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1.
J Pediatr ; 259: 113395, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-37001636

RESUMEN

OBJECTIVE: To assess the association between deprivation and the incidence and clinical severity of tuberculosis (TB) in children. STUDY DESIGN: Children ≤18 years old who were admitted for TB between 2007 and 2020 at a tertiary hospital were included in this retrospective study. Deprivation was assessed using the French Deprivation Index. TB severity was assessed using the Wiseman classification. Multivariate analyses were carried out. RESULTS: In total, 222 patients were included. The median age was 10.8 years (IQR 4.5-14.4). TB was considered severe in 126 patients (56.8%), with 50% of the patients included in the 2 most deprived groups. The most-deprived children had a TB incidence that was 58 times greater than that of the least-deprived children (95% CI 28.49-119.40). There was no significant association between deprivation and severity in the multivariable analysis after adjusting for age and circumstances of diagnosis. Deprivation was associated with an increased length of stay in the most-deprived groups (OR 3.79, 95% CI 1.55-10.23). There was a trend toward a greater proportion of symptomatic children in the most-deprived group. CONCLUSIONS: TB incidence and hospital length of stay increased with deprivation levels but not with the severity of TB.


Asunto(s)
Tuberculosis , Humanos , Niño , Adolescente , Estudios Retrospectivos , Centros de Atención Terciaria , Paris/epidemiología , Incidencia , Tuberculosis/epidemiología , Francia/epidemiología
2.
Ann Hum Biol ; 47(1): 42-47, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31989850

RESUMEN

Background: The Paris Catacombs contain the remains of approximately 6 million people dating back to the 15th century, when leprosy was endemic in France.Aims: The aim of this palaeopathological study was to identify the presence of leprosy in skulls from the Paris Catacombs.Subjects and methods: Macroscopic examination of skulls in situ for bone changes secondary to oronasal soft tissue infection by leprosy. Skulls were categorised as having "probable" signs of leprosy if they had an enlarged nasal (pyriform) aperture, resorption of the anterior nasal spine, and resorption of the alveolar processes of maxilla, and as having "possible" signs of leprosy if they met one of these three criteria.Results: Skulls from 123 sections within the Catacombs (approximately 1500 remains in total) were triaged, with 367 skulls identified as suitable for examination. Of these, 74 had central facial bone alterations/abnormalities and underwent detailed examination, yielding 0.5% (2/367) classified as having probable, and 5.7% (21/367) possible signs of leprosy.Conclusions: The proportion of skulls with probable signs of leprosy gives an approximate estimate (0.5%) for the prevalence of this disease in the population of Paris (or districts of Paris) during the 15-18th centuries.


Asunto(s)
Lepra/historia , Cráneo/patología , Femenino , Historia del Siglo XV , Historia del Siglo XVI , Historia del Siglo XVII , Historia del Siglo XVIII , Humanos , Lepra/epidemiología , Lepra/patología , Masculino , Paris/epidemiología
3.
J Immigr Minor Health ; 22(4): 682-690, 2020 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-31863405

RESUMEN

Migration can affect reproductive outcomes due to different socioeconomic and cultural contexts before and after migration, to changes in the affective and conjugal status of women and to their life conditions. The aim of this study is to investigate the association between international migration and abortion. The data came from a retrospective life-event survey from sub-Saharan African women living in Île-de-France. Differences in abortion distribution before and after migration were assessed using the Pearson chi-square test, and the association between the predictor and the outcome was investigated using Generalized Estimating Equations. A total of 363 women and 1377 pregnancies were investigated. Among these pregnancies, 15.6% that occurred before and 11.0% that occurred after migration was reported as ended in abortion (p = 0.011). The odds of reporting having had an abortion was lower after migration (OR 0.59, 95% CI 0.42-0.84), even after adjustment. However, after including intendedness of pregnancy in the model, this association lost its significance. The difference in induced abortion occurrence between before and after migration is almost entirely due to a change in the intendedness of pregnancy. Thus, socioeconomic and cultural issues have a greater weight in the decision to abort than the legal interdiction of this practice.


