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La leishmaniasis cutánea o mucocutánea presenta variedad de formas clínicas, siendo la más frecuente la úlcera moldurada. Una forma poco frecuente es la llamada leishmaniasis cutánea difusa caracterizada por presentar pápulas, tubérculos, nódulos, placas e infiltración. Inicialmente localizadas, pero con tendencia a la progresión, pudiendo llegar a ser diseminadas. Es una forma aún no comunicada en Paraguay. Presentamos el caso de una mujer adulta mayor, con placas y nódulos en ambos miembros inferiores, y cuyo frotis y anatomía patológica confirmaron el diagnóstico de leishmaniasis. Clínicamente clasificada como leishmaniasis cutánea difusa, la PCR y HRM demostraron ser producida por Leishmania (Viannia) brasiliensis.

Cutaneous or mucocutaneous leishmaniasis presents a variety of clinical forms, the most common being a molded ulcer. A rare form is the so-called diffuse cutaneous leishmaniasis characterized by presenting papules, tubers, nodules, plaques and infiltration; initially located but with a tendency to progression, and may become widespread. It is a form not reported in Paraguay. We present the case of an older adult woman, with plaques and nodules on both lower limbs, and whose smear and pathological anatomy confirmed the diagnosis of leishmaniasis. Clinically classified as diffuse cutaneous leishmaniasis, PCR and HRM were shown to be produced by Leishmania (Viannia) brasiliensis.

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This case report highlights the risk of severe cutaneous leishmaniasis (CL) by Leishmania infantum in patients undergoing immunosuppressant therapy who either live in an endemic area or are visiting in the transmission season. The case patient, resident in Majorca (Balearic Islands), presented 12 disseminated erythematous skin lesions, 1-6 cm in diameter, located on the scalp, cheek, umbilical region, and lower extremities 8 years after undergoing anti-tumor necrosis factor (TNF) therapy. Parasite presence in peripheral blood and high levels of specific antibodies were also observed, indicating a possible risk of CL shifting toward a visceral infection. However, once CL was diagnosed, anti-TNF therapy was discontinued and liposomal amphotericin B was administered, resulting in a complete healing of lesions, no Leishmania DNA detection in blood, and an important serological decrease in antibodies. The lack of data on the supposed epidemiological association between leishmaniasis and immunosuppressive therapy highlights the importance of implementing surveillance systems in endemic areas. No obvious relationship was found based on the data provided by the Balearic Islands Epidemiological System, in contrast with data reported in nearby endemic areas. This indicates that if the suspected association is to be clarified, greater efforts are needed to report information about concomitant diseases and therapies in leishmaniasis patients.

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Visceral leishmaniasis, a neglected tropical disease, is the third most common opportunistic disease in immunosuppressed patients, such as those affected by the human immunodeficiency virus (HIV)/acquired immune deficiency syndrome. Although the reports have been characterized as Leishmania/HIV coinfections, the occurrence of a mixed infection by two Leishmania species in HIV-positive patients is rare. Here, we present an atypical case of disseminated cutaneous leishmaniasis (DCL) in a 26-year-old HIV-positive man. The diagnosis of DCL was established using skin biopsy and histopathology examinations and confirmed by molecular techniques. This is the first case of a Leishmania/HIV coinfection due to a mixed infection of Leishmania infantum/Leishmania major in Iran.

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BACKGROUND: Microscopic and clinical classifications of cutaneous leishmania have been set in the 1980s. Since then, they have been used invariably. Lebanon, a nonendemic country, is suffering from a leishmaniasis epidemic because of the massive population influx from endemic Syria. DESIGN: Patients diagnosed and speciated with leishmania (n = 169) using molecular and microscopic analysis were studied. General demographic data, microscopic data [Ridley's pattern (RP), microscopic pattern, Parasitic Index (PI)] and clinical stage were documented. Clinical score was scored as: 1: inflammatory; 2: proliferative/reorganization; 3: healed phases. The three patterns were studied in comparison to the lesion age and PI. RESULTS: At low PI, the clinical score and microscopic pattern showed healing scores (scores 3 and 4, respectively). In contrast, RP showed variable distribution at low PI. The same pattern is noted when correlating the different patterns with high PI. In comparison to lesion age, none of the three patterns showed the predicted linear correlation with lesion progression. CONCLUSION: In the studied population, the previously adopted classifications did not correlate with the disease progression. Such findings may raise the possibility of evolving disease. The proposed clinical and microscopic patterns showed better correlation with the disease progression.

