RESUMEN
Melasma is acquired hyperpigmentation that mainly affects the face, can cause negative changes in self-esteem, and mostly affects women. Treatment is difficult, and different drugs can be used in mono or combination therapy. In this article, we present a brief overview of melasma, how to evaluate it, and a synthesis of the most commonly used topical therapies and their indications, including sunscreens, pharmacological agents, and plant extracts. Hydroquinone (4%) in monotherapy or combined with corticosteroids (dexamethasone and fluocinolone acetonide) and retinoids (tretinoin); arbutin (1%); methimazole (5%); kojic (2%), azelaic (20%), and tranexamic (5%) acids are the pharmacological agents that stand out. Correct application of these substances determines a variable improvement in melasma but often causes adverse reactions such as erythema, itching, and burning at the application site. Vitamin C can contribute to the reduction of melasma and have little or no adverse effects while sunscreens are normally used as coadjuvant therapies. In conclusion, we have compiled specific topical therapies for treating melasma and discussed those that are the most used currently. We consider it important that prescribers and researchers evaluate the best cost-benefit ratio of topical therapeutic options and develop new formulations, enabling efficacy in the treatment with safety and comfort during application, through the reduction of adverse effects.
Asunto(s)
Melanosis , Protectores Solares , Femenino , Humanos , Protectores Solares/uso terapéutico , Melanosis/etiología , Tretinoina/efectos adversos , Retinoides/uso terapéutico , Fluocinolona Acetonida/efectos adversos , Hidroquinonas/uso terapéutico , Resultado del TratamientoAsunto(s)
Antiinflamatorios/efectos adversos , Fluocinolona Acetonida/análogos & derivados , Tabique Nasal/lesiones , Úlcera/inducido químicamente , Administración Tópica , Antiinflamatorios/uso terapéutico , Niño , Femenino , Fluocinolona Acetonida/efectos adversos , Fluocinolona Acetonida/uso terapéutico , Humanos , Rinitis Alérgica Estacional/tratamiento farmacológicoRESUMEN
Nerisone cream (diflucortolon valerate 0.1%) has been clinically compared with fluocinolon-acetate on a double blind basis. The trial was carried out on 30 patients. The author comments that the results, in spite of some slight casuisties, appear to indicate a certain superiority of Nerisone cream when compared with the competitor's preparation.