RESUMEN
Recent evidence suggests that Fusobacterium nucleatum (Fn) is associated with the development and progression of colorectal cancer. We aimed to delineate the clinical implications of Fn in metastatic colon cancer. We performed quantitative polymerase chain reaction (qPCR) using DNA samples from synchronous metastatic colon cancer patients with either formalin-fixed paraffin-embedded (FFPE) archival primary site tumor samples or fresh colon tissues. Progression-free survival (PFS)1 and PFS2 were defined as PFS of first- and second-line palliative settings. qPCR for Fn was successfully performed using 112 samples (FFPE, n = 61; fresh tissue, n = 51). Forty-one and 68 patients had right-sided and left-sided colon cancer, respectively. Patients with Fn enriched right-sided colon cancers had shorter PFS1 (9.7 vs. 11.2 months) than the other subgroups (HR 3.54, 95% confidence interval [CI] 1.05-11.99; P = 0.04). Fn positive right-sided colon was also associated with shorter PFS2 (3.7 vs. 6.7 months; HR 2.34, 95% CI 0.69-7.91; P = 0.04). In the univariate analysis, PFS1 was affected by differentiation and Fn positive right-sided colon cancer. The multivariate analysis showed that differentiation (HR 2.68, 95% CI 1.40-5.14, P = 0.01) and Fn positive right-sided colon (HR 0.40, 95% CI 0.18-0.88, P = 0.02) were associated with PFS1. Fn enrichment in right sided colon was not associated with overall survival (OS). Fn enrichment has significantly worse prognosis in terms of PFS1 and PFS2 in patients with right-sided metastatic colon cancers.
Asunto(s)
Neoplasias del Colon/microbiología , ADN Bacteriano/genética , Infecciones por Fusobacterium/diagnóstico , Fusobacterium nucleatum/aislamiento & purificación , Neoplasias Primarias Múltiples/microbiología , Neoplasias del Colon/patología , ADN Ribosómico/genética , Femenino , Fusobacterium nucleatum/genética , Humanos , Estimación de Kaplan-Meier , Masculino , Metástasis de la Neoplasia , Pronóstico , Supervivencia sin Progresión , ARN Ribosómico 16S/genéticaRESUMEN
BACKGROUND: Despite many advantages, the development of synchronous or metachronous neoplasm is one of the main concerns with endoscopic resection. We aimed to clarify the independent risk factors for synchronous or metachronous gastric neoplasm. METHODS: We retrospectively reviewed the medical records of all patients who had undergone endoscopic resection for gastric high-grade dysplasia or early gastric cancer between April 2001 and February 2011. RESULTS: Among 971 subjects, 56 synchronous neoplasms and 42 metachronous neoplasms developed during 12-131 months of follow-up. In univariate analysis, age over 65 years, male gender, absence of Helicobacter pylori infection, lower third location, mucosal atrophy, and intestinal metaplasia were related to multiple gastric neoplasms. In multivariate analysis, absence of H. pylori infection [odds ratio (OR) 1.610, 95 % confidence interval (CI) 1.038-2.497)], lower third location (OR 1.704, 95 % CI 1.070-2.713), and intestinal metaplasia (OR 4.461, 95 % CI 1.382-14.401) were independent risk factors for multiple gastric neoplasms. For synchronous neoplasm, primary tumor size less than 1 cm was the only independent risk factor. For metachronous neoplasm, absence of H. pylori infection (OR 2.416, 95 % CI 1.214-4.810) was found to be the only independent risk factor. H. pylori eradication was found to be unrelated to the development of metachronous gastric neoplasms. CONCLUSIONS: For tumors located in the antrum and accompanied by intestinal metaplasia, meticulous endoscopic evaluation with close follow-up after endoscopic resection is recommended.
