RESUMEN
BACKGROUND: Unplanned pregnancy is a public health issue that has detrimental implications for the mother and baby alike. However, few studies have been conducted in The Gambia on this subject. As a result, the prevalence of unplanned pregnancy among women of reproductive age in The Gambia was investigated, as well as the factors associated with it. METHODS: The Gambia's Multiple Indicators Cluster Survey (MICS) was used to evaluate the 2018 results. Data was obtained from 3790 women aged 15 to 49 who had also given birth. The univariate analysis was conducted using percentage. The adjusted odds ratios (AOR) were determined using a multivariable logistic regression model (with corresponding 95% confidence interval (CI)). The degree of statistical significance was set at 5%. RESULTS: Approximately 25.3% (95% CI: 23.1%-27.6%) of the women reported unplanned pregnancy. Women aged 30-34 years had 45% reduction in unplanned pregnancy, when compared with those aged 15-19 years (AOR = 0.55; 95% CI: 0.32-0.94). The Fula and non-Gambian women had 30% and 45% reduction in unplanned pregnancy respectively, when compared with Mandinka women. Those who had no functional difficulties had 47% reduction in unplanned pregnancy, when compared with women who had functional difficulties (AOR = 0.53; 95% CI: 0.30, 0.91). Respondents who had given births to 3-4 and 5 + children were 1.79 and 3.02 times as likely to have unplanned pregnancy, when compared with women who had given birth to 1-2 children. Single/unmarried women were 11.38 times as likely to have unplanned pregnancy, when compared with women currently married/in union (AOR = 11.38; 95% CI: 6.38, 20.29). Local Government Area of residence was significantly associated with unplanned pregnancy. Furthermore, women who were neither happy nor unhappy and 18 + at sexual debut were 1.39 and 1.34 times as likely to have unplanned pregnancy, when compared with the very happy women and those < 18 at sexual debut respectively. CONCLUSION: The rate of unintended pregnancies was large (25.3%). Several causes have been linked to unplanned pregnancies. These results suggest that further efforts are required to enhance women's sex education, expand access to family planning services, and provide affordable health care to high-risk women in order to minimize unintended pregnancies.
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Embarazo no Planeado , Adolescente , Adulto , Femenino , Gambia/etnología , Humanos , Persona de Mediana Edad , Embarazo , Prevalencia , Factores Sociodemográficos , Adulto JovenRESUMEN
BACKGROUND: Women-held documents are a basic component of continuity of maternity care. The use and completion of women-held documents following discharge could improve treatment and care for postnatal women. Using a mixed-methods study design, we aimed to assess the number, type, quality and completeness of women-held discharge documents, identify factors contributing to document completeness and facilitators or barriers for effective use of the documents. METHODS: Documents given to women at discharge from three hospitals in the Greater Banjul Area, The Gambia, were reviewed for content and quality. All women completed a questionnaire on the use of the documents. Poisson regression was used to estimate factors predicting document completion. Semi-structured interviews (n = 21) and focus groups (n = 2) were carried out with healthcare professionals (HCPs). RESULTS: Nearly all (n = 211/212; 99%) women were given a document to take home. The most complete document (maternal record) had on average 17/26 (65%) items completed and 10% of women held an illegible document. None of the women's sociodemographic or clinical characteristics predicted document completeness. The following facilitators for effective use of documents were identified from the women's responses to the questionnaire and interviews with HCPs: 94% of women thought written information is important, 99% plan to have postnatal check-ups and 67% plan to use their documents, HCPs understand the importance of the documents and were familiar with the document's use and content. The following barriers for effective use of documents were identified: HCPs had too many women-held documents to complete at discharge, there is no national protocol and HCPs think women do not understand the documents due to a lack of education and that women often lose or forget their documents. CONCLUSIONS: Women-held documents are well established in The Gambia; though quality and completeness needs improving. Future research should determine the impact of using only one document at discharge, protocols and training on completeness, among other outcomes, and on ways to ensure all women are using the documents for their postnatal care.
