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BACKGROUND: The implementation of clinical practice guidelines (CPGs) is a cyclical process in which the evaluation stage can facilitate continuous improvement. Implementation science has utilized theoretical approaches, such as models and frameworks, to understand and address this process. This article aims to provide a comprehensive overview of the models and frameworks used to assess the implementation of CPGs. METHODS: A systematic review was conducted following the Cochrane methodology, with adaptations to the "selection process" due to the unique nature of this review. The findings were reported following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) reporting guidelines. Electronic databases were searched from their inception until May 15, 2023. A predetermined strategy and manual searches were conducted to identify relevant documents from health institutions worldwide. Eligible studies presented models and frameworks for assessing the implementation of CPGs. Information on the characteristics of the documents, the context in which the models were used (specific objectives, level of use, type of health service, target group), and the characteristics of each model or framework (name, domain evaluated, and model limitations) were extracted. The domains of the models were analyzed according to the key constructs: strategies, context, outcomes, fidelity, adaptation, sustainability, process, and intervention. A subgroup analysis was performed grouping models and frameworks according to their levels of use (clinical, organizational, and policy) and type of health service (community, ambulatorial, hospital, institutional). The JBI's critical appraisal tools were utilized by two independent researchers to assess the trustworthiness, relevance, and results of the included studies. RESULTS: Database searches yielded 14,395 studies, of which 80 full texts were reviewed. Eight studies were included in the data analysis and four methodological guidelines were additionally included from the manual search. The risk of bias in the studies was considered non-critical for the results of this systematic review. A total of ten models/frameworks for assessing the implementation of CPGs were found. The level of use was mainly policy, the most common type of health service was institutional, and the major target group was professionals directly involved in clinical practice. The evaluated domains differed between the models and there were also differences in their conceptualization. All the models addressed the domain "Context", especially at the micro level (8/12), followed by the multilevel (7/12). The domains "Outcome" (9/12), "Intervention" (8/12), "Strategies" (7/12), and "Process" (5/12) were frequently addressed, while "Sustainability" was found only in one study, and "Fidelity/Adaptation" was not observed. CONCLUSIONS: The use of models and frameworks for assessing the implementation of CPGs is still incipient. This systematic review may help stakeholders choose or adapt the most appropriate model or framework to assess CPGs implementation based on their specific health context. TRIAL REGISTRATION: PROSPERO (International Prospective Register of Systematic Reviews) registration number: CRD42022335884. Registered on June 7, 2022.

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BACKGROUND: No evaluation of the quality of different carotid guidelines using validated scales has been performed to date. The present study aims to analyze 3 carotid stenosis guidelines, apprizing their quality and reporting using validated tools. METHODS: A survey-based assessment of the quality of the European Society for Vascular Surgery (ESVS) 2023, European Stroke Organisation (ESO) 2021, and the Society for Vascular Surgery (SVS) 2021 carotid stenosis guidelines, was performed by 43 vascular surgeons, cardiologists, neurologist or interventional radiologists using 2 validated appraisal tools for quality and reporting guidelines, the AGREE II instrument and the RIGHT statement. RESULTS: Using the AGREE II tool, the ESVS, SVS, and ESO guidelines had overall quality scores of 87.3%, 79.4%, and 82.9%, respectively (P = 0.001) The ESVS and ESO had better scores in the scope and purpose domain, and the SVS in the clarity of presentation domain. In the RIGHT statement, the ESVS, SVS, and ESO guidelines had overall quality scores of 84.0.7%, 74.3%, and 79.0%, respectively (P = 0.001). All 3 guidelines stood out for their methodology for search of evidence and formulating evidence-based recommendations. On the contrary, were negatively evaluated mostly in the cost and resource implications in formulating the recommendations. CONCLUSIONS: The 2023 ESVS carotid stenosis guideline was the best evaluated among the 3 guidelines, with scores over 5% higher than the other 2 guidelines. Efforts should be made by guideline writing committees to take the AGREE II and RIGHT statements into account in the development of future guidelines to produce high-quality recommendations.

