RESUMEN
A captive 17-year-old male cynomolgus monkey (Macaca fascicularis) developed diffuse large B-cell lymphoma (DLBCL). This was the first report of DLBCL presenting with a mandible mass and violation of the paranasal sinus in a cynomolgus monkey. The neoplasm showed marked microscopical malignant aspects. Immunohistochemical staining showed strong positive expression of CD20. These features may contribute to the diagnosis and therapeutics of DLBCL in NHPs.
Asunto(s)
Linfoma de Células B Grandes Difuso , Macaca fascicularis , Enfermedades de los Monos , Animales , Masculino , Linfoma de Células B Grandes Difuso/veterinaria , Linfoma de Células B Grandes Difuso/patología , Linfoma de Células B Grandes Difuso/diagnóstico , Enfermedades de los Monos/patología , Enfermedades de los Monos/diagnósticoRESUMEN
Paracoccidioidomycosis (PCM) is an endemic fungal disease that occurs in Latin America and primarily affects humans. The disease has been rarely documented in non-human primates. This report details a disseminated and fatal case of PCM caused by Paracoccidioides brasiliensis in a western black-handed tamarin (Saguinus niger) under human care. Histopathological examination revealed extensive pyogranulomatous inflammation in the lungs, spleen, liver, lymph nodes, kidneys, epididymis, right testicle, heart, adrenal gland and intestines, associated with characteristic yeast forms consistent with Paracoccidioides spp and confirmed by immunohistochemistry. Molecular analysis indicated a high nucleotide similarity with P. brasiliensis sequences for both the 18S rRNA and gp43 genes. This naturally occurring infection highlights the susceptibility of these animals to PCM and their role in ecoepidemiology warrants further investigation.
Asunto(s)
Enfermedades de los Monos , Paracoccidioidomicosis , Saguinus , Animales , Paracoccidioidomicosis/veterinaria , Enfermedades de los Monos/microbiología , Enfermedades de los Monos/patología , Masculino , ParacoccidioidesRESUMEN
A captive marmoset developed metastatic endometrioid carcinoma (EnC), a rare uterine tumor in non-human primates (NHPs). The neoplasm showed marked microscopical malignant and tubulopapillary aspects, immunopositivity for pan-cytokeratin, CK7, estrogen receptor, and a high mitotic index (Ki-67). These features may contribute to the diagnosis and therapeutics of EnC in NHPs.
Asunto(s)
Callithrix , Carcinoma Endometrioide , Enfermedades de los Monos , Animales , Femenino , Carcinoma Endometrioide/veterinaria , Carcinoma Endometrioide/patología , Carcinoma Endometrioide/diagnóstico , Enfermedades de los Monos/patología , Enfermedades de los Monos/diagnóstico , Neoplasias Uterinas/veterinaria , Neoplasias Uterinas/patología , Neoplasias Uterinas/diagnósticoRESUMEN
BACKGROUND: Oral focal epithelial hyperplasia (FEH) is an uncommon infection affecting humans, chimpanzees, bonobos, and howler monkeys. This study describes 10 cases of free-ranging brown howler monkeys (Alouatta guariba clamitans) diagnosed with FEH and Alouatta guariba Papillomavirus 1 (AgPV 1). METHODS: We analyzed demographic characteristics, rescue conditions, clinical and pathological findings, and species-specific behavior factors in these cases. The study assessed the frequency of occurrence and potential contributing factors of FEH and AgPV 1 infection. RESULTS: The frequency of FEH was 8.13%. Most affected howlers were adult or geriatric males with comorbidities or stressful conditions. Clinical and pathological observations were consistent with AgPV 1 infection. Species-specific behaviors and environmental stressors were identified as contributing factors. CONCLUSIONS: FEH associated with AgPV 1 affected mainly adult or geriatric males with ongoing comorbidities or stressful conditions. Further research is needed to understand these factors for effective management.