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Continuidad de la Atención al Paciente , Registros Médicos/normas , Resumen del Alta del Paciente/normas , Atención Posnatal , Actitud del Personal de Salud , Femenino , Grupos Focales , Gambia/etnología , Humanos , Parto/etnología , Embarazo , Investigación Cualitativa , Encuestas y CuestionariosRESUMEN
Childhood detention represents an integral part of the public health response to the COVID-19 emergency. Prison conditions in Italy put detained minors at grave risk of contracting sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To date (29 April 2020), the Italian penitentiary system is housing 161 minors (147 males), most of them in pre-trial custody, as well as 50 children <3 y of age residing with their mothers in detention. Furthermore, the government reported 5265 unaccompanied minor migrants, mainly from Gambia and Egypt. The fundamental approach to be followed in childhood detention during COVID-19 is prevention of the introduction of infectious agents into detention facilities, limiting the spread within the prison and reducing the possibility of spread from the prison to the outside community. This appears challenging in countries like Italy with intense SARS-CoV-2 transmission. The current COVID-19 pandemic shows the need to provide a comprehensive childhood protection agenda, as the provision of healthcare for people in prisons and other places of detention is a state responsibility.
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COVID-19/prevención & control , Salud Infantil/estadística & datos numéricos , Emigrantes e Inmigrantes/estadística & datos numéricos , Prisioneros/estadística & datos numéricos , Salud Pública/métodos , Niño , Preescolar , Egipto/etnología , Femenino , Gambia/etnología , Humanos , Lactante , Italia , Masculino , SARS-CoV-2RESUMEN
BACKGROUND: Clinical trials require high levels of participation and low drop-out rates to be successful. However, collecting blood samples from individuals recruited into clinical trials can be challenging when there is reticence about blood-taking. In addition to concerns regarding the feasibility of medical research, fears of 'blood-stealing' and 'blood-selling' have ethical implications related to cultural sensitivity and informed consent. This study explores anxieties around blood-taking during a malaria treatment trial in the Gambia. METHODS: This case study is based on ethnographic research in one theoretically selected village due to the high reticence to screening for the clinical trial 'Primaquine's gametocytocidal efficacy in malaria asymptomatic carriers treated with dihydroartemisinin-piperaquine' carried out in the Gambia between 2013 and 2014. Data collection tools included in-depth interviews, participant observation, informal conversations and group discussions. RESULTS: In total only 176 of 411 habitants (42%) in the village accepted having a bloodspot taken to screen for malaria. Although trial recruitment was initially high in the village, some families refused screening when rumours started spreading that the trial team was taking too much blood. Concerns about 'loss of blood' were equated to loss of strength and lack of good food to replenish bodily forces. Families in the study village were concerned about the weakness of their body while they had to harvest their crops at the time of recruitment for the trial. CONCLUSION: A common recommendation to prevent and avoid rumours against public health interventions and trials is the provision of full and consistent information during the consent procedure, which is assumed to lead to more accurate knowledge of the purpose of the intervention and increased trial participation. However, even when information provision is continuous, the emergence of rumours can be related to times of uncertainty and perceptions of vulnerability, which are often a reflection of structural inequalities and diverging value orientations between communities and public health institutions.
