Asunto(s)
Herpes Zóster/diagnóstico , Enfermedades de la Lengua/diagnóstico , Enfermedades de la Lengua/virología , Anciano , Antivirales/uso terapéutico , Diagnóstico Diferencial , Servicio de Urgencia en Hospital , Femenino , Cefalea , Herpes Zóster/tratamiento farmacológico , Humanos , Enfermedades de la Lengua/tratamiento farmacológicoAsunto(s)
Úlceras Bucales/virología , Enfermedades de la Lengua/virología , Lengua/patología , Anciano , Infecciones por Citomegalovirus , Complicaciones de la Diabetes , Glucocorticoides/administración & dosificación , Humanos , Fallo Renal Crónico/complicaciones , Masculino , Poliangitis Microscópica/complicaciones , Poliangitis Microscópica/tratamiento farmacológico , Úlceras Bucales/patología , Enfermedades de la Lengua/patologíaRESUMEN
To date, there have been no reports of coinfection with bovine papular stomatitis virus (BPSV) and bovine papillomavirus (BPV) in the same lesion. In the present study, one lingual papilloma-like sample was collected at an abattoir from the tongue of a 31-month-old Japanese black cow. Coinfection with BPSV and BPV was confirmed by histopathology, immunohistochemistry, PCR and RT-PCR. The evidence for coinfection with BPSV and BPV in the same lesion and an association of BPV with lingual papillomatosis will contribute to future epidemiological studies of these two viruses.
Asunto(s)
Papillomavirus Bovino 1/aislamiento & purificación , Coinfección/veterinaria , Infecciones por Papillomavirus/complicaciones , Parapoxvirus/aislamiento & purificación , Infecciones por Poxviridae/complicaciones , Enfermedades de la Lengua/virología , Animales , Bovinos , Coinfección/virología , Papiloma/veterinaria , Papiloma/virología , Infecciones por Papillomavirus/veterinaria , Infecciones por Papillomavirus/virología , Infecciones por Poxviridae/veterinaria , Infecciones por Poxviridae/virología , Lengua/virología , Enfermedades de la Lengua/veterinariaRESUMEN
RESUMEN: El objetivo de este estudio fue reportar un caso clínico donde se realizó el manejo quirúrgico de múltiples condilomas de la mucosa oral en un paciente infectado por Virus de Inmunodeficiencia Humana (VIH) bajo Terapia Antirretroviral de Gran Actividad (TARGA). Hombre de 58 años en tratamiento por infección con VIH en TARGA hace 17 años, que acude al Servicio de Cirugía Maxilofacial del Hospital Barros Luco-Trudeau con múltiples lesiones verruciformes ubicadas en margen y cara dorsal de lengua, cara interna de ambas mejillas y labio inferior. Se realizó escisión quirúrgica de las lesiones de labio, cara dorsal de lengua y cara interna de mejilla del lado derecho, obteniéndose el diagnóstico histopatológico de condiloma. Tras 2 meses de realizar la cirugía se obtuvo recurrencia. La recurrencia de las lesiones puede originarse por la recrudescencia del virus latente adyacente al lecho quirúrgico y, por ello, deben considerarse otras alternativas de tratamiento. Por el impacto en la función, estética, potencial de contagio y malignización, es necesario su tratamiento.
ABSTRACT: The objective of this study was to report a clinical case in which surgical management of multiple condylomas in the oral mucosa was performed in a patient infected by Human Immunodeficiency Virus (HIV) who is under highly active antiretroviral therapy (HAART). A 58-yearold man, under HAART for 17 years for HIV infection, was admitted at the Maxillofacial Surgery Service at the Hospital Barros Luco-Trudeau as he was experiencing multiple verrucous lesions located on the lateral margin and dorsum of the tongue, as well as on the inner face of both cheeks and the lower lip. A surgical excision of the lesions on the lip, dorsum of the tongue and inner face of the right cheek was performed, where the histopathological diagnosis of condyloma was obtained. There was a recurrence two months after surgery. Recurrence of the lesions may be due to the recrudescence of the latent virus adjacent to the surgical bed and, therefore, other treatment alternatives should be considered. Treatment is necessary due to the impact on the function, aesthetics, and the potential to become contagious and malignant.
Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Enfermedades de la Lengua/virología , Condiloma Acuminado/virología , Terapia Antirretroviral Altamente Activa/métodos , Fotomicrografía , Condiloma Acuminado/cirugía , Condiloma Acuminado/diagnóstico , Infecciones por VIH/virología , Mucosa Bucal/virologíaRESUMEN
Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) is a newly described entity occurring in elderly or iatrogenically immunocompromised patients. We describe a case of EBVMCU arising in a post-hematopoietic cell transplant patient and followed by EBV-positive polymorphic posttransplant lymphoproliferative disorder (EBV+ polymorphic PTLD). The patient, a 52-year-old woman, received chemotherapy and autologous peripheral blood stem cell transplantation for relapsed diffuse large B-cell lymphoma (DLBCL). She achieved complete remission and was followed up in an outpatient clinic after discharge. One year later, EBVMCU appeared in the tongue and exhibited spontaneous regression. Six months after the regression of the EBVMCU, she had EBV+ polymorphic PTLD, analogous to EBV+ polymorphic DLBCL. The therapy for PTLD was not effective, and the patient finally died of disease progression. This was the first case of EBVMCU characterized by both an association with autologous peripheral blood stem cell transplantation and subsequent emergence of malignant lymphoma in a patient with relapsed DLBCL.
Asunto(s)
Colitis Ulcerosa/virología , Infecciones por Citomegalovirus/virología , Infecciones por Virus de Epstein-Barr/virología , Trasplante de Células Madre Hematopoyéticas/efectos adversos , Herpesvirus Humano 4/aislamiento & purificación , Linfoma de Células B Grandes Difuso/cirugía , Trastornos Linfoproliferativos/virología , Infecciones Oportunistas/virología , Enfermedades de la Lengua/virología , Úlcera/virología , Biopsia , Colitis Ulcerosa/diagnóstico , Colitis Ulcerosa/inmunología , Infecciones por Citomegalovirus/diagnóstico , Infecciones por Citomegalovirus/inmunología , Progresión de la Enfermedad , Infecciones por Virus de Epstein-Barr/diagnóstico , Infecciones por Virus de Epstein-Barr/tratamiento farmacológico , Infecciones por Virus de Epstein-Barr/inmunología , Resultado Fatal , Femenino , Herpesvirus Humano 4/genética , Humanos , Huésped Inmunocomprometido , Inmunohistoquímica , Inmunosupresores/efectos adversos , Hibridación in Situ , Linfoma de Células B Grandes Difuso/diagnóstico , Trastornos Linfoproliferativos/diagnóstico , Trastornos Linfoproliferativos/tratamiento farmacológico , Trastornos Linfoproliferativos/inmunología , Persona de Mediana Edad , Infecciones Oportunistas/diagnóstico , Infecciones Oportunistas/inmunología , Reacción en Cadena de la Polimerasa , ARN Viral/genética , Recurrencia , Factores de Tiempo , Enfermedades de la Lengua/diagnóstico , Enfermedades de la Lengua/inmunología , Úlcera/diagnóstico , Úlcera/inmunologíaRESUMEN
OBJECTIVES/HYPOTHESIS: To report the clinical presentation, treatment, and management outcomes of patients with Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) of the head and neck, which is a newly characterized pathologic entity with aggressive morphology but follows an indolent, self-limiting clinical course. STUDY DESIGN: Case report and literature review. METHODS: A case of EBVMCU of the base of tongue is reported and a retrospective review of all cases of EBVMCU of the head and neck at a single academic institution was conducted between January 1, 1986 and April 1, 2015. The MEDLINE database was additionally queried from January 1, 1950 to April 1, 2015 for all reports of EBVMCU of the head and neck, and all pertinent clinical data were extracted. RESULTS: The clinical presentation, treatment, and response of a patient with EBVMCU of the base of tongue are presented. Interim follow-up of the patient has revealed a complete remission with discontinuation of immunosuppression and rituximab therapy. A review of the literature supports conservative management and reduction of immunosuppression. Overall, 96.6% of patients with follow-up greater than 2 months achieved complete remission with conservative management. The current study is the largest series to report on the clinical presentation and treatment outcomes of EBVMCU of the head and neck. CONCLUSIONS: EBVMCU tends to follow an indolent and self-limiting clinical course, responding to reduction of immunosuppression and conservative treatment. It is imperative for clinicians to consider EBVMCU in the differential diagnosis of mucocutaneous ulcers of the head and neck to avoid excessive treatment. LEVEL OF EVIDENCE: Laryngoscope, 126:2500-2504, 2016.
