RESUMEN
BACKGROUND: Trigeminal trophic syndrome is a rare cranial and facial condition caused by damage to the central or peripheral branches of the trigeminal nerve. This syndrome consists of a triad of anesthesia, paresthesia, and crescent-shaped facial ulcer involving the ala nasi and sometimes extending to the upper lip. Although previous screening for human immunodeficiency virus in some patients with trigeminal trophic syndrome was negative, we present a unique case of trigeminal trophic syndrome who tested positive for human immunodeficiency virus with eye complications. CASE PRESENTATION: We present a rare case of trigeminal trophic syndrome in a 44-year-old Black African woman who tested positive for human immunodeficiency virus. She presented with a 6-week history of progressive, persistent, and painless left sided facial and scalp ulcerations that started as small skin erosion. Diagnosis of trigeminal trophic syndrome was made on clinical grounds based on the triad of anesthesia, paresthesia, and unilateral crescent-shaped ulcer in the trigeminal dermatome and her past medical history. The ulcer healed completely after counseling and pharmacological therapy, but she later developed left periorbital cellulitis and left upper eyelid full-thickness defect. CONCLUSION: This is by far the first documented case of trigeminal trophic syndrome with a positive human immunodeficiency virus test. Testing for human immunodeficiency virus in patients with trigeminal trophic syndrome is necessary as this can help improve clinical management and treatment outcomes. Seeking the services of specialists remotely in resource constraint settings is beneficial for managing complications associated with trigeminal trophic syndrome.
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Infecciones por VIH , Humanos , Femenino , Adulto , Infecciones por VIH/complicaciones , Enfermedades del Nervio Trigémino/diagnóstico , Celulitis (Flemón)/diagnóstico , Úlcera Cutánea/etiología , Úlcera Cutánea/virología , Parestesia/etiología , Síndrome , Enfermedades de los Párpados/etiología , Enfermedades de los Párpados/diagnósticoAsunto(s)
Neoplasias de los Nervios Craneales , Melanoma , Neurilemoma , Humanos , Melanoma/diagnóstico , Melanoma/patología , Neurilemoma/diagnóstico , Neurilemoma/patología , Neurilemoma/diagnóstico por imagen , Diagnóstico Diferencial , Neoplasias de los Nervios Craneales/diagnóstico , Neoplasias de los Nervios Craneales/patología , Neoplasias de los Nervios Craneales/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Imagen por Resonancia Magnética , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/patología , FemeninoRESUMEN
Data on the state of sense of smell in patients who had a new coronavirus infection caused by the SARS-CoV-2 virus are currently reduced because of the impairment of the olfactory nerve system. There are practically no results in studies of disorders in the trigeminal nerve system. OBJECTIVE: Qualitative assessment of olfactory disorders after COVID-19 according to the system of olfactory and trigeminal nerves with a targeted assessment of the functional component of olfactory disorders. MATERIAL AND METHODS: We examined 40 patients aged 19 to 66 who had a coronavirus infection. All patients underwent neurological, otorhinolaryngological examinations, olfactometry, filled out the hospital anxiety and depression scale. RESULTS: Anosmia was diagnosed in 5 (12.5%) patients, hyposmia in 21 (52.5%) patients, and normosmia in 14 (35%) patients. Formed: the 1st group - 14 patients (35%) with normogram according to olfactometry; the 2nd group - 26 patients (65%) with anosmia/hyposmia. In the 1st group, disorders of the anxiety-depressive spectrum were significantly more common. In the 2nd group, a low identification of odors was found, lying in the spectrum of fresh, sharp, unpleasant, irritating, compared with sweet and pleasant or neutral, which indicates a predominant lesion of the trigeminal system. CONCLUSION: In patients with complaints of impaired sense of smell after undergoing COVID-19, the possible functional nature of anosmia/hyposmia should be taken into account, which requires the referral of such patients to psychotherapeutic specialists, and the possible entry of olfactory disorders into the 'trigeminal' spectrum.
