RESUMEN
The paper considers the causes of iron- and cyanobalamin-deficiency anemias caused by gastrointestinal tract (GT) diseases, among which malabsorption along with loss of these nutrients through the GT is of great importance. The paper reflects the current views of the pathogenesis of deficiency anemias that develop in gluten-sensitive celiac disease and atrophic gastritis. Among the atrophic gastritides, there are two forms caused by autoimmune processes and long-term Helicobacter pylori persistence, whose treatment is an effective measure in refractory anemia. The paper gives the provisions of the Russian Gastroenterology Association Guidelines (2012) for the management of H. pylori infection, which are based on Maastricht IV consensus (2010).
Asunto(s)
Anemia , Enfermedad Celíaca , Gastritis Atrófica , Infecciones por Helicobacter , Helicobacter pylori , Anemia/dietoterapia , Anemia/tratamiento farmacológico , Anemia/etiología , Enfermedad Celíaca/complicaciones , Enfermedad Celíaca/dietoterapia , Enfermedad Celíaca/tratamiento farmacológico , Gastritis Atrófica/complicaciones , Gastritis Atrófica/dietoterapia , Gastritis Atrófica/tratamiento farmacológico , Infecciones por Helicobacter/complicaciones , Infecciones por Helicobacter/tratamiento farmacológico , Infecciones por Helicobacter/microbiología , Helicobacter pylori/efectos de los fármacos , Helicobacter pylori/patogenicidad , HumanosRESUMEN
In the 1-year double-blind placebo-controlled intervention trial, it was shown that daily supplementation of patients with gastric premalignant lesions (intestinal metaplasia, IM) with a complex, containing Ester-C with antioxidantsand (2100 mg of Ca-ascorbate + 340 mg of bioflavonoids), produced a sharp decrease of abnormally high ornithine decarboxylase activity in IM gastric mucosa that was accom panied by practically total IM regression in 11 of 18 (61%) patients.
Asunto(s)
Antioxidantes/administración & dosificación , Ácido Ascórbico/administración & dosificación , Gastritis Atrófica/dietoterapia , Gastritis Atrófica/tratamiento farmacológico , Infecciones por Helicobacter/dietoterapia , Infecciones por Helicobacter/tratamiento farmacológico , Adulto , Anciano , Enfermedad Crónica , Método Doble Ciego , Femenino , Mucosa Gástrica/enzimología , Mucosa Gástrica/microbiología , Mucosa Gástrica/patología , Gastritis Atrófica/enzimología , Gastritis Atrófica/patología , Infecciones por Helicobacter/enzimología , Humanos , Intestinos/enzimología , Intestinos/patología , Masculino , Metaplasia/dietoterapia , Metaplasia/tratamiento farmacológico , Metaplasia/enzimología , Metaplasia/patología , Persona de Mediana Edad , Ornitina Descarboxilasa/metabolismoRESUMEN
Previous in vitro and animal experiments have shown that sulforaphane, which is abundant in broccoli, inhibits Helicobacter pylori (H. pylori) infection and blocks gastric tumor formation. This suggests that broccoli consumption prevents chronic atrophic gastritis (CAG) introduced by H. pylori infection and, therefore, gastric cancer. For an epidemiological investigation of the relationship between the broccoli consumption and CAG, a cross-sectional study of 438 male employees, aged 39 to 60 years, of a Japanese steel company was conducted. CAG was serologically determined with serum cut-off values set at pepsinogen I < or = 70 ng/ml and a ratio of serum pepsinogen I/pepsinogen II < or = 3.0. Broccoli consumption (weekly frequency) and diet were monitored by using a 31-item food frequency questionnaire. The prevalence of CAG among men who ate broccoli once or more weekly was twice as high as that among men who consumed a negligible amount (P < 0.05). Multiple logistic regression analysis indicated that broccoli consumption once or more weekly significantly increased the risk for CAG (odds ratio, 3.06; 95% confidence interval, 1.12-8.38; P < 0.05), after controlling for age, education, cigarette smoking, and alcohol consumption. The present study failed to show an expected association between frequent broccoli consumption and a low prevalence of CAG.
