RESUMEN
BACKGROUND: Many therapies involving varying degrees of complexity have been used to treat acne scars, but none is considered the gold standard treatment. OBJECTIVE: A comparative evaluation of 88% phenol and 90% trichloroacetic acid (TCA) applied using the chemical reconstruction of skin scars (CROSS) technique. MATERIALS AND METHODS: A nonrandomized, single-blinded self-controlled clinical trial was conducted among patients with ice pick-type and boxcar-type atrophic acne scars. Using 88% phenol on the left hemiface and 90% TCA on the right hemiface was adopted as the standard practice of the CROSS technique. The dermatological quality of life index (DLQI) questionnaire, acne scar grading scale Échelle d´Evaluation Clinique des Cicatrices d'Acne (ECCA), and evaluation of improvement were performed pretreatment and post-treatment. RESULTS: Regarding ECCA, significant differences were found in pretreatment and post-treatment (p < .001). Regarding tolerance to pain, it was found that the discomfort felt with 90% TCA was significantly less than that felt with 88% phenol (p = .020). Regarding the quality of life measured with the DLQI, the results showed that the mean score in post-treatment assessment was significantly lower than that in the pretreatment assessment (p < .05). Hypochromia and enlargement scar were only seen after the use of 90% TCA. CONCLUSION: This study confirmed the efficacy of both TCA and phenol for treating such scars, with less severe complications from the use of phenol.
Asunto(s)
Acné Vulgar/complicaciones , Cáusticos/uso terapéutico , Cicatriz/tratamiento farmacológico , Hidroxibenzoatos/uso terapéutico , Ácido Tricloroacético/uso terapéutico , Adolescente , Adulto , Atrofia , Cáusticos/efectos adversos , Cicatriz/etiología , Cicatriz/patología , Cicatriz Hipertrófica/inducido químicamente , Femenino , Humanos , Hidroxibenzoatos/efectos adversos , Hipopigmentación/inducido químicamente , Masculino , Persona de Mediana Edad , Neoplasias Primarias Secundarias , Dolor/inducido químicamente , Calidad de Vida , Índice de Severidad de la Enfermedad , Método Simple Ciego , Ácido Tricloroacético/efectos adversos , Adulto JovenRESUMEN
ETHNOPHARMACOLOGICAL RELEVANCE: Chlorogenic acid (CA) is one of the major ingredients in Honeysuckle which exhibits anticancer, antibacterial, antiviral, hypoglycemic and anti-HIV activities. However, with the frequent emergence of anaphylactoid reactions of traditional Chinese medicine (TCM) injections which contains Honeysuckle in recent years, many researchers found that CA exhibited allergenicity. AIM OF THE STUDY: To explore the changes of content of CA, neochlorogenic acid (NCA) and cryptochlorogenic acid (CCA) during the preparation of Honeysuckle and evaluate the anaphylactoid of these three ingredients. MATERIALS AND METHODS: Two extracts of Honeysuckle were prepared by different methods and the content of CA, NCA and CCA were determined by high performance liquid chromatography (HPLC) analysis. Guinea pig and mast cells RBL-2H3 were utilized as the animal and cell model to investigate the anaphylactoid of these three ingredients. RESULTS: The content of CA decreased while CCA and NCA increased during the preparation of Honeysuckle. In vitro and in vivo studies showed that CA and CCA could significantly increase the plasma serotonin and ß-hexosaminidase levels in guinea pigs and induce the degranulation of RBL-2H3 cell, while NCA did not show such properties. In addition, CAA had a stronger effect than CA. CONCLUSION: We believed that both CA and CCA could cause anaphylactoid reaction while NCA could not. Moreover, the anaphylactoid of CCA is higher than CA. Our result demonstrated that CA is not the only cause of anaphylactoid reactions of TCM injections which contains Honeysuckle.
