RESUMEN

This paper provides a historical overview of Professor Fulgence Raymond, Charcot's eldest pupil, who was chosen as his successor. It explores Raymond's origins as a veterinary surgeon, his evolution as a neurologist under Charcot's mentorship, and his tenure as the professor's successor at the La Salpêtrière Hospital in Paris, France, from 1894 to 1910.

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O presente artigo oferece um perfil histórico do professor Fulgence Raymond, que foi o pupilo mais velho do Professor Jean-Martin Charcot, é apresentado, destacando-se a origem de Raymond como cirurgião veterinário, sua carreira como médico neurologista sob supervisão de Charcot e, finalmente, a sua atuação como sucessor do professor , na cadeira de doenças do sistema nervoso do Hospital de La Salpêtrière, em Paris, França, entre os anos de 1894 e 1910.

Asunto(s)

Neurología , Historia del Siglo XIX , Historia del Siglo XX , Neurología/historia , Medicina Veterinaria/historia , Paris , Francia

RESUMEN

OBJECTIVE: To assess the association between deprivation and the incidence and clinical severity of tuberculosis (TB) in children. STUDY DESIGN: Children ≤18 years old who were admitted for TB between 2007 and 2020 at a tertiary hospital were included in this retrospective study. Deprivation was assessed using the French Deprivation Index. TB severity was assessed using the Wiseman classification. Multivariate analyses were carried out. RESULTS: In total, 222 patients were included. The median age was 10.8 years (IQR 4.5-14.4). TB was considered severe in 126 patients (56.8%), with 50% of the patients included in the 2 most deprived groups. The most-deprived children had a TB incidence that was 58 times greater than that of the least-deprived children (95% CI 28.49-119.40). There was no significant association between deprivation and severity in the multivariable analysis after adjusting for age and circumstances of diagnosis. Deprivation was associated with an increased length of stay in the most-deprived groups (OR 3.79, 95% CI 1.55-10.23). There was a trend toward a greater proportion of symptomatic children in the most-deprived group. CONCLUSIONS: TB incidence and hospital length of stay increased with deprivation levels but not with the severity of TB.

Asunto(s)

Tuberculosis , Humanos , Niño , Adolescente , Estudios Retrospectivos , Centros de Atención Terciaria , Paris/epidemiología , Incidencia , Tuberculosis/epidemiología , Francia/epidemiología

RESUMEN

Buildings play a key role in the transition to a low-carbon-energy system and in achieving Paris Agreement climate targets. Analyzing potential scenarios for building decarbonization in different socioeconomic contexts is a crucial step to develop national and transnational roadmaps to achieve global emission reduction targets. This study integrates building stock energy models for 32 countries across four continents to create carbon emission mitigation reference scenarios and decarbonization scenarios by 2050, covering 60% of today's global building emissions. These decarbonization pathways are compared to those from global models. Results demonstrate that reference scenarios are in all countries insufficient to achieve substantial decarbonization and lead, in some regions, to significant increases, i.e., China and South America. Decarbonization scenarios lead to substantial carbon reductions within the range projected in the 2 °C scenario but are still insufficient to achieve the decarbonization goals under the 1.5 °C scenario.

Asunto(s)

Carbono , China , Paris , América del Sur

RESUMEN

BACKGROUND/OBJECTIVES: Platelet-activating factor receptor (PAFR) activation controls adipose tissue (AT) expansion in animal models. Our objective was twofold: (i) to check whether PAFR signaling is involved in human obesity and (ii) investigate the PAF pathway role in hematopoietic or non-hematopoietic cells to control adipocyte size. MATERIALS/SUBJECTS AND METHODS: Clinical parameters and adipose tissue gene expression were evaluated in subjects with obesity. Bone marrow (BM) transplantation from wild-type (WT) or PAFR-/- mice was performed to obtain chimeric PAFR-deficient mice predominantly in hematopoietic or non-hematopoietic-derived cells. A high carbohydrate diet (HC) was used to induce AT remodeling and evaluate in which cell compartment PAFR signaling modulates it. Also, 3T3-L1 cells were treated with PAF to evaluate fat accumulation and the expression of genes related to it. RESULTS: PAFR expression in omental AT from humans with obesity was negatively correlated to different corpulence parameters and more expressed in the stromal vascular fraction than adipocytes. Total PAFR-/- increased adiposity compared with WT independent of diet-induced obesity. Differently, WT mice receiving PAFR-/--BM exhibited similar adiposity gain as WT chimeras. PAFR-/- mice receiving WT-BM showed comparable augmentation in adiposity as total PAFR-/- mice, demonstrating that PAFR signaling modulates adipose tissue expansion through non-hematopoietic cells. Indeed, the PAF treatment in 3T3-L1 adipocytes reduced fat accumulation and expression of adipogenic genes. CONCLUSIONS: Therefore, decreased PAFR signaling may favor an AT accumulation in humans and animal models. Importantly, PAFR signaling, mainly in non-hematopoietic cells, especially in adipocytes, appears to play a significant role in regulating diet-induced AT expansion.

