RESUMEN
Acaricides are used by beekeepers in honey bee (Apis mellifera L.) colonies to control parasitic mites, but may also have adverse effects to honey bees. In this study, five commonly used acaricides were tested for their sublethal effects on memory and expression of neural-related genes in honey bees. Memory measured with the proboscis extension reflex (PER) assay was significantly reduced by topical treatment of bees with a single LD05 dose of formic acid at 2 and 24 h post treatment (hpt). However, tau-fluvalinate, amitraz, coumaphos, and formic acid, but not thymol, resulted in memory loss at 48 hpt. The LD05 doses of the acraricides did not affect expression of neuroligin-1, related to memory, or expression of major royal jelly protein-1, related to both memory and development, although expression of both genes was affected at LD50 doses. The LD05 doses of thymol, formic acid, amitraz and coumaphos increased defensin-1 expression, which is related to both memory and immunity. The effect of thymol, however, may have been due to its impact on the immune response rather than memory. This study demonstrates that acaricides vary in their effects on bee's memory, and that the widely used acaricide, formic acid, is particularly damaging.
Asunto(s)
Acaricidas , Abejas/efectos de los fármacos , Memoria/efectos de los fármacos , Acaricidas/efectos adversos , Acaricidas/uso terapéutico , Animales , Abejas/metabolismo , Moléculas de Adhesión Celular Neuronal/efectos de los fármacos , Moléculas de Adhesión Celular Neuronal/genética , Moléculas de Adhesión Celular Neuronal/metabolismo , Cumafos/efectos adversos , Cumafos/uso terapéutico , Defensinas/efectos de los fármacos , Defensinas/genética , Defensinas/metabolismo , Formiatos/efectos adversos , Formiatos/uso terapéutico , Expresión Génica , Genes de Insecto , Glicoproteínas/efectos de los fármacos , Glicoproteínas/genética , Glicoproteínas/metabolismo , Proteínas de Insectos/efectos de los fármacos , Proteínas de Insectos/genética , Proteínas de Insectos/metabolismo , Timol/efectos adversos , Timol/uso terapéuticoRESUMEN
Extragenital cutaneous warts are benign epidermal tumors caused by human papillomaviruses (HPVs) and a frequent reason for patients to consult a dermatologist. Depending on wart type and site involved, the clinical presentation is highly varied. Given that warts represent a self-limiting condition, a wait-and-see approach may be justified. However, treatment is always indicated if the lesions become painful or give rise to psychological discomfort. Factors to be considered in this context include subjective disease burden, patient age, site affected, as well as the number and duration of lesions. Destructive treatment methods involve chemical or physical removal of diseased tissue. Nondestructive methods consist of antimitotic and antiviral agents aimed at inhibiting viral proliferation in keratinocytes. Some of the various immunotherapies available not only have localized but also systemic effects and are thus able to induce remission of warts located at any distance from the injection site. Especially patients with warts at multiple sites benefit from this form of treatment. Intralesional immunotherapy using the mumps-measles-rubella (MMR) vaccine is a particularly promising option for the treatment of recalcitrant warts in adult patients. For children, on the other hand, HPV vaccination is a novel and promising approach, even though it has not been approved for the treatment of cutaneous warts. At present, there is no universally effective treatment available. Moreover, many frequently employed therapies are currently not supported by conclusive clinical trials.