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Recolección de Muestras de Sangre/psicología , Sangre , Ensayos Clínicos como Asunto , Cultura , Miedo , Aceptación de la Atención de Salud/psicología , Población Rural , Adulto , Donantes de Sangre/psicología , Niño , Femenino , Gambia/etnología , Humanos , Malaria/sangre , Malaria/tratamiento farmacológico , Malaria/etnología , Masculino , Selección de Paciente , Factores SexualesRESUMEN
CONTEXT: Ethnic groups differ in fragility fracture risk and bone metabolism. Differences in diurnal rhythms (DRs) of bone turnover and PTH may play a role. OBJECTIVE: We investigated the DRs of plasma bone turnover markers (BTMs), PTH, and 1,25(OH)2D in three groups with pronounced differences in bone metabolism and plasma PTH. PARTICIPANTS: Healthy Gambian, Chinese, and white British adults (ages 60-75 years; 30 per country). INTERVENTIONS: Observational study with sample collection every 4 hours for 24 hours. MAIN OUTCOMES: Levels of plasma C-terminal telopeptide of type I collagen, procollagen type-1 N-propeptide, N-mid osteocalcin, bone alkaline phosphatase, PTH, and 1,25-dihydroxyvitamin D were measured. DRs were analyzed with random-effects Fourier regression and cross-correlation and regression analyses to assess associations between DRs and fasting and 24-hour means of BTMs and PTH. RESULTS: Concentrations of BTMs, PTH, and 1,25-dihydroxyvitamin D were higher in Gambians compared to other groups (P < .05). The DRs were significant for all variables and groups (P < .03) and were unimodal, with a nocturnal peak and a daytime nadir for BTMs, whereas PTH had two peaks. The DRs of BTMs and PTH were significantly cross-correlated for all groups (P < .05). There was a significant positive association between C-terminal telopeptide of type I collagen and PTH in the British and Gambian groups (P = .03), but not the Chinese group. CONCLUSIONS: Despite ethnic differences in plasma BTMs and PTH, DRs were similar. This indicates that alteration of rhythmicity and loss of coupling of bone resorption and formation associated with an elevated PTH in other studies may not uniformly occur across different populations and needs to be considered in the interpretation of PTH as a risk factor of increased bone loss.
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Biomarcadores/sangre , Remodelación Ósea , Ritmo Circadiano , Etnicidad , Anciano , China/etnología , Femenino , Fracturas Óseas/sangre , Fracturas Óseas/etnología , Gambia/etnología , Humanos , Masculino , Persona de Mediana Edad , Hormona Paratiroidea/sangre , Reino Unido/etnologíaRESUMEN
We report a case of urinary schistosomiasis in an adolescent refugee from Gambia (arrived to Italy illegally), who was brought to the Emergency Department of our hospital. The patient complained of gross hematuria and, in the absence of clinical evidence of bacterial urinary infection, was admitted to the pediatric ward, considering his provenience and social setting. An appropriate collection and microscopic analysis of urine samples led to the detection of bilharzia. Much attention should be paid to this emerging disease in Europe by physicians in order to recognize and treat it timely, which could prevent future and higher costs for public health systems and could reduce the potential risk of environmental spreading. In fact, there are some areas in Italy where the parasite can find its intermediate host to complete its lifecycle.
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Enfermedades Transmisibles Emergentes/etnología , Hematuria/etiología , Refugiados , Esquistosomiasis Urinaria/etnología , Adolescente , Gambia/etnología , Humanos , Italia/epidemiología , Masculino , Esquistosomiasis Urinaria/complicaciones , Esquistosomiasis Urinaria/diagnósticoRESUMEN
Melioidosis is due to Burkholderia pseudomallei and is known to be endemic in South-East Asia, while epidemiology of disease in Sub-Saharan Africa is still unclear. Prompt recognition of infection is crucial for adequate antibiotic treatment. Infection can lead to visceral abcesses and awareness of this complication is important for proper management.
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Burkholderia pseudomallei/aislamiento & purificación , Enfermedades Endémicas , Melioidosis/complicaciones , Insuficiencia Renal/etiología , Dinamarca/epidemiología , Gambia/etnología , Humanos , Masculino , Melioidosis/etnología , Melioidosis/microbiología , Persona de Mediana Edad , Insuficiencia Renal/etnología , ViajeRESUMEN
The Farafenni Health and Demographic Surveillance System (Farafenni HDSS) is located 170 km from the coast in a rural area of The Gambia, north of the River Gambia. It was set up in 1981 by the UK Medical Research Council Laboratories to generate demographic and health information required for the evaluation of a village-based, primary health care programme in 40 villages. Regular updates of demographic events and residency status have subsequently been conducted every 4 months. The surveillance area was extended in 2002 to include Farafenni Town and surrounding villages to support randomized, controlled trials. With over three decades of prospective surveillance, and through specific scientific investigations, the platform (population ≈ 50,000) has generated data on: morbidity and mortality due to malaria in children and during pregnancy; non-communicable disease among adults; reproductive health; and levels and trends in childhood and maternal mortality. Other information routinely collected includes causes of death through verbal autopsy, and household socioeconomic indicators. The current portfolio of the platform includes tracking Millennium Development Goal 4 (MDG4) attainments in rural Gambia and cause-of-death determination.