Asunto(s)
Adenocarcinoma/patología , Neoplasias Primarias Múltiples/epidemiología , Neoplasias Primarias Secundarias/epidemiología , Neoplasias Gástricas/patología , Adenocarcinoma/mortalidad , Adenocarcinoma/cirugía , Anciano , Femenino , Gastroscopía , Infecciones por Helicobacter/complicaciones , Infecciones por Helicobacter/epidemiología , Humanos , Incidencia , Estimación de Kaplan-Meier , Masculino , Persona de Mediana Edad , Neoplasias Primarias Múltiples/microbiología , Neoplasias Primarias Múltiples/patología , Neoplasias Primarias Secundarias/microbiología , Neoplasias Primarias Secundarias/patología , Prevalencia , Factores de Riesgo , Neoplasias Gástricas/microbiología , Neoplasias Gástricas/cirugíaAsunto(s)
Adenoma/complicaciones , Adenoma/patología , Colon/patología , Linfoma de Células B de la Zona Marginal/complicaciones , Linfoma de Células B de la Zona Marginal/patología , Neoplasias Primarias Múltiples/patología , Adenoma/microbiología , Colon/microbiología , Infecciones por Helicobacter/complicaciones , Infecciones por Helicobacter/tratamiento farmacológico , Helicobacter pylori/fisiología , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Primarias Múltiples/complicaciones , Neoplasias Primarias Múltiples/microbiologíaRESUMEN
Genetic and environmental factors have been implicated in the etiology of nasopharyngeal carcinoma (NPC), a tumor known to be closely associated with Epstein-Barr virus (EBV) infection. Studies have reported familial aggregation of NPC and have suggested the possible aggregation of NPC and other cancers. We evaluated familial aggregation of cancer in 358 high-risk families with two or more NPC cases enrolled in a NPC genetics study in Taiwan. Participants were linked to the Taiwan National Cancer Registry to identify incident cancers diagnosed after study enrollment (started in 1996) and before December 31, 2005, or death. In total, 2,870 individuals from the NPC Multiplex Family Study contributed 15,151 person-years over an average of 5.3 years of follow-up. One hundred ten incident cancers were identified. Multiple-primary standardized incidence ratios (MP-SIRs) were computed to evaluate overall cancer risk associated with infectious agents and with other tumors. The overall MP-SIR was 1.3 (95% CI: 1.1-1.6), which was largely explained by an excess in NPC (MP-SIR = 15; 95% CI: 10-23). Exclusion of incident NPC diagnoses led to an overall MP-SIR of 1.0 (95% CI: 0.83-1.3). Similarly, the observed excess risk of cancers associated with infectious agents (MP-SIR = 2.0; 95% CI: 1.5-2.6) was driven by the excess in NPC; exclusion of NPC cases led to a reduced MP-SIR that did not differ from 1.0. Analysis of the largest NPC multiplex family study to date confirms the presence of coaggregation of NPC within families in Taiwan but does not provide evidence for a broader familial syndrome involving NPC and other tumors.
Asunto(s)
Carcinoma/epidemiología , Neoplasias Nasofaríngeas/epidemiología , Neoplasias Primarias Múltiples/epidemiología , Carcinoma/genética , Carcinoma/virología , Infecciones por Virus de Epstein-Barr/complicaciones , Infecciones por Virus de Epstein-Barr/epidemiología , Femenino , Humanos , Masculino , Neoplasias Nasofaríngeas/genética , Neoplasias Nasofaríngeas/virología , Neoplasias Primarias Múltiples/microbiología , Linaje , Sistema de Registros , Factores de Riesgo , TaiwánRESUMEN
We report the case of a 78-year-old man with Helicobacter pylori infection and three primary neoplasms of the stomach: adenocarcinoma, mucosa-associated lymphoid tissue (MALT) lymphoma and a gastrointestinal stromal cell tumor. Helicobacter pylori infection is associated with gastric carcinoma and MALT lymphoma, although their simultaneous occurrence is rare. Gastrointestinal stromal cell tumors have not been associated with infection to date. This appears to be the first report of the synchronous occurrence of these three gastric tumors.