Asunto(s)
Aborto Inducido/estadística & datos numéricos , Emigración e Inmigración/estadística & datos numéricos , Embarazo no Planeado/etnología , Adolescente , Adulto , África del Sur del Sahara/etnología , Características Culturales , Femenino , Humanos , Paris/epidemiología , Embarazo , Estudios Retrospectivos , Factores Socioeconómicos , Adulto Joven
4.
Int J Infect Dis ; 72: 34-39, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29782922

RESUMEN

BACKGROUND: Dengue virus (DENV), chikungunya virus (CHIKV), and Zika virus (ZIKV) infections are rapidly expanding across countries and are being diagnosed in returned travellers who represent epidemiological sentinels. The French Territories of America (FTA) such as Guadeloupe and Martinique see high levels of tourism and have experienced three consecutive outbreaks by these viruses in the last decade. OBJECTIVE: This study was performed to evaluate how ill returned travellers could have represented epidemiological sentinels for these three expanding arboviral diseases over eight consecutive years. The degree of correlation between the cases of ill returned travellers arriving at a French tertiary hospital in Paris and the three outbreaks that occurred in the FTA during the study period was estimated. METHODS: All consecutive ill returned travellers diagnosed at the hospital in Paris with imported DENV, CHIKV, or ZIKV infections from January 2009 to December 2016 were included. Epidemiological and clinical variables were evaluated. Data concerning the incidence of arboviruses in the FTA, as well as the temporal relationship between the occurrence of imported cases and outbreaks in the FTA, were analyzed. RESULTS: Overall, 320 cases of arboviral infection were reported: 216 DENV, 68 CHIKV, and 36 ZIKV. Most of the patients presented with fever and exanthema. One hundred and fifteen patients were exposed in Guadeloupe or Martinique, which were the at-risk destinations in 25% of patients with DENV, 59% of patients with CHIKV, and 58% of patients with ZIKV. The occurrence of cases diagnosed in returning travellers followed the same time pattern as the outbreaks in these areas. CONCLUSIONS: A temporal correlation was found between newly diagnosed imported cases of arboviruses and the three corresponding outbreaks that occurred in Martinique and Guadeloupe during 8 consecutive years. Thus, ill returned travellers act as epidemiological sentinels from the beginning up to the end of outbreaks occurring in touristic locations.


Asunto(s)
Fiebre Chikungunya/epidemiología , Fiebre Chikungunya/transmisión , Dengue/epidemiología , Dengue/transmisión , Viaje , Infección por el Virus Zika/epidemiología , Infección por el Virus Zika/transmisión , Adolescente , Adulto , Anciano , Brotes de Enfermedades/estadística & datos numéricos , Femenino , Guadalupe/epidemiología , Humanos , Incidencia , Masculino , Martinica/epidemiología , Persona de Mediana Edad , Paris/epidemiología , Vigilancia de Guardia , Adulto Joven
5.
Intensive Care Med ; 40(3): 342-52, 2014 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-24337401

RESUMEN

PURPOSE: Cities are expanding rapidly in middle-income countries, but their supply of acute care services is unknown. We measured acute care services supply in seven cities of diverse economic background. METHODS: In a cross-sectional study, we compared cities from two high-income (Boston, USA and Paris, France), three upper-middle-income (Bogota, Colombia; Recife, Brazil; and Liaocheng, China), and two lower-middle-income (Chennai, India and Kumasi, Ghana) countries. We collected standardized data on hospital beds, intensive care unit beds, and ambulances. Where possible, information was collected from local authorities. We expressed results per population (from United Nations) and per acute illness deaths (from Global Burden of Disease project). RESULTS: Supply of hospital beds where intravenous fluids could be delivered varied fourfold from 72.4/100,000 population in Kumasi to 241.5/100,000 in Boston. Intensive care unit (ICU) bed supply varied more than 45-fold from 0.4/100,000 population in Kumasi to 18.8/100,000 in Boston. Ambulance supply varied more than 70-fold. The variation widened when supply was estimated relative to disease burden (e.g., ICU beds varied more than 65-fold from 0.06/100 deaths due to acute illnesses in Kumasi to 4.11/100 in Bogota; ambulance services varied more than 100-fold). Hospital bed per disease burden was associated with gross domestic product (GDP) (R (2) = 0.88, p = 0.01), but ICU supply was not (R (2) = 0.33, p = 0.18). No city provided all requested data, and only two had ICU data. CONCLUSIONS: Urban acute care services vary substantially across economic regions, only partially due to differences in GDP. Cities were poor sources of information, which may hinder their future planning.


