs) are abundant and highly stable in blood, and have been recently described as powerful circulating biomarkers in a wide range of diseases. In the present study, we identified concordant increases in miR-34a levels in the cochlea, auditory cortex, and plasma of C57BL/6 mice during aging. These increases were accompanied by elevated hearing thresholds and greater loss of hair cells. Levels of miR-34a targets, silent information regulator 1 (SIRT1), B-cell lymphoma-2 (Bcl-2), and E2F transcription factor 3 (E2F3), in the cochlea, auditory cortex, and plasma decreased with aging inversely to miR-34a. Moreover, plasma miR-34a levels were significantly higher in patients with AHL compared with controls who had normal hearing and had a receiver-operating characteristic curve that distinguished AHL patients from controls. However, SIRT1, Bcl-2, and E2F3 showed no correlation with AHL in humans. In summary, circulating miR-34a level may potentially serve as a useful biomarker for early detection of AHL.
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Audición/genética , MicroARNs/sangre , Presbiacusia/genética , Estimulación Acústica , Adulto , Factores de Edad , Animales , Área Bajo la Curva , Audiometría de Tonos Puros , Corteza Auditiva/metabolismo , Corteza Auditiva/fisiopatología , Umbral Auditivo , Estudios de Casos y Controles , Cóclea/metabolismo , Cóclea/fisiopatología , Modelos Animales de Enfermedad , Potenciales Evocados Auditivos del Tronco Encefálico , Femenino , Marcadores Genéticos , Predisposición Genética a la Enfermedad , Células Ciliadas Auditivas/metabolismo , Humanos , Masculino , Ratones Endogámicos C57BL , Persona de Mediana Edad , Fenotipo , Valor Predictivo de las Pruebas , Presbiacusia/sangre , Presbiacusia/fisiopatología , Curva ROC , Reacción en Cadena en Tiempo Real de la Polimerasa , Regulación hacia ArribaRESUMEN
OBJECTIVE: To investigate the effect of metabolic syndrome and its components on presbycusis. METHODS: Total of 165 cases and 202 controls were continuously collected in Harbin Ninth Hospital from June 2013 to August 2014, these subjects were investigated and received anthropometry and received biochemical test in hospital laboratory. Statistics analysis was adopted by χ2 test, t test and logistic regression model. RESULTS: Only triglyceride abnormal proportion of case group was higher than that of control group among components of metabolic syndrome, and it were associated with age-related hearing loss whether before adjustment or not after adjustment, OR (95% CI) were 1.69 (1.09-2.63) and 1.96 (1.08-3.54) respectively, and others were not associated with presbycusis. In addition, among all of the various combinations of the components of the metabolic syndrome, combination of triglycerides and high-density lipoprotein, combination of triglycerides and blood glucose, combination of triglycerides and blood pressure were associated with age-related hearing loss before adjustment and after adjustment, OR were 5.31 (95% CI 1.63-17.27), 2.66 (95% CI 1.04-6.85) and 2.09 (95% CI 1.04-4.18) respectively. Further more, the metabolic syndrome was not statistically associated with presbycusis, OR were 1.27 (95% CI 0.83-1.94) and 0.92 (95% CI 0.54-1.57) respectively before adjustment and after adjustment. In addition, stratified by age, the metabolic syndrome was still not statistically associated with presbycusis in each stratification, OR were 0.89 (95% CI 0.44-1.82) and 1.49 (95% CI 0.67-3.30) respectively. CONCLUSION: The triglyceride was associated with presbycusis. Among all of combinations of the components of the metabolic syndrome, combination of triglycerides and high-density lipoprotein, combination of triglycerides and blood glucose, combination of triglycerides and blood pressure were associated with age-related hearing loss.