Asunto(s)
Adenocarcinoma/patología , Infecciones por Helicobacter/patología , Helicobacter pylori/aislamiento & purificación , Linfoma de Células B de la Zona Marginal/patología , Neoplasias Primarias Múltiples/patología , Neoplasias Gástricas/patología , Estómago/patología , Adenocarcinoma/microbiología , Adenocarcinoma/cirugía , Anciano , Infecciones por Helicobacter/cirugía , Humanos , Linfoma de Células B de la Zona Marginal/microbiología , Linfoma de Células B de la Zona Marginal/cirugía , Masculino , Neoplasias Primarias Múltiples/microbiología , Neoplasias Primarias Múltiples/cirugía , Estómago/microbiología , Estómago/cirugía , Neoplasias Gástricas/microbiología , Neoplasias Gástricas/cirugía , Células del Estroma/microbiología , Células del Estroma/patologíaRESUMEN
The incidence of multiple polyps and number of polyps per mouse were significantly lower in conventionalized (CVz), and chloroform-resistant bacteria (CRB)- or fusiform bacteria (FB)-associated mice than in germfree (GF) BALB/c mice. The concentration of fecal fatty acids was also higher in mice associated with either CRB or FB than in GF mice. The incidence of multiple polyps and number of polyps per mouse were significantly correlated with the concentration of fatty acids in the feces of CVz and CRB-GB mice. This study demonstrated that inhibition of multiple polyps in the small intestine of BALB/c mice was affected by the production of intestinal fatty acids.
Asunto(s)
Vida Libre de Gérmenes , Neoplasias Intestinales/etiología , Neoplasias Intestinales/microbiología , Pólipos Intestinales/etiología , Pólipos Intestinales/microbiología , Intestino Delgado/microbiología , Neoplasias Primarias Múltiples/etiología , Neoplasias Primarias Múltiples/microbiología , Animales , Ácidos Grasos/análisis , Heces/química , Femenino , Neoplasias Intestinales/metabolismo , Pólipos Intestinales/metabolismo , Intestino Delgado/metabolismo , Ratones , Ratones Endogámicos BALB C , Neoplasias Primarias Múltiples/metabolismoRESUMEN
Streptococcal bacteremia is an uncommon presentation for colorectal malignancy, yet most physicians are aware of the association between Streptococcus bovis infection and these malignancies. Many are unaware, however, that other streptococcal species are associated with colon and rectal cancers. In this case report and brief review, we highlight this association and discuss a case of Streptococcus sanguis bacteremia associated with an early invasive rectal cancer.
Asunto(s)
Bacteriemia/complicaciones , Neoplasias Colorrectales/microbiología , Infecciones Estreptocócicas/complicaciones , Streptococcus sanguis , Adenocarcinoma/microbiología , Anciano , Pólipos del Colon/microbiología , Humanos , Masculino , Neoplasias Primarias Múltiples/microbiología , Neoplasias del Recto/microbiologíaRESUMEN
In this report, we describe a case with triple tiny cancers of the stomach developing adjacent to each other and resected endoscopically in a single mucosal piece. The three cancers differed from each other histologically. The surrounding mucosa was atrophic pyloric gland mucosa with moderate to severe intestinal metaplasia. Both histological and serological examinations were negative for Helicobacter pylori. Each of the three cancer lesions was positive for mutant p53 product immunohistochemically. None of the cancers were positive for Epstein-Barr virus sequence in an in situ hybridization analysis. These lesions suggest that certain local conditions in the gastric mucosa can result in carcinogenesis of different histological types of gastric cancers.