Asunto(s)
Ciudades/estadística & datos numéricos , Países Desarrollados/estadística & datos numéricos , Países en Desarrollo/estadística & datos numéricos , Unidades de Cuidados Intensivos/estadística & datos numéricos , Salud Urbana/normas , Ambulancias/estadística & datos numéricos , Boston/epidemiología , Brasil/epidemiología , China/epidemiología , Colombia/epidemiología , Enfermedad Crítica/mortalidad , Estudios Transversales , Ghana/epidemiología , Salud Global/normas , Accesibilidad a los Servicios de Salud/normas , Capacidad de Camas en Hospitales/estadística & datos numéricos , Humanos , India/epidemiología , Paris/epidemiología
6.
Bull Soc Pathol Exot ; 105(2): 95-102, 2012 May.
Artículo en Francés | MEDLINE | ID: mdl-22328065

RESUMEN

In recent days immigrants represent the main risk group for imported malaria in northern countries. Most of them are migrants returning to their country of origin to visit friends and relatives (VFR). We retrospectively examined the main clinical, biological, and therapeutic data of all malaria cases in immigrants from 2006 to 2010 in Tenon hospital, Paris. The hospital is situated in a Paris district with an important African community. During the study period 239 imported malaria cases were observed in adults of which 199 were immigrants, 186 VFR, and 13 recently arrived. Most cases were from sub-Saharan Africa and Comoro islands. Chimioprophylaxis was not taken in 81.2% of VFR. It was inadequate in 43.7% and not taken correctly in 84.4%. Plasmodium falciparum was the most frequent species identified: 190/199 (95.5%). Severe P. falciparum malaria was observed in 25 cases (13.2%); two of them were recently arrived. One patient, African VFR, died. In this series two high-risk groups were represented: HIV-infected patients and pregnant women. Six of the HIV patients had severe malaria and all pregnant women had anemia. Our results are similar to those observed recently in other European countries. Mean age of VFR is increasing and the risk for severe P. falciparum malaria became identical to the one observed in non-immune travelers. Protection measures remain still insufficient in this population of travelers.


Asunto(s)
Emigrantes e Inmigrantes/estadística & datos numéricos , Malaria/epidemiología , Adolescente , Adulto , África del Sur del Sahara/etnología , Anciano , China/etnología , Comoras/etnología , Familia , Femenino , Amigos , Haití/etnología , Hospitales/estadística & datos numéricos , Humanos , Malaria/etnología , Malaria/transmisión , Masculino , Persona de Mediana Edad , Paris/epidemiología , Embarazo , Estudios Retrospectivos , Viaje/estadística & datos numéricos , Adulto Joven
7.
Transfusion ; 50(3): 575-83, 2010 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-19906038

RESUMEN

BACKGROUND: Chagas disease is endemic in Latin America (LA). Currently 10 million people are infected despite World Health Organization efforts aimed at preventing domestic transmission. However, with the migration of infected asymptomatic individuals to nonendemic countries, transmission of Chagas disease by transfusion may become a worldwide problem. The observation that the number of cases of Chagas disease has increased over the past 10 years in French Guiana, together with the results of a previous hospital-based study in the Paris area, confirms the transmission of Chagas disease from patients coming from LA. For these reasons, the French authorities stopped the collection of blood in French Guiana in 2005 and began screening blood donors in the French Caribbean islands and, in 2007, in continental France. STUDY DESIGN AND METHODS: Data on birth place, mother's birth place, and travel in LA were recorded for at-risk donors. These subjects were tested using two enzyme-linked immunosorbent assays (ELISAs). RESULTS: Of the 312,458 individuals who gave blood in the Paris area during an 18-month period, 30,837 were tested. Of these, 972 were born in LA, three of whom were positive for the two ELISAs and immunofluorescence tests. The prevalence of Trypanosoma cruzi-positive donors was 9.7 in 100,000 tested donors, but 0.31% among donors born in LA. Serology tests gave discrepant results in 1.02% of the samples. CONCLUSION: The efficiency of blood donor screening programs could be improved by screening only blood donors who were born in LA or who have traveled in LA for extended periods, using a single enzyme immunoassay.