Asunto(s)
Brassica , Gastritis Atrófica/dietoterapia , Gastritis Atrófica/epidemiología , Adulto , Enfermedad Crónica , Estudios Transversales , Encuestas sobre Dietas , Gastritis Atrófica/prevención & control , Infecciones por Helicobacter/dietoterapia , Infecciones por Helicobacter/epidemiología , Infecciones por Helicobacter/prevención & control , Helicobacter pylori , Humanos , Japón/epidemiología , Modelos Logísticos , Masculino , Persona de Mediana Edad , Pepsinógeno A/sangre , Pepsinógeno C/sangre , PrevalenciaRESUMEN
Antioxidant vitamins have been reported to be associated with an improvement in blood lipid profiles, but results are not consistent. The present study was designed to determine whether long-term vitamin C supplementation could alter serum lipid concentrations in subjects who completed a 5-year population-based double-blind intervention trial. A total of 439 Japanese subjects with atrophic gastritis initially participated in the trial using vitamin C and beta-carotene to prevent gastric cancer. Before and upon early termination of beta-carotene supplementation, 134 subjects dropped out of the trial; finally, 161 subjects assigned to the high-dose group (500 mg vitamin C/d) and 144 subjects assigned to the low-dose group (50 mg vitamin C/d) were studied. No favourable effect of vitamin C supplementation on serum concentrations of total cholesterol, HDL- and LDL-cholesterol, and triacylglycerol was observed, although high-dose vitamin C supplementation increased serum vitamin C concentrations substantially. Among women, the mean change in serum triacylglycerol decreased (-0.12 mmol/l, 95 % CI -0.32, 0.09) in the high-dose group, but increased (+0.12 mmol/l, 95 % CI 0.03, 0.22) in the low-dose group. In addition, the mean change in serum triacylglycerol among women with hypertriacylglycerolaemia was statistically significant (-1.21, 95 % CI -2.38, -0.05) after high-dose vitamin C supplementation. The 5-year vitamin C supplementation had no markedly favourable effects on the serum lipid and lipoprotein profile. However, our present results do not preclude the possibility that vitamin C supplementation may decrease triacylglycerol concentrations among women with hypertriacylglycerolaemia.
Asunto(s)
Ácido Ascórbico/administración & dosificación , Suplementos Dietéticos , Lípidos/sangre , Adulto , Anciano , Ácido Ascórbico/sangre , Colesterol/sangre , HDL-Colesterol/sangre , LDL-Colesterol/sangre , Enfermedad Crónica , Método Doble Ciego , Femenino , Gastritis Atrófica/dietoterapia , Humanos , Hipertrigliceridemia/prevención & control , Masculino , Persona de Mediana Edad , Factores Sexuales , Fumar , Factores de Tiempo , Triglicéridos/sangreRESUMEN
Background. Only a few reported studies focus on the natural history and course of advanced and severe chronic atrophic gastritis. Methods. In this study we followed 47 men (mean age 62 years) with advanced (moderate or severe) Helicobacter pylori-positive atrophic corpus gastritis. Duration of endoscopic follow-up was 6 years and follow-up based on serum levels of pepsinogen I and antibodies to H. pylori covered a period of 10 years. None of the patients was treated for H. pylori infection prior to end of follow-up. Results. The median H. pylori antibody titre declined (IgG from 4000 to 1300; IgA from 200 to 50) in the study population, and 11 men (23%) converted to seronegative (p=0.0005, Fisher's exact test). There was a small but significant (p=0.0004, Page's test) declining trend in mean atrophy score of the corpus during follow-up (from 2.5 to 2.2). However, no significant changes were observed in grade of atrophy or intestinal metaplasia of the antral mucosa or in grade of intestinal metaplasia in the corpus. The mean SPGI level remained at the initial low level during the entire follow-up. Conclusions. H. pylori antibodies disappear spontaneously within 10 years in almost one fourth of patients with advanced atrophic corpus gastritis. The disappearance of H. pylori antibodies is accompanied by no or more than a mild improvement of the gastric mucosa.