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Introdução: Materiais educativos sobre cuidados com a voz dão apoio no atendimento clínico e prevenção de disfonia, entretanto, são escassos. Portanto, este estudo objetivou elaborar e avaliar um guia sobre saúde vocal infantil para pais e crianças. Descrição: A elaboração do guia abrangeu: Levantamento Bibliográfico nas bases de dados Biblioteca Virtual em Saúde (BVS) e Público/editora MEDLINE (PubMed); Escrita dos temas; Organização/escrita dos conteúdos/referências; Seleção de imagens. Estruturação do guia: Produção da voz; Sinais/sintomas mais comuns de alterações vocais; Causas dos distúrbios vocais infantis; Consequências do distúrbio vocal infantil; Profissionais envolvidos no diagnóstico e tratamento; Mito e Verdade sobre voz; Como prevenir o distúrbio vocal infantil; Atividades amigas da voz. A avaliação foi em grupo focal, via Google Meet, com três juízes mestrandos em Fonoaudiologia, que discutiram qualitativamente estética, conteúdo e organização. A discussão foi coordenada pela coorientadora e as indicações, realizadas por consenso entre os juízes: Estética - ajustar local das referências, elaborar jogo de trilha, uniformizar desenhos/cores e criar mascote; Conteúdo - material relevante, diminuir textos, adequar a linguagem para crianças, usar links/QR-Code para informações extras e acrescentar orientações para professores; Organização - tópicos em ordem hierárquica, conteúdo relacionado ao tema e separar assuntos por capítulos. Considerações Finais: Foram apontadas mudanças, porém, os juízes ressaltaram a importância deste material na clínica fonoaudiológica e na promoção de saúde vocal. O grupo focal foi importante para a primeira avaliação do guia. (AU)

Introduction: Educational materials on voice care support in clinical care and dysphonia prevention, however, are scarce. Therefore, this study aimed to elaborate and evaluate a guide on child vocal health for parents and children. Description: The elaboration of the guide covered: Bibliographic Survey in the databases Biblioteca Virtual em Saúde (BVS) and MEDLINE Public/Publisher (Pubmed); Themes writing; Organization/writing of the contents/references; Selection of images. Structure of the guide: Voice production; Most common signs/symptoms of vocal disorders; Causes of voice disorders in childhood; Consequences of voice disorders in childhood; Professionals involved in diagnosis and treatment; Myth and Truth about voice; How to prevent vocal disorder in childhood; Voice-friendly activities. The evaluation was in a focus group, via Google Meet, with three Master Judges in Speech Therapy, who discussed qualitatively aesthetics, content and organization. The discussion was coordinated by the co-supervisor and the following recommendations were consensus among the judges: Aesthetics - adjust location of references, elaborate track game, standardize drawings/colors and, create mascot; Content -relevant material, decrease texts, tailor language for children, use/QR-Code links for extra information and, add guidance for teachers; Organization - topics in hierarchical order, content according to theme and separate subjects by chapters. Final Considerations: Improvements were pointed out, however, the judges emphasized the importance of this material in the speech therapy clinic and vocal health promotion. The focus group was important for the guide's first evaluation. (AU)

Introducción: Los materiales educativos sobre cuidados con la voz dan apoyo en la atención clínica y prevención de la disfonía, sin embargo, son escasos. Por lo tanto, este estudio tuvo como objetivo elaborar y evaluar una guía sobre salud vocal infantil para padres e hijos. Descripción: La elaboración de la guía abarcó: Levantamiento Bibliográfico en las bases de datos Biblioteca Virtual en Salud (BVS)/MEDLINE Público/Editor (PubMed); Escritura de los temas; Organización/escritura de los contenidos/referencias; Selección de imágenes. Estructuración de la guía: Producción de la voz; Signos/síntomas más comunes de alteraciones vocales; Causas de los trastornos vocales infantiles; Consecuencias del trastorno vocal infantil; Profesionales involucrados en el diagnóstico y tratamiento; Mito y Verdad sobre voz; Cómo prevenir el trastorno vocal infantil; Actividades amigas de la voz. La evaluación fue en grupo focal, vía Google Meet, con tres jueces maestres en Fonoaudiología, que discutieron cualitativamente estética, contenido y organización. La discusión fue conducida por la coordinadora y las indicaciones, realizadas por consenso entre los jueces: Estética - ajustar lugar de las referencias, elaborar juego de pista, uniformizar dibujos/colores y crear mascota; Contenido - material relevante, disminuir textos, adecuar el lenguaje para niños, usar links/QR-Code para informaciones extras y añadir orientaciones para profesores; Organización - tópicos en orden jerárquico, contenido relacionado al tema y separar asuntos por capítulos. Consideraciones Finales: Se señalaron cambios, sin embargo, los jueces resaltaron la importancia de este material en la clínica fonoaudiológica y en la promoción de salud vocal. El grupo focal fue importante para la primera evaluación de la guía. (AU)

