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INTRODUCCIÓN: El mesotelioma peritoneal multiquístico benigno (MPMB) es una entidad con muy baja incidencia que se presentan con mayor frecuencia en mujeres jóvenes. CASO CLÍNICO: Paciente de 17 años que consulta por amenorrea secundaria. Además, refería pérdida de peso, estreñimiento y molestias abdominales. La exploración fue normal y en las pruebas de imagen se objetivó una pelvis ocupada por una masa multiquística, de unos 20 cm de diámetro máximo, de paredes finas y contenido anecoico. Se solicitaron marcadores tumorales de los cuales sólo se encontró elevado el CA 19.9 (35,2 U/mL). Se decidió realizar una laparoscopia exploradora para establecer un diagnóstico y ante los hallazgos y al considerarse la masa fácilmente resecable, en el mismo acto quirúrgico se extirpó por completo para su estudio anatomopatológico, que confirmó un MPMB. Se desestimaron tratamientos adicionales y actualmente se encuentra en seguimiento y asintomática. CONCLUSIÓN: La patogénesis del MPMB no está clara. Algunos autores defienden que se trata de una reacción peritoneal a un daño inflamatorio, otros apoyan que se trata de una neoplasia benigna. Esta naturaleza incierta, junto con la escasa experiencia, hacen que el manejo resulte complejo. Es necesario individualizar cada caso e intentar ser conservadores especialmente en pacientes jóvenes. Si se opta por un manejo activo, lo más acertado es la citorreducción completa seguida de quimioterapia hipertérmica peritoneal. El seguimiento, en cualquier caso, debe ser exhaustivo y multidisciplinar principalmente con pruebas de imagen.

BACKGROUND: Benign Multicystic Peritoneal Mesothelioma (BMPM) is an entity with a very low incidence that occurs more frequently in young women. CASE REPORT: A 17-year-old woman attended for secondary amenorrhea. She also referred to weight loss, constipation and abdominal discomfort. The examination was normal and echography revealed a pelvis occupied by a 20 centimeters multicystic mass, with thin walls and anechoic content. A preoperative study with tumor markers was requested in which only a CA 19.9 elevation was observed (35.2 U/ml 0-27). It was decided to perform an exploratory laparoscopy to establish a diagnosis. Due to the findings and because of the fact that the mass was considered easy to remove, it was completely removed in the same surgical act. The pathological result confirmed a BMPM. Additional treatments have been dismissed and are the patient is currently being followed up without symptoms. CONCLUSION: The pathogenesis of BMPM is unclear. Some authors argue that it is a peritoneal reaction to inflammatory damage, others support that it is a benign neoplasm. This uncertain nature coupled with limited experience make management complex. It is necessary to evaluate each case and try to be conservative especially in young patients. If surgery management is chosen, complete cytoreduction followed by hyperthermic peritoneal chemotherapy is the most successful option. The follow-up in any case must be exhaustive and multidisciplinary, mainly with imaging tests.

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The case of a Peruvian 15-year-old male with a left-flank abdominal mass suspected to be a peritoneal pseudomyxoma is presented. The patient underwent a R0 surgery, and the pathology review showed a benign multicystic peritoneal mesothelioma. Characterized by recurrent mesothelial peritoneal cysts originating in the epithelial and mesenchymal elements of mesothelial tissue, this benign tumor is unusual among young males.

