RESUMEN
Menetrier's disease represents a low prevalence clinical entity, characterized by complexity in its diagnosis, particularly due to the need to exclude its potential association with gastric cancer. In this context, we present the clinical case of a 54-year-old male with nonspecific gastrointestinal symptoms and hypoalbuminemia. During the upper endoscopy procedure, a noticeable thickening of gastric folds was observed, associated with multiple polypoid lesions in the stomach, predominantly in the fundus and body. Since the patient did not show improvement in symptoms and given the inability to rule out gastric cancer, total gastrectomy was chosen as the treatment. Surgical specimen and histology confirmed the presence of Menetrier's disease.
Asunto(s)
Gastritis Hipertrófica , Pólipos , Humanos , Masculino , Persona de Mediana Edad , Gastritis Hipertrófica/complicaciones , Gastritis Hipertrófica/diagnóstico , Pólipos/diagnóstico , Pólipos/complicaciones , Pólipos/cirugía , Pólipos/patología , Gastropatías/diagnóstico , Gastropatías/complicaciones , Hiperplasia , Gastrectomía , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/patología , Neoplasias Gástricas/complicaciones , Neoplasias Gástricas/cirugía , Pólipos AdenomatososRESUMEN
We investigated the occurrence and pathologic findings of transmissible viral proventriculitis (TVP) associated with the chicken proventricular necrosis virus (CPNV) in commercial broiler chickens in southeastern Brazil. Seventy-three broilers, 25-36 d old, with a history of reduced growth, were referred to our veterinary pathology services from 2013 to 2017. Broilers were clinically examined, weighed, and euthanized for postmortem examination. Broilers of different ages with proventricular histologic lesions were positive for CPNV by RT-PCR; however, the intensity of histologic lesions was higher among 33-d-old animals, and viral RNA detection was more frequent among those that were 28 d old. In the proventriculi of 35 of 73 (48%) broilers, lesions were characterized by glandular epithelial necrosis, lymphoplasmacytic and histiocytic infiltrates, and metaplasia of glandular epithelium to ductal epithelium. In 24 of 73 (36%) broilers with histologic TVP-compatible lesions, CPNV was detected by RT-PCR for the viral protein 1 (VP1) gene. Broilers with histologic lesions were lighter than expected compared to the Cobb 500 standard weight. TVP has not been reported previously in broiler chickens in Brazil, to our knowledge.
Asunto(s)
Infecciones por Birnaviridae/veterinaria , Birnaviridae/aislamiento & purificación , Enfermedades de las Aves de Corral/diagnóstico , Proventrículo/virología , Gastropatías/veterinaria , Animales , Infecciones por Birnaviridae/diagnóstico , Infecciones por Birnaviridae/transmisión , Brasil , Enfermedades de las Aves de Corral/transmisión , Estudios Prospectivos , Proventrículo/patología , Estudios Retrospectivos , Gastropatías/diagnósticoRESUMEN
Subepithelial lesions are generally an incidental diagnosis with an prevalence of 0.4%. These tumors represent a great diagnostic challenge, mainly when ruling out potentially malignant lesions, such as gastrointestinal stromal tumor (GIST), lymphomas and carcinomas. Among the many differential diagnosis, the ectopic pancreas arises with an prevalence of 1-2% in general population. The first diagnostic approach is performed using upper digestive endoscopy, computed tomography and endosonography. This last one has a diagnostic performance of less than 50%, which increases to 90% when it is associated with a histopathological examination. There is no current consensus regarding the management and monitoring of these lesions. Based on the imaging and histological characteristics, the possibilities range from observation to endoscopic or surgical resection. In this context, we will present a clinical case of ectopic pancreas as an incidental finding, and afterwards the diagnostic and therapeutic breakdown of subepithelial lesions.
Las lesiones subepiteliales son pesquisadas generalmente de manera incidental, con una prevalencia de 0,4%. Estos tumores suponen un gran desafío diagnóstico, principalmente al momento de descartar lesiones potencialmente malignas, como el tumor estromal gastrointestinal (GIST), linfomas y carcinomas. Dentro de los posibles diagnósticos, surge el páncreas ectópico, con una prevalencia de hasta 1-2% en la población general. La primera aproximación diagnóstica se realiza mediante endoscopia digestiva alta, tomografía computarizada y la endosonografía, ésta última con un rendimiento diagnóstico menor del 50%, que aumenta hasta el 90% al asociar el examen histopatológico. No existe consenso actual respecto al manejo y seguimiento de estas lesiones, que según sus características imagenológicas e histológicas, va desde la observación hasta la resección endoscópica o quirúrgica. En este contexto, se presenta un caso clínico de páncreas ectópico como hallazgo incidental y el desglose diagnóstico y terapéutico de las lesiones subepiteliales.