Asunto(s)
Anticuerpos Antibacterianos/sangre , Gastritis Atrófica/inmunología , Infecciones por Helicobacter/inmunología , Helicobacter pylori/inmunología , Anciano , Dieta , Mucosa Gástrica/inmunología , Mucosa Gástrica/microbiología , Gastritis Atrófica/sangre , Gastritis Atrófica/dietoterapia , Gastritis Atrófica/microbiología , Infecciones por Helicobacter/sangre , Infecciones por Helicobacter/dietoterapia , Infecciones por Helicobacter/microbiología , Humanos , Inmunoglobulina A/sangre , Inmunoglobulina G/sangre , Masculino , Persona de Mediana Edad , Pepsinógeno A/sangre , Placebos , alfa-Tocoferol/administración & dosificación , beta Caroteno/administración & dosificaciónRESUMEN
60 patients with chronic atrophic gastritis and secretory insufficiency allied with chelicobacterial infection in combination with chronic unlithic cholecystitis or diskinesia of choledoch ways were explored with a view to study the efficiency of dietary cure including biologically active food supplements--flavonoids source. Fortification of the patients food intake with flavonoids-containing biologically active food supplements benefits mucous membrane of gastroduodenal zone that is evidenced in decrease of activity of pyloric chelicobacteriosis and resolvent and reparative effect, it also contributes to normalization of hepatobiliaric system condition and antioxidant status.
Asunto(s)
Discinesia Biliar/dietoterapia , Colecistitis/dietoterapia , Flavonoides/administración & dosificación , Aditivos Alimentarios/administración & dosificación , Alimentos Fortificados , Gastritis Atrófica/dietoterapia , Discinesia Biliar/complicaciones , Colecistitis/complicaciones , Enfermedad Crónica , Femenino , Aditivos Alimentarios/química , Gastritis Atrófica/complicaciones , Humanos , Masculino , Resultado del TratamientoRESUMEN
Se realizo un estudio analitico de casos y controles, para explorar varios factores ambientales que se sospecha tienen relacion con la aparicion de gastritis cronica atrofica en la poblacion nariñense. Se seleccionaron de la poblacion que consulta la Clinica San Juan de Pasto, 264 pacientes (132 casos y 132 controles) procedentes de la ciudad de Pasto, entre los 15 y los 57 años de edad, a quienes se les aplico una encuesta. Los resultados del estudio indicaron que el consumo alto o frecuente de habas, arroz, cafe, tinto, bebidas alcoholicas, cigarrillo, unidos al bajo consumo de frutas y verduras, el estado emocional y la frecuencia de consumo de alimentos, constituyen un riesgo para la adquisicion de gastritis cronica atrofica; ademas, existe asociacion entre la enfermedad y el estado nutricional del paciente
Asunto(s)
Gastritis Atrófica/diagnóstico , Gastritis Atrófica/dietoterapia , Gastritis Atrófica/etiología , Conducta AlimentariaRESUMEN
The fates of 97 children hospitalized for malnutrition syndrome in the years 1983-1985 were assessed depending on the aetiology and treatment. In all cases the first biopsy of the small intestine demonstrated the so called flat mucosa. In recent years a continuous rise has been observed in the number of children with malabsorption syndromes, especially secondary syndromes caused, most frequently, by infectious factor and antibiotic treatment given for infections. The number of such cases was in 1985 four times greater than in 1983. A proper diagnostic-therapeutic management led to complete regeneration of intestinal villi in all cases. The further development of these children was normal.