RESUMEN

Pregnant rats were treated orally with aluminum lactate (400 mg Al/kg/day) during three periods of gestation to determine the treatment's influence on mortality, weight gain, neuromotor maturation, and learning abilities of their pups. No effect of treatment on litter size, mortality rate, and weight gain of pups was detected. In the negative geotaxis test, the scores of pups from females treated during the second and third weeks of gestation were diminished. In the locomotor coordination and the operant conditioning tests, significant differences in the comparison of controls vs. the three treated groups were found, indicating long-term effects of early intoxication upon the central nervous system.

Asunto(s)

Condicionamiento Operante/efectos de los fármacos , Feto/efectos de los fármacos , Lactatos/envenenamiento , Actividad Motora/efectos de los fármacos , Animales , Condicionamiento Operante/fisiología , Femenino , Ácido Láctico , Tamaño de la Camada/efectos de los fármacos , Intercambio Materno-Fetal , Mortalidad , Embarazo , Ratas , Ratas Endogámicas , Aumento de Peso/efectos de los fármacos

Asunto(s)

Lactatos/envenenamiento , Enfermedad Aguda , Adulto , Humanos , Ictericia/inducido químicamente , Masculino , Persona de Mediana Edad