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Introdução: os avanços metodológicos e tecnológicos têm se apresentado em todas as áreas da Fonoaudiologia e não seria diferente nas Ciências da Fala, especificamente na Fonética Acústica. Dermatoglifia é o estudo científico das cristas dermopapilares, encontradas na impressão digital, considerada um marcador genético e identifica habilidades físicas básicas, como força, velocidade, resistência e coordenação motora. O método dermatoglífico vem sendo utilizado no diagnóstico diferencial de algumas síndromes, assim como parte integrante de processo de avaliação da qualidade vocal de profissionais da voz falada e cantada. Objetivo: descrever uma proposta de roteiro de análise dermatoglífica (DAF), que integre a avaliação da qualidade vocal, tanto de profissionais da voz falada e cantada, quanto daqueles falantes que não usam a voz profissionalmente. Descrição: o roteiro do método dermatoglífico como possibilidade de uso para Fonoaudiologia propõe a coleta das impressões digitais, a identificação dos desenhos digitais e seu predomínio, a detecção do perfil dermatoglífico, de fórmula digital, a soma da quantidade de linhas e de deltas dos dedos das mãos e a constatação das habilidades físicas potencializadas e não-potencializadas. Considerações finais: esta comunicação aponta para a integração do método dermatoglífico ao processo avaliativo da qualidade vocal de profissionais da voz falada e cantada. Representa também uma linha de investigação acerca do enfoque das habilidades musculares de indivíduos, não apenas na área de voz, mas nas demais áreas de atuação da Fonoaudiologia, por meio do Roteiro DAF ­ Dermatoglifia Aplicada à Fonoaudiologia.

Introduction: methodological and technological advances have figured in all areas of Speech Therapy and it would not be different in speech sciences, specifically in acoustic phonetics. Dermatoglyphics is the scientific study of dermatopapillary ridges, found in fingerprints, considered a genetic marker and identifying basic physical abilities, such as strength, speed, endurance and motor coordination. The dermatoglyphic method has been used in the differential diagnosis of some syndromes, and is also an integral part of the vocal quality assessment process and spoken and singing voice professionals. Objective: to describe a proposal for a dermatoglyphic analysis script (DAF), which integrates the assessment of vocal quality, both for speaking and singing voice professionals, as well as for speakers who do not use their voice professionally. Description: the script of the dermatoglyphic method as a possible tool in Speech Therapy proposes the collection of fingerprints, the identification of the digital patterns and their predominance, the detection of the dermatoglyphic profile, of the digital formula, the sum of the number of lines and deltas of the fingers of the hands and the verification of the potentiated and non-potentiated physical abilities. Final considerations: this communication points to the integration of the dermatoglyphic method into the vocal quality assessment process of vocal and singing voice professionals. It also represents a line of inquiry about the focus on the muscular abilities of individuals, not only in the area of voice, but in other areas of activity in Speech Therapy, through the DAF Script ­ Dermatoglyphics Applied to Speech Therapy.

Introducción: Los avances metodológicos y tecnológicos se han presentado en todas las áreas de la Fonoaudiología y no sería diferente en las Ciencias del Habla, específicamente en la Fonética Acústica. La dermatoglifia es el estudio científico de las crestas dermopapilares, que se encuentran en la huella dactilar, se considera un marcador genético e identifica capacidades físicas básicas como la fuerza, la velocidad, la resistencia y la coordinación motora. El método dermatoglífico ha sido utilizado en el diagnóstico diferencial de algunos síndromes, así como parte integral del proceso de evaluación de la calidad vocal de los profesionales de la voz hablada y cantada. Objetivo: describir una propuesta de roteiro de análisis dermatoglífica (DAF), que integra la evaluación de la calidad vocal, tanto para profesionales con la voz hablada y cantada, como para aquellos locutores que no utilizan su voz profesionalmente. Descripción: el roteiro del método dermatoglífico como posibilidad de uso para la Fonoaudiología propone la toma de huellas dactilares, la identificación de dibujos digitales y su predominio, la detección del perfil dermatoglífico, de la fórmula digital, la suma del número de líneas y deltas de los dedos de las manos y la verificación de capacidades físicas potenciadas y no potenciadas. Consideraciones finales: esta comunicación apunta a la integración del método dermatoglífico al proceso de evaluación de la calidad vocal de los profesionales de la voz hablada y cantada. También representa una línea de investigación sobre el enfoque de las capacidades musculares de los individuos, no sólo en el área de la voz, sino en otras áreas de actuación de la Fonoaudiología, a través del roteiro DAF ­ Dermatoglífia aplicada a la Fonoaudiología.