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COVID-19 , Trastornos del Olfato , Nervio Trigémino , Humanos , COVID-19/complicaciones , Femenino , Masculino , Persona de Mediana Edad , Adulto , Trastornos del Olfato/etiología , Trastornos del Olfato/fisiopatología , Trastornos del Olfato/diagnóstico , Trastornos del Olfato/virología , Nervio Trigémino/fisiopatología , SARS-CoV-2 , Anciano , Olfato/fisiología , Olfatometría/métodos , Anosmia/etiología , Anosmia/fisiopatología , Federación de Rusia/epidemiología , Enfermedades del Nervio Trigémino/fisiopatología , Enfermedades del Nervio Trigémino/etiología , Enfermedades del Nervio Trigémino/diagnósticoRESUMEN
OBJECTIVES: To systematically report and document Trigeminal Trophic Syndrome (TTS), characterize its clinical presentation, diagnostic tests performed, outline management strategies, outcomes; and highlight the role of otolaryngologists in the tissue diagnosis of this rare syndrome. DATA SOURCES: PubMed/Medline, Scopus, and Cochrane databases. REVIEW METHODS: PubMed/Medline, Scopus, and Cochrane databases were systematically reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify all cases of TTS published with an English translation from inception to December 2020. RESULTS: A total of 142 articles describing 214 patients with TTS were included in the analysis. There was a female predominance (62.9 %) and a median age of 57 (range 1-93) years at presentation. A trigeminal neurological insult was identified in 200 (93.5 %) cases. The most common triggers for TTS were treatment for trigeminal neuralgia (35.7 %) and cerebrovascular accident (21.6 %). Self-inflicted trauma occurred in 137 (64 %) patients. Biopsy was done in 123 (57.5 %) patients. Patient education, barrier devices, and medications to address parasthesias were the most common treatment strategies. The majority of patients (72.5 %) received multimodal therapy. Surgery was performed in 35 (22.7 %) patients. Treatment outcomes were discussed in 120 (56.1 %) patients. CONCLUSIONS: TTS is a rare condition with poorly understood pathophysiology. It should be suspected in a patient with non-healing facial ulceration and altered sensation within the trigeminal nerve distribution. Biopsy of the ulcer is important to confirm the diagnosis and exclude malignancy. Treatment options include conservative and pharmacologic measures, and less frequently surgery.
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Neuralgia del Trigémino , Humanos , Síndrome , Femenino , Anciano , Masculino , Persona de Mediana Edad , Adulto , Anciano de 80 o más Años , Adolescente , Neuralgia del Trigémino/terapia , Neuralgia del Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/etiología , Adulto Joven , Niño , Lactante , Preescolar , Terapia CombinadaRESUMEN
Corneal neuropathy involves corneal nerve damage that disrupts ocular surface integrity, negatively impacting quality-of-life from pain and impaired vision. Any ocular or systemic condition that damages the trigeminal nerve can lead to corneal neuropathy. However, the condition currently does not have standardized diagnostic criteria or treatment protocols. The primary aim of this systematic review was to evaluate the efficacy and safety of interventions for treating corneal neuropathy. Randomized controlled trials (RCTs) that investigated corneal neuropathy treatments were eligible if the intervention(s) was compared to a placebo or active comparator. Comprehensive searches were conducted in Ovid MEDLINE, Ovid Embase and clinical trial registries from inception to July 2022. The Cochrane Risk-of-Bias 2 tool was used to assess study methodological quality. Certainty of the body of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Overall, 20 RCTs were included. Evaluated interventions comprised regenerative therapies (n = 6 studies), dietary supplements (n = 4), anti-glycemic agents (n = 3), combination therapy (n = 3), supportive therapies (n = 2) and systemic pain pharmacotherapies (n = 2). Nine RCTs were judged at high risk of bias for most outcomes. Definitions for corneal neuropathy in the populations varied substantially across studies, consistent with lack of consensus on diagnostic criteria. A diverse range of outcomes were quantified, likely reflecting absence of an agreed core outcome set. There was insufficient evidence to draw definitive conclusions on the efficacy or safety of any intervention. There was low or very low certainty evidence for several neuroregenerative agents and dietary supplements for improving corneal nerve fiber length in corneal neuropathy due to dry eye disease and diabetes. Low or very low certainty evidence was found for neuroregenerative therapies and dietary supplements not altering corneal immune cell density. This review identifies a need to standardize the clinical definition of corneal neuropathy and define a minimum set of core outcome measures. Together, this will provide a foundation for improved phenotyping of clinical populations in studies, and improve the capacity to synthesize data to inform evidence-based care. Protocol registration: PROSPERO ID: CRD42022348475.