Asunto(s)

Tejido Adiposo/fisiopatología , Obesidad/complicaciones , Glicoproteínas de Membrana Plaquetaria/farmacología , Tejido Adiposo/metabolismo , Adulto , Animales , Modelos Animales de Enfermedad , Femenino , Humanos , Masculino , Ratones , Ratones Noqueados , Persona de Mediana Edad , Obesidad/fisiopatología , Paris , Receptores Acoplados a Proteínas G , Transducción de Señal/fisiología

RESUMEN

Methane is a short-lived greenhouse gas (GHG) modelled distinctly from long-lived GHGs such as carbon dioxide and nitrous oxide to establish global emission budgets for climate stabilisation. The Paris Agreement requires a 24-47% reduction in global biogenic methane emissions by 2050. Separate treatment of methane in national climate policies will necessitate consideration of how global emission budgets compatible with climate stabilisation can be downscaled to national targets, but implications of different downscaling rules for national food production and climate neutrality objectives are poorly understood. This study addresses that knowledge gap by examining four methods to determine national methane quotas, and two methods of GHG aggregation (GWP100 and GWP*) across four countries with contrasting agriculture, forestry and other land use (AFOLU) sectors and socio-economic contexts (Brazil, France, India and Ireland). Implications for production of methane-intensive food (milk, meat, eggs and rice) in 2050 and national AFOLU climate neutrality targets are explored. It is assumed that methane quotas are always filled by food production where sufficient land is available. Global methane budgets for 1.5 °C scenarios are downscaled to national quotas based on: grand-parenting (equal percentage reductions across countries); equity (equal per capita emissions); ability (emission reductions proportionate to GDP); animal protein security (emissions proportionate to animal protein production in 2010). The choice of allocation method changes national methane quotas by a factor of between 1.7 (India) and 6.7 (Ireland). Despite projected reductions in emission-intensities, livestock production would need to decrease across all countries except India to comply with quotas under all but the most optimistic sustainable intensification scenarios. The extent of potential afforestation on land spared from livestock production is decisive in achieving climate neutrality. Brazil and Ireland could maintain some degree of milk and beef export whilst achieving territorial climate neutrality, but scenarios that comply with climate neutrality in India produce only circa 30% of national calorie and protein requirements via rice and livestock. The downscaling of global methane budgets into national policy targets in an equitable and internationally acceptable manner will require simultaneous consideration of the interconnected priorities of food security and (land banks available for) carbon offsetting.

Asunto(s)

Efecto Invernadero , Metano , Agricultura , Animales , Brasil , Bovinos , Cambio Climático , Francia , India , Irlanda , Metano/análisis , Paris

RESUMEN

The Nationally Determined Contributions (NDCs) represent the world's first effort toward the Paris Agreement goal of keeping global temperature increase well below 2 °C and pursuing 1.5 °C. Little is known about how much the proposed mitigation efforts can reduce the risks and economic damages from unabated climate change and about the consequences if key emitters drop the Paris Agreement. Here, we use CLIMRISK, an integrated assessment model designed to support climate policy at the global, national, and subnational scales where mitigation and adaptation policy decisions are made. We characterize the consequences of unabated climate change and the benefits of current climate policy proposals by means of probabilistic estimates of the economic damages of climate change and uni- and multivariate dynamic climate risk indices at a detailed spatial resolution. The results presented reveal that the economic costs and risks are highly unequally distributed between and within countries and larger than previously estimated when warming in urban areas and temporal persistence of impacts are accounted for. Costs and risks can be significantly limited by strict implementation of NDCs, but increase noticeably under noncompliance by large emitters, like the United States.

