RESUMEN
Introducción: La calidad de vida relacionada con la salud (CVRS) y los estados de ánimo son indicadores cruciales del bienestar en adolescentes, pero su relación con estudiantes de Antioquia, Colombia, no ha sido ampliamente estudiada. Objetivo: Determinar la CVRS y los estados de ánimo en escolares de Antioquia-Colombia. Materiales y métodos: Estudio transversal con 1957 escolares de 9 a 20 años. Se aplicaron mediciones de CVRS, ansiedad, depresión, hostilidad y alegría, actividad física, comportamiento sedentario, apoyo social de padres y nivel socioeconómico. Resultados: La calidad de vida alta (CVA) es más elevada en hombres, personas con alegría, estudiantes con apoyo de padres, activos físicamente y personas de nivel socioeconómico alto y medio. AL aumentar un año de edad, disminuye en un 15 % la CVA, y al aumentar la depresión, la ansiedad y el comportamiento sedentario disminuye la CVA. Además, los niveles de depresión y ansiedad son mayores en mujeres, estudiantes mayores, sin apoyo de los padres y personas sedentarias. Conclusiones: La CVRS se asocia con estados de ánimo, actividad física, comportamiento sedentario y apoyo de los padres; mientras que los estados de ánimo se asocian con el sexo, el apoyo de los padres, la CVS y el sedentarismo.
Introduction: Even though health-related quality of life (HRQL) and mood states are key indicators of the well-being of adolescents, their relationship has not been analyzed in students from Antioquia, Colombia. Objective: To determine HRQL and mood states in schoolchildren from Antioquia. Materials and methods: A cross-sectional study was conducted on 1,957 schoolchildren and adolescents aged between 9 and 20 years. Measurements of HRQL, anxiety, depression, hostility and happiness, physical activity, sedentary behavior, parental social support, and socioeconomic status were applied. Results: A high quality of life (HQL) was observed more frequently in male participants, students with parental support, physically active, and those belonging to medium and high socioeconomic status. HQL decreased 15% as their age increased by one year. Also, HQL was reduced when depression, anxiety, and sedentary behavior increased. Furthermore, depression and anxiety levels were higher in women, older students, as well as in those without parental control and with sedentary behavior. Conclusions: HRQL is associated with mood states, physical activity, sedentary behavior, and parental support. In contrast, mood states are related to gender, parental support, HQL, and sedentary lifestyle.
Introdução: A qualidade de vida relacionada à saúde (CVRS) e os estados de humor são indicadores cruciais de bem-estar em adolescentes, mas sua relação com estudantes de Antioquia, Colômbia, não foi amplamente estudada. Objetivo: Determinar a CVRS e os estados de humor em escolares de Antioquia-Colômbia. Materiais e métodos: Estudo transversal com 1.957 escolares de 9 a 20 anos. Foram aplicadas medidas de QVRS, ansiedade, depressão, hostilidade e felicidade, atividade física, comportamento sedentário, apoio social dos pais e nível socioeconômico. Resultados: A alta qualidade de vida (CVA) é maior em homens, pessoas com alegria, estudantes com apoio parental, fisicamente ativos e pessoas de nível socioeconômico alto e médio. À medida que a idade aumenta em um ano, diminui em 15% o CVA, e ao aumentar a depressão, a ansiedade e o comportamento sedentário aumentam, o CVA diminui. Além disso, os níveis de depressão e ansiedade são mais elevados nas mulheres, nos estudantes mais velhos, sem apoio dos pais e nas pessoas sedentárias. Conclusões: A QVRS está associada a estados de humor, atividade física, comportamento sedentário e apoio parental; enquanto os estados de humor estão associados ao sexo, apoio parental, CVS e estilo de vida sedentário.
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Humanos , Masculino , Femenino , Niño , Adolescente , Adulto Joven , Salud , Emociones , Felicidad , HostilidadRESUMEN
This scoping review mapped the academic literature focused on the therapeutic itinerary of children who seek care in health services and proposed an explanatory model to expand the concept and classification of these health itineraries. A total of 789 articles were reviewed, of which 28 were eligible for inclusion. In these 28 it was possible to observe that the child's therapeutic itinerary is more than a physical path, but also encompasses all choices within a specific social and cultural environment in which the child is inserted. Our proposal is to expand the concept beyond the therapeutic, classifying the itinerary also according to the objective, the decision-making agent, respect for the presence of company, the health subsystem used, according to the physical continuity of the itinerary, the perception of efficacy of the patient, the nature of the illness, the administration of healthcare, the means of transport used, the person providing information about the itinerary, the planning of the itinerary and its completeness. Knowing the child's itineraries toward healthcare allows the development of innovative discourses and practices for future public policies, through which the principles of comprehensiveness and resoluteness in children's health would be strengthened. There is still a need to deepen knowledge about the meanings and feelings regarding their interpretations of the events suffered in childhood.
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Atención a la Salud , Conducta de Búsqueda de Ayuda , Aceptación de la Atención de Salud , Niño , HumanosRESUMEN
INTRODUCTION: The role of IMP3, CDK4, MDM2 and ß-catenin proteins in Enchondroma and Central Chondrosarcoma is not totally understood. The aim of this study is to evaluate the immunoexpression of these proteins, associating histological grade, clinical data and prognosis to these tumors. METHODS: This is a retrospective-analytical study of 32 Enchondroma and 70 Central Chondrosarcoma. RESULTS: IMP3, CDK4, MDM2 and ß-catenin expression was observed in 22.82 %, 13.82 %, 17.17 % and in 8.8 % of cases, respectively. All Enchondromas positive for these immunomarkers were located in short tubular bones. The positivity for these antibodies is directly proportional to Chondrosarcoma's histological grade increase. No difference was found between Enchondroma and Chondrosarcoma, Grade 1 for IMP3, CDK4 and ß-catenin positivity. Significant metastasis outcome was observed for IMP3, CDK4, MDM2 and death for MDM2 expression. CONCLUSION: IMP3, CDK4, MDM2 and ß-catenin expression in Enchondromas of short bones phenotypically characterizes these tumors. Their expression has not proven to be useful either as diagnostic markers of these neoplasms or in distinguishing between Enchondroma and Chondrosarcoma, Grade 1. The significant immunoexpression of IMP3, CDK4 and MDM2 in metastatic Chondrosarcoma and the lower survival in those with positivity for MDM2 suggest a possible association of these proteins with tumor aggressiveness.