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Glucemia/metabolismo , Síndrome Metabólico/sangre , Presbiacusia/sangre , Triglicéridos/metabolismo , Factores de Edad , Envejecimiento , Presión Sanguínea , Estudios de Casos y Controles , China/epidemiología , Humanos , Lipoproteínas HDL , Modelos Logísticos , Presbiacusia/epidemiología , Factores de Riesgo , Triglicéridos/sangreRESUMEN
BACKGROUND: Previous animal studies have shown that vitamins may prevent age-related hearing loss. However, no concrete conclusions have been reached about the association between vitamin intake and presbycusis in humans. OBJECTIVE: We investigated the association between dietary vitamin intake and hearing thresholds in adults between 50 and 80 y of age by using data from a large population-based survey. DESIGN: We used data from the 2011 Korea National Health and Nutrition Examination Survey. A pure-tone audiogram and physical examination of the ear were performed, and vitamin intake was calculated by using the 24-h recall method. Data from 1910 participants were analyzed through univariate and multivariate linear regression analyses. RESULTS: After adjustment for age, sex, smoking, and exposure to occupational and explosive noise, intake of vitamin C correlated with better hearing at midfrequency (2000 and 3000 Hz) (coefficient: -0.012; 95% CI: -0.022, -0.002). Dietary supplement use was positively associated with better hearing at all frequencies. The univariate analysis indicated that dietary intakes of retinol, riboflavin, niacin, and vitamin C were positively correlated with better hearing at most frequencies. In contrast, serum concentrations of vitamin D were associated with worse hearing at mid and high (4000 and 6000 Hz) frequencies. CONCLUSIONS: Dietary intake of vitamin C was associated with better hearing in the older population. Because less than one-half of elderly participants in this study consumed a sufficient amount of vitamins, and vitamin intake decreased with age, we should consider proper diet counseling to prevent hearing decline.
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Envejecimiento , Dieta , Suplementos Dietéticos , Presbiacusia/prevención & control , Vitaminas/uso terapéutico , Anciano , Anciano de 80 o más Años , Ácido Ascórbico/uso terapéutico , Umbral Auditivo , Estudios Transversales , Dieta/etnología , Suplementos Dietéticos/efectos adversos , Femenino , Encuestas Epidemiológicas , Humanos , Masculino , Persona de Mediana Edad , Niacina/uso terapéutico , Presbiacusia/sangre , Presbiacusia/epidemiología , Presbiacusia/etnología , República de Corea/epidemiología , Riboflavina/uso terapéutico , Factores de Riesgo , Factores Sexuales , Vitamina A/uso terapéutico , Vitamina D/efectos adversos , Vitamina D/sangre , Vitaminas/efectos adversosRESUMEN
BACKGROUND: Although research has linked systemic inflammation to various diseases of aging, few studies have examined the potential role it may play in the development of age-related hearing impairment. METHODS: Among 1,073 participants free of hearing impairment (pure-tone average 0.5, 1, 2, 4kHz ≤ 25 dB HL) in the population-based Epidemiology of Hearing Loss Study (1998-2000), serum C-reactive protein, and interleukin-6 were measured at three time points (1988-1990, 1998-2000, and 2009-2010), and tumor necrosis factor-α was measured at one time point (1998-2000), whereas hearing impairment was measured again in 2003-2005 and 2009-2010 to determine the 10-year cumulative incidence. RESULTS: Inflammatory marker levels from a single time point (1998-2000) were not associated with an increased risk of developing hearing impairment. Associations between long-term serum C-reactive protein levels and incident hearing impairment differed by age (p = .031). Participants less than 60 years with consistently high (>3 mg/L) or increasing levels of serum C-reactive protein over 10 years were nearly two times (hazard ratio: 1.96, 95% confidence interval: 1.19, 3.23) as likely to develop hearing impairment over the subsequent 10-year period, an association not seen in participants more than or equal to 60 years. A statistically significant association (p-trend = .041) was also observed between number of markers in the highest group at baseline and incident hearing impairment in this younger age group. CONCLUSIONS: Associations between long-term serum C-reactive protein levels and incident hearing impairment were observed in the cohort as a whole, but differed significantly by age group, with statistically significant associations observed in adults less than 60 years, participants moving through the peak risk period for hearing impairment over the course of the study.