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RESUMEN Objetivos: Establecer la concordancia para evaluar el requerimiento de profilaxis farmacológica en el puerperio entre la escala del Rojal College Obstetricians and Gynaecologists y la escala de la guía colombiana en una institución de cuarto nivel en Bogotá, Colombia. Materiales y métodos: Estudio de concordancia diagnóstica ensamblado sobre un estudio transversal. Se incluyeron mujeres embarazadas con 24 o más semanas de gestación que ingresaron para inducción de trabajo de parto, en trabajo de parto activo, para cesárea electiva, o que requirieron cesárea de urgencia, hospitalizadas entre el 1 de marzo y 30 de abril de 2021 en una institución privada de alta complejidad en Bogotá, Colombia. Se realizó un muestreo por conveniencia. Se midieron variables demográficas, factores de riesgo, clasificación del riesgo y profilaxis farmacológica según las dos escalas. Se calculó la prevalencia de los factores de riesgo por cada escala y la concordancia en la indicación de la profilaxis entre las dos escalas por medio del valor de kappa ponderado. Resultados: Se incluyeron 320 pacientes. La escala del Royal College Obstetricians and Gynaecologists clasificó al 54,7 % de las pacientes en riesgo bajo, riesgo intermedio al 42,5 % y riesgo alto al 2,8 %. La escala colombiana clasificó al 80 % de las pacientes en riesgo bajo, 17,2 % riesgo intermedio, 2,2 % riesgo alto y 0,6 % con riesgo muy alto. El valor kappa ponderado para la concordancia para indicación fue de 0,47 (IC 95 %: 0,38-0,56). Conclusiones: La concordancia de las dos escalas para definir requerimiento de profilaxis farmacológica en el posparto tiene un acuerdo moderado. Se considera es necesario validar los criterios de clasificación del riesgo de la escala colombiana en una segunda cohorte, además evaluar la capacidad predictiva de la herramienta de la guía colombiana en diferentes puntos de corte en términos de las consecuencias de falsos positivos y negativos.

ABSTRACT Objectives: To determine agreement in assessing the need for postpartum pharmacological prophylaxis between the scale of the Royal College of Obstetricians and Gynaecologists and the Colombian guideline scale in a Level IV institution in Bogota, Colombia. Material and methods: Diagnostic agreement study assembled on a cross-sectional study. The included population consisted of pregnant women with 24 or more weeks of pregnancy admitted between March 1 and April 30 of 2021 to a high complexity private institution in Bogotá, Colombia, for labor induction, in active labor, for elective cesarean section, or who required urgent cesarean section. Convenience sampling was used. Measured variables included demographics, risk factors, risk classification and pharmacological prophylaxis according to the two scales. The prevalence of risk factors for each scale was estimated and agreement regarding prophylaxis indication between the two scales was measured using the weighted kappa value. Results: Overall, 320 patients were included. According to the scale of the Royal College Obstetricians and Gynaecologists, 54.7 % patients were classified as low risk, 42.5 % as intermediate risk and 2.8 % as high risk. The Colombian scale classified 80 % of patients as low risk, 17.2 % as intermediate risk, 2.2 % as high risk, and 0.6 % as very high risk. The weighted kappa value for agreement regarding the indication was 0.47 (95 % CI: 0.38-0.56). Conclusions: Agreement between the two scales to determine the need for postpartum pharmacological prophylaxis is moderate. Risk classification criteria for the Colombian scale should be validated in a second cohort. Moreover, the predictive ability of the Colombian guideline tool should be assessed at different cut-off points in terms of the consequences of false positive and false negative results.

