Asunto(s)
Granulomatosis Orofacial , Humanos , Granulomatosis Orofacial/diagnóstico , Granulomatosis Orofacial/patología , Granulomatosis Orofacial/tratamiento farmacológico , Masculino , Labio/patología , Femenino , Diagnóstico Diferencial , Enfermedades de los Labios/diagnóstico , Enfermedades de los Labios/patología , Edema/etiologíaRESUMEN
Porokeratosis is a skin condition that involves the formation of plaques, characterized by a hyperkeratotic ridge with an atrophic center. There is a histological presence of a cornoid lamella, which is a parakeratotic column that traverses through the stratum corneum. The plaques are mostly benign but have the potential to become squamous cell carcinomas if left untreated. Porokeratosis lesions typically occur on the extremities, but they can develop anywhere. The occurrence of porokeratosis on the lip is exceedingly rare. We report three cases of porokeratosis on the lip. Each incidence was treated with cryotherapy, which was unsuccessful in two. One of these two patients did not elect for topical treatment and is being monitored for lesion changes. The second patient was successfully treated via shave biopsy. The third patient was lost to follow-up post-cryotherapy.
Asunto(s)
Poroqueratosis , Humanos , Poroqueratosis/patología , Poroqueratosis/diagnóstico , Masculino , Persona de Mediana Edad , Femenino , Crioterapia , Enfermedades de los Labios/patología , Enfermedades de los Labios/diagnóstico , Adulto , Anciano , BiopsiaRESUMEN
Background and Objectives: Lichen planus of the lip (LPL) is a chronic inflammatory condition that resembles actinic cheilitis, discoid lupus erythematosus, graft-versus-host disease, and lichenoid reaction to dental materials or drugs. The purpose of this study was to conduct a literature review on lichen planus lip involvement and to report a retrospective observational study that characterises and explores the clinical, histopathological, and evolution of the lesions in a group of patients with unique involvement of LPL. Materials and Methods: Clinical data of patients diagnosed with LPL was retrieved from the medical charts of the patients referred to the Oral Pathology Department of the "Carol Davila" University of Medicine and Pharmacy. A concurrent electronic literature research was carried out using PubMed and Web of Science from 2003 to 2023. Results: Eleven patients diagnosed with unique LPL were analysed (male/female ratio was 1.75, mean age 63.64 years ± 12.52). All patients presented lesions of the lower lip; the clinical forms were atrophic (six cases) and erosive (five cases), and the histopathological exam confirmed the diagnosis. After topical treatment with corticosteroids, most of the patients had complete remission. The literature review revealed 24 studies (sixteen case reports and eight case series) which comprised 84 patients. Isolated lip involvement was reported in 17 studies, and five articles with concomitant oral lichen planus, while two articles did not mention this criterion. Conclusions: Our study brings new data on isolated lichen planus of the lip that primarily affects the lower lip with predominance in male patients. It was reported worldwide in patients between 22 and 75 years old. Topical corticosteroids were the main treatment prescribed and they usually brought remission of the lesions. Lichen planus of the lip is a challenging diagnosis for oral health practitioner providers as well as for dermatologists.
Asunto(s)
Liquen Plano Oral , Humanos , Masculino , Persona de Mediana Edad , Femenino , Anciano , Estudios Retrospectivos , Liquen Plano Oral/tratamiento farmacológico , Liquen Plano Oral/diagnóstico , Labio/patología , Liquen Plano/tratamiento farmacológico , Liquen Plano/diagnóstico , Adulto , Enfermedades de los Labios/diagnóstico , Enfermedades de los Labios/tratamiento farmacológico , Anciano de 80 o más AñosAsunto(s)
Edema , Humanos , Femenino , Adolescente , Diagnóstico Diferencial , Edema/etiología , Enfermedades de los Labios/diagnóstico , LabioAsunto(s)
Humanos , Femenino , Adulto , Enfermedades de los Labios/diagnóstico , Enfermedades de los Labios/tratamiento farmacológico , Combinación Amoxicilina-Clavulanato de Potasio/uso terapéutico , Linfadenopatía , Infecciones por Bartonella , Azitromicina , Enfermedad por Rasguño de Gato , Enfermedades Transmisibles , Microbiología , Resultado del Tratamiento , Pacientes Internos , Examen Físico , Evaluación de SíntomasRESUMEN
Abstract The caliber-persistent labial artery is a vascular anomaly in which a primary arterial branch penetrates into the submucosal tissue without reduction in diameter. Most lesions are benign and do not require treatment, except for complications and/or on patient demands. In this way, noninvasive diagnostic tools are preferred such as high-resolution and color Doppler ultrasonography which allow direct observation of the lesion, assessing its exact location and diameter at every axis, as well as the blood flow velocity. An excisional biopsy of these lesions or even their surgical extirpation could have a fatal outcome with profuse bleeding.