Asunto(s)
Alouatta , Hiperplasia Epitelial Focal , Enfermedades de los Monos , Animales , Alouatta/virología , Masculino , Enfermedades de los Monos/epidemiología , Enfermedades de los Monos/virología , Enfermedades de los Monos/patología , Femenino , Hiperplasia Epitelial Focal/epidemiología , Hiperplasia Epitelial Focal/virología , Hiperplasia Epitelial Focal/veterinaria , Hiperplasia Epitelial Focal/patología , Infecciones por Papillomavirus/veterinaria , Infecciones por Papillomavirus/epidemiología , Infecciones por Papillomavirus/virología , Papillomaviridae/aislamiento & purificaciónRESUMEN
In this report, we describe the gross, histopathology, and immunohistochemical findings of a thyroblastoma that arose in the right lobe of the thyroid gland in a 2-month-old rhesus macaque (Macaca mulatta).
Asunto(s)
Macaca mulatta , Enfermedades de los Monos , Neoplasias de la Tiroides , Animales , Enfermedades de los Monos/patología , Enfermedades de los Monos/diagnóstico , Neoplasias de la Tiroides/veterinaria , Neoplasias de la Tiroides/patología , Neoplasias de la Tiroides/diagnóstico , Masculino , FemeninoRESUMEN
BACKGROUND: Documentation of lingual tumors is scarce in nonhuman primates. METHODS: Through a multi-institutional retrospective study we compile cases of primary and metastatic neoplasia in non-human primates. RESULTS: We describe five cases of lingual neoplasia. Three cases are primary lingual tumors: chondro-osteoblastic lipoma in a howler monkey, squamous cell carcinoma, and fibroma in two baboons. We describe two cases of metastatic lymphoma in the tongue in rhesus macaques. A literature review of published lingual neoplasia in nonhuman primates is included in this manuscript. CONCLUSION: Lingual neoplasia is seldom reported in non-human primates.
Asunto(s)
Enfermedades de los Monos , Papio , Neoplasias de la Lengua , Animales , Enfermedades de los Monos/patología , Enfermedades de los Monos/diagnóstico , Masculino , Femenino , Neoplasias de la Lengua/patología , Neoplasias de la Lengua/veterinaria , Neoplasias de la Lengua/diagnóstico , Estudios Retrospectivos , Macaca mulatta , Carcinoma de Células Escamosas/veterinaria , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/diagnóstico , Lipoma/veterinaria , Lipoma/patología , Lipoma/diagnósticoRESUMEN
BACKGROUND: Oral cavity squamous cell carcinomas (OCSCCs) are relatively common in multiple non-human primate species but are poorly documented in Goeldi's monkeys. METHODS: Four Goeldi's monkeys with OCSCC, from three zoological collections, underwent necropsy with cytology, histopathology, immunohistochemistry, and pan-herpesvirus PCR analysis. RESULTS: All animals were euthanised and exhibited poor-to-emaciated body condition. Three OCSCCs arose from the maxillary oral mucosa and a single OCSCC was primarily mandibular, with bone invasion evident in three cases. Histologically, one OCSCC in situ was diagnosed, whilst the rest were typically invasive OCSCCs. Neoplastic cells were immunopositive for pancytokeratin and E-cadherin. All examined cases were negative for regional lymph node (RLN) and/or distant metastases, cyclooxygenase-2 (COX-2) immunoexpression, and panherpesvirus PCR expression. CONCLUSIONS: OCSCCs in Goeldi's monkeys may be deeply invasive, but not readily metastatic. No herpesvirus-association or COX-2 expression was evident; the latter suggesting that NSAIDs are unlikely to be a viable chemotherapeutic treatment.