Asunto(s)
Humanos , Masculino , Adulto , Páncreas/diagnóstico por imagen , Coristoma/diagnóstico por imagen , Gastropatías/diagnóstico , Endosonografía , Tumores del Estroma Gastrointestinal/diagnóstico , Diagnóstico Diferencial , Neoplasias Gastrointestinales/diagnósticoRESUMEN
Helicobacter pylori (H. pylori) is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide. However, its prevalence varies among different geographic areas, and is influenced by several factors. The infection can be acquired by means of oral-oral or fecal-oral transmission, and the pathogen possesses various mechanisms that improve its capacity of mobility, adherence and manipulation of the gastric microenvironment, making possible the colonization of an organ with a highly acidic lumen. In addition, H. pylori presents a large variety of virulence factors that improve its pathogenicity, of which we highlight cytotoxin associated antigen A, vacuolating cytotoxin, duodenal ulcer promoting gene A protein, outer inflammatory protein and gamma-glutamyl transpeptidase. The host immune system, mainly by means of a Th1-polarized response, also plays a crucial role in the infection course. Although most H. pylori-positive individuals remain asymptomatic, the infection predisposes the development of various clinical conditions as peptic ulcers, gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas. Invasive and non-invasive diagnostic methods, each of them with their related advantages and limitations, have been applied in H. pylori detection. Moreover, bacterial resistance to antimicrobial therapy is a major challenge in the treatment of this infection, and new therapy alternatives are being tested to improve H. pylori eradication. Last but not least, the development of effective vaccines against H. pylori infection have been the aim of several research studies.
Asunto(s)
Mucosa Gástrica/microbiología , Infecciones por Helicobacter/terapia , Helicobacter pylori/patogenicidad , Gastropatías/terapia , Antiácidos/uso terapéutico , Antibacterianos/farmacología , Antibacterianos/uso terapéutico , Vacunas Bacterianas/uso terapéutico , Farmacorresistencia Bacteriana , Quimioterapia Combinada , Mucosa Gástrica/efectos de los fármacos , Mucosa Gástrica/patología , Infecciones por Helicobacter/diagnóstico , Infecciones por Helicobacter/microbiología , Infecciones por Helicobacter/transmisión , Helicobacter pylori/efectos de los fármacos , Helicobacter pylori/inmunología , Humanos , Concentración de Iones de Hidrógeno/efectos de los fármacos , Probióticos/administración & dosificación , Inhibidores de la Bomba de Protones/uso terapéutico , Gastropatías/diagnóstico , Gastropatías/microbiología , Resultado del Tratamiento , Factores de Virulencia/metabolismoRESUMEN
Anisakiasis is a zoonotic parasitic disease caused by consumption of raw or undercooked fish or seafood infected with nematodes of the Anisakis, Pseudoterranova or Contracaecum genera. Here, we describe the first case of anisakiasis in Colombia and summarize the available literature. A 52-year-old female with a history of abrupt-onset sharp epigastric pain, nausea, vomit, diarrhea, and urticaria following fish consumption consulted the health service. The physical examination revealed moderate tenderness of the epigastric region; the laboratory evaluation showed leukocytosis and a simple X-ray and ECG showed no abnormalities. The diagnosis was made by endoscopic examination, which revealed a thickened gastric wall and a moving larval worm. An Anisakis larva was found and extracted endoscopically, which relieved the pain of the patient. Clinically, anisakiasis may present as a gastric, intestinal, extragastrointestinal or allergic disease. Diagnosis and treatment of anisakiasis are made by a dietary history, direct visualization and endoscopic extraction of possible larvae, which is the only effective therapy.
La anisakiasis es una enfermedad parasitaria zoonótica causada por el consumo de pescados o mariscos crudos o poco cocidos infectados con nematodos de los géneros Anisakis, Pseudoterranova y Contracaecum. Se describe el primer caso de anisakiasis en Colombia y se resume la literatura médica disponible. Una mujer de 52 años de edad consultó por dolor epigástrico agudo de inicio abrupto, náuseas, vómitos, diarrea y urticaria después de consumir pescado. El examen físico reveló sensibilidad moderada en el epigastrio. El examen de laboratorio evidenció leucocitosis, en tanto que la radiografía simple y el electrocardiograma no reflejaron ninguna anormalidad. El diagnóstico se hizo mediante una endoscopia de vías digestivas altas, la cual reveló engrosamiento de la pared gástrica y un parásito en movimiento. Se encontró una larva de Anisakis y se la extrajo por endoscopia, lo que alivió el dolor de la paciente. Clínicamente, la anisakiasis puede presentarse como una enfermedad gástrica, intestinal, en otros sistemas o alérgica. El diagnóstico se hace con base en la elaboración del historial alimentario del paciente y la visualización directa de las larvas; el único tratamiento efectivo consiste en su extracción endoscópica.