Asunto(s)

Cambio Climático/economía , Economía , Medición de Riesgo , Política Ambiental , Geografía , Humanos , Modelos Teóricos , Paris , Factores Socioeconómicos

RESUMEN

The Atlantic Rainforest is among the main biodiversity hotspots in the world, the Yabotí Biosphere Reserve (YBR) being one of the most important remaining areas. Agriculture practices could lead to intensive usage of pesticides resulting in a risk to the environment and human health. Water, suspended particulate matter (SPM), sediment, and fish (Andromakhe paris and Andromakhe saguazu) samples were collected from four streams with different degrees of protection of the YBR in two periods in order to assess the distribution of 18 organochlorine pesticides. Legacy and current-use pesticides were found in the different environmental matrices of the stream headwaters in non-anthropized areas within the buffer zone that drains the intangible area. A similar occurrence pattern of pesticides was found in all matrices. Levels of DDTs (<3.63 ng/L) and endosulfans (<21.8 ng/L) in surface water were above international guidelines for the protection of aquatic life in several streams for both sampling periods. HCHs, DDTs, endosulfans, and chlorpyrifos were detected in SPM and sediments from three streams, while γ-HCH (<60.3 ng/g lipid weight), chlorpyrifos (<698 ng/g lw), p,p´-DDD (<367 ng/g lw), and α-endosulfans (<209 ng/g lw) were detected in fish muscle in several streams. Chlorpyrifos and endosulfans were associated with current use, while DDx/DDT ratios suggested an old use. The concentration of pesticides found would not represent a risk to human health; however, it highlights the need to establish better regulation and action guidelines to reduce the anthropogenic effect on natural reserves.

Asunto(s)

Hidrocarburos Clorados , Plaguicidas , Contaminantes Químicos del Agua , Animales , Biota , China , Monitoreo del Ambiente , Sedimentos Geológicos , Humanos , Hidrocarburos Clorados/análisis , Paris , Plaguicidas/análisis , Bosque Lluvioso , Contaminantes Químicos del Agua/análisis

RESUMEN

Mangroves have among the highest carbon densities of any tropical forest. These 'blue carbon' ecosystems can store large amounts of carbon for long periods, and their protection reduces greenhouse gas emissions and supports climate change mitigation. Incorporating mangroves into Nationally Determined Contributions to the Paris Agreement and their valuation on carbon markets requires predicting how the management of different land-uses can prevent future greenhouse gas emissions and increase CO2 sequestration. We integrated comprehensive global datasets for carbon stocks, mangrove distribution, deforestation rates, and land-use change drivers into a predictive model of mangrove carbon emissions. We project emissions and foregone soil carbon sequestration potential under 'business as usual' rates of mangrove loss. Emissions from mangrove loss could reach 2391 Tg CO2 eq by the end of the century, or 3392 Tg CO2 eq when considering foregone soil carbon sequestration. The highest emissions were predicted in southeast and south Asia (West Coral Triangle, Sunda Shelf, and the Bay of Bengal) due to conversion to aquaculture or agriculture, followed by the Caribbean (Tropical Northwest Atlantic) due to clearing and erosion, and the Andaman coast (West Myanmar) and north Brazil due to erosion. Together, these six regions accounted for 90% of the total potential CO2 eq future emissions. Mangrove loss has been slowing, and global emissions could be more than halved if reduced loss rates remain in the future. Notably, the location of global emission hotspots was consistent with every dataset used to calculate deforestation rates or with alternative assumptions about carbon storage and emissions. Our results indicate the regions in need of policy actions to address emissions arising from mangrove loss and the drivers that could be managed to prevent them.