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Biomarcadores de Tumor , Neoplasias Óseas , Condroma , Condrosarcoma , Quinasa 4 Dependiente de la Ciclina , Inmunohistoquímica , Proteínas Proto-Oncogénicas c-mdm2 , beta Catenina , Humanos , Condrosarcoma/patología , Condrosarcoma/metabolismo , Proteínas Proto-Oncogénicas c-mdm2/metabolismo , Proteínas Proto-Oncogénicas c-mdm2/análisis , Masculino , Femenino , Neoplasias Óseas/patología , Neoplasias Óseas/metabolismo , Persona de Mediana Edad , beta Catenina/análisis , beta Catenina/metabolismo , Adulto , Estudios Retrospectivos , Biomarcadores de Tumor/análisis , Pronóstico , Condroma/patología , Quinasa 4 Dependiente de la Ciclina/metabolismo , Quinasa 4 Dependiente de la Ciclina/análisis , Anciano , Adulto Joven , Adolescente , Clasificación del Tumor , Niño , Proteínas de Unión al ARNRESUMEN
Influenza circulation was significantly affected in 2020-21 by the COVID-19 pandemic. During this time, few influenza cases were recorded. However, in the summer of 2021-22, an increase in atypical influenza cases was observed, leading to the resurgence of influenza in the southernmost state of Brazil, Rio Grande do Sul (RS). The present study aimed to identify the circulation of FLUAV, FLUBV and SARS-CoV-2 and characterize the influenza genomes in respiratory samples using high-throughput sequencing technology (HTS). Respiratory samples (n = 694) from patients in RS were selected between July 2021 and August 2022. The samples were typed using reverse transcriptase real-time PCR (RT-qPCR) and showed 32% (223/694) of the samples to be positive for SARS-CoV-2, 7% for FLUAV (H3) (49/694). FLUBV was not detected. RT-qPCR data also resulted in FLUAV and SARS-CoV-2 co-infections in 1.7% (4/223) of samples tested. Whole genome sequencing of FLUAV produced 15 complete genomes of the H3N2 subtype, phylogenetically classified in the 3C.2a1b.2a.2a.3 subclade and revealing the dominance of viruses in the southern region of Brazil. Mutation analysis identified 72 amino acid substitutions in all genes, highlighting ongoing genetic evolution with potential implications for vaccine effectiveness, viral fitness, and pathogenicity. This study underscores limitations in current surveillance systems, advocating for comprehensive data inclusion to enhance understanding of influenza epidemiology in southern Brazil. These findings contribute valuable insights to inform more effective public health responses and underscore the critical need for continuous genomic surveillance.
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COVID-19 , Genoma Viral , Gripe Humana , Filogenia , SARS-CoV-2 , Humanos , Brasil/epidemiología , COVID-19/epidemiología , COVID-19/virología , SARS-CoV-2/genética , SARS-CoV-2/clasificación , SARS-CoV-2/aislamiento & purificación , Gripe Humana/epidemiología , Gripe Humana/virología , Persona de Mediana Edad , Adulto , Femenino , Genoma Viral/genética , Masculino , Adulto Joven , Anciano , Adolescente , Brotes de Enfermedades , Secuenciación Completa del Genoma , Niño , Preescolar , Lactante , Coinfección/epidemiología , Coinfección/virología , Secuenciación de Nucleótidos de Alto Rendimiento , Anciano de 80 o más Años , GenómicaRESUMEN
OBJECTIVE: To identify vulnerability factors associated with unsuccessful tuberculosis treatment outcomes between 2011 and 2021 in Manaus, Amazonas. METHOD: Ecological study using tuberculosis case notification data from the Notifiable Diseases Information System, from 2011 to 2021, of residents in Manaus. The variables refer to treatment outcomes and patient vulnerability, according to the theoretical model: individual, programmatic and social. The analysis tested the association between vulnerability and tuberculosis treatment non-success, measured by the occurrence of death, loss to follow-up or treatment default. The Odds Ratio estimate with confidence interval was obtained by logistic regression, according to a hierarchical model. RESULTS: The following factors were more likely to lead to unsuccessful tuberculosis treatment: individual vulnerability (age group 20 to 29 years and over 60 years, indigenous race, HIV+, drug use); programmatic vulnerability (not having an HIV test), social vulnerability (special population). CONCLUSION: Individual vulnerability was more strongly associated with non-success. Intervention is needed to explore the points of greatest individual vulnerability, enabling effective action to prevent unsuccessful tuberculosis treatment.
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Insuficiencia del Tratamiento , Tuberculosis , Humanos , Adulto , Brasil , Masculino , Tuberculosis/tratamiento farmacológico , Adulto Joven , Persona de Mediana Edad , Femenino , Adolescente , Poblaciones Vulnerables , Niño , Preescolar , Lactante , Anciano , Factores de RiesgoRESUMEN
PURPOSE: Investigate if speech perception skills can differentiate school children with Specific Reading Disorders (SRD) with and without Persistent Speech Sound Disorders (PSSD). METHODS: 80 children, regularly enrolled in the 2nd (N=1), 3rd (N=28), 4th (N=29), 5th (N=15) and 6th (N=7) grades participated in the study. Control Group (CG) (N=48): no complaints, no speech alteration; and Resarch Group (RG) (N=32) - with SRD, RGI (N=15) without PSSD and RGII (N=17) with PSSD. Two tests evaluated auditory input reception: Simplified evaluation of auditory processing; and Perception task of nonwords, with Portuguese language structure (DNPLS). Data was analyzed by: Likelihood Ratio Test, Kruskal-Wallis test, Dunn test with Bonferroni correction, Mann-Whitney test, Spearman correlation, and construction of a ROC curve to obtain a threshold value for the correct answers in the perception of non-words test. RESULTS: Control and RGI showed higher correct answer scores than RGII. There was no difference between the correct answer distributions of the Control and RGI, and RGI and RGII in the test of DNPLS and the number of correct answers in the CG was higher than in the RGII. CONCLUSION: The ability to discriminate non-words enabled the differentiated between school-aged children with SRD associated with PSSD and typical children, thus characterizing this group for presenting a number of correct answers lower than 30.5, considering the task proposed to discriminate non-words. These results suggest that the presence of PSSD worsens the performance in speech perception of the schoolchildren with SRD.