Asunto(s)
Anisakiasis/diagnóstico , Anisakis/aislamiento & purificación , Peces/parasitología , Parasitología de Alimentos , Alimentos Crudos/efectos adversos , Gastropatías/parasitología , Urticaria/etiología , Albendazol/uso terapéutico , Animales , Anisakiasis/tratamiento farmacológico , Anisakiasis/inmunología , Anisakiasis/cirugía , Anisakis/crecimiento & desarrollo , Antihelmínticos/uso terapéutico , Colombia , Terapia Combinada , Femenino , Gastroscopía , Humanos , Larva , Persona de Mediana Edad , Alimentos Crudos/parasitología , Gastropatías/diagnóstico , Gastropatías/inmunologíaRESUMEN
Mucormycosis is a rare, usually fatal, opportunistic infection that mostly affects people with immune deficiency or associated pathologies. There are few reports of this disease in patients without the traditional risk factors, still unknown what could be the real predisposing causes involved. The forms of presentation are rhinocerebral, cutaneous, pulmonary, gastrointestinal and disseminated. This is why, due to the difficult diagnosis, high mortality and uncommon presentation, we report the case of a 4-year-old child without immunodeficiency or background pathologies who developed an esophagogastric mucormycosis.
Asunto(s)
Mucormicosis , Gastropatías/microbiología , Preescolar , Humanos , Inmunocompetencia , Masculino , Mucormicosis/diagnóstico , Gastropatías/diagnósticoRESUMEN
Resumen La anisakiasis es una enfermedad parasitaria zoonótica causada por el consumo de pescados o mariscos crudos o poco cocidos infectados con nematodos de los géneros Anisakis, Pseudoterranova y Contracaecum. Se describe el primer caso de anisakiasis en Colombia y se resume la literatura médica disponible. Una mujer de 52 años de edad consultó por dolor epigástrico agudo de inicio abrupto, náuseas, vómitos, diarrea y urticaria después de consumir pescado. El examen físico reveló sensibilidad moderada en el epigastrio. El examen de laboratorio evidenció leucocitosis, en tanto que la radiografía simple y el electrocardiograma no reflejaron ninguna anormalidad. El diagnóstico se hizo mediante una endoscopia de vías digestivas altas, la cual reveló engrosamiento de la pared gástrica y un parásito en movimiento. Se encontró una larva de Anisakis y se la extrajo por endoscopia, lo que alivió el dolor de la paciente. Clínicamente, la anisakiasis puede presentarse como una enfermedad gástrica, intestinal, en otros sistemas o alérgica. El diagnóstico se hace con base en la elaboración del historial alimentario del paciente y la visualización directa de las larvas; el único tratamiento efectivo consiste en su extracción endoscópica.
Abstract Anisakiasis is a zoonotic parasitic disease caused by consumption of raw or undercooked fish or seafood infected with nematodes of the Anisakis, Pseudoterranova or Contracaecum genera. Here, we describe the first case of anisakiasis in Colombia and summarize the available literature. A 52-year-old female with a history of abrupt-onset sharp epigastric pain, nausea, vomit, diarrhea, and urticaria following fish consumption consulted the health service. The physical examination revealed moderate tenderness of the epigastric region; the laboratory evaluation showed leukocytosis and a simple X-ray and ECG showed no abnormalities. The diagnosis was made by endoscopic examination, which revealed a thickened gastric wall and a moving larval worm. An Anisakis larva was found and extracted endoscopically, which relieved the pain of the patient. Clinically, anisakiasis may present as a gastric, intestinal, extragastrointestinal or allergic disease. Diagnosis and treatment of anisakiasis are made by a dietary history, direct visualization and endoscopic extraction of possible larvae, which is the only effective therapy.
