RESUMEN
A rabbit model of endophthalmitis was established to evaluate the antiinflammatory effect of low-level laser therapy (LLLT) as an adjunct to treatment for Staphylococcus epidermidis endophthalmitis. Rabbits were randomly divided into three groups to receive intravitreal injections into their left eye: group A received 0.5 mg vancomycin (100 µl), group B received 0.5 mg vancomycin + 0.2 mg dexamethasone (100 µl), and group C received 0.5 mg vancomycin (100 µl) and continuous wave semiconductor laser irradiation (10 mW, λ = 632 nm) focused on the pupil. Slit lamp examination and B-mode ultrasonography were conducted to evaluate the symptoms of endophthalmitis. Polymorphonuclear cells and tumour necrosis factor alpha (TNF-α) in aqueous fluid were measured at 0 h, and 1, 2, 3, 7 and 15 days. A histology test was conducted at 15 days. B-mode ultrasonography and histology revealed that groups B and C had less inflammation than group A at 15 days. Groups B and C had fewer polymorphonuclear cells and lower levels of TNF-α in aqueous fluid than group A at 2, 3 and 7 days (P < 0.05). There was no significant difference between groups B and C (P > 0.05). There was no significant difference between groups A, B and C at 15 days (P > 0.05). As an adjunct to vancomycin therapy to treat S. epidermidis endophthalmitis, LLLT has an antiinflammatory effect similar to that of dexamethasone.
Asunto(s)
Endoftalmitis/radioterapia , Terapia por Luz de Baja Intensidad , Infecciones Estafilocócicas/radioterapia , Staphylococcus epidermidis , Animales , Terapia Combinada , Dexametasona/administración & dosificación , Endoftalmitis/diagnóstico por imagen , Endoftalmitis/tratamiento farmacológico , Endoftalmitis/patología , Láseres de Semiconductores/uso terapéutico , Conejos , Infecciones Estafilocócicas/diagnóstico por imagen , Infecciones Estafilocócicas/tratamiento farmacológico , Infecciones Estafilocócicas/patología , Factor de Necrosis Tumoral alfa/metabolismo , Ultrasonografía , Vancomicina/administración & dosificaciónRESUMEN
We report a 61-year-old who developed candidemia following pancreatic tumor surgery, and presented with bilateral multifocal chorioretinitis and vitritis. Chorioretinal lesions regressed with fluconazole therapy. Pars plana vitrectomy was performed with resultant improved visual acuity, but vitritis recurred with the next chemotherapy session. With the cessation of chemotherapy, vitritis regressed without any systemic treatment.