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Encuestas Epidemiológicas , Vigilancia de la Población/métodos , Autopsia , Causas de Muerte , Femenino , Gambia/etnología , Humanos , Malaria/mortalidad , Mortalidad Materna/tendencias , Morbilidad , Embarazo , Estudios Prospectivos , Población Rural , Factores SocioeconómicosRESUMEN
UNLABELLED: Predictors of 25(OH)D3 half-life were factors associated with vitamin D metabolism, but were different between people in The Gambia and the UK. Country was the strongest predictor of plasma 25(OH)D concentration, probably as a marker of UVB exposure. 25(OH)D3 half-life may be applied as a tool to investigate vitamin D expenditure. INTRODUCTION: The aim of this study was to investigate predictors of 25(OH)D3 half-life and plasma 25(OH)D concentration. METHODS: Plasma half-life of an oral tracer dose of deuterated-25(OH)D3 was measured in healthy men aged 24-39 years, resident in The Gambia, West Africa (n = 18) and in the UK during the winter (n = 18), countries that differ in calcium intake and vitamin D status. Plasma and urinary markers of vitamin D, calcium, phosphate and bone metabolism, nutrient intakes and anthropometry were measured. RESULTS: Normally distributed data are presented as mean (SD) and non-normal data as geometric mean (95% CI). Gambian compared to UK men had higher plasma concentrations of 25(OH)D (69 (13) vs. 29 (11) nmol/L; P < 0.0001); 1,25(OH)2D (181 (165, 197) vs. 120 (109, 132) pmol/L; P < 0.01); and parathyroid hormone (PTH) (50 (42, 60) vs. 33 (27, 39); P < 0.0001). There was no difference in 25(OH)D3 half-life (14.7 (3.5) days vs. 15.6 (2.5) days) between countries (P = 0.2). In multivariate analyses, 25(OH)D, 1,25(OH)2D, vitamin D binding protein and albumin-adjusted calcium (Caalb) explained 79% of variance in 25(OH)D3 half-life in Gambians, but no significant predictors were found in UK participants. For the countries combined, Caalb, PTH and plasma phosphate explained 39 % of half-life variability. 1,25(OH)2D, weight, PTH and country explained 81% of variability in 25(OH)D concentration; however, country alone explained 74%. CONCLUSION: Factors known to affect 25(OH)D metabolism predict 25(OH)D3 half-life, but these differed between countries. Country predicted 25(OH)D, probably as a proxy measure for UVB exposure and vitamin D supply. This study supports the use of 25(OH)D half-life to investigate vitamin D metabolism.