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Introducción: el mesotelioma multiquístico es una neoplasia rara que afecta al peritoneo o al espacio extraperitoneal, el epiplón y las vísceras abdominales o pélvicas. Se deriva de las células del revestimiento de la pleura o peritoneo. El origen primario es poco frecuente, al igual que sus manifestaciones. Objetivo: presentar un caso clínico atípico con énfasis en los hallazgos aportados por los estudios imagenológicos en el diagnóstico del mesotelioma multiquístico benigno.Presentación del caso: paciente femenina, de color de piel blanco y 47 años de edad, con antecedentes de diabetes mellitus tipo II de 10 años de evolución. Acude a consulta por presentar cuadro doloroso abdominal difuso, predominantemente en las zonas del epigastrio y mesogastrio. Durante el examen físico se identificó el abdomen ligeramente distendido y doloroso a la palpación en epigastrio y parte del mesogastrio. En los estudios imagenológicos se identificó una masa de aspecto multiquístico en el mesenterio con escasa vascularización, proyectada por delante del estómago.Discusión: la sintomatología es inespecífica con dolor subagudo o crónico, sensación de plenitud, aumento del perímetro abdominal y masa palpable. Muchos casos son hallazgos identificados mediante estudios imagenológicos incidentales o durante intervenciones quirúrgicas al tratar otras enfermedades. Conclusiones: los métodos de imágenes fueron esenciales para el diagnóstico y evaluación de esta afección mesentérica, en especial la ecografía abdominal, la resonancia magnética de alto campo y la tomografía computada. Mediante ellos se pudo valorar la extensión de la lesión y los órganos involucrados en el proceso, así como diferenciar ante otros posibles diagnósticos(AU)

Introduction: multicystic mesothelioma is a rare neoplasm that affects the peritoneum or extraperitoneal space, the omentum and the abdominal or pelvic viscera. It is derived from the cells of the lining of the pleura or peritoneum. The majority of mesenteric masses correspond to intra-abdominal secondary processes. The primary origin is rare, as well as its manifestations.Objective: to present an atypical case of benign multicystic mesothelioma diagnosed through imaging studies.Presentation of the case: female patient, of white skin color and 47 years old, with a history of type II diabetes mellitus of 10 years of evolution. She came to the clinic for presenting diffuse abdominal pain, predominantly in the epigastrium and mesogastrium areas. During the physical examination the abdomen was slightly distended and painful on palpation in the epigastrium and part of the mesogastrium. Complementary examinations were carried out and in the imaging studies, a mass of multicystic aspect was observed in the mesentery, with little vascularization and projected in front of the stomach.Discussion: The symptomatology is nonspecific with subacute or chronic pain, sensation of fullness, increase of the abdominal perimeter and palpable mass. Many cases are findings identified by incidental imaging studies or during surgical procedures when treating other diseases. Conclusions: imaging methods were essential for the diagnosis and evaluation of this mesenteric condition, especially abdominal ultrasound, high field magnetic resonance imaging and computed tomography. Through them it was possible to assess the extent of the lesion and the organs involved in the process, as well as to differentiate it from other possible diagnoses(AU)

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BACKGROUND: Benign multicystic mesothelioma is a rare benign tumour derived from the peritoneal mesothelium. The aim of this paper is to present a case of this rare tumour and review the clinical features, diagnosis and treatment of this disease. CLINICAL CASE: The case is presented of a 22-year-old female diagnosed with multicystic mesothelioma after an urgent resection of intra-abdominal tumour in the context of acute abdominal pain. In the subsequent follow-up, the patient had a recurrence of the lesion, and at 2 years was treated by further resection. CONCLUSIONS: Benign multicystic mesothelioma is a benign tumour of unknown origin, and with a non-specific clinical manifestation. The most effective treatment is surgical, although there is a high tendency to local recurrence.

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Benign multicystic peritoneal mesothelioma is a rare cystic tumor with approximately 140 cases reported to date. It is found mainly in women of reproductive age and is commonly attached to the serosal surface of pelvic viscera. The pathogenesis is uncertain and debate regarding its neoplastic or reactive nature exists. The presenting symptoms are often nonspecific and most commonly include vague lower abdominal pain and fullness. Imaging studies are used to identify the lesion, but histologic studies with the aid of immunohistochemical techniques are needed for definitive diagnosis as the differential diagnosis is quite extensive. Surgical resection is the primary form of treatment, and follow-up is important due to the high rate of recurrence and the rare possibility of malignant transformation. Here, we present a case of a 50-year-old female with a recurrence of benign multicystic peritoneal mesothelioma treated through laparoscopic excision and also a review of the literature.