Asunto(s)
Animales , Femenino , Humanos , Persona de Mediana Edad , Gastropatías/parasitología , Urticaria/etiología , Parasitología de Alimentos , Anisakis/aislamiento & purificación , Anisakiasis/diagnóstico , Peces/parasitología , Alimentos Crudos/efectos adversos , Gastropatías/diagnóstico , Gastropatías/inmunología , Albendazol/uso terapéutico , Gastroscopía , Anisakis/crecimiento & desarrollo , Anisakiasis/cirugía , Anisakiasis/inmunología , Anisakiasis/tratamiento farmacológico , Colombia , Terapia Combinada , Alimentos Crudos/parasitología , Larva , Antihelmínticos/uso terapéuticoRESUMEN
La mucormicosis es una infección oportunista rara usualmente fatal, que afecta mayoritariamente a personas con déficit inmunológico o patologías asociadas. Hay pocos reportes de esta enfermedad en pacientes sin los factores de riesgo tradicionales, desconociéndose aún cuáles podrían ser las causas predisponentes reales implicadas. Las formas de presentación son rinocerebral, cutánea, pulmonar, gastrointestinal y diseminada. Es por esto que, debido al difícil diagnóstico, alta mortalidad y presentación poco común reportamos el caso de un niño de 4 años sin inmunodeficiencia ni patologías de fondo que desarrolló una mucormicosis esófago-gástrica.
Mucormycosis is a rare, usually fatal, opportunistic infection that mostly affects people with immune deficiency or associated pathologies. There are few reports of this disease in patients without the traditional risk factors, still unknown what could be the real predisposing causes involved. The forms of presentation are rhinocerebral, cutaneous, pulmonary, gastrointestinal and disseminated. This is why, due to the difficult diagnosis, high mortality and uncommon presentation, we report the case of a 4-year-old child without immunodeficiency or background pathologies who developed an esophagogastric mucormycosis.
Asunto(s)
Preescolar , Humanos , Masculino , Gastropatías/microbiología , Mucormicosis , Gastropatías/diagnóstico , Inmunocompetencia , Mucormicosis/diagnósticoRESUMEN
ABSTRACT Introduction: The incidence of gastrointestinal disorders among patients with chronic kidney disease (CKD) is high, despite the lack of a good correlation between endoscopic findings and symptoms. Many services thus perform upper gastrointestinal (UGI) endoscopy on kidney transplant candidates. Objectives: This study aims to describe the alterations seen on the upper endoscopies of 96 kidney-transplant candidates seen from 2014 to 2015. Methods: Ninety-six CKD patients underwent upper endoscopic examination as part of the preparation to receive kidney grafts. The data collected from the patients' medical records were charted on Microsoft Office Excel 2016 and presented descriptively. Mean values, medians, interquartile ranges and 95% confidence intervals of the clinic and epidemiological variables were calculated. Possible associations between endoscopic findings and infection by H. pylori were studied. Results: Males accounted for 54.17% of the 96 patients included in the study. Median age and time on dialysis were 50 years and 50 months, respectively. The most frequent upper endoscopy finding was enanthematous pangastritis (57.30%), followed by erosive esophagitis (30.20%). Gastric intestinal metaplasia and peptic ulcer were found in 8.33% and 7.30% of the patients, respectively. H. pylori tests were positive in 49 patients, and H. pylori infection was correlated only with non-erosive esophagitis (P = 0.046). Conclusion: Abnormal upper endoscopy findings were detected in all studied patients. This study suggested that upper endoscopy is a valid procedure for kidney transplant candidates. However, prospective studies are needed to shed more light on this matter.
RESUMO Introdução: A incidência de doenças gastrointestinais altas em pacientes com doença renal crônica é elevada, porém não há boa correlação entre achados endoscópicos e sintomas. Assim, muitos serviços preconizam a realização de Endoscopia Digestiva Alta (EDA) nos candidatos a transplante renal. Objetivos: Descrever alterações endoscópicas presentes em 96 candidatos a transplante renal no período de 2014 a 2015. Métodos: Noventa e seis pacientes renais crônicos submetidos à EDA como preparo para transplante renal. Prontuários médicos dos pacientes foram revisados, os dados tabulados no programa Microsoft Office Excel 2016 e apresentados de maneira descritiva. Calculou-se média, mediana, intervalo interquartílico e intervalo de confiança de 95% das variáveis utilizadas. Alterações endoscópicas foram apresentadas quanto ao número, intervalo de confiança e valor de P, e correlacionadas com a presença ou ausência de infecção por Helicobacter pylori. Resultados: Dos 96 pacientes, 54,17% eram homens e 45,83% mulheres. As medianas de idade e tempo em diálise foram 50 anos e 50 meses, respectivamente. O achado mais comum na EDA foi pangastrite enantematosa (57,30%), seguida de esofagite erosiva (30,20%). Metaplasia intestinal gástrica e úlcera péptica foram encontradas em 8,33% e 7,30% dos pacientes, respectivamente. Pesquisa para H. pylori foi positiva em 49 pacientes, e somente houve correlação entre infecção por H. pylori e esofagite não erosiva (P = 0,046). Conclusão: Afecções gastrointestinais foram detectadas em todos os pacientes estudados. Os achados deste estudo sugerem que a realização de EDA em candidatos a receber transplante renal é desejável. Entretanto, estudos prospectivos são necessários para responder a esta questão.
