RESUMEN
Thirty-six tortoises (Testudo hermanni) with naturally acquired oxyurids infections were used to assess the anthelmintic efficacy of oxfendazole (Dolthene; Merial) and fenbendazole (Panacur; Hoechst Roussel Vet). Animals were randomly assigned to three groups (A, B, and C) based on sex and weight. Animals in group A (seven males and six females) were orally treated with oxfendazole at dose rate of 66 mg/kg, group B animals (nine males and eight females) were orally treated with fenbendazole at dose rate of 100 mg/kg, and group C animals (three males and three females) were not treated and served as controls. All animals were individually stabled in plexiglas boxes under controlled conditions of temperature, humidity, and light beginning 7 days pretreatment and continuing for the duration of the trial. Individual tortoises feces were examined daily by the McMaster technique and drugs efficacy was assessed by the fecal eggs count reduction (FECR) test. Both drugs showed 100% of FECR. However, oxfendazole reached this level 12 days after treatment, whereas 31 days after treatment were necessary to obtain the same stable result with fenbendazole. The two drugs were well tolerated by all the animals and no adverse reactions were observed after treatment.
Asunto(s)
Antinematodos/uso terapéutico , Bencimidazoles/uso terapéutico , Fenbendazol/uso terapéutico , Infecciones por Oxyurida/veterinaria , Oxyurida/efectos de los fármacos , Tortugas/parasitología , Animales , Bencimidazoles/efectos adversos , Heces/parasitología , Femenino , Fenbendazol/efectos adversos , Masculino , Infecciones por Oxyurida/tratamiento farmacológico , Recuento de Huevos de ParásitosRESUMEN
The paper presents the results of studies of the effects of anthelminthic agents on the in tegumentary tissues of nematodes from the Oxyurata suborder. All used anthelmintics causes varying structural changes in the integumentary tissues of Oxyurata. At the same time, there is swelling and loosening of the cuticle, its detachment from the subcuticular layer, vacuolization of the hypodermis and the plasma part of muscular cells, as well as irreversible changes in the cellular organoids of the hypodermis and muscular cells (destruction of canals of the endoplasmic network and the Golgi apparatus, mitochondrial membrane damage, nuclear pyknosis or lysis etc.)