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Proteína C-Reactiva/metabolismo , Interleucina-6/sangre , Presbiacusia/sangre , Presbiacusia/epidemiología , Factor de Necrosis Tumoral alfa/sangre , Factores de Edad , Anciano , Anciano de 80 o más Años , Estudios de Cohortes , Femenino , Humanos , Incidencia , Inflamación/sangre , Inflamación/complicaciones , Masculino , Persona de Mediana Edad , Presbiacusia/diagnóstico , Factores de Riesgo , Factores de TiempoRESUMEN
CONCLUSION: Low plasma melatonin is significant in the development of high frequency hearing loss (HL) among the elderly. OBJECTIVE: To determine the correlation between hearing threshold and the plasma melatonin and ascorbic acid (vitamin C). METHODS: This was a cross-sectional study involving 126 apparently healthy elderly subjects, 59 males and 67 females, aged >60 years. Subjects underwent pure tone audiometry and plasma melatonin and vitamin C were assayed using high-performance liquid chromatography. RESULTS: The mean ± SD of plasma melatonin among the subjects with normal hearing (NH) (0-30 dB) and those with HL in the speech frequencies was 18.3 ± 3.6 µg/L and 16.4 ± 4.7 µg/L, respectively. In the high frequencies the values were 17.7 ± 6.2 µg/L and 13.1 ± 6.4 µg/L for NH and HL, respectively. For vitamin C, the mean ± SD among subjects with NH and those with HL in the speech frequencies were 1.2 ± 0.2 µg/L and 1.0 ± 0.1 µg/L, respectively. In the high frequencies, the values were 1.0 ± 0.2 µg/L and 0.9 ± 0.3 µg/L for NH and HL, respectively. Among subjects with high frequency HL, Spearman's correlation revealed significant correlation between increasing hearing threshold and melatonin (correlation coefficient = -0.30, p = 0.01), but not for vitamin C (correlation coefficient = -0.12, p = 0.22). Linear regression, adjusting for age, still revealed significant correlation between the melatonin (correlation coefficient = -0.03, p = 0.00) and hearing threshold in the high frequencies.
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Envejecimiento/sangre , Ácido Ascórbico/sangre , Pérdida Auditiva de Alta Frecuencia/sangre , Melatonina/sangre , Presbiacusia/sangre , Anciano , Anciano de 80 o más Años , Umbral Auditivo , Estudios Transversales , Femenino , Depuradores de Radicales Libres/sangre , Humanos , Masculino , Persona de Mediana EdadRESUMEN
OBJECTIVES: Age-related hearing loss is a common social and health problem in the older adult population. Up until now, very little scientific attention has been given to the potential role of fatty acids in age-related hearing loss. In this study we investigated whether plasma very long-chain n-3 polyunsaturated fatty acids (PUFAs) are associated with age-related hearing loss over three years. DESIGN: Cross-sectional and 3-year longitudinal analyses. SETTING: Wageningen, the Netherlands. PARTICIPANTS: 720 men and postmenopausal women (50-70 years of age) without middle ear dysfunction or unilateral hearing loss. MEASUREMENTS: Fatty acid proportions were measured in plasma cholesteryl esters. Hearing thresholds (in decibels, dB) at baseline and after three years were measured with pure-tone audiometry. Hearing loss was calculated as the increase in mean hearing thresholds in the low (0.5-kHz, 1-kHz, and 2-kHz) and high (4-kHz, 6-kHz, and 8-kHz) frequencies over three years. RESULTS: Subjects in the highest quartile of plasma very long-chain n-3 PUFA had less hearing loss in the low frequencies over three years than subjects in the lowest quartile (p < 0.01, ANCOVA, difference in mean adjusted hearing thresholds= -1.2 dB). There were no significant differences between the quartiles of plasma very long-chain n-3 PUFA in hearing loss in the high frequencies (p=0.49, ANCOVA). These associations are adjusted for baseline mean hearing thresholds, age, sex, level of education and alcohol consumption. CONCLUSION: This study is the first to show an inverse association between plasma very long-chain n-3 PUFAs and age-related hearing loss. These results are encouraging, but require confirmation from future studies.
