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Aging (Albany NY) ; 13(7): 10087-10098, 2021 03 26.
Artículo en Inglés | MEDLINE | ID: mdl-33818420

RESUMEN

Hypothalamic nuclei in the preoptic and anterior hypothalamic region (POAH) are critically involved in thermoregulation and neuroendocrine regulation and can be displaced by craniopharyngiomas (CPs). We aimed to locate the POAH by visualizing hypothalamic thermoregulation through task-related functional magnetic resonance imaging (fMRI) to guide hypothalamus protection intraoperatively. Nine adult healthy volunteers (HVs) and thirty-two adult primary CP patients underwent task-related fMRI for POAH localization by warm (60° C) and cold (0° C) cutaneous thermoreceptor stimulation. Approach selection and intraoperative POAH protection were performed based on preoperative POAH localization. In all HVs and patients, significant single positive blood oxygen level-dependent (BOLD) signal changes were located in the POAH. The BOLD activity was significantly greater for cold (P=0.03) and warm (P=0.03) stimuli in patients than in HVs. Gross total resection and near-total resection were achieved in 28 (87.5%) and 4 (12.5%) patients, respectively. New-onset diabetes insipidus and new-onset hypopituitarism occurred in 6 patients (18.8%) and 10 patients (31.3%), respectively. Our findings suggest that cutaneous thermoreceptor stimulation could accurately activate the hypothalamic thermoregulatory center and allow POAH localization through task-related fMRI. Preoperative POAH localization could help neurosurgeons protect hypothalamic function intraoperatively. The CP patients were more sensitive to thermal stimulation.


Asunto(s)
Núcleo Hipotalámico Anterior/diagnóstico por imagen , Regulación de la Temperatura Corporal/fisiología , Craneofaringioma/diagnóstico por imagen , Neoplasias Hipofisarias/diagnóstico por imagen , Área Preóptica/diagnóstico por imagen , Adulto , Frío , Femenino , Calor , Humanos , Imagen por Resonancia Magnética , Masculino , Neuronas/fisiología
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