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BACKGROUND: Management of high-risk newborns should involve the use of standardized protocols and training, continuous and specialized brain monitoring with electroencephalography (EEG), amplitude integrated EEG, Near Infrared Spectroscopy, and neuroimaging. Brazil is a large country with disparities in health care assessment and some neonatal intensive care units (NICUs) are not well structured with trained personnel able to provide adequate neurocritical care. To reduce this existing gap, an advanced telemedicine model of neurocritical care called Protecting Brains and Saving Futures (PBSF) Guidelines was developed and implemented in a group of Brazilian NICUs. METHODS: A prospective, multicenter, and observational study will be conducted in all 20 Brazilian NICUs using the PBSF Guidelines as standard-of-care. All infants treated accordingly to the guidelines during Dec 2021 to Nov 2024 will be eligible. Ethical approval was obtained from participating centers. The primary objective is to describe adherence to the PBSF Guidelines and clinical outcomes, by center and over a 3-year period. Adherence will be measured by quantification of neuromonitoring, neuroimaging exams, sub-specialties consultation, and clinical case discussions and videoconference meetings. Clinical outcomes of interest are detection of seizures during hospitalization, use of anticonvulsants, inotropes, and fluid resuscitation, death before hospital discharge, length of hospital stay, and referral of patients to specialized follow-up. DISCUSSION: The study will provide evaluation of PBSF Guidelines adherence and its impact on clinical outcomes. Thus, data from this large prospective, multicenter, and observational study will help determine whether neonatal neurocritical care via telemedicine can be effective. Ultimately, it may offer the necessary framework for larger scale implementation and development of research projects using remote neuromonitoring. TRIAL REGISTRATION: NCT03786497, Registered 26 December 2018, https://www.clinicaltrials.gov/ct2/show/NCT03786497?term=protecting+brains+and+saving+futures&draw=2&rank=1.

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A anatomia patológica, veterinária e humana, no contexto mundial, adota, com cada vez mais frequência, a prática de segunda opinião diagnóstica, como método de verificação e confirmação de pareceres técnicos, objetivando uma maior acurácia e precisão dos diagnósticos fornecidos. Este trabalho tem por objetivo discorrer sobre a importância da segunda opinião diagnóstica na anatomia patológica e seus aspectos éticos. A segunda opinião reflete uma medida de precisão diagnóstica e, apesar de alguns sítios anatômicos ou áreas de subespecialidade apresentarem maiores frequências de grandes discordâncias diagnósticas, quase todas as áreas no âmbito da anatomia patológica podem ser clinicamente afetadas pela segunda opinião. Dadas as variações entre as instituições, recomenda-se a revisão de segunda opinião de todos os locais anatômicos em todas as instituições, públicas e privadas, para maximizar a descoberta de divergências clinicamente relevantes.

Human and veterinary medicine pathological Anatomy in the world context, increasingly adopts the practice of second diagnostic opinion, as a method of verification and confirmation of technical opinions, aiming at greater accuracy and precision of the diagnoses provided. This work aims to discuss the importance of the second diagnostic opinion in pathological anatomy and its ethical aspects. The second opinion reflects a measure of diagnostic accuracy, and although some anatomical sites or areas of subspecialty have higher frequencies of major diagnostic disagreements, almost all areas within the pathological anatomy can be clinically affected by the second opinion. Given the variations between institutions, a second opinion review of all anatomic sites in all institutions, public and private, is recommended to maximize the discovery of clinically relevant discrepancies.

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Introduction: French Guiana is a multicultural overseas territory in the Amazon, where precariousness and difficulties in access to care are widespread. The prevalence of diabetes is double that of other French departments, and cardiovascular morbidity and mortality is high. The objective of the study was to analyze the biological, clinical and therapeutic follow-up of patients with diabetes mellitus using exhaustive data and to correlate it with national and European recommendations. Material and Methods: Using the national health insurance data, 9079 and 10075 patients with diabetes mellitus were analyzed in 2018 and 2019, respectively. We analyzed antidiabetic treatments, medical, dental, and podiatric consultations, examinations prescribed as part of the annual follow-up, and home nursing care. Results: There was a significant increase over one year in the number of patients (+10%) with diabetes, mainly women (60%), and 31% were under 54 years of age, with a disparity depending on the area of the territory, the most isolated having less access to screening. Less than 56% of patients had HbA1c measurements twice a year, less than 43% had an annual renal check-up, only 19% had an ophthalmic check-up at least every two years, less than 25% had an annual dental check-up, and less than 4% had an annual follow-up with the podiatrist. Conclusions: Substandard diabetes monitoring is a major problem likely to increase morbidity and mortality. Adapting health care to the specificities of the territory is crucial, notably by formalizing the delegation of care to advanced practice nurse and non-healthcare professionals in precarious or geographically isolated areas.