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Calcifediol/sangre , Vitamina D/sangre , Adulto , Biomarcadores/metabolismo , Deuterio , Dieta/etnología , Alimentos , Gambia/etnología , Semivida , Humanos , Masculino , Fosfatos/metabolismo , Factores de Riesgo , Reino Unido/etnología , Adulto JovenRESUMEN
UNLABELLED: Ethnic differences in renal calcium and phosphate excretion exist, which may depend on differences in their dietary intakes and regulatory factors. We report highly significant differences in urinary calcium and phosphate excretion between white British and Gambian adults after statistical adjustment for mineral intakes, indicating an independent effect of ethnicity. INTRODUCTION: Populations vary in their risk of age-related osteoporosis. There are racial or ethnic differences in the metabolism of the bone-forming minerals calcium (Ca) and phosphate (P), with a lower renal Ca and P excretion in African-Americans compared to white counterparts, even at similar intakes and rates of absorption. Also, Africans in The Gambia have a lower Ca excretion compared to white British subjects, groups known to differ in their dietary Ca intake. Here, we report on differences in urinary Ca and P excretion between Gambian and white British adults while allowing for known predictors, including dietary intakes. METHODS: Participants were healthy white British (n = 60) and Gambian (n = 61) men and women aged 60-75 years. Fasting blood and 2-h urine samples were collected. Markers of Ca and P metabolism were analysed. Dietary intake was assessed with country-specific methods. RESULTS: White British older adults had higher creatinine-corrected urinary Ca and P excretion (uCa/uCr, uP/uCr) and lower tubular maximum of Ca and P compared to Gambian counterparts. The predictors of urinary Ca and P differed between groups. Multiple regression analysis showed that dietary Ca and Ca/P were predictors of uCa/uCr and uP/uCr, respectively. Ethnicity remained a significant predictor of uCa/uCr and uP/uCr after adjustment for diet and other factors. CONCLUSIONS: Gambian older adults have higher renal Ca conservation than British counterparts. Dietary mineral intakes were predictors of the differences in urinary Ca and P excretion, but ethnicity remained a highly significant predictor after statistical adjustment. This suggests that ethnicity has an independent effect on renal Ca and P handling.
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Calcio/orina , Dieta/etnología , Alimentos , Fosfatos/orina , Anciano , Estudios Transversales , Femenino , Gambia/etnología , Humanos , Modelos Logísticos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Reino Unido/etnologíaRESUMEN
BACKGROUND: Community violence exposure among youth can lead to various negative outcomes, including post-traumatic stress symptoms. Research in the Western world indicates that a number of social support factors may moderate the relation between violence exposure and internalizing symptoms. Little research has been carried out in non-Western countries. This study aimed to fill this gap by exploring the relations among violence exposure, parental warmth, positive school climate, and post-traumatic stress reactions among youth in The Republic of The Gambia, Africa. METHODS: A school-based survey of youth behaviors, feelings, attitudes, and perceptions was administered to 653 students at senior secondary schools in four Gambian communities. RESULTS: Students reported high levels of exposure to violence. Over half of students reported witnessing someone threatened with serious physical harm, beaten up or mugged, attacked or stabbed with a knife/piece of glass, or seriously wounded in an incident of violence. Nearly half of students reported being beaten up or mugged during the past year, and nearly a quarter reported being threatened with serious physical harm. There were no sex differences in levels of exposure. Traumatic stress symptoms were common, especially among females. Both violence witnessing and violent victimization significantly predicted post-traumatic stress symptoms, and positive school climate moderated the relationship. Among youth victimized by violence, positive school climate was most strongly correlated with lower levels of post-traumatic stress at low levels of exposure. Among youth who had witnessed violence, positive school climate was most strongly correlated with lower levels of post-traumatic stress at high levels of exposure. CONCLUSION: Community-based programs that bring together parents, schools, and youth may play an important role in combating the negative effects of some types of violence exposure among Gambian youth. Youth experiencing high levels of violent victimization represent a sample of particular concern and merit special research and clinical attention.
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Población Negra/estadística & datos numéricos , Víctimas de Crimen/estadística & datos numéricos , Instituciones Académicas/estadística & datos numéricos , Trastornos por Estrés Postraumático/epidemiología , Estudiantes/psicología , Violencia/estadística & datos numéricos , Adolescente , Población Negra/etnología , Población Negra/psicología , Víctimas de Crimen/psicología , Recolección de Datos/estadística & datos numéricos , Femenino , Gambia/epidemiología , Gambia/etnología , Humanos , Masculino , Psicología del Adolescente , Instituciones Académicas/organización & administración , Medio Social , Trastornos por Estrés Postraumático/etnología , Estudiantes/estadística & datos numéricos , Población Urbana/estadística & datos numéricos , Violencia/etnología , Violencia/psicologíaRESUMEN
Post-malaria neurological syndrome (PMNS) defined by a post-infective encephalopathy occurring within 2 months after an episode of Plasmodium falciparum infection is still a debated entity. We describe 2 cases of PMNS in 2 patients of African origin, born and living in France. Both patients had severe P. falciparum infection, followed by PMNS. They recovered with no sequelae. These are the first-reported cases of PMNS in patients of African ethnicity and living in France.
