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Otolaryngol Head Neck Surg ; 130(2): 187-91, 2004 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-14990914

RESUMEN

OBJECTIVE: The purpose of this study was to evaluate whether the use of fluticasone propionate, mometasone furoate, or beclomethasone dipropionate for the treatment of rhinitis produced, as a side effect, an increase in the intraocular pressure; only one printed article proclaims that the increase of secondary intraocular pressure is due to the use of local nasal steroids. PATIENTS AND STUDY DESIGN: We conducted a comparative, double-blind, experimental, prospective, longitudinal study in which 360 patients were divided at random into 4 groups; 90 of them were given a placebo (control group) and the other 270 were divided into 3 other groups of 90 patients each and given a different local nasal steroid for each group. Measurement parameters All patients had their intraocular pressure measured by Goldman's tonometry at 3 weeks, 6 weeks, 3 months, 6 months, and 1 year after using the placebo or local nasal steroid. RESULTS: Variations were found in the intraocular pressure of patients who used local steroid, with discreet elevations in the beclomethasone dipropionate and mometasone furoate groups; however, variations were always within normal limits. CONCLUSION: Fluticasone propionate, mometasone furoate, and beclomethasone dipropionate cause variations in the intraocular pressure, but the variations are within normal limits.


Asunto(s)
Androstadienos/farmacología , Antiinflamatorios/farmacología , Beclometasona/farmacología , Glucocorticoides/farmacología , Presión Intraocular/efectos de los fármacos , Pregnadienodioles/farmacología , Adolescente , Adulto , Androstadienos/uso terapéutico , Antiinflamatorios/uso terapéutico , Beclometasona/uso terapéutico , Método Doble Ciego , Fluticasona , Glucocorticoides/uso terapéutico , Humanos , Persona de Mediana Edad , Furoato de Mometasona , Pregnadienodioles/uso terapéutico , Estudios Prospectivos , Rinitis/tratamiento farmacológico
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