Asunto(s)
Enfermedades Cutáneas Virales/terapia , Verrugas/terapia , Acetatos/uso terapéutico , Adulto , Antivirales/uso terapéutico , Crioterapia/métodos , Legrado/métodos , Femenino , Fluorouracilo/uso terapéutico , Formiatos/uso terapéutico , Humanos , Terapia por Láser/métodos , Masculino , Fototerapia/métodos , Ácido Salicílico/uso terapéutico , Enfermedades Cutáneas Virales/patología , Enfermedades Cutáneas Virales/transmisión , Verrugas/patología , Verrugas/transmisión , Espera VigilanteAsunto(s)
Suplementos Dietéticos , Formiatos/uso terapéutico , Defectos del Tubo Neural/genética , Tubo Neural/metabolismo , Aminohidrolasas/genética , Animales , Modelos Animales de Enfermedad , Ácido Fólico/genética , Ácido Fólico/metabolismo , Formiato-Tetrahidrofolato Ligasa/genética , Formiatos/metabolismo , Humanos , Proteínas de Transporte de Membrana/genética , Metilenotetrahidrofolato Deshidrogenasa (NADP)/genética , Metilenotetrahidrofolato Reductasa (NADPH2)/genética , Ratones , Complejos Multienzimáticos/genética , Tubo Neural/efectos de los fármacos , Tubo Neural/crecimiento & desarrollo , Tubo Neural/patología , Defectos del Tubo Neural/dietoterapia , Defectos del Tubo Neural/metabolismo , Defectos del Tubo Neural/patologíaRESUMEN
Controlling Salmonella at farm level can act as the first line of defence in reducing salmonellosis from pork. This study investigated the efficacy of an encapsulated blend of formic acid, citric acid, and essential oils (FormaXOL™) administered to finisher pigs for 28days prior to slaughter in controlling Salmonella shedding on a commercial farm with a history of high Salmonella seroprevalence. Fourteen pens of 8-10 pigs/pen were randomly assigned to a control (finisher diet without additive) or a treatment group (the same diet with 4kg/t of FormaXOL™) for 28 days. Faeces were collected from each pig on days 0, 14, and 28, while on day 29 blood, caecal digesta and ileocaecal-mesenteric lymph nodes were collected at slaughter. Pigs were weighed at the start and end of the trial, feed intake was recorded, and carcass quality parameters were recorded at slaughter. On day 14, Salmonella shedding was reduced in the treatment compared to the control group (27.9% versus 51.7% probability of detecting Salmonella in faeces, respectively; p=0.001). However, on day 28, no reduction was observed (20.6% versus 35.9% probability of detecting Salmonella in faeces, respectively; p=0.07). Interestingly, Salmonella shedding rates in the treated pigs remained stable throughout the trial compared to the control group. This suggests that the feed additive prevented additional pigs from acquiring the Salmonella infection. A lower Salmonella seroprevalence was detected at slaughter in the treatment compared to the control group using the 40% optical density cut-off (64.5% versus 88.5%, respectively; p=0.01). However, no significant differences in Salmonella recovery rates were observed in the caecal digesta or lymph nodes between treated and control groups. Treated pigs had a lower feed intake than pigs fed the control diet (p=0.001); however, average daily gain and feed conversion efficiency were not affected by treatment (p=0.45 and 0.55, respectively). Consequently, supplementing the diet with FormaXOL™ for 28days increased the feed cost per kg of live-weight gain by 0.08. Overall, results suggest that strategic administration of an encapsulated blend of formic acid, citric acid, and essential oils, to finishing pigs for 28days prior to slaughter has potential to prevent increased Salmonella shedding at certain time points as well as seroprevalence. However, this additive did not lower intestinal carriage, nor did it reduce seroprevalence to below the cut-off used for the high Salmonella risk category in Ireland (50%) or improve growth performance.
Asunto(s)
Ácido Cítrico/uso terapéutico , Formiatos/uso terapéutico , Aceites Volátiles/uso terapéutico , Salmonelosis Animal/tratamiento farmacológico , Enfermedades de los Porcinos/tratamiento farmacológico , Animales , Ácido Cítrico/administración & dosificación , Combinación de Medicamentos , Femenino , Formiatos/administración & dosificación , Masculino , Aceites Volátiles/administración & dosificación , Salmonelosis Animal/epidemiología , Estudios Seroepidemiológicos , Porcinos/microbiología , Enfermedades de los Porcinos/epidemiologíaRESUMEN
Formate, the only non-tetrahydrofolate (THF)-linked intermediate in one-carbon metabolism, is produced in mammals from a variety of metabolic sources. It occurs in serum of adults at a concentration of approximately 30 µM. Its principal function lies as a source of one-carbon groups for the synthesis of 10-formyl-THF and other one-carbon intermediates; these are primarily used for purine synthesis, thymidylate synthesis, and the provision of methyl groups for synthetic, regulatory, and epigenetic methylation reactions. Although formate is largely produced in mitochondria, these functions mostly occur in the cytoplasm and nucleus. Formate plays a significant role in embryonic development, as evidenced by the effectiveness of formate in the pregnant dam's drinking water on the incidence of neural tube defects in some genetic models. High formate concentrations in fetal lambs may indicate a role in fetal development and suggest that extracellular formate may play a role in the interorgan distribution of one-carbon groups.