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Córnea , Humanos , Córnea/patología , Córnea/inervación , Enfermedades de la Córnea/terapia , Enfermedades de la Córnea/diagnóstico , Ensayos Clínicos Controlados Aleatorios como Asunto , Enfermedades del Nervio Trigémino/terapia , Enfermedades del Nervio Trigémino/diagnóstico , Calidad de VidaRESUMEN
Neurotrophic keratopathy (NK) is a rare degenerative disease in which damage to the corneal nerves leads to corneal hypoesthesia or anesthesia. Neurotrophic corneal ulcers are notoriously difficult to treat and can lead to blindness. Corneal neurotization (CN) is a recent surgical technique aimed at restoring corneal sensation and may offer a definitive treatment in the wake of NK. Herein, we review the surgical techniques utilized in direct and indirect CN. Technical considerations, outcomes, current limitations and future perspectives are also discussed. This article highlights the key points of this promising procedure and biological aspects that will help provide the best treatment options for patients with severe NK.
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Enfermedades de la Córnea , Distrofias Hereditarias de la Córnea , Queratitis , Transferencia de Nervios , Enfermedades del Nervio Trigémino , Humanos , Transferencia de Nervios/métodos , Enfermedades de la Córnea/diagnóstico , Enfermedades de la Córnea/cirugía , Córnea/cirugía , Córnea/inervación , Regeneración Nerviosa/fisiología , Queratitis/cirugía , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/cirugía , Distrofias Hereditarias de la Córnea/cirugía , Enfermedades Raras/cirugíaRESUMEN
Ocular symptomatology in lesions of the facial nerve is associated with disturbed innervation of the circular muscle of the eye that leads to disruption of the protective function of the eyelids and the development of exposure symptoms, and is accompanied by a breach in corneal tear film integrity. The main clinical manifestation of the trigeminal nerve damage is the loss of sensory innervation of the cornea and disruption of the supply of neurotransmitters to its cells, manifesting as corneal hypo- or anesthesia. This triggers a cascade of pathological processes that lead to the development of neurotrophic keratopathy. In combined pathology of the facial and trigeminal nerves, a number of interrelated and mutually aggravating problems arise that require correction of lagophthalmos and functional restoration of the trigeminal nerve, since there is an interaction between the corneal epithelium and trigeminal neurons through trophic neuromodulators, which normally contribute to the proliferation of epithelial cells, their differentiation, migration and adhesion, and are essential for vital functions, metabolism and healing of surface lesions of the eye. Classical methods of treating neurotrophic keratopathy aim to protect the ocular surface, and are palliative or auxiliary, do not provide radical relief of the symptoms of neurotrophic keratopathy. Modern surgical technique of neurotization of the cornea allows restoring the structural growth of the nerve, which provides nerve trophism and corneal sensitivity, and is the only pathogenetically substantiated method of effective treatment of neurotrophic keratopathy. At the same time, direct neurotization has undeniable advantages over methods involving intercalary donor nerves, since neuropeptides from nerve fibers are immediately released into the recipient tissue and start reparative processes. Taking into account the accumulated positive experience of neurotization surgeries, scientific and clinical research should be continued in order to improve the most effective methods of corneal neurotization and promote their wider implementation into clinical practice.