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Encefalopatías/parasitología , Malaria Falciparum/complicaciones , Aciclovir/uso terapéutico , Adolescente , Adulto , Encefalopatías/etiología , Côte d'Ivoire/etnología , Encefalitis por Herpes Simple/tratamiento farmacológico , Francia , Gambia/etnología , Humanos , Masculino , Síndrome , Resultado del TratamientoRESUMEN
Mycetomas are chronic, progressive infections caused either by fungi (eumycetoma) or filamentous bacteria (actinomycetoma) and are characterized by the triad of draining sinuses, tumefaction, and the presence of macroscopic grains. We describe a case of eumycetoma in a cardiac transplant recipient caused by the soil saprophyte Acremonium species. This represents only the fifth case of eumycetoma reported in a solid organ transplant recipient. With the population of immunosuppressed patients and the incidence of invasive fungal infections increasing, consideration should be given to unusual saprophytic fungal infections as emerging opportunistic pathogens.
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Acremonium/aislamiento & purificación , Dermatosis del Pie/etiología , Trasplante de Corazón , Micetoma/etiología , Complicaciones Posoperatorias/etiología , Antifúngicos/uso terapéutico , Cardiomiopatía Dilatada/cirugía , Dermatosis del Pie/tratamiento farmacológico , Dermatosis del Pie/microbiología , Gambia/etnología , Humanos , Huésped Inmunocomprometido , Inmunosupresores/efectos adversos , Itraconazol/uso terapéutico , Masculino , Persona de Mediana Edad , Micetoma/tratamiento farmacológico , Complicaciones Posoperatorias/tratamiento farmacológico , Complicaciones Posoperatorias/microbiologíaRESUMEN
OBJECTIVE: We investigated the attitudinal and perceptual components of body image and its link with body mass index (BMI) in a sample of urban Gambians. We also looked at cross-cultural differences in body image and views on attractiveness between Gambians and Americans. METHODS: Four groups of 50 subjects were assessed: men 14- 25y (YM); women 14-25y (YW); men 35-50y (OM); women 35-50y (OW). Socio-economic status, education, healthy lifestyle and western influences were investigated. Height and weight were measured. Body dissatisfaction was assessed with the body dissatisfaction scale of the Eating Disorder Inventory. Perceptions of body image and attractiveness were assessed using the Body Image Assessment for Obesity (BIA-O) and Figure Rating Scale (FRS). RESULTS: Different generations of Gambians had very different perceptions and attitudes towards obesity. Current body size was realistically perceived and largely well tolerated. Older women had a higher body discrepancy (current minus ideal body size) than other groups (p<0.001). Regression analysis showed they were not worried about their body size until they were overweight (BMI=27.8 kg/m2), whilst OM, YM and YW started to be concerned at a BMI respectively of 22.9, 19.8 and 21.5 kg/m2. A cross-cultural comparison using published data on FRS showed that Gambians were more obesity tolerant than black and white Americans. DISCUSSION: The Gambia is a country in the early stage of demographic transitions but in urban areas there is an increase in obesity prevalence. Inherent tensions between the preservation of cultural values and traditional habits, and raising awareness of the risks of obesity, may limit health interventions to prevent weight gain.