OBJETIVO: Investigar se a habilidade de percepção de fala pode diferenciar escolares com Transtorno específico de aprendizagem (TAp) com e sem Transtorno Persistente dos Sons da Fala (TPSF). MÉTODO: Participaram da pesquisa 80 crianças, regularmente matriculadas no 2º (N=1), 3º (N=28), 4º (N=29), 5º (N=15), e 6º (N=7) anos, assim reunidos: Grupo Controle (N= 48) - sem queixas, sem alteração de fala; e Grupos Pesquisa (N = 32) - com TAp, sendo GPI (N = 15) sem TPSF e, GPII (N = 17), com TPSF. Duas provas avaliaram input auditivo: Avaliação simplificada do processamento auditivo; e Tarefa de percepção de pseudopalavras com estrutura da língua portuguesa - TDP. Os dados foram analisados pelos testes: Razão de Verossimilhanças, Kruskal-Wallis, Dunn com correção de Bonferroni, Mann-Whitney, correlação de Spearman, além da construção de uma curva ROC para obter um valor de corte para o número de acertos na prova de percepção de não palavras. RESULTADOS: Controle e GPI mostraram maiores escores de acerto que GPII. Não houve diferença entre as distribuições de acertos do Controle e GPI e do GPI e GPII na TDP e o número de acertos do GC foi maior que o do GPII. CONCLUSÃO: A habilidade de discriminação de pseudopalavras diferenciou os escolares com TAp e TPSF das crianças sem TPSF, caracterizando, assim esse grupo por apresentar número de acertos menor que 30,5, considerada a tarefa proposta para discriminar pseudopalavras. Esses resultados sugerem que a presença do TPSF piorou o desempenho em percepção de fala dos escolares com TAp.
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Percepción del Habla , Trastorno Fonológico , Humanos , Percepción del Habla/fisiología , Niño , Trastorno Fonológico/fisiopatología , Trastorno Fonológico/diagnóstico , Masculino , Femenino , Estudios de Casos y Controles , Trastorno Específico de Aprendizaje/fisiopatología , Dislexia/fisiopatología , Dislexia/diagnósticoRESUMEN
Coal mining activities release harmful air pollutants, which affect children's health, particularly the lung function. Brazil has a large coal reserve in the southern region, where a coal-fired power plant and two coal mines are located. The study aimed to evaluate the prevalence of altered respiratory function and associated factors in children living in this region. A cross-sectional study was conducted in seven cities. It collected socioeconomic and demographic, prenatal and postnatal care, neonatal outcomes, child health information as well as lung function and air quality. The study included 396 children who lived in a high socio-environmental vulnerability due to low education levels and family income, high percentage of unemployed and families with a high bedroom density. There was a high prevalence of preterm birth, low birth weight and long-term exposure to environmental conditions. The most common respiratory problem in the parents was rhinitis, while in the children was wheezing and pneumonia. The prevalence of respiratory function alteration in the region was 7.78%. Variables associated with altered respiratory function were passive smoking, low birth weight, history of wheezing. The concentration of pollutants was equivalent when comparing stations within the coal mining host town (Candiota) and surrounding towns.
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Factores Socioeconómicos , Humanos , Brasil/epidemiología , Estudios Transversales , Femenino , Masculino , Niño , Preescolar , Pruebas de Función Respiratoria , Prevalencia , Minas de Carbón , Recién Nacido , Lactante , Exposición a Riesgos Ambientales/efectos adversos , Contaminantes Atmosféricos/análisis , Contaminantes Atmosféricos/efectos adversos , Factores de Riesgo , Pulmón/fisiopatologíaRESUMEN
INTRODUCTION: The increase in the production of substances to enhance the quality of life, the biodiversity of the different ecosystems in Mexico, and the unique characteristics of pediatric patients, contribute to intoxications within this population. METHOD: Analytical retrospective study of admissions to pediatric emergency care due to poisoning in < 16-year-old (2016 to 2020). Included variables were age, gender, type of toxic substance, exposure characteristics, and the season of the year. Frequencies, percentages, range, average and standard deviation were obteined. In the bivariate análisis, the Chi square test was used. A p-value < 0.05 was considered statistically significant. RESULTS: Over 5 years, there were 459 cases, with a prevalence of 3.16%. No gender predominance was observed. The most common was caused by venomous animals (28.5%), followed by medication ingestion (27.6%). Only 5% of cases were suicide attempts, the rest were accidental (95%). Children up to 5 years old were more commonly by medication ingestion, hydrocarbons, or household products (p = 0.03, p = 0.0001), while the causes in older children were contact with venomous animals and ingestion of stimulants drugs (alcohol, amphetamines, cannabis, cocaine) (p = 0.0001, p = 0.006). Intoxication with quaternary ammonium herbicides was lethal in all cases. CONCLUSIONS: Children under the age of 5 are more susceptible to intoxication from common household products. Older kids tend to be more frequently a combination of stimulants drugs.
INTRODUCCIÓN: El aumento en la producción de sustancias para mejorar la calidad de vida, la biodiversidad de los diferentes ecosistemas en México, así como las características propias de los pacientes pediátricos, contribuyen a la intoxicación dentro de esta población. MÉTODO: Estudio retrospectivo analítico de los ingresos por envenenamiento en niños menores de 16 años en urgencias pediátricas (2016 a 2020). Se analizaron la edad, el sexo, el tipo de xenobiótico, las características de exposición y la estación del año. Se obtuvieron frecuencias, porcentajes, rango, promedio y desviación estándar. En el análisis bivariado se utilizó la prueba chi al cuadrado, considerando estadísticamente significativo un valor p < 0.05. RESULTADOS: En el periodo de 5 años se atendieron 459 casos, con una prevalencia del 3.16%. No se observó predominio de sexo. La intoxicación más frecuente fue por animales venenosos (28.5%), seguida de la ingesta de medicamentos (27.6%). El 95% de los casos fueron accidentales y el 5% por intento de suicidio. En los menores de 5 años, lo más frecuente fue la ingesta de medicamentos, hidrocarburos o productos de uso doméstico (p = 0.03, p = 0.0001), mientras que en los mayores de 6 años fue por contacto con animales venenosos e ingesta de drogas estimulantes (alcohol, anfetaminas, cannabis, cocaína) (p = 0.0001, p = 0.006). El 100% de los intoxicados por herbicida cuaternario de amonio fallecieron. CONCLUSIONES: Los menores de 5 años son más propensos a la intoxicación con productos que se utilizan en sus propios domicilios. En los mayores de 6 años es más frecuente la combinación de drogas estimulantes.