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Enfermedades de la Córnea , Distrofias Hereditarias de la Córnea , Queratitis , Enfermedades del Nervio Trigémino , Córnea , Enfermedades de la Córnea/diagnóstico , Enfermedades de la Córnea/etiología , Enfermedades de la Córnea/cirugía , Nervio Facial , Humanos , Queratitis/cirugía , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/etiología , Enfermedades del Nervio Trigémino/cirugíaRESUMEN
PURPOSE: Neurotrophic keratitis (NK) is a rare condition which may result in visual loss. This case review investigates if there may be an association between NK and the blink reflex in the absence of facial nerve palsy and lagophthalmos. METHODS: This is a retrospective case review of 5 patients with trigeminal nerve damage referred to the oculoplastic department with suspected anesthetic corneae. Information on etiology, symptoms, duration, associated medical conditions, medications, examination findings including Mackie stage of keratopathy, management of keratopathy, and blink electrophysiology results was obtained. RESULTS: All 5 patients demonstrated absence of corneal sensation. All patients had preserved facial nerve function with no evidence of lagophthalmos. Keratopathy ranged from Mackie stage 0-2. Management ranged from ocular lubricants to Botulinum-toxin-induced ptosis. Blink studies demonstrated reduction in amplitude as well as increased latency in 2 patients, conferring reduced blink strength. Two patients demonstrated an absent blink reflex on the affected side. One patient had blink latency within the normative range; this patient recovered corneal sensation and was discharged. CONCLUSIONS: Our finding of reduced amplitude in blink studies offers both a factor in pathogenesis of NK and a potential therapeutic target. Additionally, blink studies may provide prognostic information for recovery and therefore guide management. We suggest performing blink electrophysiology in patients with trigeminal nerve damage to assess nerve function.
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Enfermedades de la Córnea , Enfermedades de los Párpados , Queratitis , Enfermedades del Nervio Trigémino , Parpadeo , Enfermedades de la Córnea/diagnóstico , Enfermedades de la Córnea/etiología , Enfermedades de los Párpados/etiología , Humanos , Queratitis/complicaciones , Queratitis/diagnóstico , Estudios Retrospectivos , Enfermedades del Nervio Trigémino/complicaciones , Enfermedades del Nervio Trigémino/diagnósticoRESUMEN
PURPOSE: To report 12 patients with neurotrophic keratopathy due to the trigeminal nerve injury after intracranial tumor surgeries underwent minimally invasive corneal neurotization and evaluate the outcomes of corneal reinnervation. METHODS: Twelve patients (12 eyes) with neurotrophic keratopathy caused by the trigeminal nerve injury after intracranial surgeries received minimally invasive corneal neurotization. All the preoperative central corneal sensation was under 5 mm, and minimally invasive corneal neurotization was performed over 6 months after the intracranial surgery. Follow-up was conducted 1 week and 1 month after the surgery and then every 3 months. Twelve healthy age-matched participants were enrolled as controls. The indicators included corneal sensation, best-corrected visual acuity, corneal nerve fiber length and branch density, diameter of nerve trunk, corneal ulcer lesion ratio, and sensation of the contralateral forehead. RESULTS: Mean follow-up was 24.7 ± 7.1 months. Mean central corneal sensation rose from 0.4 ± 1.4 to 31.7 ± 21.8 mm. Corneal nerve fiber length improved from 9.56 ± 5.00 to 14.96 ± 4.65 mm/mm2 and corneal nerve branch density and diameter of nerve trunk both increased (p < .01 and p < .05, respectively). Corneal lesion ratio decreased from 0.17 ± 0.12 to 0.10 ± 0.10 (p < .01). CONCLUSIONS: Minimally invasive corneal neurotization promotes corneal reinnervation for patients with neurotrophic keratopathy induced by the trigeminal nerve injury after intracranial surgeries. The process of corneal reinnervation after minimally invasive corneal neurotization often lasts over 12 months, and it takes about 18 months to return to a higher level. Corneal sensation and corneal nerve fiber length are related to clinical outcomes such as corneal ulcer lesion and best-corrected visual acuity. The effect on the sensation of the contralateral side forehead is temporary, and most patients can restore normal forehead sensation of the contralateral side.
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Enfermedades de la Córnea , Distrofias Hereditarias de la Córnea , Úlcera de la Córnea , Transferencia de Nervios , Enfermedades del Nervio Trigémino , Traumatismos del Nervio Trigémino , Ángulo Pontocerebeloso , Córnea/inervación , Córnea/cirugía , Enfermedades de la Córnea/diagnóstico , Enfermedades de la Córnea/etiología , Enfermedades de la Córnea/cirugía , Distrofias Hereditarias de la Córnea/cirugía , Úlcera de la Córnea/cirugía , Humanos , Transferencia de Nervios/métodos , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/etiología , Enfermedades del Nervio Trigémino/cirugía , Traumatismos del Nervio Trigémino/cirugíaRESUMEN
Trigeminal neuropathy (TNO) manifests with unilateral or bilateral facio-oral sensory disturbances accompanied by pain and trigeminal nerve dysfunction. Although TNO may be posttraumatic or idiopathic, a thorough history and examination including magnetic resonance imaging is needed to exclude the multitude of secondary TNO causes. TNO-related pain necessitates multimodal treatment which in severe cases may encompass neurosurgical neuromodulation.