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Envejecimiento/fisiología , Umbral Auditivo/fisiología , Ácidos Grasos Omega-3/sangre , Presbiacusia/sangre , Anciano , Audiometría , Estudios Transversales , Ácidos Grasos Omega-3/fisiología , Femenino , Humanos , Estudios Longitudinales , Masculino , Persona de Mediana Edad , Presbiacusia/etiologíaRESUMEN
OBJECTIVES/HYPOTHESIS: Presbycusis is the most prevalent cause of hearing-loss in the older, but pathogenesis is not well-know. The premise of this study is that hyperlipemia increase risk of age-related hearing-loss. PATIENTS AND METHODS: 180 patient more than 65 years-old were studied. All patients had bilateral hearing-loss and no renal, neurological, thyriod or middle-ear pathology. We explored serum levels of cholesterol, HDL, LDL and triglycerides. We performed tonal audimetry in all patients. RESULTS: The 71% of patients has hypercholesteremia and the highest serum levels were detected in 65-69 years-old men (mean media 5,27). Patients with hypercholesteremia had worse hearing-loss than patients with normal lipid serum levels (p < .05). CONCLUSIONS: Our study sugest that hypercholesteremia are associated to age-related hearing-loss, possibly by an atherosclerosis mechanism.
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Envejecimiento , Hipercolesterolemia/complicaciones , Presbiacusia/etiología , Anciano , Audiometría , Femenino , Humanos , Hipercolesterolemia/sangre , Lípidos/sangre , Masculino , Presbiacusia/sangre , Factores de RiesgoRESUMEN
Objetivo y antecedentes: La sordera ligada al envejecimiento es la causa más frecuente de sordera a partir de los 65 años, pero su patogenia es aún mal conocida. El objetivo de este estudio es valorar el impacto de la hiperlipemia en su patogenia. Ámbito del estudio: Población mayor de 65 años del área de Salud de El Bierzo. Pacientes: Incluimos en el estudio 180 pacientes con hipoacusia neurosensorial bilateral, sin antecedentes de patología renal, neurológica, tiroidea o de oído medio. Intervenciones: Se realizó audiometría tonal y estudio de lípidos plasmáticos (colesterol, HDL, LDL y triglicéridos). Se utilizan métodos estadísticos. Resultados: Los más destacados fueron: 1) el 71% de los pacientes presentaban niveles altos de lípidos en sangre, sobre todo las mujeres entre 65-69 años (media 256 mg/dl); 2) los hombres entre 65-69 años presentaban un alto índice aterogénico (media 5,27); 3) los pacientes con hiperlipemia presentaban peor audición (p < .05). Conclusiones: Nuestros resultados sugieren que los lípidos están implicados en el envejecimiento de la vía auditiva por un mecanismo aterogénico (AU)
Objectives/hypothesis: Presbycusis is the most prevalent cause of hearing-loss in the older, but pathogenesis is not well-know. The premise of this study is that hyperlipemia increase risk of age-related hearing-loss. Patients and methods: 180 patient more than 65 years-old were studied. All patients had bilateral hearing-loss and no renal, neurological, thyriod or middle-ear pathology. We explored serum levels of cholesterol, HDL, LDL and triglycerides. We performed tonal audiometry in all patients. Results: The 71% of patients has hypercholesteremia and the highest serum levels were detected in 65-69 years old men (mean media 5,27). Patients with hypercholesteremia had worse hearing-loss than patients with normal lipid serum levels (p < .05). Conclusions: Our study suggest that hypercholesteremia are associated to age-related hearing-loss, possibly by an atherosclerosis mechanism (AU)
Asunto(s)
Masculino , Femenino , Anciano , Humanos , Envejecimiento , Hipercolesterolemia/complicaciones , Presbiacusia/etiología , Audiometría , Hipercolesterolemia/sangre , Lípidos/análisis , Presbiacusia/sangre , Factores de RiesgoRESUMEN
