RESUMEN
A rare case involving an attempt to commit suicide by ingestion of a commercially available product containing methoxychlor as the active ingredient is presented. Clinical symptoms exhibited by the patient included no response to stimuli, pale skin, and profuse sweating. A serum sample collected at the time of admission to the hospital was found to contain 0.67 microg/mL of methoxychlor. The determination of methoxychlor was performed using gas chromatography-mass spectrometry.
Asunto(s)
Insecticidas/envenenamiento , Metoxicloro/envenenamiento , Intento de Suicidio , Anciano , Cromatografía de Gases y Espectrometría de Masas , Humanos , Insecticidas/sangre , Masculino , Metoxicloro/sangreAsunto(s)
Metoxicloro/toxicidad , Solanum tuberosum/efectos de los fármacos , Animales , Relación Dosis-Respuesta a Droga , Dosificación Letal Mediana , Concentración Máxima Admisible , Metoxicloro/envenenamiento , Ratones , Residuos de Plaguicidas/envenenamiento , Residuos de Plaguicidas/toxicidad , Intoxicación/fisiopatología , RatasAsunto(s)
Ácido 2,4-Diclorofenoxiacético/envenenamiento , Eritrocitos/enzimología , Glucosafosfato Deshidrogenasa/metabolismo , Hígado/enzimología , Metoxicloro/envenenamiento , Ácido 2,4-Diclorofenoxiacético/administración & dosificación , Animales , Relación Dosis-Respuesta a Droga , Activación Enzimática/efectos de los fármacos , Eritrocitos/efectos de los fármacos , Femenino , Glucosafosfato Deshidrogenasa/antagonistas & inhibidores , Hígado/efectos de los fármacos , Masculino , Metoxicloro/administración & dosificación , Ratas , Factores de TiempoRESUMEN
A case of combined poisoning due to exposure to an aerosol containing both malathion and methoxychlor (sold under the trade name Ortho TM Orchard Spray in the United States) ps presented. The following unusual features occurred in the course and outcome of the poisoning: slow onset of symptoms and signs, bilateral profound and permanent sensorineural hearing loss, and residual peripheral neuropathies in the extremites. The possible potentiation of the usually low toxicity of malathion is suggest and discussed.