Asunto(s)
Infecciones por Virus de Epstein-Barr/complicaciones , Herpesvirus Humano 4 , Úlceras Bucales/virología , Enfermedades de la Lengua/virología , Anciano , Infecciones por Virus de Epstein-Barr/virología , Femenino , HumanosAsunto(s)
Enfermedades de los Nervios Craneales/diagnóstico , Enfermedades de los Nervios Craneales/virología , Infecciones por Virus de Epstein-Barr/complicaciones , Infecciones por Virus de Epstein-Barr/diagnóstico , 2-Aminopurina/análogos & derivados , 2-Aminopurina/uso terapéutico , Adulto , Aminoquinolinas/uso terapéutico , Antivirales/uso terapéutico , Atrofia , Inhibidores de la Colinesterasa/uso terapéutico , Enfermedades de los Nervios Craneales/tratamiento farmacológico , Infecciones por Virus de Epstein-Barr/tratamiento farmacológico , Famciclovir , Humanos , Masculino , Enfermedades de la Lengua/patología , Enfermedades de la Lengua/virología , Resultado del TratamientoAsunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/inmunología , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Células Dendríticas/inmunología , Herpes Simple/inmunología , Enfermedades de la Lengua/inmunología , Síndrome de Inmunodeficiencia Adquirida/inmunología , Adulto , Antígenos CD/inmunología , Antígenos CD1/inmunología , Femenino , VIH-1 , Herpes Simple/complicaciones , Humanos , Inmunoglobulinas/inmunología , Masculino , Glicoproteínas de Membrana/inmunología , Persona de Mediana Edad , Enfermedades de la Lengua/virología , Antígeno CD83RESUMEN
OBJECTIVE: The aim of this study was to evaluate cases of oral epithelial dysplasia for biologically significant human papillomavirus (HPV) infection. STUDY DESIGN: Forty consecutive cases of high-grade dysplasia and 37 cases of low-grade dysplasia were examined for p16(INK4a) expression by immunohistochemistry. High-risk HPV infection was assessed in p16-positive cases using in situ hybridization. Proliferation index was assessed with MIB-1 immunohistochemistry. RESULTS: Eleven of 40 high-grade dysplasias and one of 37 low-grade dysplasias were p16 positive. High-risk HPV was detected in seven cases of p16-positive high-grade dysplasia. The difference between high- and low-grade dysplasia was statistically significant (P = .01). HPV-positive high-grade dysplasias showed a distinctive histologic appearance and MIB-1 labeling pattern. Most high-risk HPV-positive cases were seen in the floor of mouth. CONCLUSION: High-risk HPV was associated with a subset of cases of severe epithelial dysplasia/carcinoma in situ that demonstrated diffuse loss of squamous differentiation and a high proliferation index.
Asunto(s)
Alphapapillomavirus/fisiología , Enfermedades de la Boca/virología , Mucosa Bucal/virología , Infecciones por Papillomavirus/virología , Infecciones Tumorales por Virus/virología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma in Situ/virología , Estudios de Casos y Controles , Diferenciación Celular , Proliferación Celular , Inhibidor p16 de la Quinasa Dependiente de Ciclina/análisis , Femenino , Papillomavirus Humano 16/fisiología , Papillomavirus Humano 18 , Papillomavirus Humano 6/fisiología , Humanos , Antígeno Ki-67/análisis , Masculino , Persona de Mediana Edad , Suelo de la Boca/virología , Neoplasias de la Boca/virología , Lesiones Precancerosas/virología , Estudios Retrospectivos , Factores de Riesgo , Enfermedades de la Lengua/virología , Adulto JovenRESUMEN
AIMS: To quantify and compare the expression of Langerhans cells (LCs) in the tongue mucosa of AIDS patients with different opportunistic infections, and from acquired immune deficiency syndrome (AIDS) and non-AIDS patients with normal tongues, using autopsy material. METHODS AND RESULTS: Human leucocyte antigen D-related (HLA-DR), CD1a and CD83 antibodies were used to identify and quantify LCs by immunohistochemistry in tongue tissue of 40 AIDS patients (10 with lingual candidiasis, 10 with lingual herpes, 10 with oral hairy leukoplakia and 10 with no lesions) and 23 tongues from human immunodeficiency virus (HIV)-negative control patients. Quantification was performed by means of conventional morphometry in four different regions (anterior, middle, posterior and lateral) of the tongue. The results were expressed as positive cells per area of epithelium. The AIDS patients presented a lower density of CD1a(+) cells (P < 0.001), HLA-DR (P < 0.003) and CD83 (P < 0.001) in all regions of the tongue compared to the non-AIDS control group. However, no differences in any of the markers were found when AIDS patients with different opportunistic infections were compared with AIDS patients without tongue infection. CONCLUSIONS: Advanced stage AIDS patients showed a depletion of LCs in the tongue mucosa. HIV infection induces cytopathic changes in LCs, contributing to their depletion regardless of the presence of oral infections.