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Intoxicación , Humanos , México/epidemiología , Masculino , Femenino , Estudios Retrospectivos , Niño , Preescolar , Intoxicación/epidemiología , Adolescente , Lactante , Prevalencia , Intento de Suicidio/estadística & datos numéricos , Estaciones del Año , Urgencias Médicas , Servicio de Urgencia en Hospital/estadística & datos numéricosRESUMEN
INTRODUCTION: Epstein-Barr virus (EBV) infection, with a global prevalence exceeding 95%, typically manifests in children as infectious mononucleosis. However, clinical practice frequently encounters diverse atypical presentations characterized by multisystem involvement, often resulting in an unfavorable clinical course. Our objective is to describe the clinical manifestations and results of EBV infection in a tertiary pediatric hospital in Mexico. METHOD: An observational, transversal, retrospective, and descriptive study that included a systematic review of medical records (2012-2022) of patients under 18 years of age with detectable EBV particles in peripheral blood. RESULTS: The study included 26 patients with a median age of 5 years and a male predominance of 53.8%. Predominant symptoms were fever (85%) and lymphadenopathy (35%). Sixty-five percent had severe and atypical manifestations, including pneumonia and hepatic, hematologic-oncologic, and autoimmune diseases. Anemia, thrombocytopenia and leukopenia were common, with lymphocytosis in 19% of cases. The median EBV viral load was 2816 copies/mL (range: 555-355,500 copies/mL). Four deaths related to EBV infection were reported. Viral load in these cases also varied widely from 594 to 121,000 copies/mL. Supportive care was administered to 85% of patients, while others received antiviral treatment, steroids, and rituximab. CONCLUSION: Atypical manifestations were common, especially in children with multisystem involvement. EBV should be considered as a potential contributor to a diverse spectrum of clinical presentations, emphasizing the need for comprehensive evaluation and awareness in clinical diagnosis.
INTRODUCCIÓN: La infección por el virus de Epstein-Barr (VEB) tiene una prevalencia mundial superior al 95%. Se considera que en los niños se manifiesta principalmente como mononucleosis infecciosa; sin embargo, en la práctica clínica, a menudo encontramos numerosas manifestaciones atípicas con compromiso multisistémico que llevan a un curso desfavorable. Nuestro objetivo es describir las manifestaciones clínicas y los resultados de la infección por VEB en un hospital pediátrico de tercer nivel en México. MÉTODO: Estudio observacional, transversal, retrospectivo y descriptivo, en el cual se revisaron sistemáticamente los expedientes médicos de pacientes menores de 18 años con una detección positiva de partículas de VEB en sangre periférica en el periodo 2012-2022. RESULTADOS: Se incluyeron 26 pacientes con una mediana de edad de 5 años y predominio de varones (53.8%). El 65% presentaron manifestaciones graves y atípicas, incluyendo enfermedades respiratorias, hepáticas, hematooncológicas y autoinmunitarias. Los síntomas más frecuentes fueron fiebre (85%) y linfadenopatía (35%). El 54% presentaron manifestaciones atípicas, incluyendo linfohistiocitosis hemofagocítica, neumonía y neoplasia. La anemia, la trombocitopenia y la leucocitopenia fueron comunes, mientras que el 19% presentaron linfocitosis. La media de la carga viral fue de 2816 copias/ml (555-355,500). Se informaron cuatro muertes atribuidas a la infección por VEB, con valores de carga viral de 594 a 121,000 copias/ml. El 85% de los pacientes recibieron solo tratamiento sintomático, mientras que otros recibieron antivirales, esteroides y rituximab. CONCLUSIÓN: Las manifestaciones atípicas se observaron comúnmente, en especial en niños con compromiso multisistémico. El VEB debe considerarse como un potencial factor contribuyente en el diagnóstico de una amplia gama de manifestaciones clínicas.
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Infecciones por Virus de Epstein-Barr , Centros de Atención Terciaria , Humanos , México/epidemiología , Masculino , Femenino , Infecciones por Virus de Epstein-Barr/epidemiología , Infecciones por Virus de Epstein-Barr/diagnóstico , Niño , Estudios Retrospectivos , Preescolar , Adolescente , Lactante , Estudios Transversales , Carga Viral , Hospitalización/estadística & datos numéricos , Herpesvirus Humano 4/aislamiento & purificación , Herpesvirus Humano 4/genética , Fiebre/virología , Linfadenopatía/virologíaRESUMEN
BACKGROUND: Intramuscular vascular malformations (IVMs) are rare developmental congenital structural abnormalities. Their clinical diagnosis is difficult, and imaging studies are essential to determine the type and extent of vessels involved. Treatment can be challenging and must be managed by a multidisciplinary team. METHODS: A descriptive, observational, retrospective, longitudinal study of clinical records of patients diagnosed with IVMs who were evaluated at the vascular anomalies clinic from January 2011 to December 2021 was performed. Demographic, clinical, imaging, diagnosis, treatment, and response data were collected. RESULTS: Seven patients (five females and two males) with a mean age of 13.66 years (standard deviation 5.82 years) were included in the study. In all cases, the clinical diagnosis was venous and lymphatic malformation. The radiological findings were dilated and tortuous vascular structures or multilobulated lesions with septa inside, with or without vascular flow; these findings allowed diagnosis in all cases. Treatment modalities included sclerotherapy in five patients, surgical resection in two, medical treatment with sirolimus in three, and surveillance in one. Subsequent clinical evolution was favorable in all patients, with decreased pain in six (partial in four and total in two) and size reduction in one patient. CONCLUSION: IVMs in our pediatric population most frequently affect the lower extremities. The main symptoms and signs were pain on exertion and volume increase. Treatment can be challenging given the extension and depth of the malformations, so a combination of therapeutic modalities may be necessary to obtain the best outcome.