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Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma (STS) in children and adolescents. In Spain the annual incidence is 4.4 cases per million children < 14 years. It is an uncommon neoplasm in adults, but 40% of RMS are diagnosed in patients over 20 years of age, representing 1% of all STS in this age group. RMS can appear anywhere in the body, with some sites more frequently affected including head and neck, genitourinary system and limbs. Assessment of a patient with suspicion of RMS includes imaging studies (MRI, CT, PET-CT) and biopsy. All patients with RMS should receive chemotherapy, either at diagnosis in advanced or metastatic stages, or after initial resection in early local stages. Local control includes surgery and/or radiotherapy depending on site, stage, histology and response to chemotherapy. This guide provides recommendations for diagnosis, staging and treatment of this neoplasm.

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Background: The level of scientific evidence in National Comprehensive Cancer Network (NCCN) guidelines for malignant hematological conditions haven't been recently investigated. We describe the distribution of categories of evidence and consensus (EC) among the 10 most common hematologic malignancies with regard to recommendations for staging, initial and salvage therapy, and surveillance. Methods: We reviewed the level of evidence for the 10 most common hematological malignancies by incidence in the United States as of 2020. The NCCN definitions for EC are: category 1, high level of evidence, such as randomized controlled trials, with uniform consensus; category 2A, lower level of evidence with uniform consensus; category 2B, lower level of evidence without a uniform consensus but with no major disagreement; and category 3, any level of evidence but with major disagreement. We compared our results with previously published results from 2011. Results: Of 1353 recommendations, 5%, 91%, 4%, and 1% fell into EC categories 1, 2A, 2B, and 3, respectively, while in 2011 the comparable percentages were 3%, 93%, 4%, and 0%, respectively. Recommendations with category 1 EC were found in all guidelines, except for Burkitt lymphoma. Of all therapeutic recommendations, 6.3% were category 1 EC, with the majority of these (56.4%) pertaining to initial therapy. Guidelines with highest proportions of therapeutic recommendations with category 1 EC were multiple myeloma (12.4%), chronic lymphocytic leukemia/small lymphocytic lymphoma (6.9%), and acute myeloid leukemia (5.6%). Conclusions: Recommendations in the 2020 NCCN guidelines are largely developed from lower levels of evidence but with uniform expert opinion, underscoring the urgent need and available opportunities to expand the current evidence base in malignant hematological disorders.

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In this consensus statement, we provide updated recommendations on multiple sclerosis (MS) management during the COVID-19 crisis and the post-pandemic period applicable to neurology services around the world. Statements/recommendations were generated based on available literature and the experience of 13 MS expert panelists using a modified Delphi approach online. The statements/recommendations give advice regarding implementation of telemedicine; use of disease-modifying therapies and management of MS relapses; management of people with MS at highest risk from COVID-19; management of radiological monitoring; use of remote pharmacovigilance; impact on MS research; implications for lowest income settings, and other key issues.

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OBJECTIVE: To summarize the knowledge about recommendations for the use of personal protective equipment necessary for the provision of care by health professionals to patients suspected or infected by the new coronavirus. METHOD: Scoping review with search for primary studies, reviews and preprints articles in English, Portuguese and Spanish, in the last 20 years on the bases WOS/ISI, SCOPUS, MEDLINE/PuBMed, CINAHL, LILACS and SciELO. Unpublished studies in journals were surveyed on bioRxiv and SciELO preprints. RESULTS: 23 studies were eligible. Experiences with coronavirus prior to SARS-CoV-2 revealed that the equipment was an essential barrier in preventing transmission and followed the recommendations for standard precautions, contact, droplet and aerosol. In 13 (57%) studies, this equipment complied international recommendations and in 10 (45%) local recommendations. CONCLUSION: The personal protective equipment used does not follow global standardization according to type, quality and adequate provision, exposing these professionals to the risk of contamination.

