RESUMEN

2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide extensively used in agriculture. It was considered of interest to study its toxicity on animal cells. We had previously determined that 1 mM 2,4-D can inhibit cell growth, DNA and protein synthesis of cultured Chinese hamster ovary cells (CHO) with cell accumulation in the G1/S interphase of the cell cycle. The present work examined the effects of 2,4-D on polyamine biosynthesis. The results suggest some possible mechanism of the herbicide's toxic effects on animal cells.

Asunto(s)

Ácido 2,4-Diclorofenoxiacético/toxicidad , Poliaminas/metabolismo , Animales , División Celular/efectos de los fármacos , Línea Celular , Medios de Cultivo , ADN/biosíntesis , ADN/efectos de los fármacos , Ornitina Descarboxilasa/análisis , Biosíntesis de Proteínas , Proteínas/efectos de los fármacos , Putrescina/biosíntesis , Putrescina/farmacología , Espermidina/biosíntesis , Espermidina/farmacología , Espermidina Sintasa/análisis , Espermina/biosíntesis , Espermina/farmacología , Espermina Sintasa/análisis