Asunto(s)
Donantes de Sangre , Enfermedad de Chagas/sangre , Enfermedad de Chagas/epidemiología , Selección de Donante , Tamizaje Masivo , Trypanosoma cruzi , Enfermedad de Chagas/prevención & control , Enfermedad de Chagas/transmisión , Femenino , Humanos , Masculino , Paris/epidemiología , Estudios Retrospectivos , América del Sur
8.
Bull Soc Pathol Exot ; 102(5): 295-9, 2009 Dec.
Artículo en Francés | MEDLINE | ID: mdl-20131423

RESUMEN

2009 is marked by the centenary of the discovery by Carlos Chagas of Human American Trypanosomiasis. As a result of international cooperation its incidence has been falling in endemic areas, whereas North America and Europe are witnessing an increase in the number of imported cases. In metropolitan France, 18 such cases were reported between 2004 and 2007. Recently, estimates based on immigration figures have been made and suggest that about 1,500 imported cases can be expected in France. The object of this article is to assess the value of targeted screening of an at-risk population, originally from Latin America and now living in the Ile-de-France (area centred on Paris). The serological techniques employed were indirect immunofluorescence (IIF) and, depending on the case, 2 or 3 Elisa tests (Biomérieux, Biokit and Wiener). Trypanosoma cruzi serology was considered positive when the IIF was superior or equal to 200, or when two Elisa's were > 1, or when the IIF was superior or equal to 100 with at least one Elisa > 1. PCR was performed in 48 cases, which were considered to be positive. The tests were carried out on a voluntary basis after a publicity campaign within the Latin American community in the Ile-de-France. In this article, we present the findings of the first year of screening. Two hundred and fifty-four individuals were screened for Chagas' disease between June 2008 and June 2009. The median age was 33 years [11-63], the male/female ratio 102/152. Overall prevalence of positive serology was 23.6% (60/254). For six patients, the results were classified as "uncertain" (discordant serological tests). Of the seropositive group, 87.4% were Bolivian and 100% presented as a chronic form. Of these, 23.6% presented with functional cardiac manifestations and 22% with gastro-intestinal problems. The PCR was positive in 61% of the seropositive individuals. Clinical evaluation together with other investigations and therapeutic intervention is being carried out at present. These results confirm that metropolitan France is subject to the emergence of Chagas' disease in a non-endemic zone. This confirms the value of screening in at-risk populations, in particular because of the recent broadening of indications for antiparasitic treatment. In addition it is relevant to the prevention of vertical transmission or infection via organ donation, which could arise in France. These results also demonstrate continuing difficulties in the interpretation of serological results and the usefulness of PCR, which might increase sensitivity substantially.


Asunto(s)
Enfermedad de Chagas/diagnóstico , Animales , Brasil/epidemiología , Enfermedad de Chagas/epidemiología , Enfermedad de Chagas/prevención & control , Emigración e Inmigración/estadística & datos numéricos , Europa (Continente)/epidemiología , Humanos , Tamizaje Masivo/métodos , América del Norte/epidemiología , Paris/epidemiología , Prevalencia , Trypanosoma cruzi/aislamiento & purificación
9.
Am J Trop Med Hyg ; 78(4): 595-8, 2008 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-18385354

