RESUMEN
E relatada a experiência pessoal do autor de abordagem de casos índices de estados psicóticos esquizofrênicos, utilizando novo fármaco e penfluridol.
It's related index cases of personal experience with perfluridol. A new drug was utilized with success in the psicotic states of schizophrenia.
Asunto(s)
Humanos , Esquizofrenia/tratamiento farmacológico , Penfluridol/uso terapéuticoRESUMEN
Twenty schizophrenic patients were treated for a year with long term neuroleptic Penfluridol to test its antipsychotic and re-socializing effect. They underwent a clinical follow up and an evaluation of psychosocial aspects was also performed by a psychiatric social worker. Their social behaviour and reinsertion to work and family were studied by the use of specially designed scales. Clinical improvement and significant changes in all of the studied aspects of social behaviour were observed after a year of treatment. Also a reduction of treatment abandonment and of frequency of relapse through family handling was detected. Finally a number of preliminary observations on family structure and dynamics as well as changes determined on it by the treatment of the psychotic patient are summarized.
Asunto(s)
Penfluridol/uso terapéutico , Piperidinas/uso terapéutico , Esquizofrenia/tratamiento farmacológico , Adolescente , Adulto , Escalas de Valoración Psiquiátrica Breve , Familia , Femenino , Estudios de Seguimiento , Humanos , Masculino , Rehabilitación Vocacional , Ajuste Social , Factores Socioeconómicos , Encuestas y CuestionariosAsunto(s)
Discapacidad Intelectual/tratamiento farmacológico , Penfluridol/uso terapéutico , Piperidinas/uso terapéutico , Trastornos Psicóticos/tratamiento farmacológico , Adolescente , Adulto , Ensayos Clínicos como Asunto , Evaluación de Medicamentos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Penfluridol/administración & dosificación , Esquizofrenia/tratamiento farmacológico , Comprimidos , Factores de TiempoRESUMEN
The difficulties of regular drug intake in long term treatments for psychotic patients gave rise to the need of using medicines at the longest possible intervals, facilitating thus adequate control and regularity. Penfluridol is a neuroleptic meeting that requirement: it is necessary only one dose per week. This paper reviews the results of Penfluridol in 26 patients (20 inpatients and 6 outpatients), ages between 17 and 54 with a mean of 36.8, sex feminine, and the following diagnoses: schizophrenia, paranoid: 14, simple: 8, hebephrenic: 3, catatonic: 1. The patients, divided in two groups of 13 each, had one oral dose a week, of between 10 and 100 mg, during 90 days. The first group took only Penfluridol, suppressing any other medicaments. The other group added Penfluridol to the prescriptions already in use. The results, as described in tables I and II, were evaluated according to 36 items. The general evaluation was positive with no negative biases. The side effects were scarce and temporary: insomnia in 7 cases during the first week, and extra-pyramidal symptoms in another 7 cases, that were controlled with antiparkinsonians. The conclusion is that Penfluridol is a valuable contribution to longterm treatments in psychoses.
Asunto(s)
Trastornos Mentales/tratamiento farmacológico , Penfluridol/uso terapéutico , Piperidinas/uso terapéutico , Administración Oral , Adolescente , Adulto , Evaluación de Medicamentos , Femenino , Humanos , Persona de Mediana Edad , Penfluridol/administración & dosificaciónRESUMEN
Thirty female patients were studied while taking penfluridol, continuous neuroleptic antipsychotic medication given orally. These patients were hospitalized making observation and control adequate in 73.3% of the cases. Colateral effects that we observed were minimum and variable in nearly all the patients, and many of these effects are of little significance as they are observed with other neuroleptics.