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Actitud Frente a la Salud , Imagen Corporal , Índice de Masa Corporal , Adolescente , Adulto , Factores de Edad , Ansiedad , Belleza , Población Negra , Comparación Transcultural , Femenino , Gambia/etnología , Humanos , Masculino , Persona de Mediana Edad , Obesidad , Estados Unidos , Población Urbana , Población BlancaRESUMEN
There is presently much interest in utilizing patterns of linkage disequilibrium (LD) to further genetic association studies. This is particularly pertinent in the class III region of the human major histocompatibility complex (MHC), which has been extensively studied as a disease susceptibility locus in a number of ethnic groups. To date, however, few studies of LD in the MHC have considered non-Caucasian populations. With the advent of large-scale haplotyping of the human genome, the question of utilizing LD patterns across populations has come to the fore. We have previously used LD mapping to direct an MHC class III association study in a UK Caucasian population. As an extension of this, we sought to determine to what extent the pattern of LD observed in that study could be used to conduct a similar study in a West African Gambian population. We found that broad patterns of LD were similar in the two populations, resulting in similar candidate region delineations, but at a higher resolution, marker-specific patterns of LD and population-dependent allele frequencies confounded the choice of regional tagging SNPs. Our results have implications for the applicability of large-scale haplotype maps such as the HapMap to complex regions like the MHC.
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Etnicidad/genética , Predisposición Genética a la Enfermedad/genética , Desequilibrio de Ligamiento , Complejo Mayor de Histocompatibilidad/genética , Mapeo Cromosómico , Gambia/etnología , Haplotipos , Humanos , Polimorfismo de Nucleótido Simple , Población/genéticaRESUMEN
Mortality from childhood cerebral malaria remains unacceptably high in endemic regions. This survey was conducted between June and December 2001 among 69 primary caregivers of children admitted for cerebral malaria in Bansang Hospital, Central River Division (CRD), The Gambia to describe decision-making process at the family level that could have impact on malaria mortality. Thirty two percent of children presented in coma after 24 h of onset of illness. The eldest person in the compound or the father was responsible for taking decision on when hospital treatment was necessary in 85% of the cases. Mothers who were the primary caregivers made such decisions only in 7% of the cases. Cultural norms in a community are important factors affecting preferences at the household level and could influence important medical decisions. This survey suggests that patriarchs and/or fathers are important target groups for health education and project implementation programs.
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Toma de Decisiones , Composición Familiar , Malaria Cerebral/mortalidad , Malaria Cerebral/psicología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Animales , Cuidadores/economía , Cuidadores/educación , Cuidadores/psicología , Niño , Preescolar , Coma/etiología , Coma/parasitología , Coma/patología , Progresión de la Enfermedad , Composición Familiar/etnología , Padre , Femenino , Fiebre/etiología , Fiebre/parasitología , Fiebre/patología , Gambia/epidemiología , Gambia/etnología , Humanos , Lactante , Malaria Cerebral/complicaciones , Malaria Cerebral/parasitología , Masculino , Persona de Mediana Edad , Madres , Plasmodium falciparum/fisiología , Convulsiones/complicaciones , Convulsiones/parasitología , Convulsiones/patología , Factores de TiempoAsunto(s)