Asunto(s)
Desarrollo Fetal , Formiatos/metabolismo , Mitocondrias/metabolismo , Modelos Biológicos , NADP/metabolismo , Animales , Metilación de ADN , Suplementos Dietéticos , Epigénesis Genética , Femenino , Formiatos/sangre , Formiatos/uso terapéutico , Humanos , Masculino , Fenómenos Fisiologicos Nutricionales Maternos , Metilación , Mitocondrias/enzimología , Defectos del Tubo Neural/sangre , Defectos del Tubo Neural/metabolismo , Defectos del Tubo Neural/prevención & control , Vía de Pentosa Fosfato , Embarazo , Procesamiento Proteico-Postraduccional , Purinas/biosíntesis , Procesamiento Postranscripcional del ARN , Timidina Monofosfato/biosíntesisRESUMEN
BACKGROUND: Seasonal allergic rhinitis (SAR), also known as hay fever, is a widespread chronic respiratory disease. In treatment of SAR the use of complementary therapies is increasing, but little has been published about homeopathic complex remedies so far. Therefore, we think it is time to conduct and publish an appropriate observational study. METHODS: Course of single symptoms, impairment of quality of life, general efficacy, and tolerability of a homeopathic complex remedy containing active substances on a low dilution level have been assessed and analyzed. Altogether, 123 patients with a history of allergic rhinitis of up to 45 years have been observed for about 4 weeks. RESULTS: The majority of symptoms were shown to improve substantially and the patients' quality of life increased clearly. The overall symptom score decreased significantly from 10.3 ± 4.7 to 3.9 ± 3.1 points (p < 0.0001), and reduction of impairment of quality of life from 5.7 ± 2.3 to 1.9 ± 1.8 score points was also significant (p < 0.0001). Rating of efficacy of study medication was markedly better than efficacy rating of previous therapies (p = 0.0193). Apart from one temporary allergic reaction, the treatment was well tolerated. CONCLUSION: The homeopathic complex remedy (Pascallerg®) tested in this observational study offers a useful option in treatment of SAR in children and adults.
Asunto(s)
Terapias Complementarias/normas , Materia Medica/uso terapéutico , Rinitis Alérgica Estacional/tratamiento farmacológico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Compuestos de Cromo/uso terapéutico , Enfermedad Crónica/terapia , Femenino , Formiatos/uso terapéutico , Gelsemium/química , Humanos , Masculino , Persona de Mediana Edad , Extractos Vegetales/uso terapéutico , Compuestos de Potasio/uso terapéutico , Estudios Prospectivos , Calidad de Vida , Sulfatos/uso terapéutico , Resultado del TratamientoRESUMEN
Nosemosis type C caused by the microsporidium Nosema ceranae is one of the most widespread of the adult honey bee diseases, and due to its detrimental effects on both strength and productivity of honey bee colonies, an appropriate control of this disease is advisable. Fumagillin is the only veterinary medicament recommended by the World Organization for Animal Health (OIE) to suppress infections by Nosema, but the use of this antibiotic is prohibited in the European Union and few alternatives are available at present to control the disease. In the present study three therapeutic agents (Nosestat®, Phenyl salicylate and Vitafeed Gold®) have been tested to control N. ceranae infection in honey bee colonies, and have been compared to the use of fumagillin. None of the products tested was effective against Nosema under our experimental conditions. Low consumption of the different doses of treatments may have had a strong influence on the results obtained, highlighting the importance of this issue and emphasizing that this should be evaluated in studies to test therapeutic treatments of honey bee colonies.
