RESUMEN
BACKGROUND: Pityriasis Alba (PA) is a common skin disorder affecting the children and it has multiple risk factors. OBJECTIVES: To assess the serum levels of trace elements (copper, zinc, and magnesium) and hemoglobin (Hb) level in patients with PA. METHOD: This is a case control study; 110 participants (55 cases and 55 controls) were recruited from pediatric dermatology and family medicine clinics, Cairo university hospitals. Patients were allocated into two groups, PA group (randomly selected male and female children age group (6-16) with PA lesions) and a matched control group. Full history was taken including sociodemographic data, present history of the lesions. Full general and dermatological examination was done. Blood samples were taken to asses iron and trace elements levels. The gained measures were analyzed by (SPSS) program version 22. RESULTS: This study showed that Hb levels, serum ferritin, copper, zinc and magnesium were significantly lower in PA group. There was statistically significant difference between both cases and controls regarding trace elements (copper, zinc, and magnesium) with (p value was 0.000, 0.000 and 0.003) respectively. Zinc deficiency increased the risk by more than 15 folds. Also, there was statistically significant difference between both groups regarding Hb levels and serum ferritin (p value was 0.000). The reduced Hb level increases the risk of PA by more than nine folds (OR 9.6) CONCLUSION: PA is associated with reduced levels of Hb, serum zinc, ferritin, copper and magnesium; sun exposure, skin phototype were found to be important risk factors for PA.
Asunto(s)
Pitiriasis/sangre , Oligoelementos/sangre , Adolescente , Estudios de Casos y Controles , Niño , Egipto , Femenino , Humanos , Masculino , Pitiriasis/diagnóstico , Factores de RiesgoRESUMEN
BACKGROUND: Pityriasis rotunda (PR) is an uncommon dermatosis characterized by multiple, round or oval, sharply demarcated scaling patches that are dyschromic and asymptomatic. It has been described in Japanese and in blacks, usually in association with certain infective or malignant systemic diseases. OBJECTIVE: The aim of this study is to further clarify this rare entity which in Italy seems to be confined to the island of Sardinia. METHODS: We studied 42 Sardinian patients, 22 males and 20 females, in an age range of 3-32 years. In 29 cases, the disease involved more than one family member. The patients were observed in Cagliari, the capital city of Sardinia. RESULTS: Bacterial, viral and fungal investigation yielded negative results. Haematochemical and immunological examination and thyroid, hypophyseal and adrenal hormones did not reveal any alterations. No systemic pathologies were found associated with the disease. CONCLUSIONS: The cases studied by us and those previously reported seem to indicate the presence of two distinct types of PR with significant prognostic differences.
Asunto(s)
Pitiriasis/patología , Adolescente , Corticoesteroides/análisis , Adulto , Bacterias/aislamiento & purificación , Niño , Preescolar , Femenino , Estudios de Seguimiento , Hongos/aislamiento & purificación , Humanos , Italia , Queratosis/patología , Masculino , Hormonas Hipofisarias/análisis , Pitiriasis/sangre , Pitiriasis/genética , Pitiriasis/inmunología , Pitiriasis/microbiología , Pitiriasis/virología , Pronóstico , Remisión Espontánea , Hormonas Tiroideas/análisis , Virus/aislamiento & purificaciónAsunto(s)
Pitiriasis/sangre , Oligoelementos/sangre , Femenino , Humanos , Masculino , Espectrofotometría AtómicaRESUMEN
Using 2 color fluorescein activated cytometric analysis, HLA-DR antigen expression in T cell subsets was studied in pityriasis rosea (PR) and compared to the results from herpes zoster (HZ) of viral origin and psoriasis (Ps). In HZ and PR, HLA-DR was significantly expressed on the T cell surface (Leu-4+ cells). Among the T cell subsets, HLA-DR antigen was predominantly expressed on suppressor/cytotoxic cells (Leu-2a+) in HZ. In contrast, it was predominantly expressed on helper cells (Leu-3a+) in PR. However, activated T cell antigen (Tac) was not significantly expressed on T cells (Leu-4+) in either HZ or in PR. This HLA-DR antigen expression of T cell subsets was depressed to the normal level in the recovery phases of HZ and PR.
Asunto(s)
Antígenos HLA-DR/análisis , Herpes Zóster/inmunología , Pitiriasis/inmunología , Psoriasis/inmunología , Linfocitos T/inmunología , Herpes Zóster/sangre , Humanos , Recuento de Leucocitos , Pitiriasis/sangre , Psoriasis/sangreRESUMEN
A recent 5-year period study of the incidence of pityriasis rosea among dermatologic outpatients was conducted at the Lagos University Teaching Hospital. Three hundred fifty-two patients with pityriasis rosea were seen. The average annual incidence was 4.8 per 100 dermatologic patients. Women predominated by a margin of 1.2:1.0. More than 91% of the patients were between the ages of 5 and 35 years, with a peak at ages 10-14. The incidence of the disease was significantly higher in the early part of the rainy season. No declining incidence was observed over the years. A blood picture of a leukopenia with relative lymphocytosis was observed early in the disease. Ampicillin, when consumed after the onset of the eruption, made the patient with pityriasis rosea clinically worse.