Asunto(s)

Carbono , Humedales , Asia , Brasil , Secuestro de Carbono , Región del Caribe , Ecosistema , Paris

Asunto(s)

Neurología , Brasil , Humanos , Paris

RESUMEN

In this paper, the BASIC (Brazil, South Africa, India, and China) countries, which play an increasingly significant role in combating climate change, are selected as the research objects. First, we investigate the driving factors of the evolution of carbon emissions in the BASIC group from 2000 to 2016. Second, we use the Monte Carlo simulation to analyze the potential evolution trend of carbon emissions in the benchmark scenario, optimization scenario, and enhanced scenario in the BASIC group from 2017 to 2030 to judge whether the countries can achieve their own autonomous contribution goals. Third, we evaluate whether the BASIC INDC can provide practical support for making the global temperature control goals described in the Paris Agreement. The results show that first, the contribution rate of the energy consumption structure and population size to the carbon emissions of the BASIC are low, and the contributions of R&D efficiency, R&D intensity, and investment intensity to the carbon emission change in the BASIC group are more prominent. Second, under the benchmark scenario, Brazil, South Africa, India, and China from the difference between the complete INDC targets respectively is 265.50 Mt, 207.86 Mt, 1034.70 Mt, and 4660.82 Mt. Under the optimization scenario, China could meet the INDC goals. The gap between Brazil, South Africa, and India is 60.06 Mt, 9.50 Mt, and 413.74 Mt, respectively. Under the enhanced scenario, China and South Africa could meet the INDC target, while Brazil and India are 15.69 Mt and 228.28 Mt away from the INDC target, respectively. Third, although the INDC goals of Brazil and India can achieve the carbon reduction allocated under the 2 °C targets, the INDC targets submitted by the BASIC are not enough to reach the carbon reduction allocated under the global 1.5 °C destination; Brazil, South Africa, India, and China's gap is 64.14 Mt, 246.15 Mt, 236.84 Mt, 3399.64 Mt, respectively. Fourth, Brazil, South Africa, and China should increase its R&D on energy-saving and emission reduction technologies, and India should develop reasonable population policies and green economic development policies.

Asunto(s)

Dióxido de Carbono , Brasil , Dióxido de Carbono/análisis , China , India , Paris , Sudáfrica , Temperatura

RESUMEN

The study described in this manuscript analyzed the effects of quarantine and social distancing policies implemented due to the Coronavirus Disease 2019 (COVID-19) pandemic on air pollution levels in four western megacities: São Paulo in Brazil; Paris in France; and Los Angeles and New York in the United States. The study investigated the levels of four air pollutants-Carbon monoxide (CO), Ozone (O3), Fine Particulate (PM2.5) and Nitrogen dioxide (NO2)-during the month of March 2020, compared to 2015-2019, in the urban air of these metropolitan areas, controlling for meteorological variables. Results indicated reductions in the levels of PM2.5, CO and NO2, with reductions of the latter two showing statistical significance. In contrast, tropospheric ozone levels increased, except in Los Angeles. The beneficial health effects of cleaner air might also help prevent deaths caused by the epidemic of COVID-19 in megacities by diminishing pressure on hospitals and health equipment. Future actions for the re-starting of non-essential economic activities in these cities should take into consideration the overall importance of health for the individual, as well as for societies.

Asunto(s)

Contaminación del Aire/análisis , Betacoronavirus/aislamiento & purificación , Infecciones por Coronavirus/epidemiología , Material Particulado/análisis , Neumonía Viral/epidemiología , Brasil , COVID-19 , Ciudades , Infecciones por Coronavirus/virología , Humanos , Los Angeles , Ciudad de Nueva York , Pandemias , Paris , Neumonía Viral/virología , Salud Pública , SARS-CoV-2

RESUMEN

OBJECTIVE: to suggest a script for surgical oncology assistance in COVID-19 pandemic in Brazil. METHOD: a narrative review and a "brainstorming" consensus were carried out after discussion with more than 350 Brazilian specialists and renowned surgeons from Portugal, France, Italy and United States of America. RESULTS: consensus on testing for COVID-19: 1- All patients to be operated should be tested between 24 and 48 before the procedure; 2- The team that has contact with sick or symptomatic patients should be tested; 3 - Chest tomography was suggested to investigate pulmonary changes. Consensus on protection of care teams: 1 - Use of surgical masks inside the hospitals. Use of N95 masks for all professionals in the operating room; 2 - Selection of cases for minimally invasive surgery and maximum pneumoperitoneal aspiration before removal of the surgical specimen; 2 - Optimization of the number of people in teams, with a minimum number of professionals, reducing their occupational exposure, the consumption of protective equipment and the circulation of people in the hospital environment; 3 - Isolation of contaminated patients. Priority consensus: 1- Construction of service priorities; 2 - Interdisciplinary discussion on minimally invasive or conventional pathways. CONCLUSION: the Brazilian Society of Surgical Oncology (BSSO) suggests a script for coping with oncological treatment, remembering that the impoundment in the assistance of these cases, can configure a new wave of overload in health systems.