RESUMEN

During home visits and using a point-of-care test for brucellosis, we screened the household members of adult patients found to have brucellosis by investigation at the Hospital Nacional Daniel Alcides Carrión in Callao, Peru. A total of 206 household members of 43 patients were screened, and 15 (7.3%) household members in 10 (23.3%) households tested seropositive. Brucellosis was diagnosed in 14 of them, all but 4 presenting with acute or subacute uncomplicated disease. Regardless of attempts to control brucellosis in Peru, the disease continues to be reasonably common among household members of brucellosis patients. Household members presumably remain the single most important identifiable risk group in an urban setting, and screening them provides an effective means for their early diagnosis. Although contact with livestock was rare, the consumption of unpasteurized dairy products was reported by almost all patients with brucellosis, their household members, and hospitalized non-brucellosis patients.


Asunto(s)
Brucelosis/epidemiología , Población Urbana/estadística & datos numéricos , Enfermedad Aguda , Anticuerpos Antibacterianos/sangre , Brucelosis/prevención & control , Composición Familiar , Femenino , Humanos , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Masculino , Tamizaje Masivo , Paris/epidemiología
10.
J Pediatr ; 137(2): 165-71, 2000 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-10931406

RESUMEN

OBJECTIVES: To determine the value of open lung biopsy (OLB) in terms of diagnosis, morbidity, mortality, and benefits in immunocompromised children with pulmonary involvement. STUDY DESIGN: We retrospectively reviewed 36 OLBs performed in 32 immunocompromised children between 1985 and 1998. Seventeen biopsies were performed in patients with primary immunodeficiency syndromes and 19 in patients with secondary immunodeficiency syndromes. Twenty-eight biopsies were performed because of a lack of response to ongoing antimicrobial treatments with negative or positive findings on bronchoalveolar lavage (BAL) and a deteriorating clinical or radiologic course, and 8 biopsies were performed because of persistent chest x-ray infiltrates. RESULTS: Diffuse pulmonary infiltrates were observed on chest x-ray in 28 cases, hyperinflation in 3 cases, and nodular infiltrates in 5 cases. A histopathologic diagnosis was possible for all 36 OLBs. Specific diagnosis was obtained in 22 (61%) (12 infectious agents, 6 tumors, 4 bronchiolitis obliterans) and non-specific diagnosis in 14 (39%). Fungi were the main infectious agents (8 of 12). For the diagnosed infections, BAL provided 4 true-positive, 3 false-positive, and 6 false-negative results. Specific treatment was changed in 77% of cases, providing real benefits in 12 (33%) cases. The morbidity and overall mortality rates were 31% and 33%, respectively. The mortality rate was significantly higher in the first 30 days after OLB in patients receiving ventilatory assistance (58%). CONCLUSIONS: OLB in immunocompromised children with deteriorating clinical or radiologic course is a sensitive diagnostic tool.


Asunto(s)
Huésped Inmunocomprometido , Síndromes de Inmunodeficiencia/complicaciones , Enfermedades Pulmonares/diagnóstico , Pulmón/patología , Adolescente , Biopsia , Líquido del Lavado Bronquioalveolar , Niño , Preescolar , Humanos , Síndromes de Inmunodeficiencia/epidemiología , Síndromes de Inmunodeficiencia/mortalidad , Lactante , Enfermedades Pulmonares/epidemiología , Enfermedades Pulmonares/etiología , Enfermedades Pulmonares/mortalidad , Paris/epidemiología , Complicaciones Posoperatorias/epidemiología , Respiración Artificial , Estudios Retrospectivos , Sensibilidad y Especificidad
11.
J Med Virol ; 58(4): 321-4, Aug. 1999.
Artículo en Inglés | MedCarib | ID: med-1316