OBJECTIVE: [corrected] To evaluate the existence of blood viscosity alterations in presbyacusis as an eventual pathophysiological mechanism. MATERIAL AND METHODS: Nine 75 year-old subjects bearing of bilateral slowly progressive sensorineural deafness were considered to be studied on a yearly basis in a ten year folow-up period, evaluating the binaural hearing loss in speech tones (500, 1000, 2000 and 3000 Hz). Hemorheological profile on peripheral blood included total blood viscosity (BV) at different shear rates (SR), blood filterability (BF), erythrocyte deformability and aggregability (EA). RESULTS: There was a trend of all parameters towards hyperviscosity, with an increase at ten years of BV at high SR and EA at total stasis which were statistically significant. The level of deafness correlated significativelly to low values of BF and increases on BV at high SR. CONCLUSIONS: Presbyacustic patients do show hemorheological evidences that suggest a tendency towards hyperviscosity as a predisposing factor for hearing loss.
Asunto(s)
Viscosidad Sanguínea , Presbiacusia/sangre , Anciano , Anciano de 80 o más Años , Estudios de Seguimiento , Humanos , Estudios ProspectivosRESUMEN
Objetivo: Evaluar la presencia de alteraciones en la viscosidad sanguínea en la presbiacusia como eventual mecanismo fisiopatológico. Material y métodos: Fueron incluídos 9 sujetos de 75 años de edad con hipoacusia neurosensorial bilateral lentamente progresiva, estudiados una vez anualmente durante 10 años consecutivos, valorando pérdida auditiva binaural en frecuencias conversacionales (500, 1000,2000 y 3000 Hz). El perfil hemorreológico en sangre periférica valoró viscosidad en sangre total (VST) a diferentes velocidades decizallamiento (VC), filtrabilidad sanguínea (FS), deformabilidad y agregabilidad eritrocitarias (AE). Resultados: Todos los parámetros tendieron a la hiperviscosidad, con VST a altas VC y AE en estasis total elevadas a los 10 años de forma estadísticamente significativa. La intensidad de la hipoacusia se correlacionó significativamente con los valores bajos de FS y los incrementos en VST a altas VC. Conclusiones: Los pacientes presbiacúsicos muestran evidencias hemorreológicas que sugieren tendencia a la hiperviscosidad como factor predisponente de la hipoacusia (AU)
OBJECTIVE: To evaluate the existence of blood viscosity alterations in presbyacusis as an eventual pathophysiological mechanism. MATERIAL AND METHODS: Nine 75 year-old subjects bearing of bilateral slowly progressive sensorineural deafness were considered to be studied on a yearly basis in a ten year folow-up period, evaluating the binaural hearing loss in speech tones (500, 1000, 2000 and 3000 Hz). Hemorheological profile on peripheral blood included total blood viscosity (BV) at different shear rates (SR), blood filterability (BF), erythrocyte deformability and aggregability (EA). RESULTS: There was a trend of all parameters towards hyperviscosity, with an increase at ten years of BV at high SR and EA at total stasis which were statistically significant. The level of deafness correlated significativelly to low values of BF and increases on BV at high SR. CONCLUSIONS: Presbyacustic patients do show hemorheological evidences that suggest a tendency towards hyperviscosity as a predisposing factor for hearing loss (AU)
Asunto(s)
Humanos , Presbiacusia/sangre , Viscosidad Sanguínea , Hemorreología , Factores de RiesgoRESUMEN