Asunto(s)

Betacoronavirus , Consenso , Infecciones por Coronavirus/epidemiología , Neoplasias/cirugía , Neumonía Viral/epidemiología , Brasil/epidemiología , COVID-19 , Infecciones por Coronavirus/diagnóstico , Personal de Salud , Humanos , Cooperación Internacional , Italia , Pulmón/diagnóstico por imagen , Máscaras , Procedimientos Quirúrgicos Mínimamente Invasivos , Neoplasias/complicaciones , Exposición Profesional/prevención & control , Pandemias , Paris , Equipo de Protección Personal , Neumonía Viral/diagnóstico , Portugal , Cuidados Preoperatorios , SARS-CoV-2 , Manejo de Especímenes , Washingtón

Asunto(s)

Calentamiento Global/legislación & jurisprudencia , Calentamiento Global/prevención & control , Objetivos , Cooperación Internacional/legislación & jurisprudencia , Liderazgo , Optimismo , Desarrollo Sostenible/economía , Desarrollo Sostenible/tendencias , Animales , Conservación de los Recursos Energéticos/tendencias , Costa Rica , Toma de Decisiones , Unión Europea , Agricultura Forestal , Calentamiento Global/economía , Paris , Desarrollo Sostenible/legislación & jurisprudencia , Suiza , Temperatura

RESUMEN

Background: The Paris Catacombs contain the remains of approximately 6 million people dating back to the 15th century, when leprosy was endemic in France.Aims: The aim of this palaeopathological study was to identify the presence of leprosy in skulls from the Paris Catacombs.Subjects and methods: Macroscopic examination of skulls in situ for bone changes secondary to oronasal soft tissue infection by leprosy. Skulls were categorised as having "probable" signs of leprosy if they had an enlarged nasal (pyriform) aperture, resorption of the anterior nasal spine, and resorption of the alveolar processes of maxilla, and as having "possible" signs of leprosy if they met one of these three criteria.Results: Skulls from 123 sections within the Catacombs (approximately 1500 remains in total) were triaged, with 367 skulls identified as suitable for examination. Of these, 74 had central facial bone alterations/abnormalities and underwent detailed examination, yielding 0.5% (2/367) classified as having probable, and 5.7% (21/367) possible signs of leprosy.Conclusions: The proportion of skulls with probable signs of leprosy gives an approximate estimate (0.5%) for the prevalence of this disease in the population of Paris (or districts of Paris) during the 15-18th centuries.

Asunto(s)

Lepra/historia , Cráneo/patología , Femenino , Historia del Siglo XV , Historia del Siglo XVI , Historia del Siglo XVII , Historia del Siglo XVIII , Humanos , Lepra/epidemiología , Lepra/patología , Masculino , Paris/epidemiología

RESUMEN

Migration can affect reproductive outcomes due to different socioeconomic and cultural contexts before and after migration, to changes in the affective and conjugal status of women and to their life conditions. The aim of this study is to investigate the association between international migration and abortion. The data came from a retrospective life-event survey from sub-Saharan African women living in Île-de-France. Differences in abortion distribution before and after migration were assessed using the Pearson chi-square test, and the association between the predictor and the outcome was investigated using Generalized Estimating Equations. A total of 363 women and 1377 pregnancies were investigated. Among these pregnancies, 15.6% that occurred before and 11.0% that occurred after migration was reported as ended in abortion (p = 0.011). The odds of reporting having had an abortion was lower after migration (OR 0.59, 95% CI 0.42-0.84), even after adjustment. However, after including intendedness of pregnancy in the model, this association lost its significance. The difference in induced abortion occurrence between before and after migration is almost entirely due to a change in the intendedness of pregnancy. Thus, socioeconomic and cultural issues have a greater weight in the decision to abort than the legal interdiction of this practice.