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El mesotelioma peritoneal maligno es una neoplasia de presentación infrecuente, de curso insidioso, sintomática y de presentación poco específica en fase avanzada, de difícil diagnóstico y alta letalidad. Es la neoplasia más común de la serosa peritoneal, ocupando el segundo lugar de localización de los mesoteliomas, después del mesotelioma pleural. Es más frecuente en hombres, en mayores de 60 años y se ha relacionado en un 80% a la exposición crónica al asbesto. Generalmente su primera manifestación es ascitis, que se acompaña de dolor abdominal, astenia, hiporexia y pérdida de peso. Se puede diagnosticar a través del estudio histológico e inmunohistoquímico de líquido ascítico, biopsia peritoneal, y como métodos complementarios, TC de Abdomen y CT-PET. Presentamos el caso de un paciente masculino de 70 años de edad, con antecedente de adenocarcinoma prostático tratado con radioterapia y bloqueo hormonal, en remisión, Cardiopatía Isquémica e Hipertensiva en condición post-Bypass coronario, quien consulta por disnea, ascitis, hiporexia, astenia, con evidencia de líquido ascítico hemorrágico y GASA de bajo gradiente.

Malignant peritoneal mesothelioma is an infrequent neoplasm, of insidious course, symptomatic presentation and usually is diagnosed at an advanced stage diagnosis. It is the most common malignancy of the peritoneum and the the second location of mesothelioma, preceded by pleural mesothelioma. It is more common in men older than 60 year sand has been linked in 80% to chronic exposure to asbestos. Usually ascites, abdominal pain, fatigue, decreased appetite and weight loss are the first signs. It can be diagnosed through histological and immunohistochemical study of ascitic fluid, peritoneal biopsy, abdominal CT and CT-PET. We report the case of a male patient. 70 years with a history of heart disease and prostatic carcinoma treated with radiotherapy and immunosupressive therapy, who consults with dyspnea, ascites, hyporexia, fatigue and evidence of hemorrhagic ascites.

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Se presenta el caso de una mujer de 41 años que consulta por dolor abdominal y pelviano de carácter sordo de 6 semanas de evolución sin compromiso del estado general. Refiere el antecedente de una histerectomía por mioma realizada hace 3 años. La ecotomografía y la TAC de abdomen y pelvis revelan una lesión quística gigante de 15 x 8 x 12 cm que ocupa parte del abdomen y la pelvis. Luego de una resección parcial y marsupialización es referida a cirugía por recidiva precoz del tumor quístico. Es reintervenida, lográndose una extirpación completa más anexectomía bilateral con buena evolución posterior. El estudio histopatológico confirma el diagnóstico inicial de quiste mesotelial simple. La ubicación pelviana de la lesión, el comportamiento clínico (recidiva precoz con crecimiento rápido) y las dimensiones son más característicos de un mesotelioma quístico benigno. Sin embargo, el carácter unilocular permite catalogarlo como un quiste mesotelial de crecimiento excepcional. La distinción entre ambas entidades no es menor, toda vez que el mesotelioma quístico benigno tiene una recidiva alta y puede malignizarse.

We report a 41 years old women presenting with abdominal and pelvic pain lasting six weeks. She had a history of hysterectomy three years ago. Abdominal ultrasound and CAT scan showed a giant cystic lesion of 15 x 8 x 12 cm that occupied a great portion of the abdomen and pelvis. After a partial resection and marsupialization, she was refereed to surgery due to an early relapse of the cyst. She was operated again, performing a complete cyst excision and bilateral anexectomy, with a good postoperative evolution. Pathology confirmed the diagnosis of a simple omental cyst. The unilocular feature of the lesion is characteristic of omental cysts. However, due to the pelvic location and dimensions, the differential diagnosis must be made with benign cystic mesothelioma, that had a high rate of relapse and may become malignant.

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