RESUMEN

Experimental evidence suggests the occurrence of endogenous antidepressant-like compounds in the brain, blood plasma, and urine. After extensive purification by calmodulin-sepharose affinity chromatography, and further purification of the urine-derived sample by exclusion chromatography, at least three distinctive fractions have been identified. These fractions effectively inhibited serotonin uptake, imipramine, and/or paroxetine binding, and they apparently contained some compounds that were recognized by the anti-imipramine or anti-paroxetine antibodies. Their identification may have significant implications for studies of affective illness.

Asunto(s)

Factores Biológicos/metabolismo , Inhibidores Selectivos de la Recaptación de Serotonina , Serotonina/metabolismo , Adulto , Anticuerpos/análisis , Factores Biológicos/análisis , Encéfalo/metabolismo , Calmodulina/metabolismo , Cromatografía en Agarosa , Cromatografía en Gel , Trastorno Depresivo/tratamiento farmacológico , Trastorno Depresivo/inmunología , Trastorno Depresivo/metabolismo , Femenino , Humanos , Imipramina/inmunología , Imipramina/metabolismo , Imipramina/uso terapéutico , Masculino , Paroxetina/inmunología , Paroxetina/metabolismo , Paroxetina/uso terapéutico , Radioinmunoensayo , Serotonina/inmunología , Serotonina/uso terapéutico , Relación Estructura-Actividad