INTRODUCCIÓN: Las malformaciones vasculares intramusculares (MVI) son anomalías estructurales congénitas del desarrollo raras. Su diagnóstico clínico es difícil y los estudios de imagen son fundamentales para determinar su tipo y extensión. Su tratamiento puede ser un desafío y debe ser dirigido por un equipo multidisciplinario. MÉTODOS: Se realizó un estudio descriptivo, observacional, retrospectivo y longitudinal de los expedientes clínicos de pacientes con diagnóstico de MVI que fueron valorados en la Clínica de Anomalías Vasculares desde enero 2011 a diciembre 2021. Se recolectaron datos demográficos, clínicos, imagenológicos, diagnóstico, tratamiento y respuesta al mismo. RESULTADOS: Se incluyeron 7 pacientes (5 mujeres y 2 hombres) con una edad media de 13.66 años (DE 5.82 años). En todos, el diagnóstico clínico fue malformación venosa y/o linfática. Los hallazgos radiológicos mediante ultrasonido y/o resonancia magnética nuclear fueron estructuras vasculares dilatadas y tortuosas o lesiones multilobuladas con septos en su interior, con o sin flujo vascular; y en todos los casos permitieron hacer el diagnóstico. El tratamiento fue escleroterapia en 5 pacientes, resección quirúrgica en 2, tratamiento con Sirolimus en 3 y vigilancia en 1. La evolución clínica posterior fue favorable en todos, con disminución del dolor en 6 (parcial en 4 y total en 2) y reducción del tamaño en 1 paciente. CONCLUSIÓN: Las MVI en nuestra población pediátrica, afectan con mayor frecuencia las extremidades inferiores. Los principales síntomas fueron dolor de esfuerzo y aumento de volumen. Su tratamiento puede ser un reto dada su extensión y profundidad, por lo que la combinación de modalidades terapéuticas puede ser necesarias para obtener el mejor desenlace.
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Escleroterapia , Malformaciones Vasculares , Humanos , Estudios Retrospectivos , Femenino , Masculino , Niño , Adolescente , Malformaciones Vasculares/terapia , Malformaciones Vasculares/diagnóstico , Estudios Longitudinales , Escleroterapia/métodos , Sirolimus/administración & dosificación , Anomalías Linfáticas/terapia , Anomalías Linfáticas/diagnóstico , Anomalías Linfáticas/patología , Preescolar , Músculo Esquelético/irrigación sanguínea , Resultado del TratamientoRESUMEN
INTRODUCTION: Linear IgA bullous dermatosis (LABD) is a rare autoimmune disease. Although dapsone is the initial treatment, other immunomodulators are used in resistant cases or when dapsone is unavailable. CASE REPORT: A 12-year-old Mexican child, with no relevant medical history, developed in May 2023 a disseminated dermatosis affecting all body segments, including mucous membranes, characterized by erythematous patches and plaques evolving into the formation of serous and serosanguinous blisters and vesicles, distributed in a "string of pearls" pattern. LABD was suspected and confirmed by skin biopsy, which showed a subepidermal blister with neutrophilic infiltration and linear Immunoglobulin A deposits at the dermo-epidermal junction by direct immunofluorescence. Treatment with prednisone (2 mg/kg/day) and cyclosporine (5 mg/kg/day) resulted in improvement and lesion remission within 2 weeks. Both drugs needed to be discontinued for 3 months due to intermittent blistering. Cyclosporine was continued as maintenance therapy at a dose of 4 mg/kg/day for 8 months. CONCLUSIONS: The report highlights the use of cyclosporine as an alternative immunomodulator for DAAL, an immunosuppressive agent used in autoimmune disorders. Few cases, including this one, have described complete remission and control of the dermatosis with cyclosporine, accompanied by prednisone at the start of treatment.
INTRODUCCIÓN: La dermatosis ampollosa por IgA lineal es una enfermedad autoinmunitaria rara. Aunque la dapsona es el tratamiento inicial, se usan otros inmunomoduladores en casos resistentes o cuando la dapsona no está disponible. CASO CLÍNICO: Un niño mexicano de 12 años, sin antecedentes relevantes, desarrolló en mayo de 2023 una dermatosis diseminada a todos los segmentos corporales, incluyendo las mucosas, caracterizada por manchas y placas eritematosas que evolucionaron hacia la formación de ampollas y vesículas serosas y serohemáticas, distribuidas en forma de «cadena de perlas¼. Se sospechó dermatosis ampollosa por IgA lineal y se confirmó mediante biopsia cutánea, que mostró una ampolla subepidérmica con infiltrado neutrófilo y depósitos lineales de IgA en la unión dermoepidérmica mediante inmunofluorescencia directa. El tratamiento con prednisona (2 mg/kg al día) y ciclosporina (5 mg/kg al día) resultó en mejoría y la remisión de las lesiones a las 2 semanas. Fue necesario dejar ambos fármacos durante 3 meses debido a la aparición intermitente de ampollas. Se dejó ciclosporina como terapia de mantenimiento a dosis de 4 mg/kg al día por 8 meses. CONCLUSIONES: El reporte destaca el uso de ciclosporina como inmunomodulador alternativo para la dermatosis ampollosa por IgA lineal, un agente inmunosupresor utilizado en trastornos autoinmunitarios. Pocos casos, incluido este, han descrito la remisión completa y el control de la dermatosis con ciclosporina, acompañada de prednisona al inicio del tratamiento.
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Ciclosporina , Inmunosupresores , Dermatosis Bullosa IgA Lineal , Prednisona , Humanos , Ciclosporina/administración & dosificación , Ciclosporina/uso terapéutico , Niño , Dermatosis Bullosa IgA Lineal/tratamiento farmacológico , Dermatosis Bullosa IgA Lineal/diagnóstico , Dermatosis Bullosa IgA Lineal/patología , Prednisona/administración & dosificación , Prednisona/uso terapéutico , Inmunosupresores/administración & dosificación , Inmunosupresores/uso terapéutico , Masculino , Glucocorticoides/administración & dosificación , Quimioterapia Combinada , Resultado del Tratamiento , MéxicoRESUMEN
BACKGROUND: Pilomatricoma is a common benign adnexal neoplasm in children. There are few epidemiological studies on this subject, with most relying solely on descriptive statistics. METHODS: A cross-sectional study conducted in two tertiary hospitals in Mexico City from January 2017 to December 2023. Clinical and electronic records of patients with histopathological diagnosis of pilomatricoma, both sexes, under 18 years old, with any type of present comorbidity were selected. Records of patients with diagnosis not confirmed by histopathology or incomplete records were not included in the study. RESULTS: Fifty-two cases with pilomatrixoma were included in the study, showing a total of 74 lesions. About 23.1% of the cases had multiple pilomatrixomas. 40.4% of the cases experienced pain; this symptom was associated with lesions > 15 mm in diameter and with multiple pilomatrixomas. Risk factors for lesions > 15 mm included age under 8 years, positive tent sign, tumor evolution longer than a year, and a non-classical clinical variety. The head and neck were the most commonly affected areas. The left upper extremity presented larger pilomatrixomas (median 18.5 mm) and occurred more frequently in adolescent patients (mean age 12.1 years) compared to other body areas. CONCLUSIONS: Pilomatrixoma in children shows clinical diversity, with specific findings based on size, number, and anatomical location.