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Leishmania parasites isolated, between 1979 and 1988 by the late Bryce Walton, from Dominican Republic (DR) patients with diffuse cutaneous leishmaniasis, were characterized using a panel of 12 isoenzymes, 23 monoclonal antibodies, small subunit ribosomal DNA (SSu rDNA), and multilocus sequence analysis (MLSA). The isoenzyme and monoclonal antibody profiles and the MLSA results showed that the Dominican Republic parasites were distinct from other described Leishmania species. This new species belongs to the mexicana complex, which is distributed in central and parts of northern South America. It is suggested that the parasites uniqueness from other members of the mexicana complex is related to it being isolated on an island for millions of years. If Leishmania (Leishmania) waltoni fails to adapt to some imported mammal, such as the house rat, it will be the only Leishmania to be classified as an endangered species. The excessive destruction of habitats on Hispaniola threatens the survival of its vectors and presumed natural reservoirs, such as the rodent hutias and the small insectivorous mammal solenodon. The concept of Leishmania species is discussed in the light of recent evaluations on criteria for defining bacterial species.

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Leishmaniasis is a parasitic infection endemic to more than 90 countries worldwide. As travel to endemic areas increases, dermatologists need to keep this entity in the differential for any chronic skin lesion in persons who may have had a possible exposure for any duration. It can be difficult to diagnose because manifestations are varied and sometimes subclinical. This article discusses the current state of epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment options. A special focus is placed on cutaneous manifestations and their treatment.

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Introdução: A Leishmaniose Tegumentar é uma doença endêmica no Brasil.Sua transmissão depende de características específicas, como: vetores estritamente limitados a certos fatores ambientais, diversidade de agentes e reservatórios. Apresenta padrões de transmissão urbano e rural, relacionados ao tipo de trabalho,deslocamentos para áreas endêmicas e tipo de moradia dos indivíduos infectados, o que torna necessário o conhecimento do território e ao fluxo de pessoas nas áreas onde a doença se insere para ações de vigilância. Objetivo: Estudar a relação damobilidade espacial de pessoas e a distribuição espaço temporal da leishmaniose tegumentar, na Amazônia Legal, no período de 2007 a 2009, considerando os fluxos no território a partir do município de residência para o município provável de infecção e os processos de produção e trabalho ocorridos na região a partir de décadade 1990. Material e Método: estudo epidemiológico descritivo voltado para oentendimento da relação entre a mobilidade espacial e a distribuição de casos da LT na Região da Amazônia Legal, identificando áreas de relevância epidemiológica, considerando os fluxos no território a partir do município de residência para o município provável de infecção. Assim como as transformações ocorridas na Amazônia Legal, principalmente no processo de trabalho, que contribuíram para o processo de produção e reprodução da LT nesta área. Resultados: Foram identificados 09 circuitos, formados por 15,01 por cento dos municípios da região, 15182casos (39,71 por cento), detecção média 46,14 casos/100.000 hab. e densidade média 4,40 casos/km2. Coincidindo com as regiões dos circuitos quando analisados por município de residência, porém com redução do quantitativo de municípios envolvidos. Quanto aos fluxos, 5891 casos (11,69 por cento) apresentam município deresidência diferente do município de infecção. Sendo identificados inúmeros fluxos com baixa média de casos. Estes fluxos ocorreram, geralmente entre municípios próximos. Os fluxos de entrada e saída do pólo de relevância epidemiológica (Paragominas) foram associados ao tipo de economia da região (mineração), que serve como atrativo para chegada de trabalhadores e a saída destes indivíduos devidoàs precárias condições de estrutura urbana ainda presentes no município. Conclusão: A análise de dados utilizando município de infecção e fluxos de pessoas permitem perceber a diferença dos pólos de relevância epidemiológica, quando utilizado diferentes critérios. Atualmente utiliza-se somente o município de residência. Esteassociado aos demais critérios, permite o aperfeiçoamento das ações de vigilância, identificação de padrões de transmissão, novas áreas de relevância epidemiológica, principalmente os relacionados aos processos de trabalho, viabilizando a melhoria do controle da endemia.