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Enfermedades del Nervio Trigémino , Neuralgia del Trigémino , Humanos , Imagen por Resonancia Magnética , Dolor , Nervio Trigémino/diagnóstico por imagen , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/terapia , Neuralgia del Trigémino/diagnóstico , Neuralgia del Trigémino/terapiaRESUMEN
BACKGROUND: Neurotrophic keratopathy (NK) is a rare degenerative corneal disease caused by damage to the trigeminal nerve. We hereby describe a severe case with bilateral corneal perforation due to leprosy (Hansen's disease)-associated NK. CASE PRESENTATION: An 89-year-old man with a history of leprosy treated 40 years previously in our sanatorium developed bilateral corneal perforation due to NK. He had a history of bilateral persistent epithelial defects and bacterial keratitis. Although epithelialization was obtained with the use of autologous serum eye drops, progressive corneal thinning concomitant with stromalysis led to bilateral perforation. Over one month treatment with topical antibiotics, anti-inflammatory and lubricants resulted in healing of the epithelial defects and corneal perforations. A Cochet-Bonnet esthesiometer demonstrated a total absence of corneal sensation in both eyes. CONCLUSIONS: The present case indicated the irreversible nerve damage due to leprosy that had been cured 23 years ago, which can progress over the years and cause bilateral corneal perforations.
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Distrofias Hereditarias de la Córnea , Perforación Corneal , Queratitis , Lepra , Enfermedades del Nervio Trigémino , Anciano de 80 o más Años , Perforación Corneal/diagnóstico , Perforación Corneal/etiología , Humanos , Queratitis/diagnóstico , Queratitis/etiología , Masculino , Enfermedades del Nervio Trigémino/complicaciones , Enfermedades del Nervio Trigémino/diagnósticoRESUMEN
Herein, the authors report an unusual case of a 6-year-old boy with right-sided Goldenhar syndrome and trigeminal nerve aplasia who developed neurotrophic keratopathy (NK). Despite the use of therapeutic contact lenses and multiple temporary tarsorrhaphy, NK worsened showing a central corneal scar, neovascularization, and significant stromal thinning, with risk of corneal perforation. Cochet-Bonnet esthesiometry revealed complete corneal anesthesia. To minimize additional corneal complications, the patient underwent indirect corneal neurotization by a sural nerve autograft anastomosed to the contralateral supratrochlear nerve. At 24-month follow up, no epithelial defects, complications, or recurrence were observed. Significant improvements in corneal sensitivity with esthesiometry score of 20 mm and reflex blinking were achieved. This case highlights corneal anesthesia should be suspected among Goldenhar syndrome ophthalmologic abnormalities and monitored before corneal changes become irreversible. Since corneal neurotization can successfully improve corneal sensation, it could be considered as an early therapeutic option to avoid refractory NK.
