RESUMEN
Forty five cases of chronic pancreatitis have been diagnosed between January 1966 to July 1983 in the Hospital A. Posadas. The diagnosis was confirmed by the presence of one or more of the following data: pancreatic calcifications positive in 35, abnormal secretin test 37, ultrasonography and computed tomography pathological findings 10. Surgical operations were carried out in 25 patients and biopsy taken in 5. Thirty nine (86.6%) were males, 6 (13.3%) females, the mean age in each group was 47.4 and 39.8 years. Chronic alcoholism was certain in 41 (91.9) patients, in the remainder 4 no other etiologic factors were found. The main clinical data were: Weight loss 38 (84.4%) diabetes 34 (75.5%) pain 33 (73.3% in 7 as acute pancreatitis) Steatorrhea 23 (51.1%) jaundice 16 (35.5%- 11 by extrahepatic biliary tree obstruction, 5 by hepatic cirrhosis) pseudocysts 12 (26.6%). The more common associated diseases were: hepatic cirrhosis 6, fatty liver 2 (17.7%) gastroduodenal ulcer 6 (13.3%) cancer 4 (8.8%--gastric 1, pancreatic 3). In order to study the frequency of the clinical data the patients were grouped according to the presence or absence of calcifications and the etiologic factor Symptoms and signs were matched and statistic analysis (coefficient association phi) was made. Only a moderate association between acute pancreatitis in no calcified group and diabetes in calcified group were found. The chronologic study of certains clinical data shows that acute pancreatitis, jaundice, pseudo-cyst and surgical operations were significative more frequent in the first five years while diabetes has little more frequency in the second five year period. Twenty six surgical operations were carried out in 25 patients; 20 (76.9%) due to complications, 6 (23.1%) secondary to pain (pancreatic resection 3, pancreatoyeyunostomy 2, exploration 1). Twenty three patients were lost to follow-up, 12 died and 10 are still alive. This last group was followed at regular period, 8 remained asymptomatic and 2 have intermittent abdominal pain related to alcoholic ingestion.
Asunto(s)
Calcinosis/diagnóstico , Pancreatitis/diagnóstico , Consumo de Bebidas Alcohólicas , Alcoholismo/complicaciones , Enfermedad Crónica , Femenino , Humanos , Lactoferrina/análisis , Masculino , Jugo Pancreático/análisis , Pancreatitis/etiología , Secretina/sangre , Factores Sexuales , Tomografía Computarizada por Rayos X , UltrasonografíaRESUMEN
A 5 1/2-year-old boy is reported with congenital lipase deficiency and the presence of colipase. He presented with greasy-oily stools since infancy, but growth and development have been normal. No other cause for exocrine pancreatic insufficiency could be found. Intraluminal (jejunal) fat digestion was defective, but some hydrolytic products of dietary long-chain triglyceride were present. The di- and monoglycerides were probably generated by pregastric lipases, although this was not measured directly. Amylase activity was depressed to some extent, a finding which could not be explained. Our studies do not clarify the issue of whether or not the absence of pancreatic lipase is explained as an inherited defect of lipase synthesis, or if it was acquired in utero or in the early postnatal period.
Asunto(s)
Lipasa/deficiencia , Enfermedades Pancreáticas/congénito , Amilasas/inmunología , Niño , Colipasas/sangre , Diagnóstico Diferencial , Grasas de la Dieta/metabolismo , Humanos , Inmunodifusión , Lipasa/inmunología , Errores Innatos del Metabolismo Lipídico/sangre , Masculino , Enfermedades Pancreáticas/sangre , Pruebas de Función Pancreática , Jugo Pancreático/análisisAsunto(s)
Fibrosis Quística/diagnóstico , Adulto , Niño , Fibrosis Quística/genética , Fibrosis Quística/metabolismo , Duodeno/análisis , Femenino , Financiación Gubernamental , Organización de la Financiación , Asesoramiento Genético , Humanos , Recién Nacido , Métodos , Mucinas/metabolismo , Membrana Mucosa/metabolismo , Páncreas/metabolismo , Jugo Pancreático/análisis , Embarazo , Diagnóstico Prenatal , Proteínas/metabolismo , Investigación , Cloruro de Sodio/análisis , Sudor/análisis , Glándulas Sudoríparas/metabolismo , Estados UnidosAsunto(s)
Alcoholismo/complicaciones , Calcinosis/complicaciones , Pancreatitis/etiología , Corticoesteroides/efectos adversos , Corticoesteroides/uso terapéutico , Adulto , Animales , Calcinosis/epidemiología , Calcinosis/patología , Enfermedad Crónica , Perros , Etanol , Europa (Continente) , Humanos , India , Japón , Persona de Mediana Edad , Jugo Pancreático/análisis , Pancreatitis/inducido químicamente , Pancreatitis/epidemiología , Pancreatitis/patología , Proteínas/análisis , Ratas , Sudáfrica , América del SurAsunto(s)
Ácido Etacrínico/farmacología , Furosemida/farmacología , Ouabaína/farmacología , Páncreas/metabolismo , Jugo Pancreático/metabolismo , Sodio/metabolismo , Adenosina Trifosfatasas/antagonistas & inhibidores , Animales , Perros , Femenino , Masculino , Páncreas/efectos de los fármacos , Jugo Pancreático/análisis , Potasio/análisis , Sodio/análisisAsunto(s)
Trastornos de la Nutrición del Lactante/enzimología , Páncreas/fisiopatología , Jugo Pancreático/análisis , Amilasas/metabolismo , Bicarbonatos/metabolismo , Colecistoquinina/metabolismo , Colecistoquinina/farmacología , Dietoterapia , Humanos , Lactante , Trastornos de la Nutrición del Lactante/fisiopatología , Trastornos de la Nutrición del Lactante/terapia , Lipasa/metabolismo , Páncreas/enzimologíaAsunto(s)
Páncreas/fisiología , Adolescente , Factores de Edad , Amilasas/análisis , Bicarbonatos/análisis , Peso Corporal , Niño , Preescolar , Colecistoquinina , Fibrosis Quística/fisiopatología , Duodeno , Glándulas Exocrinas , Humanos , Lactante , Intubación Gastrointestinal , Páncreas/metabolismo , Enfermedades Pancreáticas/fisiopatología , Jugo Pancreático/análisis , Secretina , Agua/análisisAsunto(s)
Anemia Aplásica , Jugo Pancreático/análisis , Tripsina/análisis , Adolescente , Niño , Femenino , Humanos , Lactante , MasculinoRESUMEN
A brief note is presented on the present state of knowledge regarding the mechanisms controlling pancreatic secretion. The parasympathetic nervous system and the harmone pancreozymin are described as having an ecbolic influence upon the pancreas. The hormone secretin has a hydrokinetic influence on the pancreas (AU)