Asunto(s)
Animales de Zoológico , Carcinoma de Células Escamosas , Enfermedades de los Monos , Neoplasias de la Boca , Animales , Carcinoma de Células Escamosas/veterinaria , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/etiología , Carcinoma de Células Escamosas/virología , Neoplasias de la Boca/veterinaria , Neoplasias de la Boca/patología , Neoplasias de la Boca/etiología , Enfermedades de los Monos/patología , Enfermedades de los Monos/virología , Masculino , FemeninoRESUMEN
Sulawesi crested macaques (Macaca nigra) (SCMs) are critically endangered and frequently suffer from chronic intestinal disease in captivity. Often, despite routine diagnostic investigations and confirmation of intestinal inflammation, an aetiology cannot be identified, leading to a non-specific categorization as chronic enterocolitis rather than an aetiological diagnosis. This study evaluates the histological features of gastrointestinal tissues from 23 SCMs, comparing animals with a clinical history suggestive of chronic enterocolitis (n = 14) with those without gastrointestinal clinical signs (n = 9). Tissues were graded according to the Nancy index (NI), a scoring system used in human medicine to evaluate disease activity in ulcerative colitis, a common form of human inflammatory bowel disease (IBD). Additionally, inflammatory cells in the colonic lamina propria were visually identified by type, counted and subsequently compared between diseased and control animals. Moderate to severe lymphoplasmacytic inflammation and structural changes were most common in the colons of affected SCMs, whereas histopathological changes were absent or mild in all examined small intestine (n = 17) and stomach (n = 11) tissues. The colonic NI had a significant positive correlation with clinical disease severity and 57% (n = 8) of animals with clinical signs had a NI grade of ≥2, consistent with moderate to severe, active IBD. Half of SCMs with recurrent rectal prolapse (n = 6) had a NI grade of 0, suggesting that intestinal inflammation is not always part of this condition's pathogenesis. The numbers of colonic lymphocytes, plasma cells, neutrophils, macrophages and total leucocytes were significantly higher in diseased animals. This study validated the use of the NI in SCMs, enabling a more standardized histopathological evaluation of the colon in this species.
Asunto(s)
Enterocolitis , Macaca , Enfermedades de los Monos , Animales , Enterocolitis/veterinaria , Enterocolitis/patología , Enfermedades de los Monos/patología , Masculino , Enfermedad Crónica , FemeninoRESUMEN
Neotropical primates rarely exhibit active tuberculosis. A brown howler monkey was found injured in an urban area. Histopathology revealed granulomatous inflammation in the lungs, lymph nodes, and liver. Immunohistochemistry and molecular analysis confirmed the presence of Mycobacterium tuberculosis complex. The findings highlight the importance of TB surveillance in nonhuman primates.
Asunto(s)
Alouatta , Enfermedades de los Monos , Mycobacterium tuberculosis , Tuberculosis , Animales , Enfermedades de los Monos/microbiología , Enfermedades de los Monos/patología , Brasil , Mycobacterium tuberculosis/aislamiento & purificación , Tuberculosis/veterinaria , Tuberculosis/microbiología , Tuberculosis/patología , Masculino , FemeninoRESUMEN
BACKGROUND: Platynosomiasis in non-human primates kept under human care causes chronic disease of the bile ducts and liver, which initially presents with nonspecific signs and can culminate in the death of the animal. Diagnosing this disease is a challenge, and an ultrasound examination can be an excellent tool when it is suspected. METHODS: This study describes the ultrasound findings from 57 marmosets with suspected infection by Platynosomum sp., the correlated hepatobiliary changes, and the anatomopathological findings that confirmed the occurrence of platynosomiasis. RESULTS: In six marmosets (one C. aurita, two C. jacchus, and three Callithrix sp.), Platynosomum infection was confirmed macroscopically (presence of adult trematodes in the gallbladder) and microscopically (adults, larvae, and eggs in histological examinations and eggs in bile and feces). These findings were compatible with the hepatobiliary changes and with images suggestive of parasitic structures in ante-mortem assessments. CONCLUSION: Ultrasound examination demonstrated its usefulness within the clinical routine for investigating this parasitosis.