Asunto(s)
Enfermedades de la Córnea , Síndrome de Goldenhar , Queratitis , Transferencia de Nervios , Enfermedades del Nervio Trigémino , Niño , Córnea/inervación , Córnea/cirugía , Enfermedades de la Córnea/cirugía , Síndrome de Goldenhar/complicaciones , Síndrome de Goldenhar/cirugía , Humanos , Queratitis/complicaciones , Queratitis/diagnóstico , Masculino , Enfermedades del Nervio Trigémino/complicaciones , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/cirugíaRESUMEN
BACKGROUND: Neurotrophic keratopathy (NK) is a relatively uncommon, underdiagnosed degenerative corneal disease that is caused by damage to the ophthalmic branch of the trigeminal nerve by conditions such as herpes simplex or zoster keratitis, intracranial space-occupying lesions, diabetes, or neurosurgical procedures. Over time, epithelial breakdown, corneal ulceration, corneal melting (thinning), perforation, and loss of vision may occur. The best opportunity to reverse ocular surface damage is in the earliest stage of NK. However, patients typically experience few symptoms and diagnosis is often delayed. Increased awareness of the causes of NK, consensus on when and how to screen for NK, and recommendations for how to treat NK are needed. METHODS: An 11-member expert panel used a validated methodology (a RAND/UCLA modified Delphi panel) to develop consensus on when to screen for and how best to diagnose and treat NK. Clinicians reviewed literature on the diagnosis and management of NK then rated a detailed set of 735 scenarios. In 646 scenarios, panelists rated whether a test of corneal sensitivity was warranted; in 20 scenarios, they considered the adequacy of specific tests and examinations to diagnose and stage NK; and in 69 scenarios, they rated the appropriateness of treatments for NK. Panelist ratings were used to develop clinical recommendations. RESULTS: There was agreement on 94% of scenarios. Based on this consensus, we present distinct circumstances when we strongly recommend or may consider a test for corneal sensitivity. We also present recommendations on the diagnostic tests to be performed in patients in whom NK is suspected and treatment options for NK. CONCLUSIONS: These expert recommendations should be validated with clinical data. The recommendations represent the consensus of experts, are informed by published literature and experience, and may improve outcomes by helping improve diagnosis and treatment of patients with NK.
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Distrofias Hereditarias de la Córnea , Queratitis , Enfermedades del Nervio Trigémino , Consenso , Córnea , Humanos , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/terapiaAsunto(s)
Enfermedades del Nervio Abducens/etiología , Barotrauma/complicaciones , Seno Cavernoso/diagnóstico por imagen , Estornudo , Enfermedades del Nervio Trigémino/etiología , Enfermedades del Nervio Abducens/diagnóstico , Anciano , Femenino , Humanos , Imagen por Resonancia Magnética , Síndrome , Tomografía Computarizada por Rayos X , Enfermedades del Nervio Trigémino/diagnósticoRESUMEN
PURPOSE: To characterize corneal subbasal nerve plexus features of normal and simian immunodeficiency virus (SIV)-infected macaques by combining in vivo corneal confocal microscopy (IVCM) with automated assessments using deep learning-based methods customized for macaques. METHODS: IVCM images were collected from both male and female age-matched rhesus and pigtailed macaques housed at the Johns Hopkins University breeding colony using the Heidelberg HRTIII with Rostock Corneal Module. We also obtained repeat IVCM images of 12 SIV-infected animals including preinfection and 10-day post-SIV infection time points. All IVCM images were analyzed using a deep convolutional neural network architecture developed specifically for macaque studies. RESULTS: Deep learning-based segmentation of subbasal nerves in IVCM images from macaques demonstrated that corneal nerve fiber length and fractal dimension measurements did not differ between species, but pigtailed macaques had significantly higher baseline corneal nerve fiber tortuosity than rhesus macaques (P = 0.005). Neither sex nor age of macaques was associated with differences in any of the assessed corneal subbasal nerve parameters. In the SIV/macaque model of human immunodeficiency virus, acute SIV infection induced significant decreases in both corneal nerve fiber length and fractal dimension (P = 0.01 and P = 0.008, respectively). CONCLUSIONS: The combination of IVCM and robust objective deep learning analysis is a powerful tool to track sensory nerve damage, enabling early detection of neuropathy. Adapting deep learning analyses to clinical corneal nerve assessments will improve monitoring of small sensory nerve fiber damage in numerous clinical settings including human immunodeficiency virus.