RESUMEN

To design a vaccination strategy against hepatitis A among hospital employees, we carried out a serological survey against hepatitis A virus (HAV) infection in 10 university hospitals in the Paris area. Subjects under 60 years of age were consecutively enrolled by occupational health services and tested for IgG to HAV by ELISA. Of the 1,516 subjects recruited, 926 were health workers (HW), 322 clerks, and 268 cooks or kitchen employees. Among HW and clerks the HAV seroprevalence was 53.8 percent (95 percent CI: 44.0-65.6), increasing with age and being higher among Europe (83.6 percent vs 45.6 percent, P < .001). Age correlated closely with the duration of hospital work, so only age was taken into account for further analysis. The HAV seroprevalences among HW and clerks originating from Europe were close (48.8 percent vs 42.6 percent) and remained so after adjustment for age. HAV seroprevalences in HW caring for adults and those caring for children were also similar (45.2 percent vs 40.1 percent). Seroprevalence was higher in assistant nurses than in nurses (51.3 percent vs 39.8 percent, P < .02). Among cooks and kitchen employees, 53.4 percent were HAV-seropositive. This study shows that hospital employees need not routinely be vaccinated against HAV; the decision should be taken by the occupational physician according to the type of work, but should be routine for cooks and kitchen employees. The need for prevaccinal screening for anti-HAV should be assessed in the light of employees' geographical origin and age.(Au)


Asunto(s)
Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Hepatitis A/sangre , Personal de Hospital , África/etnología , Región del Caribe/etnología , Infección Hospitalaria/sangre , Infección Hospitalaria/virología , Europa (Continente)/etnología , Servicio de Alimentación en Hospital , Hepatitis A/etnología , Hepatitis A/transmisión , Paris/epidemiología , Estudios Seroepidemiológicos
12.
J Am Soc Nephrol ; 9(12): 2327-35, 1998 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-9848787

RESUMEN

Records of 102 patients with biopsy-proven HIV-associated nephropathy (HIVAN) admitted to 18 hospitals in the Paris area from 1984 through 1996 were retrospectively reviewed. Demographics and clinical and laboratory features of the cohort were determined, and prognostic factors of renal and patient survival were analyzed. Renal and patient survival curves were estimated with the actuarial method. Prognostic factors were assessed by uni- and multidimensional analyses based on Cox regression models. Values were expressed as median with interquartile. The total population (median age 34) included 97% blacks and 71.5% males. Median patient follow-up was 165 d (range, 43 to 493). At the time of renal biopsy, median values of serum creatinine, proteinuria, and CD4+ cell count were 496 micromol/L, 6.5 g/24 h, and 48.5 cells/mm3, respectively. Fifteen patients were given steroids after the onset of HIVAN. Overall patient survival at 0.5, 1, and 3 yr was 73 +/- 5, 55 +/- 6, and 38 +/- 7%, respectively. The proportion of patients free of dialysis at 0.5, 1, and 3 yr was 73 +/- 5, 60 +/- 7, and 18 +/- 10%, respectively. Predictors of poor patient prognosis were a low CD4+ cell count (relative risk [RR; per 50 cells/mm3 decrease] 1.35; confidence interval [CI], 1.13 to 1.6) and antiretroviral therapy before the onset of HIVAN (RR 1.9; CI, 1.05 to 3.6). Main independent factors associated with better renal outcome were: steroid therapy (RR 0.29; CI, 0.1 to 0.9); low proteinuria level (RR [per 50% decrease] 0.7; CI, 0.5 to 0.98); low serum creatinine (RR [per 1.1 mg/dl decrease] 0.78; CI, 0.7 to 0.87); and hemoglobin level (RR [per g/dl increase] 0.76; CI, 0.58 to 1.00). HIVAN is not a rare nephropathy in Paris and its suburbs. Renal prognosis and patient survival are better than what was reported previously. Steroids may delay the downward course of HIVAN. It is not certain that in the new era of HIV therapy, the possible renal benefits of corticosteroids outweigh their potential risks. The only reliable predictor of patient survival is the intensity of immunodeficiency.