Asunto(s)
Humanos , Malformaciones Vasculares/diagnóstico , Enfermedades de los Labios/diagnóstico , Anomalías Musculoesqueléticas , Arterias/diagnóstico por imagen , Ultrasonografía Doppler en ColorRESUMEN
The caliber-persistent labial artery is a vascular anomaly in which a primary arterial branch penetrates into the submucosal tissue without reduction in diameter. Most lesions are benign and do not require treatment, except for complications and/or on patient demands. In this way, noninvasive diagnostic tools are preferred such as high-resolution and color Doppler ultrasonography which allow direct observation of the lesion, assessing its exact location and diameter at every axis, as well as the blood flow velocity. An excisional biopsy of these lesions or even their surgical extirpation could have a fatal outcome with profuse bleeding.
Asunto(s)
Enfermedades de los Labios , Anomalías Musculoesqueléticas , Malformaciones Vasculares , Arterias/diagnóstico por imagen , Humanos , Enfermedades de los Labios/diagnóstico , Ultrasonografía Doppler en Color , Malformaciones Vasculares/diagnósticoRESUMEN
Laugier-Hunziker syndrome (LHS) is characterized by lentiginous hyperpigmentation of the oral mucosa and lips. In addition, longitudinal melanonychia and palmoplantar hyperpigmented lesions may occur. LHS is a clinical diagnosis of exclusion. Herein, we report the case of a 66-year-old woman with LHS. The clinical and histopathologic features of LHS are presented and important differential diagnoses are discussed.
Asunto(s)
Hiperpigmentación , Enfermedades de los Labios , Enfermedades de la Uña , Anciano , Diagnóstico Diferencial , Femenino , Humanos , Hiperpigmentación/diagnóstico , Hiperpigmentación/patología , Enfermedades de los Labios/diagnóstico , Mucosa Bucal/patología , Enfermedades de la Uña/diagnóstico , Enfermedades de la Uña/patología , SíndromeAsunto(s)
Monoterpenos Ciclohexánicos/efectos adversos , Hipersensibilidad a las Drogas/etiología , Granulomatosis Orofacial/inducido químicamente , Hipersensibilidad Tardía/inducido químicamente , Enfermedades de los Labios/inducido químicamente , Niño , Hipersensibilidad a las Drogas/diagnóstico , Granulomatosis Orofacial/diagnóstico , Humanos , Hipersensibilidad Tardía/diagnóstico , Enfermedades de los Labios/diagnósticoRESUMEN
Laugier-Hunziker syndrome (LHS) is a sporadic, acquired, and infrequent condition characterized by the onset of brown macules on the lips, the oral mucosa, and the acral glabrous skin (mainly fingers and toes) in middle-aged patients. In several cases melanonychia of fingernails and toenails coexists. No other systemic involvement is observed. A case of LHS in a 50-year-old woman is described, with particular attention to dermoscopic features. No dermoscopic specific findings of mucosal/cutaneous maculae have been to date described in the literature. Accumulation of dermoscopic observations of pigmented lesions in LHS is needed and if found to be distinct, it may contribute to a more accurate diagnosis in the future.