Asunto(s)
Adenocarcinoma Papilar/patología , Adenocarcinoma Papilar/cirugía , Adenocarcinoma/patología , Adenocarcinoma/cirugía , Neoplasias Primarias Múltiples/patología , Neoplasias Primarias Múltiples/cirugía , Neoplasias Gástricas/patología , Neoplasias Gástricas/cirugía , Adenocarcinoma/microbiología , Adenocarcinoma Papilar/microbiología , Anciano , Endoscopía , Genes p53 , Humanos , Linfoma Cutáneo de Células T/patología , Masculino , Neoplasias Primarias Múltiples/microbiología , Factores de Riesgo , Neoplasias Gástricas/microbiologíaRESUMEN
A 27-year-old woman suffering from panmyelopathy for six years presented with a cervical low grade squamous intraepithelial lesion (SIL), vulvar high grade SIL and perianal squamous cell carcinoma with an inguinal metastasis. Southern blot hybridization with 32P-labeled human papillomavirus (HPV) DNA revealed HPV 16 DNA in varying copy numbers in material from the four locations. HPV 16 genomes persisting after surgery on the perianal tumor area were no longer detectable after betatron radiotherapy.
Asunto(s)
Neoplasias Abdominales/microbiología , Neoplasias del Ano/microbiología , Enfermedades de la Médula Ósea/complicaciones , Carcinoma in Situ/microbiología , Carcinoma de Células Escamosas/microbiología , ADN Viral/aislamiento & purificación , Neoplasias de los Genitales Femeninos/microbiología , Huésped Inmunocomprometido , Neoplasias Primarias Múltiples/microbiología , Papillomaviridae/aislamiento & purificación , Neoplasias Abdominales/patología , Neoplasias Abdominales/secundario , Adulto , Neoplasias del Ano/patología , Enfermedades de la Médula Ósea/inmunología , Carcinoma in Situ/patología , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/secundario , Femenino , Neoplasias de los Genitales Femeninos/patología , Humanos , Conducto Inguinal , Neoplasias Primarias Múltiples/patologíaRESUMEN
It is recognized that a significant number of patients with vulvar neoplasia have had previous, concurrent, or subsequent genital tract neoplasia. This has resulted in speculation that there may be a common etiology and, in particular, of the possibility of an infection element. Among 59 cases of vulvar cancer diagnosed at the National Taiwan University Hospital from 1976 to 1991, there were seven cases (12%) associated with other primary malignancies. Carcinoma of the cervix was the most frequent other primary cancer (6/7, 86%). The possible role of human papilloma virus infection in genital neoplasia is discussed.
Asunto(s)
Neoplasias Primarias Múltiples , Neoplasias del Cuello Uterino/patología , Neoplasias de la Vulva/patología , Adulto , Anciano , Femenino , Humanos , Persona de Mediana Edad , Neoplasias Primarias Múltiples/microbiología , Papillomaviridae , Infecciones por Papillomavirus/patología , Infecciones Tumorales por Virus/patología , Neoplasias del Cuello Uterino/microbiología , Neoplasias de la Vulva/microbiologíaRESUMEN
Immune suppression from human immunodeficiency virus (HIV) infection is frequently associated with the development of certain neoplasms, including Kaposi's sarcoma and non-Hodgkin's lymphoma. A young patient with a 5-year history of HIV infection was found simultaneously to have invasive carcinoma of the breast, microinvasive carcinoma of the cervix, and intraepithelial neoplasia of the vulva. In view of the early nature of these neoplasms, conservative therapy was utilized; lumpectomy and adjuvant radiation therapy, conservative hysterectomy, and local therapy for the breast carcinoma, cervical carcinoma and vulvar intraepithelial neoplasia, respectively. Epithelial malignancies appear to be more common in the HIV-positive population than previously appreciated. To our knowledge this is the first report of multiple primary gynecologic neoplasms in association with HIV infection.