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Gastropatías/etiología , Enfermedades Duodenales/etiología , Enfermedades del Esófago/etiología , Insuficiencia Renal Crónica/complicaciones , Gastropatías/diagnóstico , Estudios Transversales , Endoscopía Gastrointestinal , Trasplante de Riñón , Enfermedades Duodenales/diagnóstico , Enfermedades del Esófago/diagnóstico , Insuficiencia Renal Crónica/cirugíaRESUMEN
BACKGROUND: Helicobacter pylori is the most significant pathogen associated with gastric diseases, including gastric cancer. Infected patients with strains that are CagA-positive generally have worse outcomes than those infected with CagA-negative strains. Patients infected with CagA-positive strains have a higher risk for developing gastric cancer. AIM: To determine the prevalence of CagA-positive H. pylori strains in fecal samples of patients from the Coquimbo Region of Chile, using a non-invasive, nested-qPCR method. MATERIAL AND METHODS: We evaluated 160 patients with gastrointestinal symptoms subjected to an upper gastrointestinal endoscopy. DNA was extracted from fecal samples and tested for the presence of H. pylori using nested-qPCR for the ureC gene, and subsequently compared with the results of histology-Giemsa stain from the patients' endoscopic biopsies. When H. pylori was found, the presence of CagA-positive strains was determined via nested-qPCR. RESULTS: The histology-Giemsa stain was positive for H. pylori infection in 123 patients (76.9%), while the analysis of fecal samples detected H. pylori in 129 patients (80.6%). The sensitivity and specificity of nested-qPCR to detect the bacterium was 96.7 and 73.0% respectively. Among patients with the infection, 25% had CagA-positive strains. CONCLUSIONS: In this sample of patients, there is a low prevalence of CagA-positive H. pylori strains.
Asunto(s)
Antígenos Bacterianos/genética , Proteínas Bacterianas/genética , ADN Bacteriano/análisis , Heces/microbiología , Infecciones por Helicobacter/diagnóstico , Helicobacter pylori/genética , Gastropatías/microbiología , Antígenos Bacterianos/aislamiento & purificación , Proteínas Bacterianas/aislamiento & purificación , Endoscopía del Sistema Digestivo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Sensibilidad y Especificidad , Gastropatías/diagnósticoRESUMEN
INTRODUCTION: The incidence of gastrointestinal disorders among patients with chronic kidney disease (CKD) is high, despite the lack of a good correlation between endoscopic findings and symptoms. Many services thus perform upper gastrointestinal (UGI) endoscopy on kidney transplant candidates. OBJECTIVES: This study aims to describe the alterations seen on the upper endoscopies of 96 kidney-transplant candidates seen from 2014 to 2015. METHODS: Ninety-six CKD patients underwent upper endoscopic examination as part of the preparation to receive kidney grafts. The data collected from the patients' medical records were charted on Microsoft Office Excel 2016 and presented descriptively. Mean values, medians, interquartile ranges and 95% confidence intervals of the clinic and epidemiological variables were calculated. Possible associations between endoscopic findings and infection by H. pylori were studied. RESULTS: Males accounted for 54.17% of the 96 patients included in the study. Median age and time on dialysis were 50 years and 50 months, respectively. The most frequent upper endoscopy finding was enanthematous pangastritis (57.30%), followed by erosive esophagitis (30.20%). Gastric intestinal metaplasia and peptic ulcer were found in 8.33% and 7.30% of the patients, respectively. H. pylori tests were positive in 49 patients, and H. pylori infection was correlated only with non-erosive esophagitis (P = 0.046). CONCLUSION: Abnormal upper endoscopy findings were detected in all studied patients. This study suggested that upper endoscopy is a valid procedure for kidney transplant candidates. However, prospective studies are needed to shed more light on this matter.