Asunto(s)
Enfermedades de los Monos , Infecciones por Trematodos , Ultrasonografía , Animales , Ultrasonografía/veterinaria , Ultrasonografía/métodos , Enfermedades de los Monos/diagnóstico por imagen , Enfermedades de los Monos/parasitología , Enfermedades de los Monos/patología , Enfermedades de los Monos/diagnóstico , Infecciones por Trematodos/veterinaria , Infecciones por Trematodos/diagnóstico por imagen , Infecciones por Trematodos/diagnóstico , Infecciones por Trematodos/parasitología , Infecciones por Trematodos/patología , Masculino , Femenino , Callithrix , Hígado/patología , Hígado/diagnóstico por imagen , Hígado/parasitologíaRESUMEN
BACKGROUND: Common marmosets (Callithrix jacchus) are widely used as primate experimental models in biomedical research. Duodenal dilation with chronic vomiting in captive common marmosets is a recently described life-threatening syndrome that is problematic for health control. However, the pathogenesis and cause of death are not fully understood. CASE PRESENTATION: We report two novel necropsy cases in which captive common marmosets were histopathologically diagnosed with gastric emphysema (GE) and pneumatosis intestinalis (PI). Marmoset duodenal dilation syndrome was confirmed in each case by clinical observation of chronic vomiting and by gross necropsy findings showing a dilated, gas-filled and fluid-filled descending duodenum that adhered to the ascending colon. A diagnosis of GE and PI was made on the basis of the bubble-like morphology of the gastric and intestinal mucosa, with histological examination revealing numerous vacuoles diffused throughout the lamina propria mucosae and submucosa. Immunostaining for prospero homeobox 1 and CD31 distinguished gas cysts from blood and lymph vessels. The presence of hepatic portal venous gas in case 1 and possible secondary bacteremia-related septic shock in case 2 were suggested to be acute life-threatening abdominal processes resulting from gastric emphysema and pneumatosis intestinalis. CONCLUSIONS: In both cases, the gross and histopathological findings of gas cysts in the GI tract walls matched the features of human GE and PI. These findings contribute to clarifying the cause of death in captive marmosets that have died of gastrointestinal diseases.
Asunto(s)
Callithrix , Enfisema , Neumatosis Cistoide Intestinal , Animales , Neumatosis Cistoide Intestinal/veterinaria , Neumatosis Cistoide Intestinal/patología , Neumatosis Cistoide Intestinal/complicaciones , Enfisema/veterinaria , Enfisema/patología , Masculino , Enfermedades de los Monos/patología , Gastropatías/veterinaria , Gastropatías/patología , Femenino , Enfermedades Duodenales/veterinaria , Enfermedades Duodenales/patología , Enfermedades Duodenales/complicacionesRESUMEN
From 2016 to 2019, Southeastern Brazil faced an outbreak of yellow fever (YF) affecting both humans and New World primates (NWP). The outbreak was associated with a marked increase in traumatic lesions in NWP in the affected regions. Non-thrombotic pulmonary embolization (NTPE) can be a consequence of massive traumatic events, and it is rarely reported in human and veterinary medicine. Here, we describe NTPE of the brain, liver, and bone marrow in free-ranging NWP, highlighting the epidemiological aspects of these findings and the lesions associated with this condition, including data on traumatic injuries in wild NWP populations during the course of a recent YF outbreak. A total of 1078 NWP were necropsied from January 2017 to July 2019. Gross traumatic injuries were observed in 444 marmosets (44.3%), 10 howler monkeys (23.2%), 9 capuchins (31.0%), 1 titi-monkey (50.0%), and 1 golden lion tamarin (33.3%). NTPE was observed in 10 animals, including 9 marmosets (2.0%) and 1 howler monkey (10.0%). NTPE was identified in the lung and comprised hepatic tissue in 1 case, brain tissue in 1 case, and bone marrow tissue in 8 cases. Although uncommon, it is important to consider NTPE with pulmonary vascular occlusion during the critical care of traumatized NWP. In addition, this study highlights the importance of conservational strategies and environmental education focusing on One Health, not only to protect these free-ranging NWP populations but also to maintain the efficacy of epidemiological surveillance programs.