Asunto(s)
Antifúngicos/uso terapéutico , Abejas/microbiología , Microsporidiosis/veterinaria , Nosema , Animales , Beta vulgaris , Ciclohexanos/uso terapéutico , Ácidos Grasos Insaturados/uso terapéutico , Formiatos/uso terapéutico , Yodo/uso terapéutico , Microsporidiosis/prevención & control , Fitoterapia/veterinaria , Extractos Vegetales/uso terapéutico , Salicilatos/uso terapéutico , Sesquiterpenos/uso terapéuticoRESUMEN
Comparative evaluation of the infusion of reamberin and mafusol has been carried out on the model of toxic liver damage caused by ammonium chloride. Reamberin contributed to more rapid normalization of indices due to an increase in the substrate reserve for energy metabolism. In a group of animals with alcohol intoxication, only the treatment with Reamberin allowed the system of antioxidant protection (reduced glutathione, thiol groups) and functional activity of the liver to be to normalized by the end of experiments on a level of the control group (intact animals).
Asunto(s)
Enfermedad Hepática Inducida por Sustancias y Drogas/tratamiento farmacológico , Citoprotección , Formiatos/uso terapéutico , Meglumina/análogos & derivados , Succinatos/uso terapéutico , Adenosina Trifosfato/metabolismo , Intoxicación Alcohólica/complicaciones , Cloruro de Amonio/administración & dosificación , Cloruro de Amonio/efectos adversos , Animales , Antioxidantes/farmacología , Etanol/administración & dosificación , Etanol/efectos adversos , Glutatión/metabolismo , Hígado/metabolismo , Meglumina/uso terapéutico , Ratas , Ratas Wistar , Cloruro de Sodio/administración & dosificaciónRESUMEN
The effect of organic acids and mannanoligosaccharide addition to the diet was assessed in pigs orally inoculated with Salmonella typhimurium. Forty-six growers were distributed among four treatments: Basal Diet (BD); BD+encapsulated organic acids; BD+free organic acids; BD+mannanoligosaccharide. Seroconversion was monitored, and feces and tissue samples were tested for Salmonella isolation. No treatment prevented the carrier state, but a tendency of lower fecal excretion was observed in the group treated with mannanoligosaccharide.
Asunto(s)
Heces/microbiología , Salmonelosis Animal/microbiología , Salmonella typhimurium/efectos de los fármacos , Enfermedades de los Porcinos/microbiología , Animales , Portador Sano/microbiología , Portador Sano/prevención & control , Ácido Cítrico/administración & dosificación , Ácido Cítrico/uso terapéutico , Dieta/veterinaria , Suplementos Dietéticos , Formiatos/administración & dosificación , Formiatos/uso terapéutico , Fumaratos/administración & dosificación , Fumaratos/uso terapéutico , Malatos/administración & dosificación , Malatos/uso terapéutico , Mananos/administración & dosificación , Mananos/uso terapéutico , Oligosacáridos/administración & dosificación , Oligosacáridos/uso terapéutico , Ácidos Fosfóricos/administración & dosificación , Ácidos Fosfóricos/uso terapéutico , Propionatos/administración & dosificación , Propionatos/uso terapéutico , Salmonelosis Animal/prevención & control , Porcinos/microbiología , Enfermedades de los Porcinos/prevención & controlRESUMEN
BACKGROUND/AIMS: We aimed to investigate the hepatoprotective effects of dihydromyrcenol and geranyl formate extracted from the Vitis vinifera L. plant in a rat model of acute hepatic injury induced by carbon tetrachloride. METHODS: The study was performed on 54 Sprague-Dawley male rats. The animals were divided into 9 study groups with 6 rats in each. At the end of the 7-day study period, the animals were sacrificed. The effects of dihydromyrcenol and geranyl formate on hepatic injury were evaluated based on the comparisons of the changes in the weight, serum levels of alanine aminotransferase and aspartate aminotransferase, and histopathological changes in the liver. RESULTS: Dihydromyrcenol significantly reduced the carbon tetrachloride-associated ballooning degeneration and apoptotic cell counts; this reduction was moderate with low doses of geranyl formate, while no reductions were observed with high doses of geranyl formate. The changes in the alanine aminotransferase and aspartate aminotransferase levels were in accordance with these findings. CONCLUSIONS: It can be concluded that in an experimental model of acute hepatic injury induced by carbon tetrachloride, dihydromyrcenol presents a hepatoprotective effect, while geranyl formate presents partial hepatoprotective effects at low doses and no hepatoprotective effects at high doses.