INTRODUCCIÓN: El pilomatricoma es una neoplasia anexial benigna frecuente en la infancia. Hay muy pocos estudios epidemiológicos al respecto y la mayoría solo han utilizado estadística descriptiva. MÉTODOS: Estudio transversal realizado en dos hospitales de concentración de la Ciudad de México de enero de 2017 a diciembre de 2023. Se seleccionaron expedientes clínicos y electrónicos de pacientes con diagnóstico histopatológico de pilomatricoma, ambos sexos, menores de 18 años, con cualquier tipo de comorbilidad presente. No se incluyeron los expedientes de pacientes con diagnóstico no confirmado por histopatología o expediente incompleto. RESULTADOS: Se incluyeron 52 casos con diagnóstico de pilomatricoma que mostraron un total de 74 lesiones. El 23.1% de los pacientes tuvieron pilomatricomas múltiples. El 40.4% experimentaron dolor; este signo se asoció con lesiones de diámetro superior a 15 mm y pilomatricomas múltiples. La edad menor de 8 años, el signo de la tienda de campaña positivo, un tiempo de evolución mayor de 1 año y una variedad clínica no clásica son factores de riesgo asociados con las lesiones mayores de 15 mm. La cabeza y el cuello fueron las áreas más comúnmente afectadas por estos tumores. La extremidad superior izquierda presento pilomatricomas de mayor tamaño (mediana 18.5 mm), y ocurrieron más en pacientes adolescentes (media 12.1 años), en comparación con otras áreas del cuerpo. CONCLUSIONES: El pilomatricoma en niños muestra diversidad clínica. Presenta hallazgos y asociaciones específicas según el tamaño, el número y la ubicación anatómica.
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Enfermedades del Cabello , Pilomatrixoma , Neoplasias Cutáneas , Humanos , Pilomatrixoma/patología , Pilomatrixoma/epidemiología , Pilomatrixoma/diagnóstico , México/epidemiología , Masculino , Niño , Femenino , Estudios Transversales , Adolescente , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/epidemiología , Preescolar , Enfermedades del Cabello/epidemiología , Enfermedades del Cabello/patología , Factores de Riesgo , Lactante , Dolor/epidemiología , Dolor/etiologíaRESUMEN
OBJECTIVES: Mexican children with obesity are at a higher risk of developing type 2 diabetes mellitus (T2DM). The aim of the study was to compare oral glucose tolerance test (OGTT) characteristics: time of peak glucose, glucose level ≥155â¯mg/dL at 1â¯h, presence of metabolic syndrome (MetS), sensitivity, secretion, and oral disposition index (oDI) in children with and without obesity, according to oral glucose tolerance curve shape: monophasic or biphasic. METHODS: Cross-sectional study including 143 children. Groups were divided into (a) obese: biphasic (B-Ob) (n=55) and monophasic (M-Ob) (n=50), (b) without obesity: biphasic (B-NonOb) (n=20) and monophasic (M-NonOb) (n=18). RESULTS: Late glucose peak was more frequent in the M-Ob group (p<0.001). Glucose levels ≥155â¯mg/dL and MetS were more frequent in the M-Ob group but did not show significance. The groups with obesity (biphasic and monophasic) had higher indices of insulin resistance and insulin secretion compared to the nonobese groups (biphasic and monophasic) (p<0.001). AUC glucose was higher in the M-Ob group (p<0.05), and AUC insulin was higher in the M-NonOb group. oDI (Matsuda) was significantly lower in the M-Ob group compared to the other groups (p<0.001), and oDI-HOMA IR was higher in M-NonOb group (p=0.03). CONCLUSIONS: All OGTT parameters could help to identify Mexican children at increased risk of developing T2DM, not only fasting plasma glucose and 2â¯h glucose. M-Ob in non-T2DM Mexican children reflects an early defect in glucose metabolism. Higher level of IR indexes in M-NonOb vs. B-NonOb could indicate an increased risk for T2DM of genetic origin.
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Glucemia , Diabetes Mellitus Tipo 2 , Prueba de Tolerancia a la Glucosa , Resistencia a la Insulina , Humanos , Estudios Transversales , Niño , Femenino , Masculino , Adolescente , México/epidemiología , Glucemia/análisis , Diabetes Mellitus Tipo 2/epidemiología , Síndrome Metabólico/epidemiología , Síndrome Metabólico/etiología , Obesidad Infantil/epidemiología , Pronóstico , Obesidad/epidemiología , Estudios de Seguimiento , Biomarcadores/análisis , Biomarcadores/sangre , Estudios de Casos y ControlesRESUMEN
OBJECTIVE: This study assessed patient's satisfaction after orthodontic treatment in the postgraduate orthodontic clinic of the Dental School at the University of Athens (Athens, Greece), and investigated possible correlations between satisfaction after orthodontic treatment and life satisfaction, alongside the influence of age, gender, severity of initial orthodontic malocclusion and duration of retention period. MATERIAL AND METHODS: Patients aged 12 years and above, who had recently completed comprehensive orthodontic treatment, participated completing two questionnaires: a 37-item questionnaire, validated for assessing orthodontic treatment satisfaction; and the 5-item Satisfaction with Life Scale, a valid and reliable measure of life satisfaction. Scores from each questionnaire were summed for each patient. Demographic details, Index of Orthodontic Treatment Need (IOTN) and the duration of the retention period up to questionnaire completion were collected. Multiple regression analysis assessed the relationship between the questionnaires and the evaluated variables. RESULTS: A total of 150 patients answered the questionnaires, being 82 women (55%) and 68 men (45%). The mean age of patients was 18.87 ± 5.97 years (range: 12-47). Most patients expressed satisfaction with treatment outcomes (grades 5 and 6). Satisfaction with orthodontic treatment showed a significant correlation with life satisfaction (p=0.002), but not with gender, age, dental/esthetic components of IOTN, or the duration of the retention period. CONCLUSION: Satisfaction after orthodontic treatment exhibited a significant correlation with life satisfaction, but it was not affected by gender, age, dental/esthetic components of IOTN, or the duration of the retention period.