Asunto(s)
Enfermedades Duodenales/etiología , Enfermedades del Esófago/etiología , Insuficiencia Renal Crónica/complicaciones , Gastropatías/etiología , Adulto , Estudios Transversales , Enfermedades Duodenales/diagnóstico , Endoscopía Gastrointestinal , Enfermedades del Esófago/diagnóstico , Femenino , Humanos , Trasplante de Riñón , Masculino , Persona de Mediana Edad , Insuficiencia Renal Crónica/cirugía , Gastropatías/diagnósticoRESUMEN
Background: Helicobacter pylori is the most significant pathogen associated with gastric diseases, including gastric cancer. Infected patients with strains that are CagA-positive generally have worse outcomes than those infected with CagA-negative strains. Patients infected with CagA-positive strains have a higher risk for developing gastric cancer. Aim: To determine the prevalence of CagA-positive H. pylori strains in fecal samples of patients from the Coquimbo Region of Chile, using a non-invasive, nested-qPCR method. Material and Methods: We evaluated 160 patients with gastrointestinal symptoms subjected to an upper gastrointestinal endoscopy. DNA was extracted from fecal samples and tested for the presence of H. pylori using nested-qPCR for the ureC gene, and subsequently compared with the results of histology-Giemsa stain from the patients' endoscopic biopsies. When H. pylori was found, the presence of CagA-positive strains was determined via nested-qPCR. Results: The histology-Giemsa stain was positive for H. pylori infection in 123 patients (76.9%), while the analysis of fecal samples detected H. pylori in 129 patients (80.6%). The sensitivity and specificity of nested-qPCR to detect the bacterium was 96.7 and 73.0% respectively. Among patients with the infection, 25% had CagA-positive strains. Conclusions: In this sample of patients, there is a low prevalence of CagA-positive H. pylori strains.
Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Gastropatías/microbiología , Proteínas Bacterianas/genética , ADN Bacteriano/genética , Helicobacter pylori/genética , Infecciones por Helicobacter/diagnóstico , Heces/microbiología , Antígenos Bacterianos/genética , Gastropatías/diagnóstico , Proteínas Bacterianas/aislamiento & purificación , Reacción en Cadena de la Polimerasa , Endoscopía del Sistema Digestivo , Sensibilidad y Especificidad , Antígenos Bacterianos/aislamiento & purificaciónRESUMEN
Resumen Introducción: Los pólipos gástricos suelen ser hallazgos en la endoscopia digestiva alta. Objetivo: Realizar una revisión de los pólipos gástricos más frecuentes y presentar un caso de manejo de estos con gastrectomía total laparoscópica según el protocolo fast track. Caso clínico: Se presenta el caso de un paciente hombre de 46 años, sin antecedentes mórbidos con poliposis difusa del estómago sintomática, en el que se realiza una gastrectomía total laparoscópica siguiendo el protocolo fast track, siendo dado de alta al cuarto día posoperatorio. Discusión: Los pólipos gástricos más frecuentes son los hiperplásicos, de glándula fúndica, adenomas e inflamatorios. Es fundamental obtener biopsias de estos ya que su histología comandará su manejo y pronóstico. En algunos casos, la gastrectomía total es la indicación debido a su riesgo de malignidad o sintomatología. El protocolo fast track ha demostrado ser una modalidad de manejo posoperatorio que disminuye el tiempo de estadía hospitalaria y presenta una recuperación precoz en comparación con la práctica habitual, sin comprometer la seguridad del paciente.
Introduction: Gastric polyps are commonly found incidentally on upper gastrointestinal endoscopy. Objective: Review the most common gastric polyps and present a case of symptomatic polyps managed with laparoscopic total gastrectomy following the fast track protocol. Clinical case: Patient with symptomatic diffuse gastric polyps who had a total laparoscopic gastrectomy following the fast track protocol, who is discharged at home at fourth day post-surgery. Discussion: The most common are hyperplastic polyps, fundic gland polyps, adenomas and inflammatory fibroid polyps. Is very important to obtain biopsies to assess the histology and malignant potential. In certain cases a total gastrectomy is recommended. The fast track rehabilitation protocol is a safe method to decrease hospital stay and improve recovery.