Asunto(s)
Enfermedad Hepática Inducida por Sustancias y Drogas/prevención & control , Formiatos/uso terapéutico , Monoterpenos/uso terapéutico , Octanoles/uso terapéutico , Fitoterapia , Extractos Vegetales/uso terapéutico , Terpenos/uso terapéutico , Alanina Transaminasa/sangre , Animales , Apoptosis , Aspartato Aminotransferasas/sangre , Peso Corporal , Tetracloruro de Carbono , Enfermedad Hepática Inducida por Sustancias y Drogas/sangre , Enfermedad Hepática Inducida por Sustancias y Drogas/patología , Masculino , Ratas , Ratas Sprague-Dawley , VitisRESUMEN
After the experimental investigations performed, the 0.6-0.8% solution of Pervomur (as irrigation of the operation area or application) was used in 103 patients. As compared with the control group the intraoperative using of Pervomur allowed the frequency of postoperative complications to be reduced from 21% to 15% and the time of treatment was shortened.
Asunto(s)
Abdomen/cirugía , Antiinfecciosos Locales/uso terapéutico , Infecciones Bacterianas/etiología , Infecciones Bacterianas/prevención & control , Formiatos/uso terapéutico , Peróxido de Hidrógeno/uso terapéutico , Procedimientos Quirúrgicos Operativos/efectos adversos , Animales , ConejosAsunto(s)
Transfusión de Sangre Autóloga , Formiatos/uso terapéutico , Hemostáticos/uso terapéutico , Espondilitis Anquilosante/terapia , Actividades Cotidianas , Humanos , Inyecciones Intramusculares , Estudios Prospectivos , Ensayos Clínicos Controlados Aleatorios como Asunto , Espondilitis Anquilosante/tratamiento farmacológico , Resultado del TratamientoRESUMEN
Pathopsychological examination, biochemical analysis of blood and urine as well as electroencephalogram (REG) were made in patients of the second (II) stage of alcoholism. The state of higher nervous activity (HNA) before and after treatment with antialcoholic drug medichronal was also analyzed. It has been shown that the course of treatment with medichronal applied to patients with alcoholism results in the removal of the inclination to alcohol, to improvement of functional state of the central nervous system, as well as ethanol (E), acetaldehyde (AcA) and catecholamines (CA) exchange, the disturbances in their metabolism (and first of all AcA) apparently being the basis of pathogenetic mechanisms of alcoholism.
Asunto(s)
Disuasivos de Alcohol/uso terapéutico , Alcoholismo/tratamiento farmacológico , Formiatos/uso terapéutico , Glucosa/uso terapéutico , Glicina/uso terapéutico , Adulto , Disuasivos de Alcohol/farmacología , Alcoholismo/metabolismo , Alcoholismo/fisiopatología , Alcoholismo/psicología , Encéfalo/efectos de los fármacos , Encéfalo/fisiopatología , Combinación de Medicamentos , Electroencefalografía/efectos de los fármacos , Formiatos/farmacología , Glucosa/farmacología , Glicina/farmacología , Actividad Nerviosa Superior/efectos de los fármacos , Actividad Nerviosa Superior/fisiología , Humanos , Masculino , PsicofisiologíaRESUMEN
An analysis of biological properties of blood substitutes has shown the expedience of wider clinical use instead of polyglucin of such substitutes as polyglucol, polifer, rondex, neorondex, polyoxidin, volecam; instead of rheopolyglucin--the rheopolyglucin with glucose, rheogluman and rheoglusol prepared for clinical tests; instead of haemodesin--haemodesin-H, neohaemodesin, gluconeodesin; instead of protein hydrolysates--polyamine and purified from peptides infusamine, hydromine, amicin; instead of 0.9% solution of sodium chloride--disol, quintasol, lactasol, mafusol. They have polyfunctional properties and considerably increase the effectiveness of the infusion--transfusion therapy.