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Indice de Necesidad de Tratamiento Ortodóncico , Maloclusión , Ortodoncia Correctiva , Satisfacción del Paciente , Humanos , Femenino , Masculino , Niño , Adolescente , Ortodoncia Correctiva/psicología , Maloclusión/terapia , Maloclusión/psicología , Adulto , Encuestas y Cuestionarios , Adulto Joven , Persona de Mediana Edad , Factores Sexuales , Factores de Edad , Calidad de Vida , Resultado del Tratamiento , Satisfacción Personal , Estética Dental , Retenedores OrtodóncicosRESUMEN
INTRODUCTION: The long pathway that the canines take as they emerge into the maxillary arch makes them vulnerable to disruption during their natural emergence time. The process of planning treatment for impacted maxillary canine (IMC) presents significant challenges, underscoring the need for careful consideration and expertise. OBJECTIVE: The aim of this article was to shed light on these complexities by discussing clinical case studies involving IMC, providing insights into the intricacies of their management. CONCLUSIONS: The management of IMC within orthodontics presents a multifaceted challenge that include the necessity for precise diagnostic processes, prudent use of cone beam computed tomography (CBCT), the strategic selection between open and closed exposure techniques, a in-depth understanding of the specific orthodontic biomechanics involved, and a keen awareness of potential adverse outcomes such as ankylosis, prolonged treatment times, root resorption, and additional complications.
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Tomografía Computarizada de Haz Cónico , Diente Canino , Maxilar , Diente Impactado , Diente Impactado/terapia , Diente Impactado/diagnóstico por imagen , Humanos , Diente Canino/diagnóstico por imagen , Maxilar/diagnóstico por imagen , Planificación de Atención al Paciente , Extrusión Ortodóncica/métodos , Resorción Radicular/diagnóstico por imagen , Resorción Radicular/terapia , Femenino , Adolescente , Fenómenos Biomecánicos , Masculino , Anquilosis del Diente/terapia , Anquilosis del Diente/diagnóstico por imagen , Niño , Técnicas de Movimiento Dental/métodosRESUMEN
INTRODUCTION: Patients with Class II, division 1 malocclusion generally seek treatment to improve facial esthetics. Therefore, the orthodontist needs to know the changes in the soft profile produced by functional appliances. OBJECTIVE: This study evaluated the soft tissue profile changes in patients treated during the peak of the pubertal growth spurt. METHODS: Thirty selected patients were randomized into three treatment groups: Twin Block (TB), Herbst with dental anchorage (HDA), and Herbst with skeletal anchorage (HSA). All patients had computed tomographic images: pretreatment (T1) and after 12 months of active treatment (T2). Twenty-four soft tissue cephalometric measures were analyzed. The normality of all data was assessed by the Shapiro-Wilk test. Intragroup comparisons were analyzed using the t-paired test; the inter-group comparisons were determined through ANOVA and the post-hoc Tukey test. RESULTS: At T1, no significant differences were observed between groups. At T2, in the intragroup comparison, facial soft tissue changes were statistically significant in the three groups for the lower lip, sulcus inferioris, facial soft tissue convexity in HDA group and TB group, and H angle in HDA group and HSA group, and soft tissue pogonium in TB group. In the inter-group comparison, no statistically significant differences were observed. CONCLUSION: It can be concluded that there were significant changes in soft tissue measurements that benefited Class II, division 1 patient's facial profile treated with the functional appliances Twin Block, Herbst, and Herbst with skeletal anchorage. Nevertheless, no significant differences were detected among the effects obtained by the three treatment protocols.
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Cefalometría , Cara , Maloclusión Clase II de Angle , Aparatos Ortodóncicos Funcionales , Humanos , Adolescente , Cara/anatomía & histología , Cara/diagnóstico por imagen , Maloclusión Clase II de Angle/terapia , Maloclusión Clase II de Angle/diagnóstico por imagen , Masculino , Femenino , Métodos de Anclaje en Ortodoncia/instrumentación , Tomografía Computarizada por Rayos X , Labio/diagnóstico por imagen , Diseño de Aparato Ortodóncico , NiñoRESUMEN
OBJECTIVE: The aim of this study was to describe the epidemiological characteristics of pediatric patients with sickle cell disease (SCD) and evaluate the use of medicinal plants in these patients concomitantly with their drug treatment. METHODS: This is a review of the medical records of pediatric patients at a public institution with tertiary care. The selection criterion was to be a child or adolescent with SCD undergoing pediatric follow-up at this outpatient clinic. In the medical records of the patients selected, records of the use of plants for medicinal purposes were sought. RESULTS: In total, 154 records (100% of total active patients followed in this clinic) were reviewed: 99 children and 55 adolescents. The predominant genotype was SS (58.4%), followed by SC (29.2%). The use of at least one medication for SCD was reported in 95.5% of the medical records. The use of medicinal plants was reported by 70.1% of patients, with 276 citations in the medical records referring to 64 different types of plants. Six plants were used for the treatment of SCD, the main one being Lemonvine/Ora-pro-nóbis (Pereskia aculeata). The use of medicinal plants was reported for flu-like symptoms and/or COVID-19 (both for prevention and treatment) by 60.5% of the citations, with 35 different plants reported for this use, exclusively or not. This use was followed by pain symptoms (14.2% of citations). CONCLUSIONS: The majority of patients in this study use both conventional and traditional/complementary/alternative medicine, highlighting the need for more studies in the area, with a special focus on patient safety.
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Anemia de Células Falciformes , Fitoterapia , Plantas Medicinales , Humanos , Anemia de Células Falciformes/tratamiento farmacológico , Anemia de Células Falciformes/epidemiología , Niño , Adolescente , Masculino , Femenino , Fitoterapia/estadística & datos numéricos , Preescolar , Estudios RetrospectivosRESUMEN
BACKGROUND: To analyze the associations among autonomous motivation, self-efficacy, satisfaction of basic psychological needs, social support and perceived environment with physical activity practice of adolescents aged between 12 and 15 years; and to test autonomous motivations and self-efficacy as potential mediators of the associations between these environmental factors and physical activity practice. METHODS: We evaluated 553 adolescents, that participated in the ActTeens Program. Physical activity was assessed using the Physical Activity Questionnaire for Adolescents. Autonomous motivation, self-efficacy, satisfaction of basic psychological needs, parents' social support and perceived environment were assessed using specifics questionnaires. Linear regression models were used to test the associations. RESULTS: Parents' support (ß = 0.32), satisfaction of basic psychological needs of colleagues (ß = 0.21) and teachers (ß = 0.12), and perceived environment (ß = 0.10) had significant associations with physical activity (p < 0.05). The direct effect value was reduced when autonomous motivation was added as a mediator of the association between parents' support and physical activity (ß = 0.24), with a 25% mediated effect. Autonomous motivation was mediator of the relationship between basic psychological needs of colleagues (ß = 0.13; EM = 38%), teachers (ß = 0.02; EM = 83%), and perceived environment (ß = 0.03; EM = 70%) with physical activity. CONCLUSION: Self-efficacy was not associated with physical activity and autonomous motivation was an important mediator of adolescents' physical activity.