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A leishmaniose tegumentar americana (LTA) é uma doença infecciosa, não contagiosa, causada por um protozoário do gênero Leishmania, que acomete pele e mucosas; é, primariamente, uma infecção zoonótica afetando outros animais que não o ser humano, o qual pode ser envolvido, secundariamente (BRASIL, 2007). Segundo a Organização Mundial de Saúde existem mais de 12 milhões de doentes de LTA no mundo, no Brasil em torno de 1,2 milhões. É uma das seis doenças infecciosas mais importantes, pela sua alta incidência e potencial capacidade de produzir deformidades. O presente trabalho refere-se a um estudo descritivo retrospectivo que teve como objetivo caracterizar o perfil epidemiológico da leishmaniose tegumentar americana no município de Rio Branco-Acre, no período de 2000 a 2008. Foram analisados 2671 casos de LTA autóctones, notificados no município de Rio Branco. Os dados foram obtidos através do Sistema Nacional de Agravos de Notificação - SINAN. As variáveis e indicadores analisados foram: coeficiente de detecção, distribuição da doença segundo os meses do ano, unidade notificadora, tipo de entrada no sistema, métodos de diagnósticos, formas clínicas, sexo, faixa etária, escolaridade, ocupação e possível local de infecção.

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Las leishmaniasis son enfermedades causadas por protozoos del género Leishmania. España es uno de los países en los que la leishmaniasis es endémica. Los casos adquiridos en nuestro país (tanto cutáneos como viscerales) se deben a Leishmania infantum, pero puede haber otros causados por otras especies en viajeros o inmigrantes. Las lesiones cutáneas aparecen fundamentalmente en áreas expuestas y tienden a la curación espontánea dejando cicatriz. El diagnóstico es difícil por la inespecificidad de la clínica y el lento crecimiento del parásito en cultivo. Existen distintas opciones terapéuticas, por lo que cada caso debe ser valorado individualmente según las características de la lesión, la especie causante y el potencial de afectación mucosa. En nuestro país, la primera línea de tratamiento está constituida por los antimoniales pentavalentes intralesionales. En casos refractarios o con riesgo de diseminación mucosa debe emplearse un tratamiento sistémico (AU)

Leishmaniasis are a group of diseases caused by protozoa of the genus Leishmania. Spainis one of the countries where leishmaniasis is endemic. All cases acquired in our country(both cutaneous and visceral) are caused by Leishmania infantum, although cases due to other species may appear in travelers or immigrants. Cutaneous lesions appear mainly in exposed areas and tend to heal spontaneously leaving scars. Diagnosis is often difficult due to the non-specific clinical manifestations and the slow growth of the parasite when cultured. There are different available treatment options and each case should be individually considered,taking into account the characteristics of the lesion, the species of Leishmania and the potential for mucosal spread. In Spain, intralesional pentavalent antimonials are the first-line therapeutic option. In those cases at risk for mucosal dissemination or refractory to local therapy,systemic treatment must be given (AU)

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To determine whether disease outcomes and clades of Leishmania braziliensis genotypes are associated, we studied geographic clustering of clades and most severe disease outcomes for leishmaniasis during 1999-2003 in Corte de Pedra in northeastern Brazil. Highly significant differences were observed in distribution of mucosal leishmaniasis versus disseminated leishmaniasis (DL) (p<0.0001). Concordance was observed between distribution of these disease forms and clades of L. braziliensis genotypes shown to be associated with these disease forms. We also detected spread of DL over this region and an inverse correlation between frequency of recent DL diagnoses and distance to a previous DL case. These findings indicate that leishmaniasis outcomes are distributed differently within transmission foci and show that DL is rapidly spreading in northeastern Brazil.

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Leishmaniasis is a protozoan infection rarely reported in Australia. However, with the advent of increased international tourism and migration of refugees from endemic regions, leishmaniasis has emerged as an increasingly imported infection. We report 20 cases (17 cutaneous, 2 visceral, and 1 post-kala-azar dermal leishmaniasis). These data highlight the range of species causing leishmaniasis imported in Australia and demonstrate the importance of species identification in determining proper treatment.

