RESUMEN

Internal bis-substituted propargylic diols were subjected to enzymatic kinetic resolution promoted by CAL-B. Employing a two round sequence EKR, mono- and bis-acetoxy propargylic products were obtained in a high enantiomeric ratio (E > 200). The efficiently resolved chiral 8b was applied in a concise synthesis of (S)-1b, an optically active natural product produced by fungi Clitocybe catinus.

Asunto(s)

Alquinos/síntesis química , Basidiomycota/química , Productos Biológicos/síntesis química , Pentanoles/síntesis química , Alquinos/química , Productos Biológicos/química , Técnicas de Química Sintética , Proteínas Fúngicas/química , Proteínas Fúngicas/metabolismo , Cinética , Lipasa/química , Lipasa/metabolismo , Pentanoles/química , Estereoisomerismo