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OBJECTIVES/HYPOTHESIS: This study aimed to evaluate the prevalence of peripheral vestibular disorders in an Asian population of predominantly Han Chinese ethnicity. STUDY DESIGN: Cross-sectional study. METHODS: Patients with a peripheral vertigo disorder were identified from the Taiwan Health Insurance Research Database, a database of all medical claims of a randomly selected, population-representative sample of 2 million enrollees of Taiwan's National Health Insurance system covering over 99% of Taiwan's citizens. In 2016, 59,986 patients received a diagnosis of peripheral vestibular disorders in Taiwan. We calculated the population-wide prevalence rates of peripheral vestibular disorders in 2016 by sex and age group (20 to 24, 25 to 29, 30 to 34, 35 to 39, 40 to 44, 45 to 49, 50 to 54, 55 to 59, 60 to 64, 65 to 69, and ≥ 70 years) stratified into five urbanization levels. RESULTS: The prevalence rate of peripheral vestibular disorders was 2,833.4 per 100,000 population during the year. Prevalence of Meniere's disease was 70.4 per 100,000, benign paroxysmal positional vertigo, 446.4, vestibular neuritis 307.2, and other or unspecified peripheral vestibular dizziness, 2,009.5 per 100,000. Prevalence rates steadily increased with age for every type of peripheral vestibular disorder, and were higher among females compared to males. The female-to-male gender ratios were 1.84, 1.89, and 1.93 for Meniere's disease, vestibular neuritis, and other peripheral vestibular dizziness, respectively. Counties with the lowest urbanization level had the highest prevalence rates of all types of peripheral vestibular disorders except vestibular neuritis. CONCLUSIONS: Results showed that peripheral vestibular disorders are common in Taiwan, increase with age, are predominantly female, and show higher prevalence in rural areas. LEVEL OF EVIDENCE: 2b Laryngoscope, 131:639-643, 2021.
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Pueblo Asiatico/estadística & datos numéricos , Población Rural/estadística & datos numéricos , Población Urbana/estadística & datos numéricos , Enfermedades Vestibulares/epidemiología , Adulto , Distribución por Edad , Anciano , Pueblo Asiatico/etnología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Distribución por Sexo , Taiwán/epidemiología , Enfermedades Vestibulares/etnología , Adulto JovenRESUMEN
OBJECTIVE: To generate an Arabic version of the Dizziness Handicap Inventory (DHI), and to assess its reliability by applying it to a group of patients with vestibular disorders and control healthy subjects of Arabic origin. METHODS: The Arabic version of the DHI was developed using the standard protocol for test translation. This pilot study was carried out between January 2009 and January 2011 at the Otology/Neurotology Clinic at King Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia. The translated version was then tested using 50 patients with vestibular disorders, and 50 control subjects. Participants` responses were statistically analyzed for internal consistency within and between the patient and control groups. RESULTS: An Arabic DHI showed a significantly high internal consistency and reliability. Cronbach`s alpha coefficient with 95% confidence interval for functional score among patients was 0.87 (0.81-0.92), 0.81 (0.72-0.88) for physical score, 0.79 (0.69-0.87) for emotional score, and 0.92 (0.89-0.95) for the overall DHI score. A significant difference was found in domain scores and total DHI score between the dizzy and control groups (p=0.00). CONCLUSION: The Arabic version of the DHI is a valid and reliable self-assessment tool for the severity of vestibular disorders.
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Árabes , Evaluación de la Discapacidad , Mareo/diagnóstico , Encuestas y Cuestionarios/normas , Enfermedades Vestibulares/diagnóstico , Adulto , Características Culturales , Mareo/etnología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Proyectos Piloto , Reproducibilidad de los Resultados , Enfermedades Vestibulares/etnologíaRESUMEN
PURPOSE: Usher syndrome (USH) is a rare autosomal recessive disorder characterized by deafness and retinitis pigmentosa. The purpose of this study was to determine the genetic cause of USH in a four generation Indian family. METHODS: Peripheral blood samples were collected from individuals for genomic DNA isolation. To determine the linkage of this family to known USH loci, microsatellite markers were selected from the candidate regions of known loci and used to genotype the family. Exon specific intronic primers for the MYO7A gene were used to amplify DNA samples from one affected individual from the family. PCR products were subsequently sequenced to detect mutation. PCR-SSCP analysis was used to determine if the mutation segregated with the disease in the family and was not present in 50 control individuals. RESULTS: All affected individuals had a classic USH type I (USH1) phenotype which included deafness, vestibular dysfunction and retinitis pigmentosa. Pedigree analysis suggested an autosomal recessive mode of inheritance of USH in the family. Haplotype analysis suggested linkage of this family to the USH1B locus on chromosome 11q. DNA sequence analysis of the entire coding region of the MYO7A gene showed a novel insertion mutation c.2663_2664insA in a homozygous state in all affected individuals, resulting in truncation of MYO7A protein. CONCLUSIONS: This is the first study from India which reports a novel MYO7A insertion mutation in a four generation USH family. The mutation is predicted to produce a truncated MYO7A protein. With the novel mutation reported here, the total number of USH causing mutations in the MYO7A gene described to date reaches to 75.