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BACKGROUND: American tegumentary leishmaniasis (ATL) caused by Leishmania (Viannia) braziliensis is endemic in Rio de Janeiro State (RJ), where the disease shows epidemiologic and clinical characteristics distinct from those of ATL in other Brazilian regions. Paraty is the second most important endemic area in RJ; however, reports on leishmaniasis in this region refer to the occurrence of the disease without describing its characteristics. METHODS: The clinical features of 71 cases of ATL reported between 1991 and 1997 in Paraty are presented. Thirty patients were re-evaluated 10 years later. RESULTS: Males and females were affected in similar proportions, and the disease was more prevalent in patients aged between 10 and 49 years (63.4%). Cutaneous leishmaniasis was the most prevalent clinical form observed. Unique lesions were present in 69% of cases, 91.6% of which displayed an ulcerated aspect. Although mucosal leishmaniasis was not observed, severe clinical manifestations, such as disseminated cutaneous lesions caused by L. braziliensis, were diagnosed in two patients. These patients presented skin lesions with different clinical aspects spread throughout the body, as well as low cellular immune responses. Montenegro skin test (92% positivity) and serology (8% IgM and 56% IgG anti-Leishmania positive results) were the most utilized tests for supporting the diagnosis of leishmaniasis. Parasites, detected in 27 of the 33 cases analyzed, were characterized as L. braziliensis. CONCLUSION: ATL in Paraty shares the clinical and laboratory characteristics reported for ATL in other regions of RJ, probably because of the similar epidemiologic context related to the Atlantic rainforest region.

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São apresentadas neste artigo a distribuição da leishmaniose tegumentar (LT) e descrição das populações de flebotomíneos em Acrelândia, Acre. Os dados epidemiológicos foram obtidos a partir de fichas de notificação de casos ocorridos entre 2001 e 2004, e os dados entomológicos são provenientes de capturas com armadilhas luminosas efetuadas entre 2004 e 2005 na zona rural de Acrelândia. Ocorreram 82 novos casos de LT, com idade entre 2 e 69 anos, sendo 75,6 por cento em homens e 83,9 por cento na zona rural. Predominou a LT com lesões únicas (78 por cento). A microscopia direta da lesão, intradermorreação de Montenegro e biópsia apresentaram positividade de 100 por cento, 98 por cento e 79,5 por cento, respectivamente. A resposta ao tratamento farmacológico foi bem sucedida em 71,6 por cento dos casos; a falência terapêutica foi maior em pacientes com diagnóstico exclusivamente clínico (41,2 por cento) e nos que receberam dose diária inadequada de antimonial pentavalente (64,3 por cento). Foram coletados 40 espécimes de flebotomíneos em propriedades rurais com casos de LT (3 gêneros, 14 espécies), sendo 3 espécies conhecidas como vetoras ou possíveis vetoras de Leishmania: Nyssomyia antunesi predominou no peridomicílio (59,1 por cento) e em margens de matas; Nyssomyia whitmani foi freqüente no peridomicílio (15 por cento) e a única espécie encontrada no intradomicílio, e Trichophoromyia ubiquitalis foi capturada no peridomicílio. O uso de dados epidemiológicos existentes no serviço de saúde de Acrelândia, embora com várias limitações, permitiu avaliar a eficácia do diagnóstico e o tratamento empregados no município, enquanto os dados entomológicos coletados podem orientar estudos mais amplos visando identificar os vetores e espécies circulantes na região.

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Diffuse cutaneous leishmaniasis (DCL) is characterised by multiple and progressive cutaneous lesions, resistance to chemotherapy and Leishmania-specific T-cell anergy. We report the first autochthonous DCL case and the first human infection with Leishmania amazonensis in Rio de Janeiro State, Brazil, where only L. braziliensis is considered to be the causative agent of cutaneous leishmaniasis. Leishmania amazonensis was identified by multilocus enzyme electrophoresis and PCR-RFLP. Our case was diagnosed as DCL according to clinical, parasitological, histopathological and immunological criteria. These observations indicate that L. amazonensis is increasing its geographical distribution in Brazil, accounting for unusual clinical presentations in new transmission areas.

