RESUMEN
We report a case of spontaneous calf muscle haematoma, formed during the recovery phase of dengue haemorrhagic fever, which, to the best of our knowledge, has never been encountered before. A 45-year-old man presented with features of severe dengue and got admitted to our intensive care unit. He was treated with intravenous fluid therapy and supportive measures, and gradually improved, initially. However, during the recovery phase, he suddenly developed painful left calf, which was found tender, hot and swollen on physical examination. Colour Doppler ultrasound revealed left calf haematoma. As the patient rapidly developed local compartmental syndrome, surgical evacuation of the haematoma followed by urgent fasciotomy was performed. He recovered without further complication and was discharged home. At follow-up after 2 months, he remained well.
Asunto(s)
Síndromes Compartimentales/virología , Hematoma/virología , Enfermedades Musculares/virología , Dengue Grave/complicaciones , Humanos , Pierna/virología , Masculino , Persona de Mediana Edad , Músculo Esquelético/virologíaRESUMEN
Postvaricella protein S deficiency is a rare and severe disease. We report a case of extensive necrotic skin lesions of acute onset 7 days after varicella in a 4-year-old girl. Protein S antigen and activity were <10%, and antiprotein S antibodies were detected. She was treated with anticoagulation, plasmapheresis and fresh frozen plasma. She survived but required leg amputation.
Asunto(s)
Varicela/complicaciones , Deficiencia de Proteína S/diagnóstico , Piel/patología , Amputación Quirúrgica , Preescolar , Femenino , Herpesvirus Humano 3 , Humanos , Pierna/patología , Pierna/virología , Deficiencia de Proteína S/etiología , Deficiencia de Proteína S/terapia , Piel/virologíaAsunto(s)
Herpes Zóster/patología , Femenino , Humanos , Lactante , Pierna/patología , Pierna/virologíaRESUMEN
The etiology of Merkel cell carcinoma (MCC) was recently linked to a newly identified human virus, the Merkel cell polyomavirus (MCPyV). The discovery that MCPyV plays an important role in the tumorigenesis of >80% of MCCs provides an explanation for the increased incidence of this rare malignancy in human immunodeficiency virus (HIV)-positive and immunocompromised patients. We report an unusual metastasis of MCC to the mandibular gingiva of an HIV-positive patient. In addition to routine hematoxylin-eosin and immunohistochemical studies, we also performed a molecular biologic analysis to look for the presence of MCPyV in this case. We detected evidence of the MCPyV genome in this lesion similar to what has been observed for MCCs reported in other immunocompromised patients. These results stress the importance of combining morphologic and molecular biologic analyses in the evaluation of MCC, because confirmation of viral etiology would likely affect the choice of treatment and prognosis when specific antiviral therapy becomes available for this aggressive tumor.
Asunto(s)
Carcinoma de Células de Merkel/secundario , Neoplasias Gingivales/secundario , Seropositividad para VIH/complicaciones , Poliomavirus de Células de Merkel/aislamiento & purificación , Infecciones por Polyomavirus/diagnóstico , Infecciones Tumorales por Virus/diagnóstico , Infecciones Oportunistas Relacionadas con el SIDA/virología , Carcinoma de Células de Merkel/virología , Genoma Viral/genética , Neoplasias Gingivales/virología , Humanos , Huésped Inmunocomprometido , Pierna/virología , Masculino , Poliomavirus de Células de Merkel/genética , Persona de Mediana Edad , Neoplasias Cutáneas/virologíaRESUMEN
This is a case of classic type Kaposi sarcoma occurring in an 85-year-old woman who presented with indurated vascular plaques on both legs below the knee that has been present for two years. A brief review of the literature on Kaposi sarcoma is included.
Asunto(s)
Pierna/patología , Sarcoma de Kaposi/diagnóstico , Neoplasias Cutáneas/diagnóstico , Anciano de 80 o más Años , Antígenos CD34/análisis , Antígenos CD34/inmunología , Biopsia , Femenino , Herpesvirus Humano 8/inmunología , Humanos , Pierna/virología , Sarcoma de Kaposi/virología , Neoplasias Cutáneas/virologíaAsunto(s)
Crioglobulinemia/virología , Infecciones por Parvoviridae/virología , Parvovirus B19 Humano , Adulto , Anticuerpos Antivirales/sangre , Crioglobulinemia/sangre , Crioglobulinemia/diagnóstico , Femenino , Humanos , Pierna/virología , Imagen por Resonancia Magnética , Infecciones por Parvoviridae/sangre , Infecciones por Parvoviridae/diagnósticoAsunto(s)
Herpes Zóster/diagnóstico , Pierna/virología , Acetaminofén/uso terapéutico , Aciclovir/análogos & derivados , Aciclovir/uso terapéutico , Analgésicos no Narcóticos/uso terapéutico , Analgésicos Opioides/uso terapéutico , Antivirales/uso terapéutico , Diagnóstico Diferencial , Femenino , Herpes Zóster/tratamiento farmacológico , Humanos , Lidocaína/uso terapéutico , Masculino , Persona de Mediana Edad , Tramadol/uso terapéutico , Valaciclovir , Valina/análogos & derivados , Valina/uso terapéuticoRESUMEN
To evaluate the transmission of genital human papillomavirus (HPV) through the floor and seats of humid dwellings, samples were collected with a toothbrush from the floor and seat surfaces of humid dwellings; showers, saunas and dressing rooms. The survey included 3 bathing resorts, 1 indoor swimming pool, 2 schools and 2 private homes. Polymerase chain reaction (PCR) was used to amplify the human beta-globin gene and HPV DNA. The results for HPV DNA amplification were confirmed by Southern blot hybridization under low stringency using a probe mixture of HPV types 6, 16, 18 and 31. beta-globin could be amplified only from 3 sample taken from a dressing room of and indoor public swimming pool. No HPV DNA-positive samples were found. These results indicate that transmission of genital HPV infection via floor or seat surfaces in the above dwellings in general or family use is highly unlikely.