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Pólipos/cirugía , Gastropatías/cirugía , Laparoscopía/métodos , Gastrectomía/métodos , Pólipos/diagnóstico , Gastropatías/diagnóstico , Factores de TiempoRESUMEN
Lymphomas are solid tumors of the lymphatic system and these are divided into Hodgkin's and non-Hodgkin lymphoma. Non-Hodgkin tumors may originate from non-nodal tissues such as the gastrointestinal tract and they are considered primary when extranodal involvement is equal to or greater than 75% according to the nodal involvement. Extranodal gastrointestinal lymphomas represent 1% to 4% of tumors of the digestive tract, and 10 to 15% of all non-Hodgkin lymphomas. The stomach is the most common extranodal lymphomas site. We present the clinical case of a sexagenarian male natural of Chiclayo who had an upper GI endoscopy for non-specific symptoms of dyspepsia that only reports gastritis and when admitted to our institution is diagnosed by endoscopy, biochemical markers and pathology as a perforated gastric non-Hodgkin lynphoma.
Asunto(s)
Linfoma no Hodgkin/diagnóstico , Perforación Espontánea/etiología , Neoplasias Gástricas/diagnóstico , Anciano , Humanos , Linfoma no Hodgkin/complicaciones , Masculino , Perforación Espontánea/diagnóstico , Gastropatías/diagnóstico , Gastropatías/etiología , Neoplasias Gástricas/complicacionesRESUMEN
Los linfomas son tumores sólidos del sistema linfático y se subdividen en linfomas de Hodgkin y no-Hodgkin. Los tumores no Hodgkin pueden originarse en tejidos no ganglionares como el tubo digestivo y son considerados primarios cuando el compromiso extranodal es igual o superior al 75% con relación al compromiso nodal. Los linfomas extranodales gastrointestinales representan del 1% al 4% de los tumores del tracto digestivo y del 10 al 15% de todos los linfomas no Hodgkin. El estómago es el sitio extranodal más común de los linfomas. Presentamos el caso clínico de un paciente varón sexagenario natural de Chiclayo que se realiza una endoscopía particular por síntomas inespecíficos de dispepsia y sólo se informa gastritis eritematosa y al ser admitido en nuestra institución se le diagnostica por endoscopía, marcadores bioquímicos y anatomopatología como un linfoma gástrico no Hodgkin perforado
Lymphomas are solid tumors of the lymphatic system and these are divided into Hodgkin's and non-Hodgkin lymphoma. Non-Hodgkin tumors may originate from non-nodal tissues such as the gastrointestinal tract and they are considered primary when extranodal involvement is equal to or greater than 75% according to the nodal involvement. Extranodal gastrointestinal lymphomas represent 1% to 4% of tumors of the digestive tract, and 10 to 15% of all non-Hodgkin lymphomas. The stomach is the most common extranodal lymphomas site. We present the clinical case of a sexagenarian male natural of Chiclayo who had an upper GI endoscopy for non-specific symptoms of dyspepsia that only reports gastritis and when admitted to our institution is diagnosed by endoscopy, biochemical markers and pathology as a perforated gastric non-Hodgkin lynphoma
Asunto(s)
Anciano , Humanos , Masculino , Neoplasias Gástricas/diagnóstico , Linfoma no Hodgkin/diagnóstico , Perforación Espontánea/etiología , Gastropatías/diagnóstico , Gastropatías/etiología , Neoplasias Gástricas/complicaciones , Linfoma no Hodgkin/complicaciones , Perforación Espontánea/diagnósticoRESUMEN
ABSTRACT BACKGROUND Gastric subepithelial lesion is a relatively common diagnosis after routine upper endoscopy. The diagnostic workup of an undetermined gastric subepithelial lesion should take into consideration clinical and endoscopic features. OBJECTIVE We aimed to investigate the association between patients' characteristics, endoscopic and echographic features with the histologic diagnosis of the gastric subepithelial lesions. METHODS This is a retrospective study with 55 patients, who were consecutively diagnosed with gastric subepithelial lesions, from October 2008 to August 2011. Patients' characteristics, endoscopic and echografic features of each gastric subepithelial lesion were analysed. Histologic diagnosis provided by EUS-guided fine needle aspiration or endoscopic/surgical resection was used as gold standard. RESULTS The probability of gastrointestinal stromal tumors to be located in the cardia was low (4.5%), while for leiomyoma it was high (>95%). In addition, there was a higher risk of gastrointestinal stromal tumors in patients older than 57 years (OR 8.9; 95% CI), with lesions ≥21 mm (OR 7.15; 95% CI), located at 4th layer (OR 18.8; 95% CI), with positive Doppler sign (OR 9; 95% CI), and irregular outer border (OR 7.75; 95% CI). CONCLUSION The location of gastric subepithelial lesions in the gastric cardia lowers the risk of gastrointestinal stromal tumors. While gastric subepithelial lesions occurring in elderly patients, located in the gastric body, with positive Doppler signal and irregular outer border increase the risk of gastrointestinal stromal tumors.
