RESUMEN
OBJECTIVE: To assess prospectively the incidence with time of asymptomatic bacteriuria in patients with orthotopic ileal neobladders, and the possible effect on neobladder function. PATIENTS AND METHODS: In all, 47 patients (mean age 52.7 years, sd 8.7, range 31-68) with uncomplicated orthotopic ileal neobladders were prospectively evaluated. With no antibiotic manipulation, consecutive urine cultures were assessed monthly. Continence was assessed by direct information from the patients at each follow-up visit. RESULTS: Overall, 797 samples were cultured from the 47 patients (mean 17.6, sd 7.1). There was a steady decrease in the incidence of positive cultures, from 74.5%, to 35.6% and 6.7% at 1, 6 and 18 months, respectively. While there was persistently sterile urine in only eight patients (17%), 32 had occasional and seven had persistent bacteriuria. Escherichia coli was the commonest organism (76.6%) followed by Klebsiella pneumonia (15.7%); 54% of E. coli and 38% of K. pneumonia infections were sensitive to nitrofurantoin. Diurnal continence was achieved in 98% of the patients at 6 months after surgery. There was a gradual decrease in the frequency of nocturnal enuresis (NE) with time, from 87%, to 42%, 28% and 27% at 1, 6, 12 and 18 months, respectively. There was a significant correlation between the presence of bacteriuria and NE during the first 6 months, but it was not sustained after that. The age of the patients was also related significantly to the incidence of NE; at 6 months, only one of 18 men aged < or = 50 years had NE, while 19 of 29 aged > 50 years had (P < 0.001). At 1 year all patients aged < or = 50 years were nocturnally continent, while half of those aged > 50 years had NE (P = 0.001). CONCLUSIONS: Ileal neobladders are associated with a high incidence of asymptomatic bacteriuria during the first year after surgery. There was spontaneous clearance of bacteriuria with time, with no antimicrobial manipulation. Soon after surgery there was a significant association between bacteriuria and NE. The effect of antimicrobials on patients with NE should be evaluated.
Asunto(s)
Bacteriuria/etiología , Enuresis/microbiología , Derivación Urinaria/efectos adversos , Adulto , Anciano , Antibacterianos/uso terapéutico , Infecciones Bacterianas/tratamiento farmacológico , Infecciones Bacterianas/orina , Enuresis/orina , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Resultado del Tratamiento , Orina/microbiologíaRESUMEN
Se estudiaron 114 niños con enuresis, a los que se les sometió estudios de examen general de orina y urocultivo. Los niños que presentaron bacteriuria, compatible con infección urinaria, se sometieron a estudios de cistograma miccional y de ultrasonido renal y de las vías urinarias. Los exámenes clínicos y de laboratorio no dieron datos de anormalidad en 109 niños; en cinco niñas se encontró evidencia de infección por E. coli, cuatro de ellas con síntomas clínicos compatibles con esta enfermedad. En ninguna de estas niñas se encontró alguna malformación de las vías urinarias que estuviese asociada a la infección, y ambos problemas con la enuresis. Se discuten estos hallazgos y se propone la secuencia de estudio, seguida en la investigación, para el manejo de los niños enuréticos