RESUMEN

1. The effects produced by discontinuation of long-term treatment with fencamfamine (FCF) were evaluated recording behavioral and body weight changes. 2. 48 hr after withdrawal of FCF rats showed a significant decrease in exploratory behavior when compared to saline-treated ones. 3. Discontinuation of treatment with FCF resulted in a significant increase in body weight on days of drug withdrawal. 4. These results suggest that FCF caused signs of withdrawal similar to other psychostimulant drugs.

Asunto(s)

Estimulantes del Sistema Nervioso Central/efectos adversos , Norbornanos/efectos adversos , Síndrome de Abstinencia a Sustancias , Animales , Peso Corporal/efectos de los fármacos , Conducta Exploratoria/efectos de los fármacos , Masculino , Ratas , Ratas Wistar