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Córnea/inervación , Aprendizaje Profundo , Infecciones Virales del Ojo/diagnóstico , Microscopía Confocal , Fibras Nerviosas/patología , Síndrome de Inmunodeficiencia Adquirida del Simio/diagnóstico , Virus de la Inmunodeficiencia de los Simios/patogenicidad , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedad Aguda , Animales , Córnea/diagnóstico por imagen , Modelos Animales de Enfermedad , Infecciones Virales del Ojo/virología , Femenino , Humanos , Macaca mulatta , Macaca nemestrina , Masculino , Persona de Mediana Edad , Fibras Nerviosas/virología , Redes Neurales de la Computación , ARN Viral/genética , Reacción en Cadena en Tiempo Real de la Polimerasa , Síndrome de Inmunodeficiencia Adquirida del Simio/virología , Virus de la Inmunodeficiencia de los Simios/genética , Enfermedades del Nervio Trigémino/virologíaRESUMEN
PURPOSE: To report a case of neurotrophic keratopathy (NK) in a patient with complex regional pain syndrome (CRPS) with ipsilateral facial involvement. METHODS: Case report. RESULTS: An 18-year old woman with a 5-year history of CRPS type I, a systemic disorder with a neuropathic component with associated limb and right facial involvement, presented with an insidious onset of blurred vision and pain in the right eye. Ocular examination revealed decreased corneal sensation, as measured by Cochet-Bonnet testing, associated with recurrent epithelial defects and whorl-like superficial corneal epitheliopathy. NK was suspected and confirmed by in vivo confocal microscopy (IVCM), which revealed rarefaction of the subbasal nerve plexus in the affected eye. To enhance corneal nerve health, plasma rich in growth factors drops were used. Persistence of NK prompted a superficial keratectomy with placement of an amniotic membrane graft and a course of cenegermin 0.002% (Oxervate; Dompé Farmaceutici SpA, Italy) in the postoperative period. This combination therapy resulted in successful epithelial closure and vision improvement after 8 weeks of therapy with no recurrence of disease for 11 months. Importantly, at that final visit, IVCM demonstrated growth of corneal nerves for the first time in this patient. CONCLUSIONS: This is the first case report of NK occurring in the context of CRPS, a neuropathy with ipsilateral facial pain involvement. IVCM was important in the diagnosis of NK, which responded successfully to ocular surface treatments focused on nerve health stimulation that ultimately resulted in corneal nerve growth.
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Síndromes de Dolor Regional Complejo/complicaciones , Córnea/inervación , Enfermedades de la Córnea/etiología , Enfermedades del Nervio Trigémino/complicaciones , Adolescente , Apósitos Biológicos , Síndromes de Dolor Regional Complejo/diagnóstico , Córnea/diagnóstico por imagen , Enfermedades de la Córnea/diagnóstico , Enfermedades de la Córnea/terapia , Femenino , Humanos , Queratectomía/métodos , Microscopía Confocal , Factor de Crecimiento Nervioso/administración & dosificación , Soluciones Oftálmicas/administración & dosificación , Proteínas Recombinantes/administración & dosificación , Enfermedades del Nervio Trigémino/diagnósticoRESUMEN
In the present report, we discussed the case of a 57-year-old man with unilateral masticatory muscle weakness, nystagmus, skew deviation and facial hypesthesia due to pontine tegmental infarction. Trigeminal motor neuropathy attributed to brain infarction is very rare. Brain magnetic resonance imaging revealed a small dot-like infarction lesion in the pontine tegmentum. Masticatory muscle weakness was confirmed by an electrophysiological study performed on the day after admission in which there was an incomplete interference pattern without spontaneous denervation activity, suggesting that the patient's masseter muscle weakness was caused by an infarction of the trigeminal motor nucleus proper or trigeminal motor nerve fascicles rather than Wallerian degeneration of the trigeminal nerve or the progression of masseter muscle degeneration.