RESUMO CONTEXTO O diagnóstico das lesões subepiteliais gástricas é relativamente comum após a endoscopia digestiva alta de rotina. A posterior investigação diagnóstica de uma lesão subepitelial gástrica indeterminada deve levar em consideração os aspectos clínicos e endoscópicos. OBJETIVO O objetivo foi avaliar a associação entre as características particulares dos pacientes, endoscópicas e ecográficas dos casos de lesões subepiteliais gástricas com os seus diagnósticos histológicos finais. MÉTODOS Estudo retrospectivo com 55 pacientes, consecutivamente diagnosticados com lesão subepitelial gástrica de outubro de 2008 a agosto de 2011. As características do paciente, endoscópica e ecográfica de cada caso com lesão subepitelial gástrica foram analisadas. O diagnóstico histológico fornecido pela punção aspirativa com agulha fina guiada por ecoendoscopia e/ou a ressecção endoscópica/cirúrgica foram utilizadas como padrão-ouro. RESULTADOS A probabilidade de tumor estromal gastrintestinal ser localizado na cárdia foi baixa (4,5%), enquanto que para o leiomioma foi elevada (>95%). Além disso, houve um maior risco de tumor estromal gastrintestinal em pacientes acima de 57 anos (OR 8,9; IC 95%), com lesão ≥21 mm (OR 7,15; IC 95%), localizada na 4ª camada (OR 18,8; IC 95%), com sinal positivo no Doppler (OR 9; IC 95%), e borda externa irregular (OR 7,75; IC 95%). CONCLUSÃO A localização de uma lesão subepitelial gástrica na cárdia reduz o risco de tumor estromal gastrintestinal. Enquanto que lesões subepiteliais gástricas que ocorrem em pacientes idosos, localizadas no corpo gástrico, com sinal positivo no Doppler e com borda externa irregular aumentam significativamente o risco de tumor estromal gastrintestinal.
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Anciano , Anciano de 80 o más Años , Adulto Joven , Gastropatías/diagnóstico , Gastropatías/patología , Neoplasias Gástricas , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Gastroscopía , Endosonografía , Biopsia con Aguja Fina , Persona de Mediana EdadRESUMEN
BACKGROUND: - Gastric subepithelial lesion is a relatively common diagnosis after routine upper endoscopy. The diagnostic workup of an undetermined gastric subepithelial lesion should take into consideration clinical and endoscopic features. OBJECTIVE: - We aimed to investigate the association between patients' characteristics, endoscopic and echographic features with the histologic diagnosis of the gastric subepithelial lesions. METHODS: - This is a retrospective study with 55 patients, who were consecutively diagnosed with gastric subepithelial lesions, from October 2008 to August 2011. Patients' characteristics, endoscopic and echografic features of each gastric subepithelial lesion were analysed. Histologic diagnosis provided by EUS-guided fine needle aspiration or endoscopic/surgical resection was used as gold standard. RESULTS: - The probability of gastrointestinal stromal tumors to be located in the cardia was low (4.5%), while for leiomyoma it was high (>95%). In addition, there was a higher risk of gastrointestinal stromal tumors in patients older than 57 years (OR 8.9; 95% CI), with lesions ≥21 mm (OR 7.15; 95% CI), located at 4th layer (OR 18.8; 95% CI), with positive Doppler sign (OR 9; 95% CI), and irregular outer border (OR 7.75; 95% CI). CONCLUSION: - The location of gastric subepithelial lesions in the gastric cardia lowers the risk of gastrointestinal stromal tumors. While gastric subepithelial lesions occurring in elderly patients, located in the gastric body, with positive Doppler signal and irregular outer border increase the risk of gastrointestinal stromal tumors.
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Gastropatías/diagnóstico , Adulto , Anciano , Anciano de 80 o más Años , Biopsia con Aguja Fina , Endosonografía , Femenino , Gastroscopía , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Gastropatías/patología , Neoplasias Gástricas , Adulto JovenRESUMEN
Gastric syphilis is an uncommon extracutaneous manifestation of syphilis, occurring in less than 1% of patients, presenting nonspecific clinical manifestations. In general, it occurs on secondary stage. The critical point is the recognition of the syphilitic gastric involvement, without which there may be incorrect diagnosis of malignancy of the digestive tract. In this report, a case of secondary syphilis with gastric involvement that had complete remission with benzathine penicillin will be described.