Asunto(s)
Alouatta , Enfermedades de los Monos , Embolia Pulmonar , Fiebre Amarilla , Animales , Médula Ósea/patología , Encéfalo/patología , Brasil/epidemiología , Callithrix , Hígado/patología , Enfermedades de los Monos/epidemiología , Enfermedades de los Monos/patología , Embolia Pulmonar/epidemiología , Embolia Pulmonar/veterinaria , Fiebre Amarilla/patología , Fiebre Amarilla/veterinariaRESUMEN
Rhesus cytomegalovirus (RhCMV) infection of rhesus macaques (Macaca mulatta) is a valuable nonhuman primate model of human CMV (HCMV) persistence and pathogenesis. In vivo studies predominantly use tissue culture-adapted variants of RhCMV that contain multiple genetic mutations compared to wild-type (WT) RhCMV. In many studies, animals have been inoculated by nonnatural routes (e.g., subcutaneous, intravenous) that do not recapitulate disease progression via the normative route of mucosal exposure. Accordingly, the natural history of RhCMV would be more accurately reproduced by infecting macaques with strains of RhCMV that reflect the WT genome using natural routes of mucosal transmission. Here, we tested two WT-like RhCMV strains, UCD52 and UCD59, and demonstrated that systemic infection and frequent, high-titer viral shedding in bodily fluids occurred following oral inoculation. RhCMV disseminated to a broad range of tissues, including the central nervous system and reproductive organs. Commonly infected tissues included the thymus, spleen, lymph nodes, kidneys, bladder, and salivary glands. Histological examination revealed prominent nodular hyperplasia in spleens and variable levels of lymphoid lymphofollicular hyperplasia in lymph nodes. One of six inoculated animals had limited viral dissemination and shedding, with commensurately weak antibody responses to RhCMV antigens. These data suggest that long-term RhCMV infection parameters might be restricted by local innate factors and/or de novo host immune responses in a minority of primary infections. Together, we have established an oral RhCMV infection model that mimics natural HCMV infection. The virological and immunological parameters characterized in this study will greatly inform HCMV vaccine designs for human immunization. IMPORTANCE Human cytomegalovirus (HCMV) is globally ubiquitous with high seroprevalence rates in all communities. HCMV infections can occur vertically following mother-to-fetus transmission across the placenta and horizontally following shedding of virus in bodily fluids in HCMV-infected hosts and subsequent exposure of susceptible individuals to virus-laden fluids. Intrauterine HCMV has long been recognized as an infectious threat to fetal growth and development. Since vertical HCMV infections occur following horizontal HCMV transmission to the pregnant mother, the nonhuman primate model of HCMV pathogenesis was used to characterize the virological and immunological parameters of infection following primary mucosal exposures to rhesus cytomegalovirus.
Asunto(s)
Infecciones por Citomegalovirus/veterinaria , Citomegalovirus/fisiología , Susceptibilidad a Enfermedades , Interacciones Huésped-Patógeno , Enfermedades de los Monos/inmunología , Enfermedades de los Monos/virología , Animales , Anticuerpos Neutralizantes/inmunología , Anticuerpos Antivirales/inmunología , Biopsia , ADN Viral , Susceptibilidad a Enfermedades/inmunología , Interacciones Huésped-Patógeno/inmunología , Inmunoglobulina G/inmunología , Inmunohistoquímica , Macaca mulatta , Enfermedades de los Monos/patología , Enfermedades de los Monos/transmisión , Sistemas de Lectura Abierta , Especificidad de Órganos , Carga Viral , Viremia , Esparcimiento de VirusRESUMEN
The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 disease, has killed over five million people worldwide as of December 2021 with infections rising again due to the emergence of highly transmissible variants. Animal models that faithfully recapitulate human disease are critical for assessing SARS-CoV-2 viral and immune dynamics, for understanding mechanisms of disease, and for testing vaccines and therapeutics. Pigtail macaques (PTM, Macaca nemestrina) demonstrate a rapid and severe disease course when infected with simian immunodeficiency virus (SIV), including the development of severe cardiovascular symptoms that are pertinent to COVID-19 manifestations in humans. We thus proposed this species may likewise exhibit severe COVID-19 disease upon infection with SARS-CoV-2. Here, we extensively studied a cohort of SARS-CoV-2-infected PTM euthanized either 6- or 21-days after respiratory viral challenge. We show that PTM demonstrate largely mild-to-moderate COVID-19 disease. Pulmonary infiltrates were dominated by T cells, including CD4+ T cells that upregulate CD8 and express cytotoxic molecules, as well as virus-targeting T cells that were predominantly CD4+. We also noted increases in inflammatory and coagulation markers in blood, pulmonary pathologic lesions, and the development of neutralizing antibodies. Together, our data demonstrate that SARS-CoV-2 infection of PTM recapitulates important features of COVID-19 and reveals new immune and viral dynamics and thus may serve as a useful animal model for studying pathogenesis and testing vaccines and therapeutics.
