RESUMEN
An osteoma is an infrequent tumor documented in avian species. An adult female Peach-Faced Lovebird (Agapornis roseicollis) with a history of previous trauma was examined due to the presence of bilateral hard and yellowish-white masses in the radio-cubital humerus junction. Histopathological dermal examination revealed a non-neoplastic process of mesenchymal origin, characterized by the formation of well-differentiated trabecular bone, multiple areas of medullary bone and loose connective tissue and coagulation of the necrosis foci. Based on the histological findings and the medical history, the masses were diagnosed as bilateral secondary osteoma cutis. To our knowledge, this is the first report of this pathology with an acute course in this exotic pet bird. The previous trauma could be the initiating cause.
Asunto(s)
Agapornis , Enfermedades de las Aves/diagnóstico , Enfermedades Óseas Metabólicas/veterinaria , Osificación Heterotópica/veterinaria , Enfermedades Cutáneas Genéticas/veterinaria , Animales , Enfermedades de las Aves/patología , Enfermedades Óseas Metabólicas/diagnóstico , Enfermedades Óseas Metabólicas/patología , Femenino , Osificación Heterotópica/diagnóstico , Osificación Heterotópica/patología , Enfermedades Cutáneas Genéticas/diagnóstico , Enfermedades Cutáneas Genéticas/patologíaRESUMEN
Este relato descreve e discute os achados clínicos, anatomopatológicos e imuno-histoquímicos de um caso de adenocarcinoma gástrico com ossificação heterotópica em cão macho de doze anos com histórico de vômitos frequentes não responsivos a tratamento. Na necropsia, o estômago na região fúndica e no corpo próximo à curvatura menor apresentava parede intensamente espessada, elevada, irregular e firme. A microscopia demonstrou áreas multifocais de proliferação neoplásica maligna de células epiteliais, formando ácinos ou túbulos contendo quantidade variável de mucina e múltiplos focos de ossificação heterotópica. As células neoplásicas foram positivas para citoqueratina e negativas para vimentina e osteocalcina. Metástases da neoplasia foram observadas nos Iinfonodos gástricos e nos pulmões.
This report describes and discusses the clinical, pathological and immunohistochemical findings in a case of gastric adenocarcinoma with heterotopic ossification in a 12-year-old male dog with a history of non responsive and frequent vomiting. At necropsy, the stomach fundus and body near the lesser curvature had a markedly thick, raised, irregular and firm wall. Light microscopy showed multifocal areas of malignant neoplastic proliferation of epithelial cells, forming tubules containing acini with variable amount of mucin and multiple foci of heterotopic ossification. The neoplastic cells were positive for cytokeratin and negative for vimentin and osteocalcin. Metastases of gastric cancer were observed in lymph nodes and lungs.
Este reporte describe y analiza los aspectos clínicos, patológicos e inmunohistoquímicos en un caso de adenocarcinoma gástrico con osificación heterotópica en un perro, macho, de 12 años, con un cuadro de vómitos frecuentes no responsivos al tratamiento. Durante la necropsia el paciente presentaba la pared de la región fúndica y de la curvatura menor muy engrosada, elevada, irregular y firme. La microscopia mostró áreas multifocales de una proliferación neoplásica maligna de células epiteliales, que formaban acinos o túbulos, y que contenían una cantidad variable de mucina y focos múltiples de osificación heterotópica. Las células neoplásicas fueron positivas para citoqueratina y negativas para vimentina y osteocalcina. Se observaron metástasis de la neoplasia en linfonódulos gastricos y en pulmones.