Asunto(s)
Glomeruloesclerosis Focal y Segmentaria/epidemiología , Infecciones por VIH/complicaciones , Corticoesteroides/uso terapéutico , Adulto , África/etnología , Población Negra , Creatinina/sangre , Femenino , Estudios de Seguimiento , Glomeruloesclerosis Focal y Segmentaria/tratamiento farmacológico , Glomeruloesclerosis Focal y Segmentaria/etnología , Glomeruloesclerosis Focal y Segmentaria/etiología , Hemoglobinas/análisis , Humanos , Fallo Renal Crónico/epidemiología , Fallo Renal Crónico/etiología , Fallo Renal Crónico/prevención & control , Masculino , Paris/epidemiología , Pronóstico , Proteinuria/epidemiología , Proteinuria/etiología , Diálisis Renal , Estudios Retrospectivos , Factores de Riesgo , Tasa de Supervivencia , Resultado del Tratamiento , Indias Occidentales/etnología
13.
Int J Pediatr Otorhinolaryngol ; 45(2): 177-81, 1998 Oct 02.
Artículo en Inglés | MEDLINE | ID: mdl-9849687

RESUMEN

We report a very rare case of disseminated pharyngo-laryngeal histoplasmosis with systemic spread in a 10-year-old, immunocompetent child from Guyana. The main signs were a marked deterioration in his general condition, hepato-splenomegaly, multiple lymphadenopathy and ulcerated pharyngo-laryngeal lesions. The diagnosis was made from brushings of the ulcerative lesions, a lymph node biopsy and serological tests performed in the national reference center for histoplasmosis. The initial treatment was with amphotericin B, which was then replaced by oral itraconazole. We report here the main epidemiological, clinical and therapeutic characteristics.


Asunto(s)
Histoplasmosis , Enfermedades de la Laringe/microbiología , Enfermedades Faríngeas/microbiología , Anfotericina B/uso terapéutico , Antifúngicos/uso terapéutico , Niño , Guyana/etnología , Histoplasmosis/diagnóstico , Histoplasmosis/tratamiento farmacológico , Histoplasmosis/epidemiología , Humanos , Itraconazol/uso terapéutico , Masculino , Paris/epidemiología
14.
Sante ; 4(1): 21-6, 1994.
Artículo en Francés | MEDLINE | ID: mdl-8162360

RESUMEN

The Comede health care center for political refugees received 4,414 first arrivals from 70 African, Asian and South American countries in 1989. Many arrived from areas where intestinal parasitic infections are endemic, and where infections by nematodes (Ancyclostoma duodenale, Necator americanus, Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis), trematodes (Schistosoma hematobium, Schistosoma stercoralis) and protozoa (Entamoeba coli) cause significant morbidity. The question that arises is whether we should screen stools and urine only in the case of African refugees, or treat all refugees empirically (mass treatment program). We carried out a retrospective study of 1,425 patients seen for the first time in the Comede from August 1, 1989 to December 31, 1989. Three-quarters of the subjects were men and the mean age was 29 years. 63.2% of the subjects were from 28 African countries, 18.6% from 8 Asian countries, 10% from 5 South American countries and the West Indies, and 6.4% from 4 countries of the Mediterranean basin. 4 countries of the Mediterranean basin. All the subjects were asked to provide stool and urine specimens at the Paris City Laboratory, which were examined using the merthiolate iodo formol direct methods, two concentration methods (MIF and Kato) and Baermann's technique. Patients with infestations were prescribed appropriate treatment at a second visit, compliance with which was good (86%). The prevalence of intestinal parasite infections was 60%. Albendazole was given to 44% of patients, while 45% of African patients were given praziquantel and 2.7% tinidazole.(ABSTRACT TRUNCATED AT 250 WORDS)


Asunto(s)
Parasitosis Intestinales/prevención & control , Tamizaje Masivo/métodos , Refugiados , Adulto , África/etnología , Asia/etnología , Protocolos Clínicos , Centros Comunitarios de Salud/organización & administración , Análisis Costo-Beneficio , Árboles de Decisión , Costos de los Medicamentos , Heces/parasitología , Femenino , Humanos , Parasitosis Intestinales/etnología , Parasitosis Intestinales/parasitología , Parasitosis Intestinales/orina , Masculino , Tamizaje Masivo/economía , Paris/epidemiología , Prevalencia , Estudios Retrospectivos , Sensibilidad y Especificidad , América del Sur/etnología
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