Asunto(s)
Anafilaxia/etiología , Ácido Clorogénico/efectos adversos , Hidroxibenzoatos/efectos adversos , Lonicera/química , Anafilaxia/inmunología , Animales , Línea Celular , Ácido Clorogénico/inmunología , Ácido Clorogénico/aislamiento & purificación , Cromatografía Líquida de Alta Presión , Cobayas , Hidroxibenzoatos/inmunología , Hidroxibenzoatos/aislamiento & purificación , Masculino , Mastocitos/efectos de los fármacos , Mastocitos/inmunología , Medicina Tradicional China/efectos adversos , RatasRESUMEN
Bleeding is the most common and serious adverse effect of currently available antiplatelet drugs. Many efforts are being made to develop novel antithrombotic agents without bleeding risks. Shear stress-induced platelet aggregation (SIPA), which occurs under abnormally high shear stress, plays a crucial role in the development of arterial thrombotic diseases. Here, we demonstrate that protocatechuic acid (PCA), a bioactive phytochemical from Lonicera (honeysuckle) flowers, selectively and potently inhibits high shear (>10,000 s(-1))-induced platelet aggregation. In isolated human platelets, PCA decreased SIPA and attenuated accompanying platelet activation, including intracellular calcium mobilization, granule secretion, and adhesion receptor expression. The anti-SIPA effect of PCA was mediated through blockade of von Willebrand factor binding to activated glycoprotein Ib, a primary and initial event for the accomplishment of SIPA. Conspicuously, PCA did not inhibit platelet aggregation induced by other endogenous agonists like collagen, thrombin, or ADP that are important in both pathological thrombosis and normal hemostasis. Antithrombotic effects of PCA were confirmed in vivo in a rat arterial thrombosis model, where PCA significantly delayed the arterial occlusion induced by FeCl(3). Of particular note, PCA did not increase bleeding times in a rat tail transection model, whereas conventional antiplatelet drugs, aspirin, and clopidogrel substantially prolonged it. Collectively, these results suggest that PCA may be a novel antiplatelet agent that can prevent thrombosis without increasing bleeding risks.
Asunto(s)
Plaquetas/efectos de los fármacos , Hidroxibenzoatos/farmacología , Inhibidores de Agregación Plaquetaria/farmacología , Agregación Plaquetaria/efectos de los fármacos , Adolescente , Adulto , Animales , Plaquetas/citología , Células Cultivadas , Modelos Animales de Enfermedad , Relación Dosis-Respuesta a Droga , Flores/química , Hemorragia/inducido químicamente , Humanos , Hidroxibenzoatos/efectos adversos , Hidroxibenzoatos/aislamiento & purificación , Hidroxibenzoatos/uso terapéutico , Lonicera/química , Masculino , Inhibidores de Agregación Plaquetaria/efectos adversos , Inhibidores de Agregación Plaquetaria/aislamiento & purificación , Inhibidores de Agregación Plaquetaria/uso terapéutico , Ratas , Ratas Sprague-Dawley , Estrés Mecánico , Trombosis/prevención & control , Adulto Joven , Factor de von Willebrand/metabolismoAsunto(s)
Cosméticos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Hidroxibenzoatos/efectos adversos , Administración Tópica , Cosméticos/química , Femenino , Humanos , Hidroxibenzoatos/química , Persona de Mediana Edad , Estructura Molecular , Pigmentación de la Piel/efectos de los fármacos , Pruebas CutáneasRESUMEN
We report the case of a middle-aged woman who developed a typical picture of acute pancreatitis together with systemic features of immunoallergy after the intake of two capsules (200 mg) of nifuroxazide. Even if acute pancreatitis is a rare adverse event of nitrofuran derivative therapy, nifuroxazide-induced pancreatitis as not been previously described. As suggested by associated systemic features, the disease is likely of immunoallergic origin.
Asunto(s)
Antiinfecciosos/efectos adversos , Hidroxibenzoatos/efectos adversos , Nitrofuranos/efectos adversos , Pancreatitis/inducido químicamente , Enfermedad Aguda , Erupciones por Medicamentos/etiología , Femenino , Humanos , Persona de Mediana EdadRESUMEN
Pulses supply many bioactive substances found in minor amounts in food, but which may have significant metabolic and/or physiological effects. These compounds have long been classified as antinutritional factors, but many studies have reconsidered their impact on health. Some could play a role in the prevention of the major diseases of affluent societies. As these compounds can be beneficial or adverse, depending on conditions, an assessment of their various physiological effects is necessary to determine whether they should be preserved or eliminated in each main nutritional situation.