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BACKGROUND: The incidence of breast cancer (BC) in LMICs has increased by more than 20% within the last decade. In areas such as Latin America (LA), addressing BC at national levels evoke discussions surrounding fragmented care, limited resources, and regulatory barriers. Precision Medicine (PM), specifically companion diagnostics (CDx), links disease diagnosis and treatment for better patient outcomes. Thus, its application may aid in overcoming these barriers. RECENT FINDINGS: A panel of LA experts in fields related to BC and PM were provided with a series of relevant questions to address prior to a multi-day conference. Within this conference, each narrative was edited by the entire group, through numerous rounds of discussion until a consensus was achieved. The panel proposes specific, realistic recommendations for implementing CDx in BC in LA and other LMIC regions. In these recommendations, the authors strived to address all barriers to the widespread use and access mentioned previously within this manuscript. CONCLUSION: This manuscript provides a review of the current state of CDx for BC in LA. Of most importance, the panel proposes practical and actionable recommendations for the implementation of CDx throughout the Region in order to identify the right patient at the right time for the right treatment.

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The POSEIDON (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number) criteria were developed to help clinicians identify and classify low-prognosis patients undergoing assisted reproductive technology (ART) and provide guidance for possible therapeutic strategies to overcome infertility. Since its introduction, the number of published studies using the POSEIDON criteria has increased steadily. However, a critical analysis of existing evidence indicates inconsistent and incomplete reporting of critical outcomes. Therefore, we developed guidelines to help researchers improve the quality of reporting in studies applying the POSEIDON criteria. We also discuss the advantages of using the POSEIDON criteria in ART clinical studies and elaborate on possible study designs and critical endpoints. Our ultimate goal is to advance the knowledge concerning the clinical use of the POSEIDON criteria to patients, clinicians, and the infertility community.

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RESUMEN La preparación del personal docente en las universidades exige un alto nivel científico y de maestría pedagógica. Todo esto requiere un esmerado trabajo metodológico que garantice una planificación organización, regulación y control del proceso docente educativo. Para esto se diseñó una clase metodológica instructiva sobre mucosa oral, de la asignatura Sistema Masticatorio, en la disciplina Histología, con el objetivo de instruir al profesor en la utilización de la vinculación básico-clínica. Se indicó a los profesores cómo relacionar el contenido de la clase con la clínica, desde el punto de vista de las lesiones precancerosas y sus factores de riesgo. Se logró la instrucción de los docentes en la utilización del contenido de las asignaturas y disciplinas de las Ciencias Básicas con la relación básico-clínica, y así se contribuyó a ampliar el espectro científico metodológico de los docentes en la Universidad de Ciencias Médicas de Matanzas (AU).

ABSTRACT Training the teaching staff in the universities demands a high scientific level and pedagogical expertise. All of these requires a careful methodological work guaranteeing the teaching-learning process planning, organization, regulation and control. For that the authors designed an instructive methodological lesson aimed to train the teaching staff in the use of the basic-clinical link during a lesson of the subject Masticatory System about Oral Mucosa, in the subject Histology. They indicate to professors how to relate the lesson content to clinic from the point of view of pre-cancer lesions and its risk factors. Training the teaching staff in the use of subjects and disciplines of the Basic Sciences with the basic-clinical relation, the authors contribute to widening the scientific methodological spectrum of the teaching staff of the Matanzas University of Medical Sciences (AU).

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BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive malignancy, associated with poor outcomes in patients with metastatic disease (mMCC). Management has been dramatically altered as a result of incorporating immune checkpoint blockade agents. MCC data from Latin America (LATAM) come from case-series or individual records. Regional registries are lacking. A need for better registries to improve current knowledge about MCC is highlighted. Our objectives were to describe a real-world experience with avelumab as a second-line (or first-line in unfit patients) treatment in a subset of LATAM participants enrolled in a global Expanded Access Program (EAP) for patients with mMCC, and to evaluate its contribution to the resolution of the concerns described in a recent regional experts review. MATERIALS AND METHODS: We reviewed data of LATAM participants in an avelumab EAP for mMCC treatment (NCT03089658). EAP patient had unresectable or mMCC with progressive disease after one line of chemotherapy, and were ineligible for clinical trials or unfit for chemotherapy. RESULTS: 46 patients (median age: 71.6 years; 60.9% males; median treatment duration: 7.9 months) were included in the LATAM EAP. Physician-assessed objective responses were available for 19 patients. Complete response rate was 15.8% and partial response rate reached 42.1%, summarizing an objective response rate of 57.9%. Stable disease rate was 10.5%, with a disease control response of 68.4%. CONCLUSION: Avelumab showed robust efficacy and a safety profile consistent with global EAP data. Results are aimed to improve current knowledge about mMCC treatment and access to immunooncologic strategies for treating LATAM patients.

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