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Em algumas áreas endêmicas de leishmaniose tegumentar(LT) causada por Leishmania (Viannia) braziliensis existem evidências de transmissão domiciliar, e de que cães infectados estariam associados a casos humanos de LT. Neste trabalho, são apresentados os resultados de um estudo realizado na Serra de Baturité, no Ceará, em 1993, quando foram investigadas as evidências de transmissão domiciliar e a associação entre LT humana e infecção canina. Casos humanos de LT foram indivíduos que apresentavam úlceras de bordas elevadas, arredondadas, de diâmetro > 5 mm, duração > 15 dias e uma Reação de Montenegro positiva. Cães soropositivos foram aqueles que apresentavam uma prova de imunofluorescência indireta positiva. A idade foi dividida em dois estratos, de 1 a 10 e 11 a 89 anos. A incidência de LT não estava associada ao sexo (Razão de Incidência (RI) = 1,21; IC 95 por cento: 0,86 - 1,72) e nem à idade (RI = 1,38; IC 95 por cento: 0,97 - 1,96). Para os indivíduos que conviviam com um ou mais cães soropositivos, a incidência de LT humana foi 45 por cento mais elevada (RI = 1,45; IC 95 por cento: 1,02 - 2,06) depois de ajustar para o sexo, e 48 por cento (RI = 1,48 por cento; IC 95 por cento: 1,04 - 2,10) depois de ajustar para idade. Considerando-se o risco domiciliar, a incidência de LT humana foi duas vezes mais elevada (RI = 2,01; IC 95 por cento:1,32 - 3,06) nos domicílios que possuíam um ou mais cães soropositivos. Conclui-se que os indivíduos foram acometidos de LT independente do sexo e da idade e que os casos humanos estavam associados à presença de cães infectados. Portanto, estes resultados suportam a hipótese de transmissão domiciliar da leishmaniose tegumentar na Serra de Baturité, no Ceará.

There is evidence of domestic transmission and infected dogs associated with human cases in some endemic areas for American Cutaneous Leishmaniasis (ACL), associated with Leishmania (Viannia) braziliensis. This paper presents the results of a study conducted in Serra de Baturité, State of Ceará, Brazil, aimed to gather evidence on the domestic transmission of cutaneous leishmaniais and the association between human and canine infection. Human cases of cutaneous leishmaniasis were defined as those with > 5 mm diameter round ulcers and raised borders, lasting at least 15 days and displaying a positive Montenegro skin test. Seropositive dogs were those with a positive indirect immunofluorescence assay. Age was classified into two strata, 1 to 10, and 11 to 89 years. The incidence of ACL was associated neither with gender (Incidence Rate (IR) = 1.21; 95 percent CI: 0.86-1.72), nor with age (IR=1.38; 95 percent CI: 0.97-1.96). The incidence of human ACL was 45 percent higher for those individuals living with seropositive dogs, (IR=1.45; 95 percent CI: 1.02-2.06), after adjustment for gender, and 48 percent higher (RI=1.45; 95 percent CI: 1.02-2.06), adjusting for age. Regarding the domestic risk, the incidence of human ACL was two-fold higher (IR=2.01; 95 percent CI: 1.32-3.06) in those households with one or more seropositive dogs. Humans were infected with L. (V) braziliensis regardless of gender and age, and infected dogs were associated with human ACL. Therefore, these results support the hypothesis of domestic/peridomestic transmission of L. (V) braziliensis.

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A Vila de Pitinga, Presidente Figueiredo/AM, é uma área de exploração de minérios e endêmica para leishmaniose tegumentar americana (LTA). A vila é a sede administrativa e local de moradia de seus funcionários. O comportamento epidemiológico da endemia, avaliado para o período de 2000 a 2004, foi relacionado com as medidas de controle adotadas para reduzir a incidência da doença na área e comparado com o registrado para o município e o Estado do Amazonas. A maior proporção dos casos detectados no período ocorreu no gênero masculino, com atividades laborais de contato com a floresta. O declínio na incidência de casos de LTA na área do estudo, não foi observado como ocorrido no Município e Estado e foi considerado resultante das medidas de controle para a doença, aplicadas na área.

The village of Pitinga, Presidente Figueiredo, AM, is a mining area and endemic for American Cutaneous Leishmaniasis (ACL). The village is the administrative office of the mine and where mining workers live. This study presents the profile of ACL in the 2000-2004 period. The highest prevalence of ACL occurs in male individuals with forest-related activities. The reduction in the number of ACL cases in the study area was not observed in the municipality and the state, a fact probably related to the disease control measures put into practice in the area.