Asunto(s)
Neoplasias de la Mama/microbiología , Carcinoma/microbiología , Neoplasias de los Genitales Femeninos/microbiología , Infecciones por VIH/complicaciones , Neoplasias Primarias Múltiples/microbiología , Adulto , Carcinoma in Situ/microbiología , Carcinoma Intraductal no Infiltrante/microbiología , Femenino , Humanos , Neoplasias del Cuello Uterino/microbiología , Neoplasias de la Vulva/microbiologíaRESUMEN
We examined human papillomavirus (HPV) infection in biopsy specimens and cellular scrapes that were taken from respiratory papillomas and six nondiseased sites from the respiratory tract of seven patients. Human papillomavirus was detected by polymerase chain reaction amplification, followed by DNA hybridization with probes for specific HPV types. All papillomas (100.0%, n = 5) were positive only for HPV type 6 or 11. In the nondiseased site specimens, 61.3% (19/31) of the specimens were positive, again only for HPV type 6 or 11. Among the nondiseased site specimens from the cervical trachea, intrathoracic trachea, and bronchus, 80% to 100% were HPV positive compared with only 25% to 50% of HPV infection detected in the nasopharynx, posterior tonsillar pillar, and aryepiglottic fold. These results support the tenet that HPV infection is present in clinically normal respiratory tract tissue and that the reservoir site of reinfection is more commonly in the lower airway. However, patients with upper-airway involvement were more likely to be diagnosed as having severe disease.
Asunto(s)
Neoplasias Primarias Múltiples/microbiología , Papiloma/microbiología , Papillomaviridae/aislamiento & purificación , Sistema Respiratorio/microbiología , Neoplasias del Sistema Respiratorio/microbiología , Infecciones Tumorales por Virus/microbiología , Adulto , Bronquios/microbiología , Niño , Preescolar , ADN Viral/análisis , ADN Viral/genética , Femenino , Estudios de Seguimiento , Humanos , Laringe/microbiología , Masculino , Nasofaringe/microbiología , Recurrencia Local de Neoplasia , Neoplasias Primarias Múltiples/patología , Tonsila Palatina/microbiología , Papiloma/patología , Papillomaviridae/genética , Reacción en Cadena de la Polimerasa , Sistema Respiratorio/patología , Neoplasias del Sistema Respiratorio/patología , Tráquea/microbiología , Infecciones Tumorales por Virus/patologíaRESUMEN
Presence of human papillomavirus (HPV) as the etiologic agent in nearly all upper respiratory tract recurrent papillomas is well-established. The technique of nucleic acid hybridization now allows specific typing of HPV with a high degree of accuracy. This article reports a series of nine consecutive patients treated for nasal papillomas over the past 9 years. Eight of these patients had a personal history of genital papillomas (seven patients) or exposure (one patient). With the use of in situ hybridization and autoradiographic technique on paraffin-embedded tissue sections, HPV RNA type 6/11 was expressed in eight of nine nasal papillomas, and corresponding HPV types were also found in the two cases with which concurrent anogenital papilloma tissue was also available for analysis. Human papillomavirus RNA types 16 and 18 were not detected in any of the specimens. Signals of HPV messenger RNA type 6/11 were stronger in the fungiform areas than in the inverted areas of papillomas.
Asunto(s)
Condiloma Acuminado/microbiología , Neoplasias Primarias Múltiples/microbiología , Neoplasias Nasales/microbiología , Papiloma/microbiología , Papillomaviridae/aislamiento & purificación , Neoplasias Urogenitales/microbiología , Adulto , Núcleo Celular/ultraestructura , Citoplasma/ultraestructura , Femenino , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Nasales/patología , Hibridación de Ácido Nucleico , Papiloma/patología , Papillomaviridae/clasificación , Papillomaviridae/genética , Sondas ARN , ARN Mensajero/análisis , ARN Viral/análisisRESUMEN
Three epithelial neoplastic lesions, perineal Bowenoid papulosis, uterine cervical carcinoma, and bladder transitional cell carcinoma, which occurred in a mildly immunosuppressed patient who had aplastic anemia were studied for human papillomavirus (HPV) infection. In the Bowenoid papulosis, HPV type 16 DNA was identified by polymerase chain reaction (PCR) and by in situ hybridization (ISH). In contrast, in the uterine cervical carcinoma, HPV 16 was not detected, although possibly another unidentified type of HPV in the lesion was suggested by the ISH findings. In the bladder transitional cell carcinoma, neither papillomavirus genus-specific (PGS) antigen nor HPV DNA was found.