Asunto(s)
COVID-19 , Modelos Animales de Enfermedad , Macaca nemestrina , Enfermedades de los Monos/virología , Animales , COVID-19/inmunología , COVID-19/patología , COVID-19/fisiopatología , COVID-19/virología , Humanos , Inmunidad Humoral , Pulmón/inmunología , Pulmón/virología , Masculino , Enfermedades de los Monos/inmunología , Enfermedades de los Monos/patología , Enfermedades de los Monos/fisiopatología , Linfocitos T/inmunologíaRESUMEN
The maternal decidua is an immunologically complex environment that balances maintenance of immune tolerance to fetal paternal antigens with protection of the fetus against vertical transmission of maternal pathogens. To better understand host immune determinants of congenital infection at the maternal-fetal tissue interface, we performed a comparative analysis of innate and adaptive immune cell subsets in the peripheral blood and decidua of healthy rhesus macaque pregnancies across all trimesters of gestation and determined changes after Zika virus (ZIKV) infection. Using one 28-color and one 18-color polychromatic flow cytometry panel we simultaneously analyzed the frequency, phenotype, activation status and trafficking properties of αß T, γδ T, iNKT, regulatory T (Treg), NK cells, B lymphocytes, monocytes, macrophages, and dendritic cells (DC). Decidual leukocytes showed a striking enrichment of activated effector memory and tissue-resident memory CD4+ and CD8+ T lymphocytes, CD4+ Tregs, CD56+ NK cells, CD14+CD16+ monocytes, CD206+ tissue-resident macrophages, and a paucity of B lymphocytes when compared to peripheral blood. t-distributed stochastic neighbor embedding (tSNE) revealed unique populations of decidual NK, T, DC and monocyte/macrophage subsets. Principal component analysis showed distinct spatial localization of decidual and circulating leukocytes contributed by NK and CD8+ T lymphocytes, and separation of decidua based on gestational age contributed by memory CD4+ and CD8+ T lymphocytes. Decidua from 10 ZIKV-infected dams obtained 16-56 days post infection at third (n=9) or second (n=1) trimester showed a significant reduction in frequency of activated, CXCR3+, and/or Granzyme B+ memory CD4+ and CD8+ T lymphocytes and γδ T compared to normal decidua. These data suggest that ZIKV induces local immunosuppression with reduced immune recruitment and impaired cytotoxicity. Our study adds to the immune characterization of the maternal-fetal interface in a translational nonhuman primate model of congenital infection and provides novel insight in to putative mechanisms of vertical transmission.
Asunto(s)
Interacciones Huésped-Patógeno/inmunología , Intercambio Materno-Fetal/inmunología , Enfermedades de los Monos/etiología , Enfermedades de los Monos/metabolismo , Infección por el Virus Zika/veterinaria , Virus Zika/inmunología , Animales , Decidua/inmunología , Decidua/metabolismo , Susceptibilidad a Enfermedades , Femenino , Inmunohistoquímica , Inmunofenotipificación , Células Asesinas Naturales/inmunología , Células Asesinas Naturales/metabolismo , Recuento de Leucocitos , Macaca mulatta , Enfermedades de los Monos/patología , Enfermedades de los Monos/transmisión , Embarazo , Subgrupos de Linfocitos T/inmunología , Subgrupos de Linfocitos T/metabolismoRESUMEN
Spirurids, specifically the Rictularia, Chitwoodspirura, Streptopharagus, and Protospirura genera, have been reported to parasitize all nonhuman primate taxa. Spirurid pathogenesis in nonhuman primates has not been reported frequently; however, Protospirura muricola has been associated with serious gastric pathologies, including gastric perforation. This study was a retrospective study of 38 vervet monkey (Chlorocebus pygerythrus) necropsies performed in a primate sanctuary that houses captive orphaned or injured wild-born vervet monkeys. Individuals were categorized according to their age, sex, and body condition score to investigate the relationships between these factors and parasite presence. This study identified P. muricola in 47.37% of the necropsied carcasses. Regarding individual factors associated with P. muricola infection, no significant differences between males and females were observed; however, relationships between parasite presence and poor body condition and advanced host age were observed. Furthermore, one monkey death was potentially directly related to spirurid pathogenic action, because the individual showed gastric perforation.