Asunto(s)
Hiperpigmentación , Enfermedades de los Labios , Enfermedades de la Uña , Úlceras Bucales , Femenino , Humanos , Hiperpigmentación/diagnóstico , Hiperpigmentación/patología , Enfermedades de los Labios/diagnóstico , Enfermedades de los Labios/patología , Persona de Mediana Edad , Enfermedades de la Uña/diagnóstico , Enfermedades de la Uña/patología , SíndromeAsunto(s)
COVID-19/diagnóstico , Enfermedades de los Labios/diagnóstico , SARS-CoV-2/aislamiento & purificación , Enfermedades Cutáneas Vesiculoampollosas/diagnóstico , Trombosis/diagnóstico , Biopsia , COVID-19/complicaciones , COVID-19/inmunología , COVID-19/virología , Prueba de COVID-19 , Dexametasona/uso terapéutico , Femenino , Humanos , Labio/irrigación sanguínea , Labio/inmunología , Labio/patología , Enfermedades de los Labios/tratamiento farmacológico , Enfermedades de los Labios/inmunología , Enfermedades de los Labios/patología , Microvasos/patología , Enfermedades Cutáneas Vesiculoampollosas/tratamiento farmacológico , Enfermedades Cutáneas Vesiculoampollosas/inmunología , Enfermedades Cutáneas Vesiculoampollosas/patología , Glicoproteína de la Espiga del Coronavirus/aislamiento & purificación , Trombosis/tratamiento farmacológico , Trombosis/inmunología , Trombosis/patología , Adulto JovenRESUMEN
We report a 7-year-old boy who presented with a nodule on the upper lip. A previous clinical history of mechanical trauma in the lesional area had been noted. After surgical excision, microscopy revealed fibrocollagenous fascicles associated with neurovascular bundles and skeletal striated muscle fibers in diffuse subepithelial distribution, suggesting rhabdomyomatous mesenchymal hamartoma. However, strict clinicopathological correlation favored a healing process with trapped striated skeletal muscle tissue. After three years of follow-up, an improvement in the aesthetic appearance of the upper lip was observed. To the best of our knowledge, a case of pseudo-rhabdomyomatous mesenchymal hamartoma has not been reported to date.
Asunto(s)
Hamartoma/patología , Enfermedades de los Labios/patología , Labio/patología , Rabdomioma/patología , Niño , Diagnóstico Diferencial , Hamartoma/diagnóstico , Humanos , Enfermedades de los Labios/diagnóstico , Neoplasias de los Labios/diagnóstico , Neoplasias de los Labios/patología , Masculino , Rabdomioma/diagnósticoAsunto(s)
Granuloma de Cuerpo Extraño/diagnóstico , Enfermedades de los Labios/diagnóstico , Mucosa Bucal/patología , Sarcoidosis/complicaciones , Femenino , Granuloma de Cuerpo Extraño/inmunología , Granuloma de Cuerpo Extraño/patología , Granuloma de Cuerpo Extraño/cirugía , Humanos , Enfermedades de los Labios/inmunología , Enfermedades de los Labios/patología , Enfermedades de los Labios/cirugía , Persona de Mediana Edad , Mucosa Bucal/inmunología , Mucosa Bucal/cirugía , Sarcoidosis/inmunología , Resultado del TratamientoAsunto(s)
Enfermedades de los Labios/diagnóstico , Hepatopatías/diagnóstico , Linfadenopatía/diagnóstico por imagen , Sarcoidosis/diagnóstico , Abdomen , Adolescente , Fosfatasa Alcalina/sangre , Antiinflamatorios/uso terapéutico , Anticuerpos Antinucleares/sangre , Antirreumáticos/uso terapéutico , Edema/etiología , Femenino , Humanos , Labio/patología , Enfermedades de los Labios/tratamiento farmacológico , Enfermedades de los Labios/patología , Hígado/diagnóstico por imagen , Hepatopatías/sangre , Hepatopatías/tratamiento farmacológico , Pruebas de Función Hepática , Ganglios Linfáticos/diagnóstico por imagen , Linfadenopatía/tratamiento farmacológico , Mediastino , Metotrexato/uso terapéutico , Prednisolona/uso terapéutico , Sarcoidosis/complicaciones , Sarcoidosis/tratamiento farmacológico , Sarcoidosis/patología , Tomografía Computarizada por Rayos X , UltrasonografíaRESUMEN
Lymphoepithelial-like carcinoma (LEC) is a rare malignant neoplasm, which can be associated with Epstein-Barr virus (EBV) infection. Histologically, LEC is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. LEC appears to be an uncommon tumor type of lip carcinoma. An 82-year-old white woman presented a lesion on her lower lip that developed over the last year. The lesion was characterized by ulceration with flat edges, hardened base, painful, and absence of regional lymphadenopathy. Microscopical analysis evidenced an intense inflammatory infiltrate, composed of lymphoplasmacytic cells, associated with scarce pleomorphic epithelial cells. Immunohistochemistry highlighted the LEC cells with strong expression of pan-CK AE1/AE3, EMA, p63, and p53. CD138 was also faintly positive. Ki-67 was >85%. In situ hybridization analysis did not show evidence of EBV. A diagnostic of EBV-negative LEC was made. We present an uncommon type of lip carcinoma, which can represent a diagnostic challenge for clinicians and pathologists.