Asunto(s)
Animales , Perros , Adenocarcinoma/diagnóstico , Adenocarcinoma/veterinaria , Estómago/patología , Osificación Heterotópica/diagnóstico , Osificación Heterotópica/veterinariaRESUMEN
Este relato descreve e discute os achados clínicos, anatomopatológicos e imuno-histoquímicos de um caso de adenocarcinoma gástrico com ossificação heterotópica em cão macho de doze anos com histórico de vômitos frequentes não responsivos a tratamento. Na necropsia, o estômago na região fúndica e no corpo próximo à curvatura menor apresentava parede intensamente espessada, elevada, irregular e firme. A microscopia demonstrou áreas multifocais de proliferação neoplásica maligna de células epiteliais, formando ácinos ou túbulos contendo quantidade variável de mucina e múltiplos focos de ossificação heterotópica. As células neoplásicas foram positivas para citoqueratina e negativas para vimentina e osteocalcina. Metástases da neoplasia foram observadas nos Iinfonodos gástricos e nos pulmões.(AU)
This report describes and discusses the clinical, pathological and immunohistochemical findings in a case of gastric adenocarcinoma with heterotopic ossification in a 12-year-old male dog with a history of non responsive and frequent vomiting. At necropsy, the stomach fundus and body near the lesser curvature had a markedly thick, raised, irregular and firm wall. Light microscopy showed multifocal areas of malignant neoplastic proliferation of epithelial cells, forming tubules containing acini with variable amount of mucin and multiple foci of heterotopic ossification. The neoplastic cells were positive for cytokeratin and negative for vimentin and osteocalcin. Metastases of gastric cancer were observed in lymph nodes and lungs.(AU)
Este reporte describe y analiza los aspectos clínicos, patológicos e inmunohistoquímicos en un caso de adenocarcinoma gástrico con osificación heterotópica en un perro, macho, de 12 años, con un cuadro de vómitos frecuentes no responsivos al tratamiento. Durante la necropsia el paciente presentaba la pared de la región fúndica y de la curvatura menor muy engrosada, elevada, irregular y firme. La microscopia mostró áreas multifocales de una proliferación neoplásica maligna de células epiteliales, que formaban acinos o túbulos, y que contenían una cantidad variable de mucina y focos múltiples de osificación heterotópica. Las células neoplásicas fueron positivas para citoqueratina y negativas para vimentina y osteocalcina. Se observaron metástasis de la neoplasia en linfonódulos gastricos y en pulmones.(AU)
Asunto(s)
Animales , Perros , Adenocarcinoma/diagnóstico , Adenocarcinoma/veterinaria , Estómago/patología , Osificación Heterotópica/diagnóstico , Osificación Heterotópica/veterinariaRESUMEN
The carcass of a stranded southern right whale Eubalaena australis, discovered on the coast of Golfo Nuevo in Península Valdés, Argentina, exhibited extensive orthotopic and heterotopic ossification, osteochondroma-like lesions, and early degenerative joint disease. Extensive soft tissue ossification led to ankylosis of the axial skeleton in a pattern that, in many respects, appeared more similar to a disabling human genetic disorder, fibrodysplasia ossificans progressiva (FOP), than to more common skeletal system diseases in cetaceans and other species. This is the first reported case of a FOP-like condition in a marine mammal and raises important questions about conserved mechanisms of orthotopic and heterotopic ossification in this clade.
Asunto(s)
Osificación Heterotópica/veterinaria , Ballenas , Animales , Masculino , Osificación Heterotópica/patologíaRESUMEN
BACKGROUND: Salivary mucocele is an accumulation of saliva in a single or multiloculated cavity lined by connective tissue that is contiguous to a salivary gland-duct complex and is the most common condition affecting the salivary glands in dogs. Occasionally, different types of metaplastic lesions, such as squamous and osseous metaplasia - which are rare lesions in animals - can be observed in association with salivary mucocele. CASE PRESENTATION: A right facial enlargement was suddenly observed in a 4-year-old non-spayed female Shih-Tzu dog. The lesion presented itself as a soft and fluctuant mass located in the right side of the face near to the neck. Histologically, the mass consisted of a cavitary formation without an epithelial lining. Additionally, microscopic examination revealed the presence of osteoid-producing cells which gave rise to areas of bone formation, probably induced by irritation due to the presence sialoliths. Such cells and bone formations were also present in the cavity wall, consequently leading us to classify the condition as a salivary mucocele with osseous metaplasia. CONCLUSIONS: In the present case, the pathogenesis was probably associated with the presence of sialoliths, which can behave as etiological agents for the metaplastic lesion. The occurrence of osteoid metaplasia is a rare peculiar condition in the canine salivar y gland, and due to the rarity and lack of information about this specific disease, no clinical data can yet be associated with the development of salivary mucocele with osseous metaplasia in dogs.
Asunto(s)
Enfermedades de los Perros/patología , Mucocele/veterinaria , Osificación Heterotópica/veterinaria , Enfermedades de las Glándulas Salivales/veterinaria , Animales , Enfermedades de los Perros/cirugía , Perros , Femenino , Mucocele/patología , Mucocele/cirugía , Osificación Heterotópica/patología , Osificación Heterotópica/cirugía , Enfermedades de las Glándulas Salivales/patología , Enfermedades de las Glándulas Salivales/cirugíaRESUMEN
Collateral cartilage ossification of the distal phalanx in the Brazilian Jumper horse is a common finding. The objective of this study was to evaluate the prevalence and the degree of ossification of the collateral cartilages of the distal phalanx in Brazilian Jumper horses. In an analysis of 652 collateral cartilages from the front feet of 163 horses, 93% of these cartilages had collateral cartilage ossification (P < 0.005), and 7% of these cartilages did not have any type of ossification. In ossified cartilages, 86.4% had ossification beginning from the base, and 6.6% had a separate center of ossification.