Asunto(s)
Anemia Aplásica/complicaciones , Enfermedad de Bowen/microbiología , Carcinoma de Células Escamosas/microbiología , Carcinoma de Células Transicionales/microbiología , Neoplasias Primarias Múltiples/microbiología , Neoplasias Cutáneas/microbiología , Neoplasias Urogenitales/microbiología , Neoplasias Urogenitales/patología , Adulto , Enfermedad de Bowen/complicaciones , Enfermedad de Bowen/patología , Carcinoma de Células Escamosas/complicaciones , Carcinoma de Células Escamosas/patología , Carcinoma de Células Transicionales/complicaciones , Carcinoma de Células Transicionales/patología , Sondas de ADN de HPV/análisis , Femenino , Humanos , Neoplasias Primarias Múltiples/complicaciones , Neoplasias Primarias Múltiples/patología , Perineo , Reacción en Cadena de la Polimerasa , Neoplasias Cutáneas/complicaciones , Neoplasias Cutáneas/patología , Neoplasias Urogenitales/complicacionesRESUMEN
Two cases of C cell hyperplasia and one case of C cell carcinoma of the thyroid glands were bilaterally recognized in 11 sheep with experimentally-induced lymphosarcoma. The serum calcium concentration in the C cell carcinoma case was slightly increased above the normal concentration of around 9 mg per dl. Bilateral C cell hyperplasia also developed in the thyroid lobes of the C cell carcinoma case. Immunohistochemically, hyperplastic C cells and tumour cells were positive for calcitonin, calcitonin gene-related peptide, chromogranin A and neurone-specific enolase. No amyloid deposition nor multiple endocrine neoplasia was demonstrated in any of the cases. Ultrastructurally, many secretory granules were observed in the cytoplasm of neoplastic cells constituting the C cell carcinoma and in the hyperplastic C cells.
Asunto(s)
Carcinoma/veterinaria , Virus de la Leucemia Bovina/patogenicidad , Linfoma no Hodgkin/microbiología , Neoplasias Primarias Múltiples/veterinaria , Enfermedades de las Ovejas/patología , Glándula Tiroides/patología , Neoplasias de la Tiroides/veterinaria , Animales , Biomarcadores de Tumor/análisis , Carcinoma/microbiología , Carcinoma/patología , Femenino , Hiperplasia , Masculino , Proteínas de Neoplasias/análisis , Neoplasias Primarias Múltiples/microbiología , Neoplasias Primarias Múltiples/patología , Ovinos , Enfermedades de las Ovejas/microbiología , Neoplasias de la Tiroides/microbiología , Neoplasias de la Tiroides/patologíaRESUMEN
Malignant transformation of laryngeal juvenile papillomatosis most often occurs in patients with previous radiation therapy or smoking histories. We report the case of a 35-year-old, nonsmoking, nonirradiated man who developed squamous cell carcinoma of the lung with a 33-year history of laryngotracheal juvenile papillomatosis. Postmortem examination showed pulmonary cavitating papillomatosis and chest wall, vertebrae, and peribronchial lymph node involvement by tumor. Molecular studies (Southern blot, polymerase chain reaction) showed extrachromosomal human papillomavirus-11 (HPV11) DNA in both carcinoma and two laryngotracheal squamous cell papillomas, including one excised 20 years previously. Our observation is analogous to the previously reported cases of spontaneous (not related to irradiation or smoking) malignant transformation of juvenile laryngotracheal papillomatosis. Although HPV11 viral infection likely played a role in the malignant transformation, other less likely factors, such as drugs given for treatment and radiography performed throughout the illness, should be considered. Repeated pulmonary infections and the host immune response are additional considerations.