Asunto(s)

Aborto Inducido/estadística & datos numéricos , Emigración e Inmigración/estadística & datos numéricos , Embarazo no Planeado/etnología , Adolescente , Adulto , África del Sur del Sahara/etnología , Características Culturales , Femenino , Humanos , Paris/epidemiología , Embarazo , Estudios Retrospectivos , Factores Socioeconómicos , Adulto Joven

RESUMEN

ABSTRACT Objective: to suggest a script for surgical oncology assistance in COVID-19 pandemic in Brazil. Method: a narrative review and a "brainstorming" consensus were carried out after discussion with more than 350 Brazilian specialists and renowned surgeons from Portugal, France, Italy and United States of America. Results: consensus on testing for COVID-19: 1- All patients to be operated should be tested between 24 and 48 before the procedure; 2- The team that has contact with sick or symptomatic patients should be tested; 3 - Chest tomography was suggested to investigate pulmonary changes. Consensus on protection of care teams: 1 - Use of surgical masks inside the hospitals. Use of N95 masks for all professionals in the operating room; 2 - Selection of cases for minimally invasive surgery and maximum pneumoperitoneal aspiration before removal of the surgical specimen; 2 - Optimization of the number of people in teams, with a minimum number of professionals, reducing their occupational exposure, the consumption of protective equipment and the circulation of people in the hospital environment; 3 - Isolation of contaminated patients. Priority consensus: 1- Construction of service priorities; 2 - Interdisciplinary discussion on minimally invasive or conventional pathways. Conclusion: the Brazilian Society of Surgical Oncology (BSSO) suggests a script for coping with oncological treatment, remembering that the impoundment in the assistance of these cases, can configure a new wave of overload in health systems.

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RESUMO Objetivo: sugerir roteiro de assistência oncológica cirúrgica em meio à pandemia COVID-19 no Brasil. Método: foi realizada revisão narrativa da literatura e consenso tipo "brainstorming" após discussão com mais de 350 especialistas brasileiros e cirurgiões renomados de Portugal, França, Itália e Estados Unidos da América. Resultados: consenso sobre testagem para COVID-19: 1-Todos os pacientes a serem operados devem ser testados entre 24 e 48 antes do procedimento; 2-Equipe que tenha contato com doentes ou sintomáticos deve ser testada; 3-Tomografia de tórax foi sugerida para pesquisa de alterações pulmonares. Consenso sobre proteção das equipes de assistência: 1-Uso de máscaras cirúrgicas dentro de hospitais. Uso de máscaras N95 para todos os profissionais na sala cirúrgica; 2-Seleção dos casos para cirurgia minimamente invasiva e aspiração máxima do pneumoperitônio antes da retirada da peça cirúrgica; 2-Otimização das equipes, com número mínimo de profissionais, reduzindo a exposição ocupacional, o consumo de equipamento de proteção e a circulação de pessoas no ambiente hospitalar; 3 -Isolamento de pacientes contaminados. Consenso sobre priorizações: 1-Construção de prioridades de atendimento; 2- Discussão interdisciplinar sobre via minimamente invasiva ou convencional. Conclusão: a Sociedade Brasileira de Cirurgia Oncológica (SBCO) sugere roteiro de enfrentamento para o tratamento oncológico, lembrando que o represamento na assistência desses casos, pode configurar uma nova onda de sobrecarga em sistemas de saúde.

Asunto(s)

Humanos , Neumonía Viral/epidemiología , Infecciones por Coronavirus/epidemiología , Consenso , Betacoronavirus , Neoplasias/cirugía , Paris , Neumonía Viral/diagnóstico , Portugal , Manejo de Especímenes , Brasil/epidemiología , Cuidados Preoperatorios , Washingtón , Exposición Profesional/prevención & control , Personal de Salud , Infecciones por Coronavirus/diagnóstico por imagen , Procedimientos Quirúrgicos Mínimamente Invasivos , Pandemias , Equipo de Protección Personal , SARS-CoV-2 , COVID-19 , Cooperación Internacional , Italia , Pulmón/diagnóstico por imagen , Máscaras , Neoplasias/complicaciones

RESUMEN

Jean-Martin Charcot, the most celebrated neurologist of the 19th century, had a profound influence on Sigmund Freud's career. Freud spent the winter of 1885-1886 working in Charcot's neurology department in Paris. During this period, he went to Charcot's house on several occasions to participate in the very famous Tuesday soirées under the guidance of Gilles de la Tourette. Freud was always very proud to be invited and curious to meet the Parisian intellectual elite. On these occasions, however, he was very apprehensive and made frequent use of cocaine. Due to anxiety and the need to appear creative in front of Charcot, it is possible that Freud used cocaine at other times.