Asunto(s)
Sustitutos Sanguíneos , Sustitutos Sanguíneos/normas , Sustitutos Sanguíneos/uso terapéutico , Dextranos/normas , Dextranos/uso terapéutico , Combinación de Medicamentos , Formiatos/normas , Formiatos/uso terapéutico , Humanos , Manitol/normas , Manitol/uso terapéutico , Sustitutos del Plasma/normas , Sustitutos del Plasma/uso terapéutico , Povidona/normas , Povidona/uso terapéuticoRESUMEN
Peculiarities of changes in the content of biogenic amines in the brain structures (hypothalamus, midbrain and new cortex) and blood of rats under alcohol intoxication and formation of alcohol dependence were investigated, and the effect of medichronal and its components on the mentioned processes was found out. It has been established that accumulation of acetaldehide plays a considerable role in the mechanism of formation of alcohol dependence. Changes in the level of ethanol (E) and AcA in blood after the arrival of exogenic E to the organism evokes phase dynamics of content of biogenic amines in the blood and brain sections. Medichronal components, binding and inactivating AcA, as well as taking the mutually supplementing effect on synthesis of biogenic amines, promote normalization of the mentioned processes and elimination of alcohol dependence.
Asunto(s)
Disuasivos de Alcohol/uso terapéutico , Intoxicación Alcohólica/tratamiento farmacológico , Alcoholismo/tratamiento farmacológico , Aminas Biogénicas/metabolismo , Encéfalo/efectos de los fármacos , Formiatos/uso terapéutico , Glucosa/uso terapéutico , Glicina/uso terapéutico , Intoxicación Alcohólica/metabolismo , Alcoholismo/metabolismo , Animales , Encéfalo/metabolismo , Química Encefálica/efectos de los fármacos , Combinación de Medicamentos , Evaluación Preclínica de Medicamentos , Masculino , Ratas , Factores de TiempoRESUMEN
At present the only drug that has an effect on biological mechanisms in alcoholism is medichronal. Exposure to microwave resonance therapy and psychocorrecting sessions was found to have an effective prophylactic action securing the results of therapeutic remission obtained during the main course of treatment. The proposed treatment option is practically free of side effects, is easy to use, which fact permits recommending it in the outpatient and hospital treatment of
Asunto(s)
Disuasivos de Alcohol/uso terapéutico , Alcoholismo/terapia , Ejercicios Respiratorios , Formiatos/uso terapéutico , Glucosa/uso terapéutico , Glicina/uso terapéutico , Microondas/uso terapéutico , Adulto , Alcoholismo/diagnóstico , Alcoholismo/psicología , Terapia Combinada , Combinación de Medicamentos , Etanol/efectos adversos , Estudios de Evaluación como Asunto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pruebas Psicológicas , Síndrome de Abstinencia a Sustancias/diagnóstico , Síndrome de Abstinencia a Sustancias/psicología , Síndrome de Abstinencia a Sustancias/terapiaRESUMEN
1. The inclusion of formic and propionic acids in the form of Bio-Add to the food of hens made no difference to the pH of the intestinal tract, but resulted in higher concentrations of these acids in the contents of the crop and gizzard. 2. Organic acids in the crop contents were bactericidal for Salmonella serotype Enteritidis PT4 in vitro, and also caused sub-lethal damage because fewer cells were recovered on selective salmonella media (brilliant green phenol red agar) than on non-selective media (nutrient agar). 3. Inclusion of Bio-Add in the food at 12g/kg may reduce the number of lactic acid-producing bacteria in the crop, and hence the amount of naturally produced organic acids.