Asunto(s)
Chlorocebus aethiops , Enfermedades de los Monos/parasitología , Infecciones por Spirurida/veterinaria , Espirúridos/aislamiento & purificación , Animales , Femenino , Vivienda para Animales , Masculino , Enfermedades de los Monos/patología , Estudios Retrospectivos , Espirúridos/anatomía & histología , Espirúridos/clasificación , Infecciones por Spirurida/parasitología , Infecciones por Spirurida/patologíaRESUMEN
Tumors of urinary origin are infrequently reported in non-human primates. Urothelial carcinoma involving the urinary bladder was diagnosed in an adult female Japanese macaque that extended transmurally to the uterus and cervix. To our knowledge, this is the first report of a primary cystic urothelial carcinoma in a Japanese macaque.
Asunto(s)
Carcinoma de Células Transicionales/diagnóstico , Macaca fuscata , Enfermedades de los Monos/diagnóstico , Neoplasias de la Vejiga Urinaria/diagnóstico , Animales , Carcinoma de Células Transicionales/patología , Cuello del Útero/patología , Femenino , Enfermedades de los Monos/patología , Neoplasias de la Vejiga Urinaria/patología , Urotelio/patología , Útero/patologíaRESUMEN
We recently identified a cynomolgus monkey with naturally occurring Parkinson's disease (PD), indicating that PD may not be a uniquely human disease (Li et al, 2020). In our previous study, four lines of evidence, including typical PD clinical symptoms, pharmacological responses, pathological hallmarks, and genetic mutations, strongly supported the identification of a monkey with spontaneous PD (Figure 1). To the best of our knowledge, this is the first reported case of naturally developed PD in animals. This suggests that PD is not a disease restricted to humans, with its existence in a non-human primate providing a novel evolutionary angle for understanding PD. As a close relative to humans (Buffalo et al, 2019; Phillips et al, 2014; Yan et al, 2011), this rare case of PD in another primate species provides solid evidence that monkeys are ideal candidates for the development of a genuine "animal version of PD", with conserved etiology and pathogenesis (Li et al, 2020). Furthermore, it allows us to compare similarities and differences in PD development between species and to understand PD pathogenesis from an evolutionary point of view.
Asunto(s)
Macaca fascicularis , Enfermedades de los Monos/patología , Enfermedad de Parkinson/veterinaria , Animales , Humanos , Masculino , Enfermedades de los Monos/genética , Mutación , Enfermedad de Parkinson/genética , Enfermedad de Parkinson/patología , Especificidad de la EspecieRESUMEN
This study described the hepatobiliary anatomopathological lesions associated with trematode Platynosomum illiciens parasitism in Neotropical primates kept in captivity. In the evaluated organs, we observed portal fibrosis, biliary epithelial hyperplasia, and inflammatory reaction with a predominance of lymphocytes and plasmocytes, and in some cases infiltration of eosinophils and neutrophils.
Asunto(s)
Dicrocoeliidae/fisiología , Enfermedades del Sistema Digestivo/veterinaria , Enfermedades de los Monos/patología , Platirrinos , Infecciones por Trematodos/veterinaria , Animales , Animales de Zoológico , Enfermedades del Sistema Digestivo/parasitología , Enfermedades del Sistema Digestivo/patología , Enfermedades de los Monos/parasitología , Especificidad de la Especie , Infecciones por Trematodos/parasitología , Infecciones por Trematodos/patologíaRESUMEN
A 13-year-old rhesus macaque presented a cervical swelling associated with sudden deterioration of its condition. This mass was surgically removed, and its histopathological examination revealed a stratified squamous epithelium. This appearance has been reported in some case of air sacculitis in others non-human primate species.