RESUMEN
OBJECTIVE: Determine the incidence of clinical cochlear ototoxicity in routine use of Cortisporin after ventilation tube placement. Cost differential between use of Cortisporin and fluoroquinolone agents was evaluated. METHODS: A retrospective review of 500 patients was performed. Cortisporin otic suspension was used for 5 days following ventilation tube insertion. RESULTS: Testing following surgery indicated a sensorineural hearing loss (SNHL) in 19 (2.1%) ears. The SNHL existed prior to the surgery and there was no deterioration in the hearing postoperatively. The total cost for our study group who used Cortisporin was $15,500. If Floxin had been prescribed the cost would have been $45,000. Had Ciprodex been prescribed, the cost would have been $49,500. CONCLUSION: Our study demonstrates no clinical cochlear ototoxicity in children who received Cortisporin following ventilation tube placement. The cost differential for prescribing fluoroquinolone drops is significant. EBM RATING: C-4.
Asunto(s)
Antibacterianos/efectos adversos , Hidrocortisona/uso terapéutico , Neomicina/uso terapéutico , Polimixina B/uso terapéutico , Administración Tópica , Adolescente , Antibacterianos/economía , Niño , Cóclea/efectos de los fármacos , Combinación de Medicamentos , Fluoroquinolonas/economía , Fluoroquinolonas/uso terapéutico , Humanos , Hidrocortisona/efectos adversos , Hidrocortisona/economía , Ventilación del Oído Medio , Neomicina/efectos adversos , Neomicina/economía , Polimixina B/efectos adversos , Polimixina B/economía , Estudios Retrospectivos , SuspensionesRESUMEN
The Netherlands' Ministry of Health and the health insurance companies have drawn up a list of preparations which will no longer be reimbursed. The ocular antibiotic preparations Polyspectran and Terramycin are on the list. However, there are no satisfactory alternative with respect to the broadness of the antibiotic spectrum required. In addition, some alternatives have serious side effects or may induce bacterial resistance.
Asunto(s)
Quimioterapia Combinada/economía , Reembolso de Seguro de Salud , Soluciones Oftálmicas/economía , Antibacterianos/economía , Bacitracina/economía , Quimioterapia Combinada/administración & dosificación , Gramicidina/economía , Humanos , Neomicina/economía , Países Bajos , Oxitetraciclina/economía , Polimixina B/economíaRESUMEN
A total of 1053 patients with superficial burn injury were treated with povidone iodine plus neosporin (PVP + N) and the results after treatment were compared with those obtained after treating 1089 patients with silver sulphadiazine (SSD). Qualitative analysis showed Staphylococcus aureus and Pseudomonas spp. to be the most common infecting organisms. Quantitatively, fewer patients showed infection on the 7th and 18th day post-treatment in the PVP + N group (P < 0.01 and P < 0.001, respectively). Similarly, healing times were also better with PVP + N, with a maximum number of patients having healed within 15 days (P < 0.001). However, the mortality rates were not much different between the two groups.