RESUMEN
Osteochondrodysplasia is a painful, progressive clinical syndrome unique to Scottish fold cats because of a heritable missense mutation in the TRPV4 gene. An 8 yr old male neutered Scottish fold cat was presented for a mass on his hind paw. The mass caused decreased mobility in the metatarsal region and digits and resulted in significant discomfort. Because of extensive skeletal abnormalities attributed to breed-related osteochondrodysplasia, the owner was reluctant to pursue amputation. Radiation therapy was pursued for palliation of pain. After coarsely fractionated external beam radiotherapy resulted in stabilization of the mass with eventual progression after 14 mo, samarium-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid was administered systemically, and the cat showed immediate, whole-body improvement in mobility. Concurrent intestinal and respiratory disease was evaluated and managed. Samarium-153-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid administration was repeated approximately every 6 mo for three treatments until the cat succumbed to thromboembolic disease attributed to previously diagnosed cardiac disease. Radiation therapy administered using either external beam or bone-seeking radioisotopes can be effective at palliating clinical signs associated with the skeletal abnormalities that accompany this disease.
Asunto(s)
Enfermedades de los Gatos/terapia , Compuestos Organofosforados/uso terapéutico , Osteocondrodisplasias/veterinaria , Radioisótopos/uso terapéutico , Samario/uso terapéutico , Animales , Gatos , Masculino , Compuestos Organofosforados/química , Osteocondrodisplasias/tratamiento farmacológico , Osteocondrodisplasias/radioterapia , Radioisótopos/química , Samario/química , Canales Catiónicos TRPV/genética , Canales Catiónicos TRPV/metabolismoAsunto(s)
Enfermedades de los Gatos/radioterapia , Osteocondrodisplasias/veterinaria , Cuidados Paliativos , Animales , Enfermedades de los Gatos/genética , Gatos , Femenino , Predisposición Genética a la Enfermedad , Masculino , Osteocondrodisplasias/genética , Osteocondrodisplasias/radioterapia , Cuidados Paliativos/métodos , Radioterapia/efectos adversos , Radioterapia/veterinariaRESUMEN
Objetivo: Analisar os achados clínicos e radiológicos da displasia cleidocraniana. Método: A Unidade de Genética do ICr-HCFMUSP, em conjunto com o setor da Radiologia, estudou 12 pacientes pertencentes a 8 famílias com displasia cleidocraniana...
Objectives: To analyse the clinical and radiological finding of cleidocranial dysplasia. Methods: The Genetics Unit of ICr-HCFMUSP, along with the Radiology department, performed the study of 12 patients from eight families of cleidocranial dysplasia...
Asunto(s)
Humanos , Masculino , Femenino , Anomalías Craneofaciales/genética , Displasia Cleidocraneal , Osteocondrodisplasias/radioterapiaRESUMEN
This report describes palliative irradiation as treatment for Scottish Fold osteochondrodysplasia. A 3-year-old female spayed Scottish Fold cat suffering from osteochondrodysplasia was referred to the Veterinary Teaching Hospital, University of Zurich. Based on the breed, history, clinical signs, radiographic findings, and the histologic diagnosis of a biopsy specimen, Scottish Fold osteochondrodysplasia was confirmed. To control the exostoses leading to inflammatory processes and pain, radiotherapy was initiated as palliative treatment. This was successful in relieving the clinical signs within a few weeks. The short- and long-term results after radiotherapy are presented and discussed with a comparable human disease, the plantar heel spur, which also responds well to radiotherapy.