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Ejercicio Físico , Motivación , Autoeficacia , Apoyo Social , Humanos , Adolescente , Femenino , Masculino , Ejercicio Físico/psicología , Niño , Encuestas y Cuestionarios , Autonomía Personal , Padres/psicología , Conducta del Adolescente/psicología , Satisfacción Personal , Medio SocialRESUMEN
INTRODUCTION: Although extensive research exists on the morbidity and mortality associated with tracheostomy in pediatrics, scarse work has been done to analyze the outcomes after hospital discharge of tracheostomized children. In our country there are no publications referring to the follow-up of this population. The general objective of this study was to describe and analyze the situation of tracheostomized children living at home in Argentina. MATERIALS AND METHODS: Descriptive, cross-sectional study through a survey with convenience sampling. Surveys sent between January and July 2023 were collected and analyzed. RESULTS: We obtained 193 surveys during the study period. One hundred eighteen children (61%) underwent tracheostomies before one year of age. The majority (n=183) have a Single Disability Certificate (94.8%). Regarding health coverage, 113 children have social insurance (58.5%), 42 have prepaid coverage (21.8%) and 38 depend on public insurance (19.7%). Almost all of the families (n=184) received some training to care for their children (95.3%). In their homes, 152 families (78.7%) had to resolve some adverse event related to the tracheostomy, and 128 families (66%) had to abandon some paid job. Although 118 children are not in school (61%), 170 (88%) receive rehabilitation therapy. DISCUSSION: Our research, the first of its kind, provides a crucial epidemiologic analysis of the situation of tracheostomized children living at home in Argentina. These findings are significant as they shed light on a previously unexplored area, emphasizing the need for further studies to confirm and expand these data.
Introducción: Si bien existe investigación sobre la morbimortalidad asociada a la traqueostomía en pediatría, pocos trabajos analizan los resultados luego del alta hospitalaria. En nuestro país no existen publicaciones referidas al seguimiento de esta población. El objetivo general de este trabajo fue describir y analizar la situación de niños traqueostomizados que viven en su hogar en Argentina. Materiales y métodos: Estudio descriptivo, transversal a través de una encuesta con muestreo por conveniencia. Se recolectaron y analizaron las encuestas remitidas entre enero y julio de 2023. Resultados: Se obtuvieron 193 encuestas durante el período de estudio. Fueron traqueostomizados antes del año de vida 118 niños (61%). La mayoría (n=183) posee Certificado Único de Discapacidad (94.8%). En relación a la cobertura de salud, 113 niños cuentan con Obra Social (58.5%), 42 con cobertura prepaga (21.8%) y 38 dependen del sector público (19.7%). Casi la totalidad de las familias (n=184) recibió capacitación para el cuidado de su hijo (95.3%). En sus hogares, 152 familias (78.7%) debieron resolver algún evento adverso relacionado con la traqueostomía y 128 familias (66%) abandonaron algún trabajo remunerado. Si bien 118 niños no se encuentran escolarizados (61%), 170 (88%) reciben terapia de rehabilitación. Discusión: Nuestra investigación, la primera de su tipo, proporciona un análisis epidemiológico crucial de la situación de los niños traqueostomizados que viven en sus hogares en Argentina. Hallazgos importantes, ya que arrojan luz sobre un área previamente inexplorada, enfatizando la necesidad de más estudios para confirmar y ampliar estos datos.
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Traqueostomía , Humanos , Argentina/epidemiología , Traqueostomía/estadística & datos numéricos , Estudios Transversales , Masculino , Femenino , Preescolar , Lactante , Niño , Adolescente , Encuestas y Cuestionarios , Niños con Discapacidad/estadística & datos numéricos , Recién NacidoRESUMEN
INTRODUCTION: Vitamin A deficiency can cause eye disease and has been related to food selectivity in children with autism spectrum disorder (ASD). METHODS: A series of 13 pediatric patients with severe ophthalmological involvement as an initial manifestation of hypovitaminosis A is described. RESULTS: With significant Vitamin A deficiency, neuroimaging was performed in 11 patients. Of these, 8 had pathological findings with the presence of cranial hyperostosis. Lumbar puncture was performed in these patients and endocranial hypertension was detected in 7 of the 8 patients. All had food selectivity and 61.5% had ASD. CONCLUSIONS: Toxic-nutritional optic neuropathy is a rare pathology in children and presents with progressive, bilateral and painless visual loss due to damage to the optic nerve, which can generate severe and irreversible damage to it. Food history allows early detection of nutrient deficiencies in children with restrictive feeding, especially in neuro-atypical patients. This is essential to implement preventive measures and treatment with vitamin A in order to avoid irreversible consequences.
Introducción: La deficiencia de vitamina A puede producir enfermedad ocular y se ha relacionado con la selectividad alimentaria en niños con trastorno del espectro autista (TEA). Métodos: Se describen una serie de 13 pacientes pediátricos con compromiso oftalmológico grave como manifestación inicial de hipovitaminosis A. Resultados: Con deficiencia significativa de Vitamina A, en 11 pacientes se realizaron neuroimágenes. De ellos, 8 tuvieron resultados patológicos con presencia de hiperostosis craneal. En estos se realizó punción lumbar y en 7 de los 8 pacientes se detectó hipertensión endocraneana. Todos tenían selectividad alimentaria y el 61.5 % TEA. Conclusiones: La neuropatía óptica toxico-nutricional es una enfermedad poco frecuente en niños y se presenta con pérdida visual progresiva, bilateral e indolora debido al daño del nervio óptico, pudiendo generar lesión severa e irreversible del mismo. La anamnesis alimentaria permite la pesquisa temprana de deficiencias de nutrientes en niños con alimentación restrictiva, especialmente en pacientes neuro atípicos. Esto es esencial para implementar medidas de prevención y el tratamiento con vitamina A con el fin de evitar consecuencias irreversibles.