Enfermedades del Pie/etiología , Herpesvirus Humano 8/aislamiento & purificación , Sarcoma de Kaposi/etiología , Neoplasias Cutáneas/etiología , Adulto , Antirretrovirales/administración & dosificación , Antirretrovirales/uso terapéutico , Antineoplásicos/uso terapéutico , Terapia Combinada , Susceptibilidad a Enfermedades , Doxorrubicina/uso terapéutico , Quimioterapia Combinada , Enfermedades del Pie/tratamiento farmacológico , Enfermedades del Pie/radioterapia , Enfermedades del Pie/virología , Gambia/etnología , Seronegatividad para VIH , Humanos , Factores Inmunológicos/uso terapéutico , Interferón alfa-2 , Interferón-alfa/uso terapéutico , Fallo Renal Crónico/complicaciones , Fallo Renal Crónico/terapia , Neoplasias Hepáticas/tratamiento farmacológico , Neoplasias Hepáticas/secundario , Masculino , Proteínas Recombinantes , Terapia Recuperativa , Sarcoma de Kaposi/tratamiento farmacológico , Sarcoma de Kaposi/radioterapia , Sarcoma de Kaposi/secundario , Sarcoma de Kaposi/virología , Neoplasias Cutáneas/tratamiento farmacológico , Neoplasias Cutáneas/radioterapia , Neoplasias Cutáneas/virología , Neoplasias del Bazo/tratamiento farmacológico , Neoplasias del Bazo/secundarioRESUMEN
No disponible
Asunto(s)
Masculino , Adulto , Humanos , Enfermedades del Pie/tratamiento farmacológico , Enfermedades del Pie/etiología , Enfermedades del Pie/radioterapia , Herpesvirus Humano 8/aislamiento & purificación , Sarcoma de Kaposi/tratamiento farmacológico , Sarcoma de Kaposi/etiología , Sarcoma de Kaposi/radioterapia , Sarcoma de Kaposi/secundario , Sarcoma de Kaposi/virología , Neoplasias Cutáneas , Antirretrovirales , Factores Inmunológicos , Quimioterapia Combinada , Gambia/etnología , Seronegatividad para VIH , Interferón-alfa/uso terapéutico , Insuficiencia Renal Crónica , Neoplasias Hepáticas , Neoplasias del Bazo , Doxorrubicina/uso terapéuticoRESUMEN
OBJECTIVE: To investigate plasma osteocalcin gamma-carboxylation and its relationship to plasma phylloquinone concentration and apolipoprotein E (apoE) genotype in women from three ethnic groups with differing osteoporotic fracture risk. DESIGN AND SUBJECTS: Fasted blood samples were collected from postmenopausal Gambian (n=50), British (n=31) and Chinese women (n=23), and 11 premenopausal women in each group from three cross-sectional studies. RESULTS: After adjustment for total osteocalcin, plasma undercarboxylated osteocalcin (adjusted ucOC) was lowest in Chinese and highest in British women postmenopause (British vs Chinese 103% higher, P<0.0001; Gambian vs Chinese 66% higher, P<0.01). No differences were observed premenopause. Within each ethnic group, adjusted ucOC was similar pre- and postmenopause. Postmenopause, plasma phylloquinone was higher in Chinese women (1.0 ng/ml) than in British (0.31 ng/ml) and Gambian women (0.36 ng/ml) (P<0.0001). Premenopause, plasma phylloquinone was higher in Gambian and Chinese women (0.6 ng/ml) than in British women (0.3 ng/ml; P=0.01). Plasma phylloquinone and adjusted ucOC were inversely related in postmenopausal British women (R2=32.4%; P=0.0008). ApoE4 frequency was Gambian 32.6%, British 13.8% and Chinese 6%. A lower adjusted ucOC was associated with apoE2 genotype in British and Chinese women. Ethnic differences in adjusted ucOC persisted after adjustment for phylloquinone and apoE genotype. CONCLUSION: These preliminary data indicate suboptimal vitamin K status in postmenopausal British compared to Chinese and Gambian women. Ethnic differences in apoE genotype may also influence osteocalcin gamma-carboxylation status. The study highlights the need for larger epidemiological investigations of ethnic differences in vitamin K status and the possible implications to bone health.
Asunto(s)
Antifibrinolíticos/sangre , Apolipoproteínas E/genética , Osteocalcina/metabolismo , Osteoporosis Posmenopáusica/etnología , Osteoporosis Posmenopáusica/epidemiología , Vitamina K 1/sangre , Adulto , Anciano , China/etnología , Estudios Transversales , Inglaterra/etnología , Femenino , Gambia/etnología , Genotipo , Humanos , Persona de Mediana Edad , Osteocalcina/sangre , Osteoporosis Posmenopáusica/metabolismo , Posmenopausia/etnología , Posmenopausia/metabolismo , Premenopausia/etnología , Premenopausia/metabolismo , Factores de Riesgo , Vitamina K 1/administración & dosificaciónRESUMEN
In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and prevalence or density of malarial parasitemia, except that, after correcting for total anti-MSP-1(19) antibody levels, individuals with anti-MSP-1(19) antibodies that compete with an invasion inhibitory monoclonal antibody (12.10) were significantly less likely to have malaria infections with densities of > or =1,000 parasites/microl than were individuals without such antibodies. This association persisted after correction for age and ethnic origin.