OBJETIVOS: Valorar en individuos mayores de 65 años la eventual correlación entre predisposición a la presbiacusia e hiperviscosidad sanguínea. PACIENTES Y MÉTODOS: Estudio sobre 20 individuos normooyentes y 80 afectos de hipoacusia perceptiva bilateral simétrica y progresiva de los siguientes parámetros hemorreológicos: filtrabilidad, deformabilidad y agregabilidad eritrocitaria, así como viscosidad en sangre total a diferentes velocidades de cizallamiento. Todos ellos con más de 65 años de edad. RESULTADOS: Se detectaron diferencias estadísticamente significativas en todos los parámetros medidos comparando individuos normooyentes y presbiacúsicos. La pérdida auditiva media se correlacionó de forma significativa con elevaciones en la agregabilidad eritrocitaria y con la viscosidad en sangre total a velocidades de cizallamiento altas (p< 0,01). Este último valor se correlacionó además con la pérdida auditiva en 2 kHz, y el descenso en la filtrabilidad eritrocitaria lo hizo con las pérdidas en 4 y 8 kHz. CONCLUSIONES: Existe un marcado deterioro en las propiedades viscoelásticas de la sangre entre sujetos mayores de 65 años afectos de presbiacusia. Un tratamiento preventivo de estas modificaciones podría reducir la incidencia de hipoacusia progresiva degenerativa en ancianos (AU)
Asunto(s)
Anciano , Anciano de 80 o más Años , Humanos , Viscosidad Sanguínea , Presbiacusia/sangre , Presbiacusia/etiología , Estudios de Casos y Controles , Envejecimiento/fisiologíaRESUMEN
Red cell basic ferritin (RCBF) was measured in 62 healthy subjects with normal hearing and 224 patients with different kinds of sensorineural hearing loss, compared with serum ferritin, haemoglobin, serum iron and circadian variation in the serum iron levels. The results showed that the RCBF concentrations in most kinds of sensorineural hearing loss were significantly lower than those in normal hearing status. It is conceivable that the RCBF assay can be used to evaluate the adequacy of iron stores that are useful in times of urgent iron needs and to diagnose relative iron deficiency in those patients with some other normal laboratory assays related to iron metabolism.
Asunto(s)
Eritrocitos/química , Ferritinas/sangre , Pérdida Auditiva Sensorineural/sangre , Adolescente , Adulto , Anciano , Niño , Preescolar , Ritmo Circadiano , Femenino , Trastornos de la Audición/sangre , Pérdida Auditiva Provocada por Ruido/sangre , Hemoglobinas/análisis , Humanos , Lactante , Hierro/sangre , Hierro/fisiología , Deficiencias de Hierro , Masculino , Enfermedad de Meniere/sangre , Persona de Mediana Edad , Presbiacusia/sangreRESUMEN
Deficiencies in blood supply can lead to impairments in cochlear function. We have reported significant associations of both measures of whole blood viscosity and derived measures of red cell rigidity with hearing threshold levels in individuals with sensorineural hearing impairments. This paper describes direct measures of red cell filterability in a group balanced across the variables of hearing threshold level and age to facilitate dissociation of the effects of factors correlated with age. After controlling for effects of age, sex and social class, there were strong correlations between whole blood viscosity at high shear rate and hearing threshold levels at 250, 500, and 1,000 and 2,000 Hz. At 4,000 and 8,000 Hz, hearing threshold level was related to red cell filterability. When the data are divided into subgroups by age, the younger age group exhibited a pattern similar to the overall one, but in the older age group the effect of red cell filterability was more apparent, extending down to 1,000 Hz. The data support a strong association between aspects of blood rheology and sensorineural hearing impairment, but in a more complex manner than suggested by previous studies. They imply that there are two processes associated with sensorineural hearing impairment, one of which can be considered as due to bulk rheological properties, while the other appears more related to the properties of individual red cells. The bulk properties are more important at lower frequencies, while the cellular properties are more influential at higher frequencies.