Asunto(s)
Fabaceae/química , Isoflavonas , Alcaloides/administración & dosificación , Alcaloides/efectos adversos , Animales , Antineoplásicos/administración & dosificación , Antineoplásicos/efectos adversos , Glucemia/análisis , Calcio/metabolismo , Inhibidores Enzimáticos/administración & dosificación , Inhibidores Enzimáticos/efectos adversos , Estrógenos no Esteroides/administración & dosificación , Estrógenos no Esteroides/efectos adversos , Femenino , Flavonoides/administración & dosificación , Flavonoides/efectos adversos , Humanos , Hidroxibenzoatos/administración & dosificación , Hidroxibenzoatos/efectos adversos , Lectinas/administración & dosificación , Lectinas/efectos adversos , Oxalatos/administración & dosificación , Oxalatos/efectos adversos , Ácido Fítico/administración & dosificación , Ácido Fítico/efectos adversos , Fitoestrógenos , Fitohemaglutininas/administración & dosificación , Fitohemaglutininas/efectos adversos , Preparaciones de Plantas , Saponinas/administración & dosificación , Saponinas/efectos adversos , Taninos/administración & dosificación , Taninos/efectos adversosRESUMEN
Biocompatibility of mineral trioxide aggregate and ethoxybenzoic acid cement was investigated by subcutaneous and intraosseous implantation of the materials in rats. Tissue reactions were studied at 15, 30, and 60 days after implantation. Subcutaneous implantation of mineral trioxide aggregate initially elicited severe reactions with coagulation necrosis and dystrophic calcification; the reactions, however, subsided to mostly moderate with time. Subcutaneous implantation of ethoxybenzoic acid cement initially elicited mostly moderate reactions that subsided to mild in time. Osteogenesis was not observed with either material upon subcutaneous implantation indicating that neither material is osteoinductive. Reactions to intraosseous implants of both materials were less intense than with subcutaneous implantation. Osteogenesis occurred in association with intraosseous implants indicating that both materials are osteoconductive.
Asunto(s)
Reacción a Cuerpo Extraño/etiología , Hidroxibenzoatos/efectos adversos , Implantes Experimentales/efectos adversos , Ensayo de Materiales , Materiales de Obturación del Conducto Radicular/efectos adversos , Compuestos de Aluminio , Animales , Compuestos de Calcio , Procedimientos Quirúrgicos Dermatologicos , Combinación de Medicamentos , Reacción a Cuerpo Extraño/inmunología , Reacción a Cuerpo Extraño/patología , Éteres de Hidroxibenzoatos , Hidroxibenzoatos/administración & dosificación , Hidroxibenzoatos/inmunología , Inflamación/inmunología , Inflamación/patología , Masculino , Microscopía Fluorescente , Osteogénesis , Óxidos , Hueso Parietal/patología , Hueso Parietal/cirugía , Ratas , Ratas Sprague-Dawley , Silicatos , Piel/patologíaRESUMEN
A 48-year-old clerical officer with a recurrent facial eruption had positive patch test reactions to nickel, fragrance mix and lichen acid mix. On testing to individual ingredients of fragrance mix and lichen acid mix, she had 2+ reactions to oak moss, which is thought to be the main allergen in fragrance mix, and to usnic acid, which is one of a number of lichen acids comprising oak moss. Avoidance of fragrance use resulted in clearing of the eruption but, subsequently, an acute vesicular flare on her face and hands occurred after exposure to lichen on garden shrubs.