Asunto(s)
Carcinoma de Células Escamosas/microbiología , Neoplasias Laríngeas/microbiología , Neoplasias Pulmonares/microbiología , Neoplasias Primarias Múltiples/microbiología , Neoplasias de la Tráquea/microbiología , Adulto , Carcinoma de Células Escamosas/patología , ADN Viral/análisis , Humanos , Neoplasias Laríngeas/patología , Neoplasias Pulmonares/patología , Masculino , Neoplasias Primarias Múltiples/patología , Papillomaviridae/genética , Reacción en Cadena de la Polimerasa , Neoplasias de la Tráquea/patologíaRESUMEN
Scanning electron microscopy of adenomatous intestinal tissue in the blue fox revealed an irregular surface topography of the colon with increased diameter of the crypt openings and prominent ridge formations between crypts. The ileum showed villous atrophy and fusion. Microvilli were short and irregular. Small ulcerations of intestinal mucosa were seen. Freeze-fracture revealed curved intracellular organisms in the altered epithelial cells. Transmission electron microscopy showed features associated with immaturity and high protein synthesis. Filamentous extensions from the basolateral plasma membrane of altered epithelial cells sometimes penetrated the basal lamina. The cytoplasm contained numerous polyribosomes, nuclei had many indentations and large and irregular nucleoli. Intracellular bacteria, with morphology corresponding to Campylobacter spp. were found in the apical epithelial cytoplasm. No host-cell-derived membrane was seen to surround the bacteria.
Asunto(s)
Adenoma/veterinaria , Neoplasias del Colon/veterinaria , Zorros , Neoplasias del Íleon/veterinaria , Neoplasias Primarias Múltiples/veterinaria , Adenoma/microbiología , Adenoma/ultraestructura , Animales , Campylobacter/ultraestructura , Neoplasias del Colon/microbiología , Neoplasias del Colon/ultraestructura , Femenino , Neoplasias del Íleon/microbiología , Neoplasias del Íleon/ultraestructura , Masculino , Microscopía Electrónica , Microscopía Electrónica de Rastreo , Microvellosidades/ultraestructura , Neoplasias Primarias Múltiples/microbiología , Neoplasias Primarias Múltiples/ultraestructuraRESUMEN
Of 4 patients who underwent cystourethroscopy, biopsy and laser excision of suspected urethral condylomata acuminata 3 had coexistent grade I papillary transitional cell carcinoma of the urethra. Human papillomavirus type 6 messenger ribonucleic acid was demonstrated within biopsy specimens using tritium-labeled single-stranded antisense ribonucleic acid probes. Compared to condylomata the papillary transitional epithelium expressed less viral message, which might be expected in an epithelium that does not show full squamous epithelial or koilocytotic differentiation. Among these patients there was 1 papillary transitional lesion in the bladder that, although histologically similar, did not express human papillomavirus message, suggesting differential susceptibility of epithelium between the bladder and urethra. The finding of active human papillomavirus transcription within the urethral papillary transitional lesions raises the possibility of an active role for the virus in the pathogenesis of these lesions. These findings broaden the spectrum of epithelial types reported to support human papillomaviruses and provides impetus for a wider search for these viruses in other transitional cell neoplasms.
Asunto(s)
Carcinoma de Células Transicionales/microbiología , Papillomaviridae/aislamiento & purificación , Neoplasias Uretrales/microbiología , Adulto , Carcinoma de Células Transicionales/patología , Condiloma Acuminado/microbiología , Condiloma Acuminado/patología , Humanos , Masculino , Neoplasias Primarias Múltiples/microbiología , Neoplasias Primarias Múltiples/patología , Neoplasias Uretrales/patologíaRESUMEN
A homosexual man in stage IV of HIV infection, who suffers from HPV 16-positive bowenoid papulosis of the anal region, is described. In one area the patient developed an HPV 16-positive squamous-cell carcinoma of the anus. Bowenoid papulosis represents a squamous-cell carcinoma in situ, and usually follows a benign clinical course. The possibility exists that immunocompromised individuals are at higher risk to develop cancer on the basis of bowenoid papulosis.