Asunto(s)
Infecciones Oportunistas Relacionadas con el SIDA/patología , Síndrome de Inmunodeficiencia Adquirida/patología , Células de Langerhans/patología , Enfermedades de la Lengua/patología , Lengua/patología , Infecciones Oportunistas Relacionadas con el SIDA/virología , Síndrome de Inmunodeficiencia Adquirida/complicaciones , Adulto , Anciano , Antígenos CD/metabolismo , Biomarcadores/metabolismo , Candidiasis/microbiología , Candidiasis/patología , Femenino , Herpes Labial/patología , Herpes Labial/virología , Humanos , Células de Langerhans/metabolismo , Células de Langerhans/virología , Leucoplasia Vellosa/patología , Leucoplasia Vellosa/virología , Masculino , Mucosa Bucal/patología , Mucosa Bucal/virología , Enfermedades de la Lengua/metabolismo , Enfermedades de la Lengua/virologíaRESUMEN
Gingivostomatitis is the most common primary and symptomatic clinical manifestation of HSV-1 infection. Painful oral lesions appear as ulcerative erosions on the gingiva, palate, buccal mucosa, and tongue, leading to eating and drinking difficulties with an evolution between 10-14 days. This paper describes a case of a 19-month-old boy with severe painful Gingivostomatitis lesions. Low level laser therapy (LLLT) was used with an immediate outcome.
Asunto(s)
Terapia por Luz de Baja Intensidad/métodos , Estomatitis Herpética/radioterapia , Estudios de Seguimiento , Humanos , Lactante , Láseres de Semiconductores/uso terapéutico , Enfermedades de los Labios/radioterapia , Enfermedades de los Labios/virología , Masculino , Úlceras Bucales/radioterapia , Úlceras Bucales/virología , Enfermedades de la Lengua/radioterapia , Enfermedades de la Lengua/virología , Resultado del TratamientoRESUMEN
Posttransplant lymphoproliferative disorders are a group of lymphoid proliferations and lymphomas that develop as a consequence of immunosuppression in recipients of solid organ or bone marrow allografts. We describe an unusual oral presentation of posttransplant Epstein-Barr virus-associated diffuse large B-cell lymphoma in a 45-year-old woman after pancreatic transplant.
Asunto(s)
Infecciones por Virus de Epstein-Barr/diagnóstico , Linfoma de Células B/virología , Linfoma de Células B Grandes Difuso/virología , Neoplasias de la Boca/virología , Úlceras Bucales/virología , Trasplante de Páncreas , Enfermedades de la Lengua/virología , Diagnóstico Diferencial , Infecciones por Virus de Epstein-Barr/etiología , Infecciones por Virus de Epstein-Barr/virología , Femenino , Herpesvirus Humano 4/aislamiento & purificación , Humanos , Inmunosupresores/efectos adversos , Linfoma de Células B/diagnóstico , Linfoma de Células B Grandes Difuso/diagnóstico , Persona de Mediana Edad , Neoplasias de la Boca/diagnóstico , Úlceras Bucales/diagnóstico , ARN Viral/análisis , Sirolimus/efectos adversos , Enfermedades de la Lengua/diagnósticoRESUMEN
BACKGROUND: A variety of different human papillomavirus (HPV) types can be found in benign and malignant lesions of the upper aerodigestive tract. Therefore a broad-spectrum assay is needed for screening reasons. METHODS: A PCR system with degenerate consensus primers originating from a very conserved region (e.g. L1) of the HPV genome was applied. The sensitivity level was improved by combining PCR and nested PCR. RESULTS: A total of 27 biopsies from laryngeal papillomas (9), exophytic (3) and inverted (6) papillomas of the nasal cavity or paranasal sinuses, papillomas of the uvula or soft palate (5), leukoplakias of the larynx (2), seborrheic keratosis (1) and granulation tumor of the tongue (1) were analyzed by the broad-spectrum PCR system. Sixteen cases showed a positive result in either PCR or nested PCR or both. CONCLUSIONS: It was shown that the applied broad-spectrum PCR system is a reliable tool in the detection of HPV DNA in benign lesions of the upper aerodigestive tract.