Asunto(s)

Trastornos Relacionados con Cocaína/historia , Neurología/historia , Ansiedad/psicología , Trastornos Relacionados con Cocaína/psicología , Coraje , Historia del Siglo XIX , Historia del Siglo XX , Paris

RESUMEN

Megadytes (Bifurcitus) ducalis Sharp, 1882 is the largest diving beetle in the world and has been considered a candidate for the world's rarest insect (Jones 2010). It was described from "Brazil", is only known from the male holotype in the Natural History Museum (London), and typically thought to be extinct. Here we report the finding of 10 additional specimens, all collected at the end of the 19th century, which were discovered incidentally in different historical collections, including drawers with unsorted diving beetle accessions of the Muséum National d'Histoire Naturelle (Paris). These specimens, whilst old, reveal exact locality data for the first time, enabling focused field campaigns to attempt to rediscover this giant alive. Locality labels all indicate Santo Antônio da Barra (present name Condeúba), in the southern part of Bahia, Brazil, suggesting that the species may have a restricted distribution in wetter parts of the Brazilian savanna or cerrado. We also describe the female of M. ducalis for the first time and present new records of the putatively closely related species Megadytes magnus Trémouilles Bachmann, 1980 and M. lherminieri (Guérin-Méneville, 1829), the latter being recorded for the first time from Ecuador. These three morphologically similar species together form the subgenus Bifurcitus Brinck, 1945 and we provide photographs of their habitus, median lobes and other morphological details.

Asunto(s)

Escarabajos , Animales , Brasil , Ecuador , Femenino , Londres , Masculino , Paris

RESUMEN

ABSTRACT Jean-Martin Charcot, the most celebrated neurologist of the 19th century, had a profound influence on Sigmund Freud's career. Freud spent the winter of 1885-1886 working in Charcot's neurology department in Paris. During this period, he went to Charcot's house on several occasions to participate in the very famous Tuesday soirées under the guidance of Gilles de la Tourette. Freud was always very proud to be invited and curious to meet the Parisian intellectual elite. On these occasions, however, he was very apprehensive and made frequent use of cocaine. Due to anxiety and the need to appear creative in front of Charcot, it is possible that Freud used cocaine at other times.

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RESUMO Jean-Martin Charcot, o neurologista mais célebre do século XIX, teve uma influência profunda na carreira de Sigmund Freud. Freud visitou o Departamento de Neurologia do Hospital Salpêtrière, em Paris, chefiado pelo professor Charcot, durante o inverno de 1885-1886. Durante este período, ele foi várias vezes à casa de Charcot para participar dos famosos saraus de terça-feira, sob a orientação de GiUes de la Tourette. Nessas ocasiões, Freud ficava sempre muito orgulhoso pelo convite, curioso por encontrar a elite intelectual Parisiense, mas também muito apreensivo, e fazia uso frequente de cocaína. Devido à ansiedade e à necessidade de aparentar-se produtivo diante de Charcot, é possível que Freud tenha usado cocaína outras vezes.

Asunto(s)

Historia del Siglo XIX , Historia del Siglo XX , Trastornos Relacionados con Cocaína/historia , Neurología/historia , Ansiedad/psicología , Paris , Trastornos Relacionados con Cocaína/psicología , Coraje

RESUMEN

This paper reviews aspects of the life and work of Professor Louis Ranvier 140 years after the publication of Leçons sur l'histologie du système nerveux, published in 1878, and shows the importance of the histological description of myelinated fibers of the nodes of Ranvier.

Asunto(s)

Sistema Nervioso/anatomía & histología , Neurología/historia , Nódulos de Ranvier , Historia del Siglo XIX , Historia del Siglo XX , Fibras Nerviosas Mielínicas , Paris