Asunto(s)
Alimentación Animal , Antibacterianos , Formiatos/uso terapéutico , Contenido Digestivo/química , Enfermedades de las Aves de Corral , Propionatos/uso terapéutico , Salmonelosis Animal/prevención & control , Animales , Pollos , Femenino , Formiatos/administración & dosificación , Formiatos/farmacología , Concentración de Iones de Hidrógeno , Pruebas de Sensibilidad Microbiana , Propionatos/administración & dosificación , Propionatos/farmacología , Salmonella enteritidis/efectos de los fármacosRESUMEN
The effects of a novel antialcoholic medication medichronal on the serotonine concentration in blood of patients with second stage alcoholism was investigated. It has been discovered that remission in 75% of the patients was connected with its hyper- and hyposerotoninemic influence, depending on the initial lowered or increased serotonine content. Similarity of medichronal and unithiol effects was observed in the form of palyndromoinversion regulation of serotoninergic activity. In a portion of the patients the increased, compared to healthy persons, serotonine concentration before and after the treatment does not differ from the average values in the whole group.
Asunto(s)
Acetaldehído/antagonistas & inhibidores , Disuasivos de Alcohol/uso terapéutico , Alcoholismo/tratamiento farmacológico , Formiatos/uso terapéutico , Glucosa/uso terapéutico , Glicina/uso terapéutico , Serotonina/sangre , Adulto , Alcoholismo/sangre , Combinación de Medicamentos , Evaluación de Medicamentos , Humanos , Masculino , Unitiol/uso terapéuticoRESUMEN
In order to investigate the preventive and therapeutic effects of formic mixture on experimental silicosis, 96 Wistar rats were divided randomly into three groups, 1st group was taken as preventive administration (Two days before exposure to dust), 2nd group-therapeutic administration (one month after exposure to dust) and 3rd control group-model of silicosis. All above-mentioned animals were instilled intratracheally with standard quartz dust. At 1st, 3rd, 6th and 12th month after instillation of dust, rats from each group were sacrificed and pathohistologic studies were performed on their lung tissue. The results showed that the progressive degree of silicotic fibrosis in various groups were greatly different, i. e. 3rd group was severest, 2nd group medium, and 1st group was mildest. Either the differences of grade or quantity of fibrosis in lung tissue was significant between 1st and 3rd group, P < 0.01. The difference of the grade of fibrosis between 2nd and 3rd group was also significant, P < 0.05, but that between 1st and 2nd group was insignificant. The results demonstrated that administration of formic mixture, in particular, preventive administration, could inhibit greatly the process of silicotic fibrosis, and provided a basis for clinical application of this drug.
Asunto(s)
Medicamentos Herbarios Chinos/administración & dosificación , Formiatos/administración & dosificación , Silicosis/prevención & control , Animales , Combinación de Medicamentos , Medicamentos Herbarios Chinos/uso terapéutico , Femenino , Formiatos/uso terapéutico , Pulmón/patología , Masculino , Fibrosis Pulmonar/etiología , Fibrosis Pulmonar/patología , Distribución Aleatoria , Ratas , Ratas Wistar , Silicosis/patologíaRESUMEN
The authors have studied the efficiency of new blood substitutes (polyoxidin and mafusol) in complex infusion-transfusion therapy in operations on lungs. During surgical interventions these medications were administered in doses of 717.0 +/- 30.0 ml and 914.0 +/- 74.0 correspondingly, and one day after the operation--400 ml each. Operational blood losses were 1.25 +/- 0.9 l. It was found out that polyoxidin and mafusol have executed positive influence upon various factors of pathophysiological mechanisms, and thus were effective in complex treatment of blood losses or shock states.