Asunto(s)
Alérgenos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Dermatosis Facial/etiología , Líquenes , Perfumes/efectos adversos , Benzofuranos/efectos adversos , Femenino , Humanos , Hidroxibenzoatos/efectos adversos , Persona de Mediana Edad , Pruebas del ParcheAsunto(s)
Agranulocitosis/inducido químicamente , Factor Estimulante de Colonias de Granulocitos/efectos adversos , Hidroxibenzoatos/efectos adversos , Reacción Leucemoide/inducido químicamente , Nitrofuranos/efectos adversos , Anciano , Complicaciones de la Diabetes , Diarrea/complicaciones , Diarrea/tratamiento farmacológico , Femenino , Factor Estimulante de Colonias de Granulocitos/uso terapéutico , Humanos , Hidroxibenzoatos/uso terapéutico , Nitrofuranos/uso terapéuticoRESUMEN
(1) Nifuroxazide, an intestinal antibacterial agent, is now available in France, without a prescription, for the treatment of acute diarrhoea in adults. (2) According to the only available comparative randomised trial, there is no effect on dehydration. Relative to a placebo, the mean number of stools is reduced by about one per day during the first two days of treatment, with no significant difference thereafter.
Asunto(s)
Antiinfecciosos , Diarrea/tratamiento farmacológico , Hidroxibenzoatos , Nitrofuranos , Enfermedad Aguda/terapia , Antiinfecciosos/efectos adversos , Antiinfecciosos/uso terapéutico , Antidiarreicos/efectos adversos , Antidiarreicos/uso terapéutico , Ensayos Clínicos como Asunto , Análisis Costo-Beneficio , Diarrea/etiología , Francia , Humanos , Hidroxibenzoatos/efectos adversos , Hidroxibenzoatos/uso terapéutico , Nitrofuranos/efectos adversos , Nitrofuranos/uso terapéutico , Medicamentos sin Prescripción/efectos adversos , Medicamentos sin Prescripción/uso terapéutico , Resultado del TratamientoAsunto(s)
Antiinfecciosos/efectos adversos , Dermatitis Alérgica por Contacto/etiología , Dermatitis Profesional/etiología , Hidroxibenzoatos/efectos adversos , Nitrofuranos/efectos adversos , Exposición Profesional/efectos adversos , Dermatitis Alérgica por Contacto/patología , Dermatitis Profesional/patología , Femenino , Humanos , Persona de Mediana Edad , Piel/efectos de los fármacos , Piel/patologíaAsunto(s)
Antiinfecciosos/efectos adversos , Exantema/inducido químicamente , Hidroxibenzoatos/efectos adversos , Nitrofuranos/efectos adversos , Enfermedad Aguda , Anciano , Eritema/inducido químicamente , Exantema/diagnóstico , Exantema/patología , Fiebre/inducido químicamente , Humanos , Masculino , Enfermedades Cutáneas Papuloescamosas/inducido químicamenteRESUMEN
Post mortem examinations of 8 infants, 11 d to 5 months old and one 12 year old girl, demonstrated foreign bodies in the lungs which could be identified as orally administered drugs: cholestyramine (Questran) and phenobarbital (Luminal, Gardenal) or phenydantin-components. The microscopic changes caused by such deposits and the histologic methods of identifying medicines are presented. The authors point to the role of aspiration in deposit formation and to the pseudomiliary granulomatous nature of subsequent changes. It is proposed to define the alterations as a separate form of aspiratory lesion in children.
Asunto(s)
Granuloma/inducido químicamente , Neumonía por Aspiración/inducido químicamente , Administración Oral , Aminopirina/efectos adversos , Niño , Resina de Colestiramina/efectos adversos , Femenino , Reacción a Cuerpo Extraño/patología , Granuloma/patología , Humanos , Hidroxibenzoatos/efectos adversos , Lactante , Recién Nacido , Pulmón/patología , Masculino , Nitrofuranos/efectos adversos , Fenobarbital/efectos adversos , Fenitoína/efectos adversos , Neumonía por Aspiración/patologíaRESUMEN
The allergenic potential of the aromatic lichen substance atranorin has been investigated by means of the guinea pig maximization test of Magnusson & Kligman. Sensitivity was induced in 30% of the animals, which corresponds to a moderate allergenic capacity (grade III). This is in agreement with the clinically-observed frequency of 1.5% among our patients. A modified photoallergy test on the same animals was performed, but irradiation did not increase the number of positive reactions. 4 patients with proven contact sensitivity to atranorin, evernic, usnic or physodic acid, were examined with different dilutions from 0.001 to 0.1%. Irradiation of the test series did not provoke any clear-cut photoallergic reaction.