Asunto(s)
Infartos del Tronco Encefálico/complicaciones , Parálisis Facial/etiología , Músculo Masetero/inervación , Debilidad Muscular/etiología , Núcleo Motor del Nervio Trigémino/irrigación sanguínea , Enfermedades del Nervio Trigémino/etiología , Enfermedad Aguda , Infartos del Tronco Encefálico/diagnóstico por imagen , Infartos del Tronco Encefálico/fisiopatología , Parálisis Facial/diagnóstico , Parálisis Facial/fisiopatología , Humanos , Masculino , Masticación , Persona de Mediana Edad , Debilidad Muscular/diagnóstico , Debilidad Muscular/fisiopatología , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/fisiopatologíaRESUMEN
SIGNIFICANCE: Ocular tilt reaction (OTR) is an abnormal eye-head postural reaction that consists of skew deviation, head tilt, and bilateral ocular torsion. Understanding of the pathway of the vestibulo-ocular reflex (VOR) is essential because this will help to localize the pathology. PURPOSE: The aim of this study was to report a case of OTR with contralateral internuclear ophthalmoplegia (INO) and fifth and seventh cranial nerve palsies. CASE REPORT: A 51-year-old gentleman with underlying diabetes mellitus presented with sudden onset of diplopia for 3 days. On examination, his visual acuity was 20/30 bilaterally without a relative afferent pupillary defect. He had a right OTR consisting of a right head tilt, a skew deviation with a left eye hypertropia, and bilateral ocular torsion (right excyclotorsion and left incyclotorsion) with nystagmus. He also had a left adduction deficit and right abduction nystagmus consistent with a left INO. Ocular examination revealed evidence of proliferative diabetic retinopathy bilaterally. Two days after the initial presentation, the patient developed left seventh and fifth cranial nerve palsies. MRI showed left pontine infarction and multiple chronic lacunar infarctions. There was an incidental finding of a vascular loop compression on cisternal portions of the left trigeminal, facial, and vestibulocochlear nerves. Antiplatelet treatment was started on top of a better diabetic control. The diplopia was gradually resolved with improved clinical signs. In this case, the left pontine infarction had likely affected the terminal decussated part of the vestibulocochlear nerve from the right VOR pathway, medial longitudinal fasciculus, and cranial nerve nuclei in the left pons. CONCLUSIONS: The OTR can be ipsilateral to the lesion if the lesion is before the decussation of the VOR pathway in the pons, or it can be contralateral to the lesion if the lesion is after the decussation. In case of an OTR that is associated with contralateral INO and other contralateral cranial nerves palsy, a pathology in the pons that is contralateral to the OTR should be considered. Neuroimaging study can hence be targeted to identify the possible cause.
Asunto(s)
Infartos del Tronco Encefálico/complicaciones , Enfermedades del Nervio Facial/etiología , Cabeza , Trastornos de la Motilidad Ocular/etiología , Postura , Anomalía Torsional/etiología , Enfermedades del Nervio Trigémino/etiología , Infartos del Tronco Encefálico/diagnóstico por imagen , Infartos del Tronco Encefálico/fisiopatología , Clopidogrel/uso terapéutico , Diplopía/diagnóstico , Diplopía/etiología , Diplopía/fisiopatología , Enfermedades del Nervio Facial/diagnóstico , Enfermedades del Nervio Facial/fisiopatología , Humanos , Angiografía por Resonancia Magnética , Masculino , Persona de Mediana Edad , Trastornos de la Motilidad Ocular/diagnóstico , Trastornos de la Motilidad Ocular/fisiopatología , Inhibidores de Agregación Plaquetaria/uso terapéutico , Reflejo Vestibuloocular/fisiología , Estrabismo/diagnóstico , Estrabismo/etiología , Estrabismo/fisiopatología , Anomalía Torsional/diagnóstico , Anomalía Torsional/fisiopatología , Enfermedades del Nervio Trigémino/diagnóstico , Enfermedades del Nervio Trigémino/fisiopatología , Agudeza Visual/fisiologíaAsunto(s)
Neoplasias de los Nervios Craneales/diagnóstico , Hipoestesia/etiología , Neurilemoma/diagnóstico , Enfermedades del Nervio Trigémino/diagnóstico , Nervio Trigémino/diagnóstico por imagen , Adulto , Neoplasias de los Nervios Craneales/complicaciones , Progresión de la Enfermedad , Humanos , Hipoestesia/diagnóstico , Imagen por Resonancia Magnética , Masculino , Mandíbula/inervación , Neurilemoma/complicaciones , Enfermedades del Nervio Trigémino/complicacionesRESUMEN
Trigeminal trophic syndrome occurs secondary to trigeminal nerve injury, leading to anaesthesia and paraesthesia, with consequent vigorous facial skin manipulation and lesion production, simulating other facial diseases such as ulcerative discoid lupus erythematosus, tumours and other artificially produced lesions. Ulceration and destruction of the ala nasi is a typical feature besides scratching end excoriations in the cutaneous segment affected. In this series, we present the features of five patients with trigeminal trophic syndrome, highlighting possible confusion with cutaneous lupus. Differential diagnoses, including discoid lupus erythematosus, are discussed, as well as possible treatment modalities.