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Natural infection with Leishmania spp. in phlebotomine sandflies was searched for during a longitudinal study carried out from July 1997 to July 1998 in the village Catarnica, Municipality Independencia, Táchira State. This hamlet is an old endemic focus of cutaneous leishmaniasis in the Venezuelan Andean region, which lies close to the Colombian border at 1,300 m a.s.l., in an agricultural area mainly used for cultivating coffee. Phlebotomine sandflies were collected using Shannon traps placed in the peridomestic habitat from 19:00 to 21:00 hs. Males were stored in alcohol 70 % while females were kept in Nunc vials with 10 % DMSO and cryopreserved in liquid nitrogen for subsequent dissection and identification. The most abundant anthropophilic species was Lutzomyia spinicrassa with 3,032 males and 4,290 females (85.4%). Among 1,633 (38%) females of Lu. spinicrassa dissected, 26 11.6%) were infected with promastigotes, while no natural infection was found in 209 females of other species. The flagellates were identified as Leishmania braziliensis braziliensis using PCR with species specific primers derived from nuclear DNA and hybridization using species specific probe labelled with digoxigenin. This parasite had been previously isolated from patients with cutaneous leishmaniasis from the same area. These results show Lu. spinicrassa as a new proven vector of Leishmania braziliensis in the Andean region of Venezuela.

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During the past decade, there has been an increase in the number of patients with disseminated leishmaniasis (DL), which is characterized by a large number of acneiform and papular skin lesions, with very few or no parasites in the skin tissue. The present report describes 42 cases of DL identified between 1992 and 1998 in an area where Leishmania braziliensis transmission is endemic; 8 of the patients were prospectively diagnosed. In a contrast to localized cutaneous leishmaniasis (LCL), acquisition of DL was associated with age >19 years (P<.05), male sex (P<.05), and agricultural occupation (P<.001). Patients with DL presented with 10-300 lesions that were a mixture of acneiform, papular, nodular, and ulcerated types. Twelve (29%) of 42 patients had mucosal involvement. Patients with DL had lower levels of interferon-gamma (P<.05) and tumor necrosis factor-alpha (P<.05) production, compared with patients with LCL. DL is an emerging clinical distinct form of leishmaniasis associated with agricultural activities and host immunological response.

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The province of Misiones reported 205 leishmaniasis cases during 1998, 98% of them from the locality of Puerto Esperanza. The reports of Puerto Esperanza Hospital (January to September 1998) for leishmaniasis were analysed (n: 129). The mainly reported lesion was the single cutaneous ulcer (97.2%), localized in the inferior limbs (72.5%), without any mucosa involvement. The results are consistent with the knowledge from other Argentinean leishmaniasis foci due to Leishmania (V.) braziliensis. The difference in incidence among sexes was not significant, leishmaniasis was reported in all age groups, and it was susceptible to the conventional treatment. The main focus was located in Km 1 neighbourhood, the transmission peak was during April 1998. The Montenegro skin test among general population (n: 205) did not show reactivity among asymptomatic people. The prevalent Phlebotominae species were Lutzomyia intermedia (79.7%) and Lu. whitmani (10.9%), among the 577 individuals belonging to 8 species collected. The Phlebotominae were abundant in peridomestic habitats of Km 1 neighbourhood, close to human dwellings, in places associated with residual primary forest and secondary vegetation. The results are discussed in the frame of surveillance and possible control strategies.

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La provincia de Misiones en 1998 notificó 205 casos de leishmaniosis, 98% de los cuales residían en la localidad de Puerto Esperanza. El análisis de las fichas clínicas (n:129) de los casos atendidos en Hospital de Puerto Esperanza (enero a septiembre 1998) mostró una mayor proporción de lesión cutánea simple (97.2%), localizada en miembros inferiores (72.5%), sin casos de lesión mucosa. Los resultados fueron coherentes con los de la literatura de otros focos epidémicos en Argentina debidos a Leishmania (V.) braziliensis. No hubo diferencia significativa de incidencia entre sexos, se registró en todos los grupos etarios, y fue susceptible al tratamiento convencional. El foco principal se registró en el Barrio Km 1 con un máximo de transmisión en abril de 1998. La intradermoreacción de Montenegro en población general (n: 205) no mostró reactividad en asintomáticos. Se capturaron 577 Phlebotominae pertenecientes a 8 especies, las más abundantes fueron Lutzomyia intermedia (79.7%) y Lu. whitmani (10.9%), presentes en peridomicilios de Km 1 asociados a selva paranaense residual y vegetación secundaria. Los resultados se discuten en el marco de estrategias posibles de vigilancia y control

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